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Original Articles

Effects of caffeine on human health

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Pages 1-30 | Published online: 10 Nov 2010

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (54)

Choongsung Yoo, Dante Xing, Drew E. Gonzalez, Victoria Jenkins, Kay Nottingham, Broderick Dickerson, Megan Leonard, Joungbo Ko, Megan H. Lewis, Mark Faries, Wesley Kephart, Martin Purpura, Ralf Jäger, Shawn D. Wells, Kylin Liao, Ryan Sowinski, Christopher J. Rasmussen & Richard B. Kreider. (2024) Paraxanthine provides greater improvement in cognitive function than caffeine after performing a 10-km run. Journal of the International Society of Sports Nutrition 21:1.
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Jose Antonio, Daniel E. Newmire, Jeffrey R. Stout, Brandi Antonio, Maureen Gibbons, Lonnie M. Lowery, Joseph Harper, Darryn Willoughby, Cassandra Evans, Dawn Anderson, Erica Goldstein, Jose Rojas, Matías Monsalves-Álvarez, Scott C. Forbes, Jose Gomez Lopez, Tim Ziegenfuss, Blake D. Moulding, Darren Candow, Michael Sagner & Shawn M. Arent. (2024) Common questions and misconceptions about caffeine supplementation: what does the scientific evidence really show?. Journal of the International Society of Sports Nutrition 21:1.
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Ayoob Lone, Ahmed Khalid Alnawah, Abdulaziz S Hadadi, Fahad Mohammed Alturkie, Yousef Abdullah Aldreweesh & Azam Tarek Alhedhod. (2023) Coffee Consumption Behavior in Young Adults: Exploring Motivations, Frequencies, and Reporting Adverse Effects and Withdrawal Symptoms. Psychology Research and Behavior Management 16, pages 3925-3937.
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Adila Saimaiti, Dan-Dan Zhou, Jiahui Li, Ruo-Gu Xiong, Ren-You Gan, Si-Yu Huang, Ao Shang, Cai-Ning Zhao, Hang-Yu Li & Hua-Bin Li. (2023) Dietary sources, health benefits, and risks of caffeine. Critical Reviews in Food Science and Nutrition 63:29, pages 9648-9666.
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Carolynne Martins Teixeira, Josefina Bressan, Arieta Carla Gualandi Leal, Sarah Aparecida Vieira Ribeiro, Leidjaira Lopes Juvanhol, Adriano Marçal Pimenta & Helen Hermana Miranda Hermsdorff. (2023) Higher caffeine consumption is associated with insufficient sleep time in Brazilian adults (CUME study). International Journal of Food Sciences and Nutrition 74:8, pages 836-844.
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Mohammadreza Askari, Elham Bazshahi, Nastran Payande, Tofigh Mobaderi, Noushin Fahimfar & Leila Azadbakht. (2023) Relationship between caffeine intake and small for gestational age and preterm birth: a dose-response meta-analysis. Critical Reviews in Food Science and Nutrition 0:0, pages 1-11.
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Rezvan Shaddel, Safoura Akbari-Alavijeh, Ilaria Cacciotti, Shima Yousefi, Merve Tomas, Esra Capanoglu, Ozgur Tarhan, Ali Rashidinejad, Atefe Rezaei, Mohammed Bhia & Seid Mahdi Jafari. (2022) Caffeine-loaded nano/micro-carriers: Techniques, bioavailability, and applications. Critical Reviews in Food Science and Nutrition 0:0, pages 1-26.
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Mansoureh Adel Ghahraman, Saeid Farahani & Elham Tavanai. (2022) A comprehensive review of the effects of caffeine on the auditory and vestibular systems. Nutritional Neuroscience 25:10, pages 2181-2194.
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Kinfe Woldegiorges, Abebe Belay & Alemu Kebede. (2022) Photophysical properties of levofloxacin and norfloxacin drugs and their fluorescence quenching mechanism with caffeine. Spectroscopy Letters 55:8, pages 500-513.
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Takashi Miyachi, Kyoko Nomura, Sachiko Minamizono, Kazuki Sakai, Toyoto Iwata, Yuta Sugano, Shun Sawaguchi, Kouhei Takahashi & Kazuo Mishima. (2021) Factors Associated with Insomnia Among Truck Drivers in Japan. Nature and Science of Sleep 13, pages 613-623.
