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Original Articles

Determination of pyrrolizidine alkaloids in honey from selected sites by solid phase extraction and HPLC‐MS

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Pages 419-428 | Received 31 Oct 1996, Published online: 10 Jan 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (10)

Bart Huybrechts & Alfons Callebaut. (2015) Pyrrolizidine alkaloids in food and feed on the Belgian market. Food Additives & Contaminants: Part A 32:11, pages 1939-1951.
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Christina Kast, Arne Dübecke, Verena Kilchenmann, Katharina Bieri, Michael Böhlen, Otmar Zoller, Gudrun Beckh & Cord Lüllmann. (2014) Analysis of Swiss honeys for pyrrolizidine alkaloids. Journal of Apicultural Research 53:1, pages 75-83.
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L.A.P. Hoogenboom, P.P.J. Mulder, M.J. Zeilmaker, H.J. van den Top, G.J. Remmelink, E.F.A. Brandon, M. Klijnstra, G.A.L. Meijer, R. Schothorst & H.P. Van Egmond. (2011) Carry-over of pyrrolizidine alkaloids from feed to milk in dairy cows. Food Additives & Contaminants: Part A 28:3, pages 359-372.
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J.A. Edgar, S.M. Colegate, M. Boppré & R.J. Molyneux. (2011) Pyrrolizidine alkaloids in food: a spectrum of potential health consequences. Food Additives & Contaminants: Part A 28:3, pages 308-324.
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A. Dübecke, G. Beckh & C. Lüllmann. (2011) Pyrrolizidine alkaloids in honey and bee pollen. Food Additives & Contaminants: Part A 28:3, pages 348-358.
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Nan Mei, Lei Guo, Peter P. Fu, James C. Fuscoe, Yang Luan & Tao Chen. (2010) Metabolism, Genotoxicity, annd Carcinogenicity of Comfrey. Journal of Toxicology and Environmental Health, Part B 13:7-8, pages 509-526.
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Peter P. Fu, Qingsu Xia, Ge Lin & Ming W. Chou. (2004) Pyrrolizidine Alkaloids—Genotoxicity, Metabolism Enzymes, Metabolic Activation, and Mechanisms. Drug Metabolism Reviews 36:1, pages 1-55.
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P. P. Fu, M. W. Chou, Q. Xia, Y.-C. Yang, J. Yan, D. R. Doerge & P. C. Chan. (2001) GENOTOXIC PYRROLIZIDINE ALKALOIDS AND PYRROLIZIDINE ALKALOID N-OXIDES—MECHANISMS LEADING TO DNA ADDUCT FORMATION AND TUMORIGENICITY. Journal of Environmental Science and Health, Part C 19:2, pages 353-385.
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Marinela Cvetanoska, Marijana Pocrnić, Marina Stefova, Nives Galić & Jasmina Petreska Stanoeva. UHPLC-Q-TOF analysis of pyrrolizidine alkaloids in North-Macedonian honey. Food Additives & Contaminants: Part B 0:0, pages 1-11.
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Articles from other publishers (44)

Kai Wang, Sha Yan & Xiaofeng Xue. 2024. Encyclopedia of Food Safety. Encyclopedia of Food Safety 544 563 .
Fawzy Eissa & El-Kazafy A. Taha. (2023) Contaminants in honey: an analysis of EU RASFF notifications from 2002 to 2022. Journal of Consumer Protection and Food Safety 18:4, pages 393-402.
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Sha Yan, Kai Wang, Yahya Al Naggar, Yvan Vander Heyden, Lingling Zhao, Liming Wu & Xiaofeng Xue. (2022) Natural plant toxins in honey: An ignored threat to human health. Journal of Hazardous Materials 424, pages 127682.
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T Heger. (2022) Senecio inaequidens (South African ragwort). CABI Compendium CABI Compendium.
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Huseyin Senturk, Ece Eksin, Ulvi Zeybek & Arzum Erdem. (2021) Detection of Senecionine in Dietary Sources by Single-Use Electrochemical Sensor. Micromachines 12:12, pages 1585.
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Se Hee Jeong, Eun Young Choi, Jonghwan Kim, Chulhyun Lee, Juhye Kang, Sooyeul Cho & Kyung Yuk Ko. (2021) LC-ESI-MS/MS Simultaneous Analysis Method Coupled with Cation-Exchange Solid-Phase Extraction for Determination of Pyrrolizidine Alkaloids on Five Kinds of Herbal Medicines. Journal of AOAC INTERNATIONAL 104:6, pages 1514-1525.
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Christoph Gottschalk, Florian Kaltner, Matthias Zimmermann, Rainer Korten, Oliver Morris, Karin Schwaiger & Manfred Gareis. (2020) Spread of Jacobaea vulgaris and Occurrence of Pyrrolizidine Alkaloids in Regionally Produced Honeys from Northern Germany: Inter- and Intra-Site Variations and Risk Assessment for Special Consumer Groups. Toxins 12:7, pages 441.
