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Xenobiotica
the fate of foreign compounds in biological systems
Volume 27, 1997 - Issue 1
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Research Article

Pharmacokinetics, disposition and biotransformation of [14C]-radiolabelled valsartan in healthy male volunteers after a single oral dose

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Pages 59-71 | Published online: 22 Sep 2008

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Shogo Matsumoto, Shotaro Uehara, Hidetaka Kamimura, Naoki Cho, Hiroshi Ikeda, Satoshi Maeda, Kensuke Kagiyama, Atsunori Miyata, Hiroshi Suemizu & Kazumasa Fukasawa. (2022) Selection of the candidate compound at an early stage of new drug development: retrospective pharmacokinetic and metabolic evaluations of valsartan using common marmosets. Xenobiotica 52:6, pages 613-624.
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Mohammad Abumayyaleh, Ibrahim El-Battrawy, Michael Behnes, Martin Borggrefe & Ibrahim Akin. (2020) Current Evidence of sacubitril/valsartan in the Treatment of Heart Failure With Reduced Ejection Fraction. Future Cardiology 16:4, pages 227-236.
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Imad Hanna, Natalya Alexander, Matthew H. Crouthamel, John Davis, Adrienne Natrillo, Phi Tran, Arpine Vapurcuyan & Bing Zhu. (2018) Transport properties of valsartan, sacubitril and its active metabolite (LBQ657) as determinants of disposition. Xenobiotica 48:3, pages 300-313.
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Jimmy Flarakos, Yancy Du, Timothy Bedman, Qusai Al-Share, Pierre Jordaan, Priya Chandra, Diego Albrecht, Lai Wang, Helen Gu, Heidi J. Einolf, Su-Er Huskey & James B. Mangold. (2016) Disposition and metabolism of [14C] Sacubitril/Valsartan (formerly LCZ696) an angiotensin receptor neprilysin inhibitor, in healthy subjects. Xenobiotica 46:11, pages 986-1000.
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Hakan Serbest, Sezgin Bakırdere & Seyfullah Keyf. (2016) Development of an analytical method for the determination of valsartan in commercial drug and sewage sludge samples by HPLC and evaluation of its stability under simulated gastric conditions. Journal of Liquid Chromatography & Related Technologies 39:11, pages 526-531.
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Jin Ah Jung, Soo-Yun Lee, Jung-Ryul Kim, Jae-Wook Ko, Seong Bok Jang, Su Youn Nam & Wooseong Huh. (2015) A pharmacokinetic and pharmacodynamic drug interaction between rosuvastatin and valsartan in healthy subjects. Drug Design, Development and Therapy 9, pages 745-752.
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Vijaykumar Nekkanti, Natarajan Venkatesan, Zhijun Wang & Guru V. Betageri. (2015) Improved oral bioavailability of valsartan using proliposomes: design, characterization and in vivo pharmacokinetics. Drug Development and Industrial Pharmacy 41:12, pages 2077-2088.
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Fotini Gialama & Nikos Maniadakis. (2013) Comprehensive overview: efficacy, tolerability, and cost-effectiveness of irbesartan. Vascular Health and Risk Management 9, pages 575-592.
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Adriaan A Voors, Bernard Dorhout & Peter van der Meer. (2013) The potential role of valsartan + AHU377 (LCZ696) in the treatment of heart failure. Expert Opinion on Investigational Drugs 22:8, pages 1041-1047.
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Cassandra D Benge & James A S Muldowney$suffix/text()$suffix/text(). (2012) The pharmacokinetics and pharmacodynamics of valsartan in the post-myocardial infarction population. Expert Opinion on Drug Metabolism & Toxicology 8:11, pages 1469-1482.
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Manu Kaushik & Syed M Mohiuddin. (2011) Clinical utility of valsartan in treatment of children and adolescents with high blood pressure. Adolescent Health, Medicine and Therapeutics 2, pages 97-103.
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Artavazd Tadevosyan, Eric J MacLaughlin & Vardan T Karamyan. (2011) Angiotensin II type 1 receptor antagonists in the treatment of hypertension in elderly patients: focus on patient outcomes. Patient Related Outcome Measures 2, pages 27-39.
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Jujhar Bains & William B Smith. (2011) Valsartan plus hydrochlorothiazide: a review of its use since its introduction. Expert Opinion on Pharmacotherapy 12:12, pages 1975-1984.
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Nisha B Mistry, Arne S Westheim & Sverre E Kjeldsen. (2006) The angiotensin receptor antagonist valsartan: a review of the literature with a focus on clinical trials. Expert Opinion on Pharmacotherapy 7:5, pages 575-581.
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Sverre E Kjeldsen, Hans R Brunner, Gordon T McInnes & Pelle Stolt. (2005) Valsartan in The Treatment of Hypertension. Aging Health 1:1, pages 27-36.
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Steffen Böhler, David Pittrow, Peter Bramlage & Wilhelm Kirch. (2005) Drug interactions with angiotensin receptor blockers. Expert Opinion on Drug Safety 4:1, pages 7-18.
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MC Thomas & CI Johnston. (2004) Valsartan. Journal of Drug Evaluation 2:3, pages 67-101.
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Petra A Thürmann. (2000) Valsartan: a novel angiotensin Type 1 receptor antagonist. Expert Opinion on Pharmacotherapy 1:2, pages 337-350.
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Arnaud Chiolro & Michel Burnier. (1998) Pharmacology of valsartan, an angiotensin II receptor antagonist. Expert Opinion on Investigational Drugs 7:11, pages 1915-1925.
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