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Kealey J. Wohlgemuth, Luke R. Arieta, Gabrielle J. Brewer, Andrew L. Hoselton, Lacey M. Gould & Abbie E. Smith-Ryan. (2021) Sex differences and considerations for female specific nutritional strategies: a narrative review. Journal of the International Society of Sports Nutrition 18:1.
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Tariq Ismail, Sabrina Donati-Zeppa, Saeed Akhtar, Eleonora Turrini, Anam Layla, Piero Sestili & Carmela Fimognari. (2021) Coffee in cancer chemoprevention: an updated review. Expert Opinion on Drug Metabolism & Toxicology 17:1, pages 69-85.
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Amer Mahmoud Sindiani, Yousef Khader & Zouhair Amarin. (2020) The Association Between Coffee and Tea Consumption During Pregnancy and Preterm Delivery: Case–Control Study. Journal of Multidisciplinary Healthcare 13, pages 2011-2019.
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Cicero Jonas R. Benjamim, Brian Kliszczewicz, David M. Garner, Taisy Cinthia Ferro Cavalcante, Amanda Alves Marcelino da Silva, Milana Drumond Ramos Santana & Vitor E. Valenti. (2020) Is Caffeine Recommended Before Exercise? A Systematic Review To Investigate Its Impact On Cardiac Autonomic Control Via Heart Rate And Its Variability. Journal of the American College of Nutrition 39:6, pages 563-573.
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Shareen Banga, Vikas Kumar, Sheenam Suri, Manisha Kaushal, Rasane Prasad & Sawinder Kaur. (2020) Nutraceutical Potential of Diet Drinks: A Critical Review on Components, Health Effects, and Consumer Safety. Journal of the American College of Nutrition 39:3, pages 272-286.
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Nicolas W. Clark, Adam J. Wells, Nicholas A. Coker, Erica R. Goldstein, Chad H. Herring, Tristan M. Starling-Smith, Alyssa N. Varanoske, Valeria L. G. Panissa, Jeffrey R. Stout & David H. Fukuda. (2020) The acute effects of thermogenic fitness drink formulas containing 140 mg and 100 mg of caffeine on energy expenditure and fat metabolism at rest and during exercise. Journal of the International Society of Sports Nutrition 17:1.
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Fiora Artusio, Ada Ferri, Valeria Gigante, Daniele Massella, Italo Mazzarino, Marco Sangermano, Antonello Barresi & Roberto Pisano. (2019) Synthesis of high payload nanohydrogels for the ecapsulation of hydrophilic molecules via inverse miniemulsion polymerization: caffeine as a case study. Drug Development and Industrial Pharmacy 45:12, pages 1862-1870.
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Muhammad Saeed, Muhammad Naveed, Jannat BiBi, Asghar Ali Kamboh, Lucas Phil & Sun Chao. (2019) Potential nutraceutical and food additive properties and risks of coffee: a comprehensive overview. Critical Reviews in Food Science and Nutrition 59:20, pages 3293-3319.
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Wendy C. Andersen, Michael VanSickle, Joseph Storey, Virginia Sheldon, Jack Lohne, Sherri B. Turnipseed, Terri Thomas & Mark Madson. (2019) Fast analysis of caffeinated beverages using laser diode thermal desorption mass spectrometry (LDTD-MS/MS). Food Additives & Contaminants: Part A 36:11, pages 1616-1625.
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Yoshihiro Miyake, Keiko Tanaka, Hitomi Okubo, Satoshi Sasaki & Masashi Arakawa. (2019) Maternal caffeine intake in pregnancy is inversely related to childhood peer problems in Japan: The Kyushu Okinawa Maternal and Child Health Study. Nutritional Neuroscience 22:11, pages 817-824.
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Tom M. McLellan, Lyndon A. Riviere, Kelly W. Williams, Dennis McGurk & Harris R. Lieberman. (2019) Caffeine and energy drink use by combat arms soldiers in Afghanistan as a countermeasure for sleep loss and high operational demands. Nutritional Neuroscience 22:11, pages 768-777.
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João Monteiro, Marco G. Alves, Pedro F. Oliveira & Branca M. Silva. (2019) Pharmacological potential of methylxanthines: Retrospective analysis and future expectations. Critical Reviews in Food Science and Nutrition 59:16, pages 2597-2625.
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Banu Akgün & Muhammet Arıcı. (2019) Evaluation of acrylamide and selected parameters in some Turkish coffee brands from the Turkish market. Food Additives & Contaminants: Part A 36:4, pages 548-560.
