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Hiroyuki Ijima, Yukako Fukuda, Mario Kokichi Uehara, Muhammad Shafiq, Fanqi Wu, Jaeyong Cho, Yusuke Sakai, Tatsunori Miyata, Takanobu Yamao, Yosuke Nakao, Yosuke Kuroda, Takashi Motomura, Yo-Ichi Yamashita & Hideo Baba. (2023) Decellularized Mouse Liver as a Small-Scale Scaffold for the Creation of a Miniaturized Human Liver. Journal of Chemical Engineering of Japan 56:1.
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Lanuza A. P. Faccioli, Zehra N. Kocas-Kilicarslan, Ricardo Diaz-Aragon, Takashi Motomura, Sriram Amirneni, Michelle R. Malizio, Michael C. Coard, Carla Frau, Nils Haep, Rodrigo M. Florentino & Alina Ostrowska. (2021) Human Hepatocytes Isolated from Explanted Livers: A Powerful Tool to Understand End-stage Liver Disease and Drug Screening. Organogenesis 17:3-4, pages 117-125.
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Si Chen, Qiangen Wu, Xilin Li, Dongying Li, Nan Mei, Baitang Ning, Montserrat Puig, Zhen Ren, William H. Tolleson & Lei Guo. (2021) Characterization of cytochrome P450s (CYP)-overexpressing HepG2 cells for assessing drug and chemical-induced liver toxicity. Journal of Environmental Science and Health, Part C 39:1, pages 68-86.
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Wei Wang, Mulder Teresa, Jingwei Cai, Chenghong Zhang, Susan Wong, Zhengyin Yan, S. Cyrus Khojasteh & Donglu Zhang. (2021) Comparative assessment for rat strain differences in metabolic profiles of 14 drugs in Wistar Han and Sprague Dawley hepatocytes. Xenobiotica 51:1, pages 15-23.
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Mingxiang Liao, Qing Zhu, Andy Zhu, Christopher Gemski, Bingli Ma, Emily Guan, Albert P. Li, Guangqing Xiao & Cindy Q. Xia. (2019) Comparison of uptake transporter functions in hepatocytes in different species to determine the optimal model for evaluating drug transporter activities in humans. Xenobiotica 49:7, pages 852-862.
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Cene Skubic, Živa Drakulić & Damjana Rozman. (2018) Personalized therapy when tackling nonalcoholic fatty liver disease: a focus on sex, genes, and drugs. Expert Opinion on Drug Metabolism & Toxicology 14:8, pages 831-841.
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Carlemi Calitz, Josias H. Hamman, Stephen J. Fey, Krzysztof Wrzesinski & Chrisna Gouws. (2018) Recent advances in three-dimensional cell culturing to assess liver function and dysfunction: from a drug biotransformation and toxicity perspective. Toxicology Mechanisms and Methods 28:5, pages 369-385.
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Imran Ullah, Yeongji Kim, Malgum Lim, Keon Bong Oh, Seongsoo Hwang, Yurianna Shin, Youngim Kim, Gi-Sun Im, Tai-Young Hur & Sun A Ock. (2017) In vitro 3-D culture demonstrates incompetence in improving maintenance ability of primary hepatocytes. Animal Cells and Systems 21:5, pages 332-340.
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Tetsuo Yamagata, Ugo Zanelli, Dieter Gallemann, Dominique Perrin, Hugues Dolgos & Carl Petersson. (2017) Comparison of methods for the prediction of human clearance from hepatocyte intrinsic clearance for a set of reference compounds and an external evaluation set. Xenobiotica 47:9, pages 741-751.
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Maria Teresa Donato, Maria José Gómez-Lechón & Laia Tolosa. (2017) Using high-content screening technology for studying drug-induced hepatotoxicity in preclinical studies. Expert Opinion on Drug Discovery 12:2, pages 201-211.
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M. José Gómez-Lechón, Laia Tolosa & M. Teresa Donato. (2017) Upgrading HepG2 cells with adenoviral vectors that encode drug-metabolizing enzymes: application for drug hepatotoxicity testing. Expert Opinion on Drug Metabolism & Toxicology 13:2, pages 137-148.
