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Research Article

Development of a new cyclosporine formulation based on poly(caprolactone) microspheres

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Pages 61-72 | Published online: 29 Sep 2008

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Jiaming Gu, Zhihua Zhou, Tianlong Huang, Wei Wu, Wenjuan Liu, Yanmin Zhao, Ping Chen, Ziwei Zhou, Dan Wang, Chao Zhang, Meilin Yi, Xiao He & Jianjun Fang. (2022) Preparation and Properties of Poly(D,L-lactide-co-glycolide-co-ε-caprolactone)/1,4-Butanediamine Modified Poly(lactide-co-glycolide) Blend Porous Microspheres. Journal of Macromolecular Science, Part B 61:2, pages 270-280.
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Meiling Yi, Zhihua Zhou, Wenjuan Liu, Tianlong Huang, Yanmin Zhao, Ping Chen, Ziwei Zhou, Dan Wang, Chao Zhang & Jianjun Fang. (2021) In-vitro Degradation Behaviors of Poly(L-lactide-co-glycolide-co-ε-caprolactone) Microspheres. Journal of Macromolecular Science, Part B 60:7, pages 521-529.
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Chao Zhang, Zhihua Zhou, Wenjuan Liu, Tianlong Huang, Yanmin Zhao, Ping Chen, Ziwei Zhou, Dan Wang, Meiling Yi & Jianjun Fang. (2021) Preparation and Characterization of Poly(l-lactide-co-glycolide-co-ε-caprolactone) Porous Microspheres. Journal of Macromolecular Science, Part B 60:5, pages 313-323.
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Rimpy Diwan, Punna Rao Ravi, Shubham Ishwar Agarwal & Vidushi Aggarwal. (2021) Cilnidipine loaded poly (ε-caprolactone) nanoparticles for enhanced oral delivery: optimization using DoE, physical characterization, pharmacokinetic, and pharmacodynamic evaluation. Pharmaceutical Development and Technology 26:3, pages 278-290.
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Sergio Miguel Espinoza, Harshal Indrabhan Patil, Eduardo San Martin Martinez, Rocio Casañas Pimentel & Pradum Pundlikrao Ige. (2020) Poly-ε-caprolactone (PCL), a promising polymer for pharmaceutical and biomedical applications: Focus on nanomedicine in cancer. International Journal of Polymeric Materials and Polymeric Biomaterials 69:2, pages 85-126.
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Lin-peng Li, Xiao-juan Wang, Jin-Yu Zhang, Lu-lu Zhang, Yong-bing Cao, Li-qun Gu, Yi-qun Yu, Qi-lian Yang, Chun-ying Shen, Bing Han & Yuan-ying Jiang. (2018) Antifungal activity of osthol in vitro and enhancement in vivo through Eudragit S100 nanocarriers. Virulence 9:1, pages 555-562.
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Avinash Budhian, Steven J. Siegel & Karen I. Winey. (2005) Production of haloperidol-loaded PLGA nanoparticles for extended controlled drug release of haloperidol. Journal of Microencapsulation 22:7, pages 773-785.
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Lian Liu, Teng Yu, Pei Wang, Guang Shuo Wang & Zhi Yong Wei. (2013) Advances in Synthesis and Properties of Poly(<i>ε-</i>caprolactone)/Carbon Nanocomposites. Applied Mechanics and Materials 320, pages 441-445.
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Aashima Hooda, Arun Nanda, Manish Jain, Vikash Kumar & Permender Rathee. (2012) Optimization and evaluation of gastroretentive ranitidine HCl microspheres by using design expert software. International Journal of Biological Macromolecules 51:5, pages 691-700.
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D. Hernán Pérez de la Ossa, A. Ligresti, M.E. Gil-Alegre, M.R. Aberturas, J. Molpeceres, V. Di Marzo & A.I. Torres Suárez. (2012) Poly-ε-caprolactone microspheres as a drug delivery system for cannabinoid administration: Development, characterization and in vitro evaluation of their antitumoral efficacy. Journal of Controlled Release 161:3, pages 927-932.
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Sanjay Dey, Soumen Pramanik & Ananya Malgope. (2011) Formulation and Optimization of Sustained Release Stavudine Microspheres Using Response Surface Methodology. ISRN Pharmaceutics 2011, pages 1-7.
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Suzanne M. D'Addio & Robert K. Prud'homme. (2011) Controlling drug nanoparticle formation by rapid precipitation. Advanced Drug Delivery Reviews 63:6, pages 417-426.
