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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 50, 2020 - Issue 7
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ARTICLES

Synthesis and antitumor activity evaluation of some pyrrolone and pyridazinone heterocycles derived from 3-((2-oxo-5-(p-tolyl)furan-3(2H)-ylidene)methyl)quinolin-2(1H)-one

Eman A. E. El-HelwDepartment of Chemistry, Faculty of Science, Ain Shams University, Cairo, EgyptCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-5104-6170
ORCID Icon &
Ahmed I. HashemDepartment of Chemistry, Faculty of Science, Ain Shams University, Cairo, EgyptORCID Iconhttps://orcid.org/0000-0002-7524-9279
ORCID Icon
Pages 1046-1055 | Received 10 Jan 2020, Published online: 26 Feb 2020

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Amna S. Elgubbi, Abdullah Y. A. Alzahrani, Eman A. E. El-Helw & Safaa S. Shaban. (2024) Facile Synthesis and Antioxidant Activity Screening of Some Novel 3-Substituted Indole Derivatives. Polycyclic Aromatic Compounds 44:3, pages 2032-2045.
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Eman A. E. El-Helw, Aya M. Abdelrahman, Abdelgawad A. Fahmi & Sameh A. Rizk. (2023) Synthesis, Density Functional Theory, Insecticidal Activity, and Molecular Docking of Some N-Heterocycles Derived from 2-((1,3-Diphenyl-1H-Pyrazol-4-yl)Methylene)Malonyl Diisothiocyanate. Polycyclic Aromatic Compounds 43:9, pages 8265-8281.
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Youssef M. Youssef, Mohammad E. Azab, Galal A. Elsayed, Amira A. El-Sayed & Eman A. E. El-Helw. (2023) Synthesis and Antiproliferative Screening of Some Heterocycles Derived from 4-((5-Chloro-3-Methyl-1-Phenyl-1H-Pyrazol-4-yl)Methylene)-2-Phenyloxazol-5(4H)-One. Polycyclic Aromatic Compounds 43:8, pages 7152-7163.
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Sayed K. Ramadan, Hisham S. M. Abd-Rabboh, Nourhan M. Gad, Wael S. I. Abou-Elmagd & David S. A. Haneen. (2023) Synthesis and Characterization of Some Chitosan-Quinoline Nanocomposites as Potential Insecticidal Agents. Polycyclic Aromatic Compounds 43:8, pages 7013-7026.
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Aya M. Abdelrahman, Abdelgawad A. Fahmi, Eman A. E. El-Helw & Sameh A. Rizk. (2023) Facile Synthesis, Biological Evaluation, DFT Studies and in Silico Prediction ADME/Pharmacokinetics Properties of N-(1-(2-Chlorobenzo[h]Quinolin-3-yl)-1-Substituted-vin-2-yl)Benzamide Derivatives. Polycyclic Aromatic Compounds 43:7, pages 6597-6614.
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Mohamed M. Kaddah, Abdelgawad A. Fahmi, Mustafa M. Kamel, Sameh A. Rizk & Sayed K. Ramadan. (2023) Rodenticidal Activity of Some Quinoline-Based Heterocycles Derived from Hydrazide–Hydrazone Derivative. Polycyclic Aromatic Compounds 43:5, pages 4231-4241.
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Youssef M. Youssef, Mohammad E. Azab, Galal A. Elsayed, Amira A. El-Sayed, Aya I. Hassaballah & Eman A. E. El-Helw. (2023) Synthesis and antioxidant activity of some pyrazole-based heterocycles using a 2(3H)-furanone building block. Synthetic Communications 53:5, pages 402-413.
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Aya M. Abdelrahman, Abdelgawad A. Fahmi, Sameh A. Rizk & Eman A. E. El-Helw. (2023) Synthesis, DFT and Antitumor Activity Screening of Some New Heterocycles Derived from 2,2'-(2-(1,3-Diphenyl-1H-Pyrazol-4-yl)Ethene-1,1-Diyl)Bis(4H-Benzo[d][1,3]Oxazin-4-One). Polycyclic Aromatic Compounds 43:1, pages 721-739.
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Amena Ali, Abuzer Ali, Salahuddin, Mohammad Afroz Bakht & Mohamed Jawed Ahsan. (2022) Synthesis and Biological Evaluations of N-(4-Substituted Phenyl)-7-Hydroxy-4-Methyl-2-Oxoquinoline-1(2H)-Carbothioamides. Polycyclic Aromatic Compounds 42:8, pages 4910-4921.
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Mohamed M. Kaddah, Alaa R. I. Morsy, Abdelgawad A. Fahmi, Mustafa M. Kamel, Mounir M. Elsafty, Sameh A. Rizk & Sayed K. Ramadan. (2021) Synthesis and biological activity on IBD virus of diverse heterocyclic systems derived from 2-cyano-N'-((2-oxo-1,2-dihydroquinolin-3-yl)methylene)acetohydrazide. Synthetic Communications 51:22, pages 3366-3378.
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Sayed K. Ramadan, Nasser A. Ibrahim, Sarah A. El-Kaed & Eman A. E. El-Helw. (2021) New potential fungicides pyrazole-based heterocycles derived from 2-cyano-3-(1,3-diphenyl-1H-pyrazol-4-yl) acryloyl isothiocyanate. Journal of Sulfur Chemistry 42:5, pages 529-546.