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Zdenek Dvorak. (2016) Opportunities and challenges in using human hepatocytes in cytochromes P450 induction assays. Expert Opinion on Drug Metabolism & Toxicology 12:2, pages 169-174.
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Konstantin N Yarygin, Alexei Y Lupatov & Irina V Kholodenko. (2015) Cell-based therapies of liver diseases: age-related challenges. Clinical Interventions in Aging 10, pages 1909-1924.
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Yubao Gao, Jiuxing Liang, Yuxi Luo & Yihong Gong. (2015) Structural optimization design of perfusion bioreactors with multilayer circular parallel plates scaffold. Biotechnology & Biotechnological Equipment 29:3, pages 602-608.
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Aurelie Vivares, Sandrine Salle-Lefort, Catherine Arabeyre-Fabre, Robert Ngo, Geraldine Penarier, Michele Bremond, Patricia Moliner, Jean-François Gallas, Gerard Fabre & Sylvie Klieber. (2015) Morphological behaviour and metabolic capacity of cryopreserved human primary hepatocytes cultivated in a perfused multiwell device. Xenobiotica 45:1, pages 29-44.
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M José Gómez-Lechón, Laia Tolosa, Isabel Conde & M Teresa Donato. (2014) Competency of different cell models to predict human hepatotoxic drugs. Expert Opinion on Drug Metabolism & Toxicology 10:11, pages 1553-1568.
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Marija Pinne & Judy L Raucy. (2014) Advantages of cell-based high-volume screening assays to assess nuclear receptor activation during drug discovery. Expert Opinion on Drug Discovery 9:6, pages 669-686.
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Vicki M. Richardson, Stephen S. Ferguson, Yusupha M. Sey & Michael J. DeVito. (2014) In vitro metabolism of thyroxine by rat and human hepatocytes. Xenobiotica 44:5, pages 391-403.
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C. Desbans, C. Hilgendorf, M. Lutz, P. Bachellier, T. Zacharias, J. C. Weber, H. Dolgos, L. Richert & A.-L. Ungell. (2014) Prediction of fraction metabolized via CYP3A in humans utilizing cryopreserved human hepatocytes from a set of 12 single donors. Xenobiotica 44:1, pages 17-27.
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Saeed Alqahtani, Loqman A Mohamed & Amal Kaddoumi. (2013) Experimental models for predicting drug absorption and metabolism. Expert Opinion on Drug Metabolism & Toxicology 9:10, pages 1241-1254.
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Sanja Juric, Patrik Lundquist, Yin Hu, Anna Juréus & Anna-Karin Sohlenius-Sternbeck. (2013) The utility of cold-preserved human hepatocytes in studies on cytochrome P450 induction and hepatic drug transport. Xenobiotica 43:9, pages 785-791.
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Eva Ramboer, Tamara Vanhaecke, Vera Rogiers & Mathieu Vinken. (2013) Primary hepatocyte cultures as prominent in vitro tools to study hepatic drug transporters. Drug Metabolism Reviews 45:2, pages 196-217.
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Ling Li, Amr Nouraldeen & Alan G. E. Wilson. (2013) Evaluation of transporter-mediated hepatic uptake in a non-radioactive high-throughput assay: a study of kinetics, species difference and plasma protein effect. Xenobiotica 43:3, pages 253-262.
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Yvonne Peck & Dong-An Wang. (2013) Three-dimensionally engineered biomimetic tissue models for in vitro drug evaluation: delivery, efficacy and toxicity. Expert Opinion on Drug Delivery 10:3, pages 369-383.
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Judy L. Raucy & Jerome M. Lasker. (2013) Cell-based systems to assess nuclear receptor activation and their use in drug development. Drug Metabolism Reviews 45:1, pages 101-109.
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Régis Baudoin, Jean Matthieu Prot, Grégory Nicolas, Jessy Brocheton, Céline Brochot, Cécile Legallais, Henri Benech & Eric Leclerc. (2013) Evaluation of seven drug metabolisms and clearances by cryopreserved human primary hepatocytes cultivated in microfluidic biochips. Xenobiotica 43:2, pages 140-152.
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Brian G. Lake & Roger J. Price. (2013) Evaluation of the metabolism and hepatotoxicity of xenobiotics utilizing precision-cut slices. Xenobiotica 43:1, pages 41-53.
