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Research Article

Preparation and in vitro characterization of gelatin microspheres containing Levodopa for nasal administration

Pages 777-784 | Published online: 29 Sep 2008

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Sema Arisoy, Ozgun Sayiner, Tansel Comoglu, Deniz Onal, Ozbeyen Atalay & Bilge Pehlivanoglu. (2020) In vitro and in vivo evaluation of levodopa-loaded nanoparticles for nose to brain delivery. Pharmaceutical Development and Technology 25:6, pages 735-747.
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Shaoqi Qu, Cunchun Dai, Mei Qiu, Ruili Zhang, Chunyuan Wang, Liangliang Cui & Zhihui Hao. (2017) Preparation and characterization of three types of cefquinome-loaded microspheres. International Journal of Polymer Analysis and Characterization 22:3, pages 256-265.
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S. L. He, Z. H. Zhou, C. Peng, H. H. Huang, L. J. Xiang, D. F. Cao, H. Zhou, J. Chen, B. L. Ou, Q. Q. Liu, W. N. Zeng & L. H. Liu. (2016) Morphology and size control of gelatin/hyaluronic acid composite microsphere for drug delivery. Materials Technology 31:3, pages 145-152.
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Zhihua Zhou, Dafu Cao, Lihua Liu, Qingquan Liu, Yanmin Zhao, Wennan Zeng, Qingfeng Yi, Zhongmin Yang & Jianan Zhou. (2013) Fabrication and Properties of Gelatin/Chitosan Microspheres Loaded with 5-Fluorouracil. Journal of Macromolecular Science, Part B 52:7, pages 973-983.
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M. Teresa Calejo, António J. Almeida & Ana I. Fernandes. (2012) Exploring a new jellyfish collagen in the production of microparticles for protein delivery. Journal of Microencapsulation 29:6, pages 520-531.
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Zhiyuan Peng, Zhiping Li & Yongqiang Shen. (2012) Preparation and in vitro Characterization of Gelatin Microspheres Containing 5-fluorouracil. Journal of Macromolecular Science, Part B 51:6, pages 1117-1124.
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Piera Sozio, Laura Serafina Cerasa, Anna Abbadessa & Antonio Di Stefano. (2012) Designing prodrugs for the treatment of Parkinson's disease. Expert Opinion on Drug Discovery 7:5, pages 385-406.
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Zhiyuan Peng, Zhiping Li, Yongqiang Shen, Fan Zhang & Xiaochun Peng. (2012) Fabrication of Gelatin/Chitosan Microspheres with Different Morphologies and Study on Biological Properties. Polymer-Plastics Technology and Engineering 51:7, pages 739-743.
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Prashant Singh & Ramesh Chandra. (2012) Noscapine-Encapsulated Nanopolymers: A Novel Drug-Carrier System to Target the Tumor Cells. International Journal of Green Nanotechnology 4:2, pages 80-92.
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Zhihua Zhou, Jianan Zhou, Lihua Liu, Qingfeng Yi, Qingquan Liu, Wennan Zeng & Zhongmin Yang. (2012) Fabrication and Characterization of Gelatin/Chitosan Microspheres for Drug Release. Journal of Macromolecular Science, Part B 51:4, pages 777-785.
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Zhiyuan Peng, Zhiping Li & Yongqiang Shen. (2012) Influence of Chemical Cross-Linking on Properties of Gelatin/Chitosan Microspheres. Polymer-Plastics Technology and Engineering 51:4, pages 381-385.
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Z.Y. Peng, Y.Q. Shen & Z.P. Li. (2012) Control of Size and Morphology of Gelatin Microspheres. Journal of Macromolecular Science, Part B 51:1, pages 12-21.
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Wing-Fu Lai. (2011) In vivo nucleic acid delivery with PEI and its derivatives: current status and perspectives. Expert Review of Medical Devices 8:2, pages 173-185.