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Thiago Bousquet Bandini, Antonio Carlos Siani & Bernardete Ferraz Spisso. (2020) A botanical census on pyrrolizidine alkaloid-producing species in Brazilian herbaria: data set for a potential health risk indication. Rodriguésia 71.
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Won Tae Jeong & Heung Bin Lim. (2019) Determination and Chemical Profiling of Toxic Pyrrolizidine Alkaloids in Botanical Samples with UPLC–Q-TOFMS. Chromatographia 82:11, pages 1653-1664.
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Fashe Muluneh, Merja R. Häkkinen, Rami El-Dairi, Markku Pasanen & Risto O. Juvonen. (2018) New glutathione conjugate of pyrrolizidine alkaloids produced by human cytosolic enzyme-dependent reactions in vitro . Rapid Communications in Mass Spectrometry 32:16, pages 1344-1352.
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Lin Zhu, Zhangting Wang, Lailai Wong, Yisheng He, Zhongzhen Zhao, Yang Ye, Peter P. Fu & Ge Lin. (2018) Contamination of hepatotoxic pyrrolizidine alkaloids in retail honey in China. Food Control 85, pages 484-494.
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Colin Crews & Till Beuerle. 2017. Analysis of Food Toxins and Toxicants. Analysis of Food Toxins and Toxicants 237 266 .
Matteo A. Lucchetti, Gaetan Glauser, Verena Kilchenmann, Arne Dübecke, Gudrun Beckh, Christophe Praz & Christina Kast. (2016) Pyrrolizidine Alkaloids from Echium vulgare in Honey Originate Primarily from Floral Nectar . Journal of Agricultural and Food Chemistry 64:25, pages 5267-5273.
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Lucatello Lorena, Merlanti Roberta, Rossi Alessandra, Montesissa Clara & Capolongo Francesca. (2015) Evaluation of Some Pyrrolizidine Alkaloids in Honey Samples from the Veneto Region (Italy) by LC-MS/MS. Food Analytical Methods 9:6, pages 1825-1836.
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Martina Bolechová, Josef Čáslavský, Markéta Pospíchalová & Petra Kosubová. (2015) UPLC–MS/MS method for determination of selected pyrrolizidine alkaloids in feed. Food Chemistry 170, pages 265-270.
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Assem El-Shazly & Michael Wink. (2014) Diversity of Pyrrolizidine Alkaloids in the Boraginaceae Structures, Distribution, and Biological Properties. Diversity 6:2, pages 188-282.
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Lizandra Czermainski Bretanha, Marcel Piovezan, Alysson Fernandez Vasques Sako, Moacir Geraldo Pizzolatti & Gustavo Amadeu Micke. (2014) Strategy for a Fast and Simple Method for Trace Determination of Senecionine and Senecionine N-Oxide in Honey Using LVI in HPLC-MS/MS. American Journal of Analytical Chemistry 05:10, pages 681-687.
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Caroline T. Griffin, Martin Danaher, Christopher T. Elliott, D. Glenn Kennedy & Ambrose Furey. (2013) Detection of pyrrolizidine alkaloids in commercial honey using liquid chromatography–ion trap mass spectrometry. Food Chemistry 136:3-4, pages 1577-1583.
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Michael Kempf, Peter Schreier, Annika Reinhard & Till Beuerle. (2010) Pyrrolizidinalkaloide in Honig und PollenPyrrolizidine Alkaloids in Honey and Pollen. Journal für Verbraucherschutz und Lebensmittelsicherheit 5:3-4, pages 393-406.
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Yu-Qi He, Yong Liu, Bin-Feng Zhang, Hui-Xin Liu, Yan-Liu Lu, Li Yang, Ai-zhen Xiong, Ling-Ling Xu, Chang-Hong Wang, Ling Yang & Zheng-Tao Wang. (2010) Identification of the UDP-Glucuronosyltransferase Isozyme Involved in Senecionine Glucuronidation in Human Liver Microsomes. Drug Metabolism and Disposition 38:4, pages 626-634.
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Colin Crews, Franz Berthiller & Rudi Krska. (2009) Update on analytical methods for toxic pyrrolizidine alkaloids. Analytical and Bioanalytical Chemistry 396:1, pages 327-338.
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Michael Kempf, Annika Reinhard & Till Beuerle. (2010) Pyrrolizidine alkaloids (PAs) in honey and pollen‐legal regulation of PA levels in food and animal feed required. Molecular Nutrition & Food Research 54:1, pages 158-168.
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Xueyong Qi, Shufang Wang, Bin Wu & Haibin Qu. (2009) Determination of Hepatotoxic Pyrrolizidine Alkaloids in Gynura segetum by MEKC. Chromatographia 70:1-2, pages 281-285.
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Colin CrewsMalcolm DriffieldFranz Berthiller & Rudolf Krska. (2009) Loss of Pyrrolizidine Alkaloids on Decomposition of Ragwort ( Senecio jacobaea ) as Measured by LC-TOF-MS . Journal of Agricultural and Food Chemistry 57:9, pages 3669-3673.
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Donald G. Barceloux. 2008. Medical Toxicology of Natural Substances. Medical Toxicology of Natural Substances 449 457 .
