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International Journal of Hyperthermia Volume 20, 2004 - Issue 2: Radiosensitization by hyperthermia: Mechanisms and clinical Implications
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Original Article

Effects of heat shock on the Mre11/Rad50/Nbs1 complex in irradiated or unirradiated cells

J. R. Dynlacht Department of Radiation Oncology and Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USACorrespondence[email protected]
,
M. Xu Division of Radiation and Cancer Biology, Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63108, USA
,
R. K. Pandita Division of Radiation and Cancer Biology, Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63108, USA
,
E. A. Wetzel Department of Radiation Oncology and Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
&
J. L. Roti Roti Division of Radiation and Cancer Biology, Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63108, USA
Pages 144-156 | Received 17 Jul 2003, Accepted 17 Oct 2003, Published online: 09 Jul 2009

Citations (17)

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Berina Eppink, Przemek M. Krawczyk, Jan Stap & Roland Kanaar. (2012) Hyperthermia-induced DNA repair deficiency suggests novel therapeutic anti-cancer strategies. International Journal of Hyperthermia 28:6, pages 509-517.
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Silvina B. Nadin, F. Darío Cuello-Carrión, Mayra L. Sottile, Daniel R. Ciocca & Laura M. Vargas-Roig. (2012) Effects of hyperthermia on Hsp27 (HSPB1), Hsp72 (HSPA1A) and DNA repair proteins hMLH1 and hMSH2 in human colorectal cancer hMLH1-deficient and hMLH1-proficient cell lines. International Journal of Hyperthermia 28:3, pages 191-201.
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Noritomo Okamoto, Akihisa Takahashi, Ichiro Ota, Ken Ohnishi, Eiichiro Mori, Natsuko Kondo, Taichi Noda, Yosuke Nakagawa, Hirokazu Uemura, Katunari Yane, Hiroshi Hosoi & Takeo Ohnishi. (2011) siRNA targeted for NBS1 enhances heat sensitivity in human anaplastic thyroid carcinoma cells. International Journal of Hyperthermia 27:3, pages 297-304.
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Joseph L. Roti Roti. (2008) Cellular responses to hyperthermia (40–46°C): Cell killing and molecular events. International Journal of Hyperthermia 24:1, pages 3-15.
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M. Xu, R. J. Myerson, Y. Xia, T. Whitehead, E. G. Moros, W. L. Straube & J. L. Roti Roti. (2007) The effects of 41°C hyperthermia on the DNA repair protein, MRE11, correlate with radiosensitization in four human tumor cell lines. International Journal of Hyperthermia 23:4, pages 343-351.
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J. W. J. Bergs, N. A. P. Franken, J. Haveman, E. D. Geijsen, J. Crezee & C. van Bree. (2007) Hyperthermia, cisplatin and radiation trimodality treatment: A promising cancer treatment? A review from preclinical studies to clinical application. International Journal of Hyperthermia 23:4, pages 329-341.
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Joseph L. Roti Roti. (2007) Heat-induced alterations of nuclear protein associations and their effects on DNA repair and replication. International Journal of Hyperthermia 23:1, pages 3-15.
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Olav Dahl. (2005) Editorial. International Journal of Hyperthermia 21:3, pages 193-197.
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J. R. Lepock. (2004) Role of nuclear protein denaturation and aggregation in thermal radiosensitization. International Journal of Hyperthermia 20:2, pages 115-130.
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Articles from other publishers (8)

Fei Shi, Zheng Deng, Zheng Zhou, Bo Jiang, Chen‐Yi Jiang, Rui‐Zhe Zhao, Feng Sun, Di Cui, Meng‐Hao Sun, Qian Sun, Xing‐Jie Wang, Qi Wu, Shu‐Jie Xia & Bang‐Min Han. (2019) Heat injured stromal cells‐derived exosomal EGFR enhances prostatic wound healing after thulium laser resection through EMT and NF‐κB signaling. The Prostate 79:11, pages 1238-1255.
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Stefan C. Genet, Yoshihiro Fujii, Junko Maeda, Masami Kaneko, Matthew D. Genet, Kiyoshi Miyagawa & Takamitsu A. Kato. (2013) Hyperthermia inhibits homologous recombination repair and sensitizes cells to ionizing radiation in a time‐ and temperature‐dependent manner. Journal of Cellular Physiology 228:7, pages 1473-1481.
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Yukihiro Furusawa, Takashi Iizumi, Yoshisada Fujiwara, Qing-Li Zhao, Yoshiaki Tabuchi, Takaharu Nomura & Takashi Kondo. (2011) Inhibition of checkpoint kinase 1 abrogates G2/M checkpoint activation and promotes apoptosis under heat stress. Apoptosis 17:1, pages 102-112.
Crossref
Joseph R. Dynlacht, Christopher N. Batuello, Jennifer T. Lopez, Kyung Keun Kim & John J. Turchi. (2011) Identification of Mre11 as a Target for Heat Radiosensitization. Radiation Research 176:3, pages 323.
Crossref
Joseph L. Roti Roti, Robert P. VanderWaal & Andrei Laszlo. 2011. Molecular Determinants of Radiation Response. Molecular Determinants of Radiation Response 227 249 .
Bogdan I. Gerashchenko, Gerirose Gooding & Joseph R. Dynlacht. (2010) Hyperthermia alters the interaction of proteins of the Mre11 complex in irradiated cells. Cytometry Part A 77A:10, pages 940-952.
Crossref
Akihisa TAKAHASHI, Eiichiro MORI & Takeo OHNISHI. (2010) The Foci of DNA Double Strand Break-recognition Proteins Localize with γH2AX after Heat Treatment. Journal of Radiation Research 51:1, pages 91-95.
Crossref
Gulshan Sunavala-Dossabhoy & Arrigo De Benedetti. (2009) Tousled homolog, TLK1, binds and phosphorylates Rad9; TLK1 acts as a molecular chaperone in DNA repair. DNA Repair 8:1, pages 87-102.
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