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Venkatachalam Natarajan, Natarajan Krithica, Balaraman Madhan & Praveen Kumar Sehgal. (2011) Formulation and Evaluation of Quercetin Polycaprolactone Microspheres for the Treatment of Rheumatoid Arthritis. Journal of Pharmaceutical Sciences 100:1, pages 195-205.
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M. Enayati, Z. Ahmad, E. Stride & M. Edirisinghe. (2010) Size mapping of electric field-assisted production of polycaprolactone particles. Journal of The Royal Society Interface 7:suppl_4.
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H.-J. Kim, T.-H. Kim, K.-C. Kang, H.-B. Pyo & H.-H. Jeong. (2010) Microencapsulation of rosmarinic acid using polycaprolactone and various surfactants. International Journal of Cosmetic Science 32:3, pages 185-191.
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Jin Whan Lee, Tae-Hong Lim & Joon B. Park. (2010) Intradiscal drug delivery system for the treatment of low back pain. Journal of Biomedical Materials Research Part A 92A:1, pages 378-385.
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J. Reiche, A. Kulkarni, K. Kratz & A. Lendlein. (2008) Enzymatic monolayer degradation study of multiblock copolymers consisting of poly(ε-caprolactone) and poly(p-dioxanone) blocks. Thin Solid Films 516:24, pages 8821-8828.
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A. Kulkarni, J. Reiche, J. Hartmann, K. Kratz & A. Lendlein. (2008) Selective enzymatic degradation of poly(ε-caprolactone) containing multiblock copolymers. European Journal of Pharmaceutics and Biopharmaceutics 68:1, pages 46-56.
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A. Kulkarni, J. Reiche, K. Kratz, H. Kamusewitz, I. M. Sokolov & A. Lendlein. (2007) Enzymatic Chain Scission Kinetics of Poly(ε-caprolactone) Monolayers. Langmuir 23:24, pages 12202-12207.
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J. Rubio-Retama, F. Tamimi Mariño & E. López-Cabarcos. (2007) Enzymatic biodegradable micro-reactors for therapeutic applications. Journal of Biomedical Materials Research Part B: Applied Biomaterials 83B:1, pages 145-152.
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Uttam MANDAL, Veeran GOWDA, Animesh GHOSH, Senthamil SELVAN, Sam SOLOMON & Tapan Kumar PAL. (2007) Formulation and Optimization of Sustained Release Matrix Tablet of Metformin HCl 500 mg Using Response Surface Methodology. YAKUGAKU ZASSHI 127:8, pages 1281-1290.
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Bhupinder Singh, Sukhwinder Kaur Chakkal & Naveen Ahuja. (2017) Formulation and optimization of controlled release mucoadhesive tablets of atenolol using response surface methodology. AAPS PharmSciTech 7:1, pages E19-E28.
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Y. Li, K.J. Zhu, J.X. Zhang, H.L. Jiang, J.H. Liu, Y.L. Hao, Hajime Yasuda, Akiko Ichimaru & Katsuhiro Yamamoto. (2005) In vitro and in vivo studies of cyclosporin A-loaded microspheres based on copolymers of lactide and ɛ-caprolactone: Comparison with conventional PLGA microspheres. International Journal of Pharmaceutics 295:1-2, pages 67-76.
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Iosif Daniel Rosca, Fumio Watari & Motohiro Uo. (2004) Microparticle formation and its mechanism in single and double emulsion solvent evaporation. Journal of Controlled Release 99:2, pages 271-280.
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V.R. Sinha, K. Bansal, R. Kaushik, R. Kumria & A. Trehan. (2004) Poly-ϵ-caprolactone microspheres and nanospheres: an overview. International Journal of Pharmaceutics 278:1, pages 1-23.
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A. Sosnik & D. Cohn. (2003) Poly(ethylene glycol)-poly(epsilon-caprolactone) block oligomers as injectable materials. Polymer 44:23, pages 7033-7042.
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Jong-Cheol Jeong, Jaeyoung Lee & Kilwon Cho. (2003) Effects of crystalline microstructure on drug release behavior of poly(ε-caprolactone) microspheres. Journal of Controlled Release 92:3, pages 249-258.
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