Michael Kempf, Till Beuerle, Manuela Bühringer, Martina Denner, Daniela Trost, Katharina von der Ohe, Vijaya B. R. Bhavanam & Peter Schreier. (2008) Pyrrolizidine alkaloids in honey: Risk analysis by gas chromatography‐mass spectrometry. Molecular Nutrition & Food Research 52:10, pages 1193-1200.
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Maciej J. Bogusz & Mohammed Al-Tufail. 2008. Forensic Science. Forensic Science 589 610 .
Fang Zhang, Chang‐hong Wang, Wan Wang, Lu‐xin Chen, Hong‐yan Ma, Chao‐feng Zhang, Mian Zhang, S. W. Annie Bligh & Zheng‐tao Wang. (2007) Quantitative analysis by HPLC‐MS 2 of the pyrrolizidine alkaloid adonifoline in Senecio scandens . Phytochemical Analysis 19:1, pages 25-31.
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Manuela G. NeumanAngela Y. JiaVanessa Steenkamp. (2007) Senecio latifolius induces in vitro hepatocytotoxicity in a human cell lineThis article is one of a selection of papers published in this special issue (part 2 of 2) on the Safety and Efficacy of Natural Health Products.. Canadian Journal of Physiology and Pharmacology 85:11, pages 1063-1075.
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M. Nasiruddin Khan, M. Qaiser, Syed Mubashir Raza & Mutiur Rehman. (2006) Physicochemical properties and pollen spectrum of imported and local samples of blossom honey from the Pakistani market. International Journal of Food Science & Technology 41:7, pages 775-781.
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Tomasz Mroczek, Karine Ndjoko-Ioset, Kazimierz Głowniak, Agnieszka Miętkiewicz-Capała & Kurt Hostettmann. (2006) Investigation of Symphytum cordatum alkaloids by liquid–liquid partitioning, thin-layer chromatography and liquid chromatography–ion-trap mass spectrometry. Analytica Chimica Acta 566:2, pages 157-166.
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Lijun Yu, Yan Xu, Huatao Feng & Sam Fong Yau Li. (2005) Separation and determination of toxic pyrrolizidine alkaloids in traditional Chinese herbal medicines by micellar electrokinetic chromatography with organic modifier. ELECTROPHORESIS 26:17, pages 3397-3404.
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Bree A. Gorman, Neil W. Barnett & Richard Bos. (2005) Detection of pyrrolizidine alkaloids using flow analysis with both acidic potassium permanganate and tris(2,2′-bipyridyl)ruthenium(II) chemiluminescence. Analytica Chimica Acta 541:1-2, pages 117-122.
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Michael Boppré, Steven M. Colegate & John A. Edgar. (2005) Pyrrolizidine Alkaloids of Echium vulgare Honey Found in Pure Pollen . Journal of Agricultural and Food Chemistry 53:3, pages 594-600.
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T MROCZEK, K NDJOKO, K GLOWNIAK & K HOSTETTMANN. (2004) On-line structure characterization of pyrrolizidine alkaloids in Onosma stellulatum and Emilia coccinea by liquid chromatography–ion-trap mass spectrometry. Journal of Chromatography A 1056:1-2, pages 91-97.
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Tomasz Mroczek, Stefan Baj, Anna Chrobok & Kazimierz Glowniak. (2004) Screening for pyrrolizidine alkaloids in plant materials by electron ionization RP‐HPLC‐MS with thermabeam interface. Biomedical Chromatography 18:9, pages 745-751.
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Roger A CoulombeJr.Jr.. 2003. Advances in Food and Nutrition Research Volume 45. Advances in Food and Nutrition Research Volume 45 61 99 .
John A. Edgar, Erhard Roeder & Russell J. Molyneux. (2002) Honey from Plants Containing Pyrrolizidine Alkaloids:  A Potential Threat to Health. Journal of Agricultural and Food Chemistry 50:10, pages 2719-2730.
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Christophe Cordella, Issam Moussa, Anne-Claire Martel, Nicolas Sbirrazzuoli & Louisette Lizzani-Cuvelier. (2002) Recent Developments in Food Characterization and Adulteration Detection:  Technique-Oriented Perspectives. Journal of Agricultural and Food Chemistry 50:7, pages 1751-1764.
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Tomasz Mroczek, Kazimierz Glowniak & Anna Wlaszczyk. (2002) Simultaneous determination of N-oxides and free bases of pyrrolizidine alkaloids by cation-exchange solid-phase extraction and ion-pair high-performance liquid chromatography. Journal of Chromatography A 949:1-2, pages 249-262.
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Michael J. Stewart & Vanessa Steenkamp. (2001) Pyrrolizidine Poisoning: A Neglected Area in Human Toxicology. Therapeutic Drug Monitoring 23:6, pages 698-708.
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Vanessa Steenkamp, Michael J. Stewart & Michele Zuckerman. (2000) Clinical and Analytical Aspects of Pyrrolizidine Poisoning Caused by South African Traditional Medicines. Therapeutic Drug Monitoring 22:3, pages 302-306.
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