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Eliane Alexandre, Audrey Baze, Céline Parmentier, Coraline Desbans, Dumrongsak Pekthong, Brigitte Gerin, Claudine Wack, Philippe Bachellier, Bruno Heyd, Jean-Christophe Weber & Lysiane Richert. (2012) Plateable cryopreserved human hepatocytes for the assessment of cytochrome P450 inducibility: experimental condition-related variables affecting their response to inducers. Xenobiotica 42:10, pages 968-979.
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Alexandra Burkard, Caroline Dähn, Stefan Heinz, Anne Zutavern, Vera Sonntag-Buck, Daniel Maltman, Stefan Przyborski, Nicola J. Hewitt & Joris Braspenning. (2012) Generation of proliferating human hepatocytes using upcyte® technology: characterisation and applications in induction and cytotoxicity assays. Xenobiotica 42:10, pages 939-956.
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Miyoung Yoon, Jerry L. Campbell, Melvin E. Andersen & Harvey J. Clewell. (2012) Quantitative in vitro to in vivo extrapolation of cell-based toxicity assay results. Critical Reviews in Toxicology 42:8, pages 633-652.
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Anna-Karin Sohlenius-Sternbeck, Christopher Jones, Douglas Ferguson, Brian J. Middleton, Denis Projean, Eva Floby, Johan Bylund & Lovisa Afzelius. (2012) Practical use of the regression offset approach for the prediction of in vivo intrinsic clearance from hepatocytes. Xenobiotica 42:9, pages 841-853.
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Edward L. LeCluyse, Rafal P. Witek, Melvin E. Andersen & Mark J. Powers. (2012) Organotypic liver culture models: Meeting current challenges in toxicity testing. Critical Reviews in Toxicology 42:6, pages 501-548.
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Guillaume Baneyx, Yumi Fukushima & Neil Parrott. (2012) Use Of Physiologically Based Pharmacokinetic Modeling For Assessment Of Drug–Drug Interactions. Future Medicinal Chemistry 4:5, pages 681-693.
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Imen Ayed-Boussema, Jean Marc Pascussi, Chiraz Zaied, Patrick Maurel, Hassen Bacha & Wafa Hassen. (2012) Ochratoxin A induces CYP3A4, 2B6, 3A5, 2C9, 1A1, and CYP1A2 gene expression in primary cultured human hepatocytes: a possible activation of nuclear receptors. Drug and Chemical Toxicology 35:1, pages 71-80.
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Matthew D. Merrell & Nathan J. Cherrington. (2011) Drug metabolism alterations in nonalcoholic fatty liver disease. Drug Metabolism Reviews 43:3, pages 317-334.
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Kornélia Szebényi, Zsuzsa Erdei, Adrienn Péntek, Attila Sebe, Tamás I Orbán, Balázs Sarkadi & Ágota Apáti. (2011) Human Pluripotent Stem Cells in Pharmacological and Toxicological Screening: New Perspectives for Personalized Medicine. Personalized Medicine 8:3, pages 347-364.
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J. G. Hengstler, H. Foth, T. Gebel, P.-J. Kramer, W. Lilienblum, H. Schweinfurth, W. Völkel, K.-M. Wollin & U. Gundert-Remy. (2011) Critical evaluation of key evidence on the human health hazards of exposure to bisphenol A. Critical Reviews in Toxicology 41:4, pages 263-291.
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Joanne A. Foster, J. Brian Houston & David Hallifax. (2011) Comparison of intrinsic clearances in human liver microsomes and suspended hepatocytes from the same donor livers: clearance-dependent relationship and implications for prediction of in vivo clearance. Xenobiotica 41:2, pages 124-136.
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A. Kaneko, M. Kato, C. Endo, K. Nakano, M. Ishigai & K. Takeda. (2010) Prediction of clinical CYP3A4 induction using cryopreserved human hepatocytes. Xenobiotica 40:12, pages 791-799.
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A.-K. Sohlenius-Sternbeck, L. Afzelius, P. Prusis, J. Neelissen, J. Hoogstraate, J. Johansson, E. Floby, A. Bengtsson, O. Gissberg, J. Sternbeck & C. Petersson. (2010) Evaluation of the human prediction of clearance from hepatocyte and microsome intrinsic clearance for 52 drug compounds. Xenobiotica 40:9, pages 637-649.
