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Research Article

Clinical Aspects of Round Window Membrane Permeability Under Normal and Pathological Conditions

Pages 437-447 | Published online: 08 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (20)

Susbin R Wagle, Corina M Ionescu, Bozica Kovacevic, Melissa Jones, Thomas Foster, Patrick Lim, Michael Lewkowicz, Maja Ðanić, Momir Mikov, Armin Mooranian & Hani Al-Salami. (2023) Pharmaceutical Characterization of Probucol Bile Acid–Lithocholic Acid Nanoparticles to Prevent Chronic Hearing Related and Similar Cellular Oxidative Stress Pathologies. Nanomedicine 18:12, pages 923-940.
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Michael Lewkowicz, Melissa Jones, Bozica Kovacevic, Corina Mihaela Ionescu, Susbin Raj Wagle, Thomas Foster, Momir Mikov, Armin Mooranian & Hani Al-Salami. (2022) Potentials and Limitations of Pharmaceutical and Pharmacological Applications of Bile Acids in Hearing Loss Treatment. Therapeutic Delivery 13:10, pages 477-488.
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Chris Valentini, Betsy Szeto, Jeffrey W. Kysar & Anil K. Lalwani. (2020) Inner ear gene delivery: vectors and routes. Hearing, Balance and Communication 18:4, pages 278-285.
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Rahul Mittal, Stefanie A. Pena, Angela Zhu, Nicolas Eshraghi, Arian Fesharaki, Elijah J. Horesh, Jeenu Mittal & Adrien A. Eshraghi. (2019) Nanoparticle-based drug delivery in the inner ear: current challenges, limitations and opportunities. Artificial Cells, Nanomedicine, and Biotechnology 47:1, pages 1312-1320.
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Liping Zhang, Yuan Xu, Wenjuan Cao, Shibao Xie, Lu Wen & Gang Chen. (2018) Understanding the translocation mechanism of PLGA nanoparticles across round window membrane into the inner ear: a guideline for inner ear drug delivery based on nanomedicine. International Journal of Nanomedicine 13, pages 479-492.
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M. Peppi, A. Marie, C. Belline & J. T. Borenstein. (2018) Intracochlear drug delivery systems: a novel approach whose time has come. Expert Opinion on Drug Delivery 15:4, pages 319-324.
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Rachael T. Richardson, Alexander C. Thompson, Andrew K. Wise & Karina Needham. (2017) Challenges for the application of optical stimulation in the cochlea for the study and treatment of hearing loss. Expert Opinion on Biological Therapy 17:2, pages 213-223.
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Kim Nguyen, Judith S. Kempfle, David H. Jung & Charles E. McKenna. (2017) Recent advances in therapeutics and drug delivery for the treatment of inner ear diseases: a patent review (2011-2015). Expert Opinion on Therapeutic Patents 27:2, pages 191-202.
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Yue Zhang, Huanpeng Su, Lu Wen, Fan Yang & Gang Chen. (2016) Mathematical modeling for local trans-round window membrane drug transport in the inner ear. Drug Delivery 23:8, pages 3082-3087.
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Meng Bu, Jingling Tang, Yinghui Wei, Yanhui Sun, Xinyu Wang, Linhua Wu & Hongzhuo Liu. (2015) Enhanced bioavailability of nerve growth factor with phytantriol lipid-based crystalline nanoparticles in cochlea. International Journal of Nanomedicine 10, pages 6879-6889.
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Dong-Kee Kim, Shi-Nae Park, Kyoung-Ho Park, Chan Woo Park, Keum-Jin Yang, Jong-Duk Kim & Min-Sik Kim. (2015) Development of a drug delivery system for the inner ear using poly(amino acid)-based nanoparticles. Drug Delivery 22:3, pages 367-374.
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Andrew M Ayoob & Jeffrey T Borenstein. (2015) The role of intracochlear drug delivery devices in the management of inner ear disease. Expert Opinion on Drug Delivery 12:3, pages 465-479.
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Hui Cai, Xingxing Wen, Lu Wen, Nicola Tirelli, Xiao Zhang, Yue Zhang, Huanpeng Su, Fan Yang & Gang Chen. (2014) Enhanced local bioavailability of single or compound drugs delivery to the inner ear through application of PLGA nanoparticles via round window administration. International Journal of Nanomedicine 9, pages 5591-5601.
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Maria C Buniel, Katie Geelan-Hansen, Peter C Weber & Vincent K Tuohy. (2009) Immunosuppressive Therapy for Autoimmune Inner Ear Disease. Immunotherapy 1:3, pages 425-434.
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Tsutomu Nakashima, Shinji Naganawa, Naomi Katayama, Masaaki Teranishi, Seiichi Nakata, Makoto Sugiura, Michihiko Sone, Sachio Kasai, Mayumi Yoshioka & Masako Yamamoto. (2009) Clinical significance of endolymphatic imaging after intratympanic gadolinium injection. Acta Oto-Laryngologica 129:sup560, pages 9-14.
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Rachael T Richardson, Andrew K Wise, Jacqueline K Andrew & Stephen J O'Leary. (2008) Novel drug delivery systems for inner ear protection and regeneration after hearing loss. Expert Opinion on Drug Delivery 5:10, pages 1059-1076.
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Chia-Der Lin, Takeshi Oshima, Kiyoshi Oda, Daisuke Yamauchi, Ming-Hsui Tsai & Toshimitsu Kobayashi. (2008) Ototoxic interaction of kanamycin and 3-nitropropionic acid. Acta Oto-Laryngologica 128:12, pages 1280-1285.
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Jun Yang, Hao Wu, Ping Zhang, Dong-Ming Hou, Jie Chen & Shun-Guo Zhang. (2008) The pharmacokinetic profiles of dexamethasone and methylprednisolone concentration in perilymph and plasma following systemic and local administration. Acta Oto-Laryngologica 128:5, pages 496-504.
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Sebahattin Cureoglu, Patricia A. Schachern, Alessandra Rinaldo, Vladimir Tsuprun, Alfio Ferlito & Michael M. Paparella. (2005) Round window membrane and labyrinthine pathological changes: an overview. Acta Oto-Laryngologica 125:1, pages 9-15.
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Larbi Chelikh, Marie Teixeira, Christian Martin, Olivier Sterkers, Evelyne Ferrary & Vincent Couloigner. (2003) High Variability of Perilymphatic Entry of Neutral Molecules Through the Round Window. Acta Oto-Laryngologica 123:2, pages 199-202.
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