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Parthasarathi Karmakar, Srimanta Manna, Kalipada Maiti, Syed Samim Ali, Uday Narayan Guria, Ripon Sarkar, Pallab Datta, Debasish Mandal & Ajit Kumar Mahapatra. (2019) A Perylene diimide based fluorescent probe for caffeine in aqueous medium. Supramolecular Chemistry 31:1, pages 28-35.
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Richard B Kreider. (2018) Current perspectives of caffeinated energy drinks on exercise performance and safety assessment. Nutrition and Dietary Supplements 10, pages 35-44.
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Joris C. Verster & Juergen Koenig. (2018) Caffeine intake and its sources: A review of national representative studies. Critical Reviews in Food Science and Nutrition 58:8, pages 1250-1259.
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Lady Catherine Cantor-Cutiva, Pasquale Bottalico & Eric Hunter. (2018) Factors associated with vocal fry among college students. Logopedics Phoniatrics Vocology 43:2, pages 73-79.
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Mauro A. Guerra Jr, Leonardo C. Caldas, Helder L. De Souza, Kaio F. Vitzel, Jason M. Cholewa, Michael J. Duncan & Lucas Guimarães-Ferreira. (2018) The acute effects of plyometric and sled towing stimuli with and without caffeine ingestion on vertical jump performance in professional soccer players. Journal of the International Society of Sports Nutrition 15:1.
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Sidney J Stohs & Nicholas A Ratamess. (2017) Effects of p-synephrine in combination with caffeine: a review. Nutrition and Dietary Supplements 9, pages 87-96.
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E. J. Watson, M. Kohler, S. Banks & A. M. Coates. (2017) Validation and reproducibility of an Australian caffeine food frequency questionnaire. International Journal of Food Sciences and Nutrition 68:5, pages 617-626.
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Camilla F. Gosvig, Susanne K. Kjaer, Jan Blaakær, Estrid Høgdall, Claus Høgdall & Allan Jensen. (2015) Coffee, tea, and caffeine consumption and risk of epithelial ovarian cancer and borderline ovarian tumors: Results from a Danish case-control study. Acta Oncologica 54:8, pages 1144-1151.
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Venetia Notara, Demosthenes B. Panagiotakos, Matina Kouvari, Despoina Tzanoglou, Georgia Kouli, Yannis Mantas, Yannis Kogias, Petros Stravopodis, George Papanagnou, Spyros Zombolos, Fotοula Babatsikou, Charilaos Koutis & Christos Pitsavos. (2015) The role of coffee consumption on the 10-year (2004–2014) Acute Coronary Syndrome (ACS) incidence among cardiac patients: the GREECS observational study. International Journal of Food Sciences and Nutrition 66:6, pages 722-728.
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Mark Glaister, Daniel Muniz-Pumares, Stephen D. Patterson, Paul Foley & Gillian McInnes. (2015) Caffeine supplementation and peak anaerobic power output. European Journal of Sport Science 15:5, pages 400-406.
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Barbara M. Thomson, Donald M. Campbell, Peter Cressey, Ursula Egan & Beverley Horn. (2014) Energy drink consumption and impact on caffeine risk. Food Additives & Contaminants: Part A 31:9, pages 1476-1488.
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Adam J Wells, Jay R Hoffman, Adam M Gonzalez, Kyle S Beyer, Adam R Jajtner, Jeremy R Townsend, Leonardo P Oliveira, David H Fukuda, Maren S Fragala & Jeffrey R Stout. (2014) Effects of 28-days ingestion of a slow-release energy supplement versus placebo on hematological and cardiovascular measures of health. Journal of the International Society of Sports Nutrition 11:1.
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Eric R Helms, Alan A Aragon & Peter J Fitschen. (2014) Evidence-based recommendations for natural bodybuilding contest preparation: nutrition and supplementation. Journal of the International Society of Sports Nutrition 11:1.
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María Carolina Talio, María Gimena Acosta, Magdalena Alesso, Marta O. Luconi & Liliana P. Fernández. (2014) Quantification of caffeine in dietary supplements and energy drinks by solid-surface fluorescence using a pre-concentration step on multi-walled carbon nanotubes and Rhodamine B. Food Additives & Contaminants: Part A 31:8, pages 1367-1374.
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Rabin Gyawali, Alani Adkins, Radiah C. Minor & Salam A. Ibrahim. (2014) Behavior and changes in cell morphology of Escherichia coli O157:H7 in liquid medium and skim milk in the presence of caffeine. CyTA - Journal of Food 12:3, pages 235-241.