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Shadab Md, Shadabul Haque, Jasjeet Kaur Sahni, Sanjula Baboota & Javed Ali. (2011) New non-oral drug delivery systems for Parkinson's disease treatment. Expert Opinion on Drug Delivery 8:3, pages 359-374.
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Werner Poewe, Angelo Antonini, Jan CM Zijlmans, Pierre R Burkhard & François Vingerhoets. (2010) Levodopa in the treatment of Parkinson’s disease: an old drug still going strong. Clinical Interventions in Aging 5, pages 229-238.
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Lingmin Jiang, Lei Gao, Xiaoqing Wang, Liang Tang & Jianli Ma. (2010) The application of mucoadhesive polymers in nasal drug delivery. Drug Development and Industrial Pharmacy 36:3, pages 323-336.
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Ndidi Ngwuluka, Viness Pillay, Lisa C Du Toit, Valence Ndesendo, Yahya Choonara, Girish Modi & Dinesh Naidoo. (2010) Levodopa delivery systems: advancements in delivery of the gold standard. Expert Opinion on Drug Delivery 7:2, pages 203-224.
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A. Kavitha, Kamala Boopalan, Ganga Radhakrishnan, S. Sankaran, B. N. Das & T. P. Sastry. (2005) Preparation of Feather Keratin Hydrolyzate‐Gelatin Composites and Their Graft Copolymers. Journal of Macromolecular Science, Part A 42:12, pages 1703-1713.
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H. Wu, Z. X. Zhang, H. P. Zhao, D. C. Wu, B. L. Wu & R. Cong. (2004) Preparation of sodium fluoride-loaded gelatin microspheres, characterization and cariostatic studies. Journal of Microencapsulation 21:8, pages 889-903.
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Savvas Dimiou, Rui M. Lopes, Ilona Kubajewska, Ryan D. Mellor, Corinna S. Schlosser, Manjunath S. Shet, Hugh Huang, Ozgur Akcan, Garth T. Whiteside, Andreas G. Schätzlein & Ijeoma F. Uchegbu. (2022) Particulate levodopa nose-to-brain delivery targets dopamine to the brain with no plasma exposure. International Journal of Pharmaceutics 618, pages 121658.
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Mrunal Patil. 2021. Direct Nose-to-Brain Drug Delivery. Direct Nose-to-Brain Drug Delivery 115 156 .
Niloufar Choubdar & Sara Avizheh. (2020) Nanotechnology Based Delivery Systems of Drugs Currently Used to Treat Alzheimer’s Disease. Nanoscience & Nanotechnology-Asia 10:3, pages 228-247.
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Jahanzeb Mudassir, Aruba Khan SherwaniAmjad HussainNasir AbbasMuhammad sohail Arshad. (2020) Formulation, Optimization and Characterization of Chitosan Monodisperse Microparticles for Sustained Delivery of Hydrochlorothiazide HCl. Pharmaceutical Sciences 26:3, pages 306-313.
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Wing-Fu Lai, Eric M. Huang & Wing-Tak Wong. 2020. Systemic Delivery Technologies in Anti-Aging Medicine: Methods and Applications. Systemic Delivery Technologies in Anti-Aging Medicine: Methods and Applications 477 493 .
Yeonoh Shin, Rutika Kokate, Vilas Desai, Alok Bhushan & Gagan Kaushal. (2018) D-cycloserine nasal formulation development for anxiety disorders by using polymeric gels. Drug Discoveries & Therapeutics 12:3, pages 142-153.
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Shaoqi Qu, Cunchun Dai, Fenfang Yang, Tingting Huang, Tianli Xu, Li Zhao, Yuwen Li & Zhihui Hao. (2018) A Comparison of Two Methods for the Preparation Cefquinome-Loaded Gelatin Microspheres for Lung Targeting. Pharmaceutical Research 35:2.
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Fatma Haddad, Maryam Sawalha, Yahya Khawaja, Anas Najjar & Rafik Karaman. (2017) Dopamine and Levodopa Prodrugs for the Treatment of Parkinson’s Disease. Molecules 23:1, pages 40.