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Azza A. El-Badawy, Amna S. Elgubbi & Eman A. E. El-Helw. (2021) Acryloyl isothiocyanate skeleton as a precursor for synthesis of some novel pyrimidine, triazole, triazepine, thiadiazolopyrimidine and acylthiourea derivatives as antioxidant agents. Journal of Sulfur Chemistry 42:3, pages 295-307.
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Nourhan M. Gad, Wael S. I. Abou-Elmagd, David S. A. Haneen & Sayed K. Ramadan. (2021) Reactivity of 5-phenyl-3-[(2-chloroquinolin-3-yl)methylene] furan-2(3H)-one towards hydrazine and benzylamine: A comparative study. Synthetic Communications 51:9, pages 1384-1397.
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P. Manikandan, M. Kumar, S. Chithra, A. Jeelani, Jamal M. Khaled, Ghulam Abbas & S. Muthu. (2023) Molecular structure solvent–solute, electronic, topology and dynamics simulation studies on 2-[[1-(cyclopropyl methoxy)-4-hydroxy-2-oxoquinoline-3-carbonyl] amino] acetic acid- an effective CKD drug. Journal of Molecular Liquids 391, pages 123251.
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Youssef M. Youssef, Mohammad E. Azab, Galal A. Elsayed, Amira A. El-Sayed, Aya I. Hassaballah, Mounir M. El-Safty, Reem A. Soliman & Eman A. E. El-Helw. (2023) Synthesis and antioxidant, antimicrobial, and antiviral activity of some pyrazole-based heterocycles using a 2(3H)-furanone derivative. Journal of the Iranian Chemical Society 20:9, pages 2203-2216.
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Austin C. Durham, Cindy R. Liu & Yi‐Ming Wang. (2023) Iron‐Mediated C−H Functionalization of Unactivated Alkynes for the Synthesis of Derivatized Dihydropyrrolones: Regioselectivity Under Thermodynamic Control. Chemistry – A European Journal 29:45.
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Yi Jiang, Jiayi Gu, Wenxing Nie, Guoqing Lu, Meixiu Xin, Zefeng Zhu, Jiayao Jiang, Yingfen Meng, Hui Miao & Yong Zou. (2022) Copper‐Catalyzed C(sp 2 )−N Coupling of ( E )‐3‐(2‐Bromophenysl)‐2‐arylacrylamides for the Synthesis of 3‐Arylquinolin‐2‐ones . ChemistrySelect 7:47.
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Fouad El Kalai, Cheriyan Ebenezer, Mustapha Bouatia, Rajadurai Vijay Solomon, Yann Bretonniere, Mustapha Allali, Noureddine Benchat & Khalid Karrouchi. (2022) Exploring the optical properties of novel pyridazin-3(2H)-one derivatives - A combined experimental and computational study. Chemical Data Collections 41, pages 100921.
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Sayed K. Ramadan, Doaa R. Abdel Haleem, Hisham S. M. Abd-Rabboh, Nourhan M. Gad, Wael S. I. Abou-Elmagd & David S. A. Haneen. (2022) Synthesis, SAR studies, and insecticidal activities of certain N-heterocycles derived from 3-((2-chloroquinolin-3-yl)methylene)-5-phenylfuran-2(3 H )-one against Culex pipiens L. larvae . RSC Advances 12:22, pages 13628-13638.
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Sayed K. Ramadan & Sameh A. Rizk. (2021) Synthesis, density functional theory, and cytotoxic activity of some heterocyclic systems derived from 3-(3-(1,3-diphenyl-1H-pyrazol-4-yl)acryloyl)-2H-chromen-2-one. Journal of the Iranian Chemical Society 19:1, pages 187-201.
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Eman A. Ghareeb, Naglaa F.H. Mahmoud, Eman A. El-Bordany & Eman A.E. El-Helw. (2021) Synthesis, DFT, and eco-friendly insecticidal activity of some N-heterocycles derived from 4-((2-oxo-1,2-dihydroquinolin-3-yl)methylene)-2-phenyloxazol-5(4H)-one. Bioorganic Chemistry 112, pages 104945.
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Eman A. E. El‐Helw, Alaa R. I. Morsy & Ahmed I. Hashem. (2021) Evaluation of some new heterocycles bearing 2‐oxoquinolyl moiety as immunomodulator against highly pathogenic avian influenza virus ( H 5 N 8 ) . Journal of Heterocyclic Chemistry 58:4, pages 1003-1014.
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Tang-Chang Xu, Yi-Han Lu, Jun-Fei Wang, Zhi-Qiang Song, Ya-Ge Hou, Si-Si Liu, Chuan-Sheng Liu & Shao-Hua Wu. (2021) Bioactive Secondary Metabolites of the Genus Diaporthe and Anamorph Phomopsis from Terrestrial and Marine Habitats and Endophytes: 2010–2019. Microorganisms 9:2, pages 217.
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