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Michael J. Duncan, Mike Smith, Joanne Hankey & Elizabeth Bryant. (2014) The effect of caffeine ingestion on coincidence anticipation timing, perceived exertion, and leg pain during submaximal cycling. Fatigue: Biomedicine, Health & Behavior 2:1, pages 14-27.
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Bill Campbell, Colin Wilborn, Paul La Bounty, Lem Taylor, Mike T Nelson, Mike Greenwood, Tim N Ziegenfuss, Hector L Lopez, Jay R Hoffman, Jeffrey R Stout, Stephen Schmitz, Rick Collins, Doug S Kalman, Jose Antonio & Richard B Kreider. (2013) International Society of Sports Nutrition position stand: energy drinks. Journal of the International Society of Sports Nutrition 10:1.
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E. Rudolph, A. Färbinger & J. König. (2012) Determination of the caffeine contents of various food items within the Austrian market and validation of a caffeine assessment tool (CAT). Food Additives & Contaminants: Part A 29:12, pages 1849-1860.
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Juan Del Coso, Juan José Salinero, Cristina González-Millán, Javier Abián-Vicén & Benito Pérez-González. (2012) Dose response effects of a caffeine-containing energy drink on muscle performance: a repeated measures design. Journal of the International Society of Sports Nutrition 9:1.
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Ben Desbrow, Caren Biddulph, Brooke Devlin, GaryD. Grant, Shailendra Anoopkumar-Dukie & MichaelD. Leveritt. (2012) The effects of different doses of caffeine on endurance cycling time trial performance. Journal of Sports Sciences 30:2, pages 115-120.
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Masood Sadiq Butt & M. Tauseef Sultan. (2011) Coffee and its Consumption: Benefits and Risks. Critical Reviews in Food Science and Nutrition 51:4, pages 363-373.
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Astrid Nehlig, Jean-Paul Armspach & Izzie J. Namer. (2010) SPECT assessment of brain activation induced by caffeine: no effect on areas involved in dependence. Dialogues in Clinical Neuroscience 12:2, pages 255-263.
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S.P. Crispim, A. Geelen, C. Le Donne, J.H.M. De Vries, S. Sette, A. Raffo, E. Siebelink, M.C. Ocke, P. van’t Veer, C. Leclercq & on behalf of the European Food Consumption Validation (EFCOVAL) Consortium. (2010) Dietary exposure to flavouring substances: from screening methods to detailed assessments using food consumption data collected with EPIC-Soft software. Food Additives & Contaminants: Part A 27:4, pages 433-446.
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Robert F. Chapman & Timothy D. Mickleborough. (2009) The Effects of Caffeine on Ventilation and Pulmonary Function During Exercise: An Often-Overlooked Response. The Physician and Sportsmedicine 37:4, pages 97-103.
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V. Olmos, N. Bardoni, A.S. Ridolfi & E.C. Villaamil Lepori. (2009) Caffeine levels in beverages from Argentina's market: application to caffeine dietary intake assessment. Food Additives & Contaminants: Part A 26:3, pages 275-281.
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Susan Meacham, Darlene Grayscott, Jau-Jiin Chen & Christine Bergman. (2008) Review of the Dietary Reference Intake for Calcium: Where Do We Go From Here?. Critical Reviews in Food Science and Nutrition 48:5, pages 378-384.
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Jennifer Lee Jenkins, Kim Fredericksen, Roger Stone & Nelson Tang. (2007) Strategies to Improve Sleep During Extended Search andRescue Operations. Prehospital Emergency Care 11:2, pages 230-233.
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JaneV. Higdon & Balz Frei. (2006) Coffee and Health: A Review of Recent Human Research. Critical Reviews in Food Science and Nutrition 46:2, pages 101-123.
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A. Pena, C. Lino & M. I. N. Silveira. (2005) Survey of caffeine levels in retail beverages in Portugal. Food Additives & Contaminants 22:2, pages 91-96.
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Merehan Alaa-ElDin. Mohamed, Shaimaa Rihan, Mustafa M.M. Elbakry & Said S. Moselhy. Molecular docking targeting autophagy pathway mediate abrogation of NASH by specific functional foods: update review. Natural Product Research 0:0, pages 1-24.
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Runyu Zheng & Mohammed Kamruzzaman. Applications of hyperspectral imaging in the coffee industry: Current research and future outlook. Applied Spectroscopy Reviews 0:0, pages 1-25.
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