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Grégory Coué, Iris Hermanns, Ronald E. Unger, C. James Kirkpatrick & Johan F. J. Engbersen. (2013) Development and in vitro Evaluation of Antigen-Loaded Poly(amidoamine) Nanoparticles for Respiratory Epithelium Applications. ChemMedChem 8:11, pages 1787-1794.
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Wing-Fu Lai. (2013) Nucleic acid delivery: Roles in biogerontological interventions. Ageing Research Reviews 12:1, pages 310-315.
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Z. Abbas & N. G. N. Swamy. (2014) MUCOADHESIVE MICROSPHERES AS INTRANASAL DRUG DELIVERY SYSTEMS: A REVIEW. INDIAN DRUGS 49:01, pages 5-23.
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Jarosław Sławek. (2012) Lewodopa w leczeniu choroby Parkinsona – wczoraj i dziś. Neurologia i Neurochirurgia Polska 46:1, pages 63-75.
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Maria Cruz Rodriguez-Oroz, Concepción Marin & Oriol de Fabregues. (2011) Continuous Dopaminergic Stimulation. The Neurologist 17, pages S30-S37.
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Yin-Chuan Jin, Seung-Woo Kim, Felice Cheng, Joo-Hyun Shin, Jin-Kuen Park, Sanghyun Lee, Jung-Eun Lee, Pyung-Lim Han, Minhyung Lee, Kyekyoon (Kevin) Kim, Hyungsoo Choi & Ja-Kyeong Lee. (2011) The effect of biodegradable gelatin microspheres on the neuroprotective effects of high mobility group box 1 A box in the postischemic brain. Biomaterials 32:3, pages 899-908.
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Baljit Singh & Nirmala Chauhan. (2010) Release dynamics of tyrosine from dietary fiber psyllium based hydrogels for use in Parkinson’s disease. Food Research International 43:4, pages 1065-1072.
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Shayne Cox GadJelena Filipović-Grčić & Anita Hafner. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia.
Wing-Fu Lai & Marie Chia-Mi Lin. (2009) Nucleic acid delivery with chitosan and its derivatives. Journal of Controlled Release 134:3, pages 158-168.
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Young Bin Choy, Felice Cheng, Hyungsoo Choi & Kyekyoon (Kevin) Kim. (2008) Monodisperse Gelatin Microspheres as a Drug Delivery Vehicle: Release Profile and Effect of Crosslinking Density. Macromolecular Bioscience 8:8, pages 758-765.
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Pradeep Karla, Deep Kwatra, Ripal Gaudana & Ashim Mitra. 2008. Modified-Release Drug Delivery Technology, Second Edition. Modified-Release Drug Delivery Technology, Second Edition 427 450 .
Antonio Di Stefano, Piera Sozio & Laura Cerasa. (2008) Antiparkinson Prodrugs. Molecules 13:1, pages 46-68.
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A. Yekta Ozer. 2007. Nanomaterials and Nanosystems for Biomedical Applications. Nanomaterials and Nanosystems for Biomedical Applications 99 112 .
N. Sree Harsha & R. H. Shobha Rani. (2006) Drug targeting to lungs by way of microspheres. Archives of Pharmacal Research 29:7, pages 598-604.
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Fa-ming CHEN, Zhi-fen WU, Qin-tao WANG, Hong WU, Yong-jie ZHANG, Xin NIE & Yan JIN. (2005) Preparation of recombinant human bone morphogenetic protein-2 loaded dextran-based microspheres and their characteristics1. Acta Pharmacologica Sinica 26:9, pages 1093-1103.
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S. E. Noorjahan & T. P. Sastry. (2004) Hydrogels based on physiologically clotted fibrin-gelatin composites. Journal of Polymer Science Part A: Polymer Chemistry 42:9, pages 2241-2252.
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