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Brandon Swift*Nathan D. Pfeifer*Kim L.R. Brouwer. (2010) Sandwich-cultured hepatocytes: an in vitro model to evaluate hepatobiliary transporter-based drug interactions and hepatotoxicity. Drug Metabolism Reviews 42:3, pages 446-471.
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Masashi Honma, Masanari Kozawa & Hiroshi Suzuki. (2010) Methods for the quantitative evaluation and prediction of CYP enzyme induction using human in vitro systems. Expert Opinion on Drug Discovery 5:5, pages 491-511.
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Olivier Fardel & Marc Le Vée. (2009) Regulation of human hepatic drug transporter expression by pro-inflammatory cytokines. Expert Opinion on Drug Metabolism & Toxicology 5:12, pages 1469-1481.
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J. A. Skare, N. J. Hewitt, E. Doyle, R. Powrie & C. Elcombe. (2009) Metabolite screening of aromatic amine hair dyes using in vitro hepatic models. Xenobiotica 39:11, pages 811-825.
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Maria A Croyle. (2009) Long-term virus-induced alterations of CYP3A-mediated drug metabolism: a look at the virology, immunology and molecular biology of a multi-faceted problem. Expert Opinion on Drug Metabolism & Toxicology 5:10, pages 1189-1211.
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E. Floby, J. Johansson, J. Hoogstraate, N. J. Hewitt, J. Hill & A.-K. Sohlenius-Sternbeck. (2009) Comparison of intrinsic metabolic clearance in fresh and cryopreserved human hepatocytes. Xenobiotica 39:9, pages 656-662.
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M. Zheng, J. Wang, J. Lubinski, O. P. Flint, R. Krishna, M. Yao, J. M. Pursley, A. Thakur, D. W. Boulton, K. S. Santone, D. M. Barten, J. J. Anderson, K. M. Felsenstein & S. B. Hansel. (2009) Studies on the pharmacokinetics and metabolism of a γ-secretase inhibitor BMS-299897, and exploratory investigation of CYP enzyme induction. Xenobiotica 39:7, pages 544-555.
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J. R. Kenny, L. Chen, D. F. McGinnity, K. Grime, K. M. Shakesheff, B. Thomson & R. Riley. (2008) Efficient assessment of the utility of immortalized Fa2N-4 cells for cytochrome P450 (CYP) induction studies using multiplex quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) and substrate cassette methodologies. Xenobiotica 38:12, pages 1500-1517.
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André Guillouzo & Christiane Guguen-Guillouzo. (2008) Evolving concepts in liver tissue modeling and implications for in vitro toxicology. Expert Opinion on Drug Metabolism & Toxicology 4:10, pages 1279-1294.
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R. Stringer, P. L. Nicklin & J. B. Houston. (2008) Reliability of human cryopreserved hepatocytes and liver microsomes as systems to predict metabolic clearance. Xenobiotica 38:10, pages 1313-1329.
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David FV Lewis & Yuko Ito. (2008) Human cytochromes P450 in the metabolism of drugs: new molecular models of enzyme–substrate interactions. Expert Opinion on Drug Metabolism & Toxicology 4:9, pages 1181-1186.
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Gregor Tuschl, Birthe Lauer & Stefan O Mueller. (2008) Primary hepatocytes as a model to analyze species-specific toxicity and drug metabolism. Expert Opinion on Drug Metabolism & Toxicology 4:7, pages 855-870.
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María José Gómez-Lechón, José V Castell & María Teresa Donato. (2008) An update on metabolism studies using human hepatocytes in primary culture. Expert Opinion on Drug Metabolism & Toxicology 4:7, pages 837-854.
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R. J. Price, M. P. Scott, A. M. Giddings, D. G. Walters, R. H. Stierum, C. Meredith & B. G. Lake. (2008) Effect of butylated hydroxytoluene, curcumin, propyl gallate and thiabendazole on cytochrome P450 forms in cultured human hepatocytes. Xenobiotica 38:6, pages 574-586.
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D. Hallifax, A. Galetin & J. B. Houston. (2008) Prediction of metabolic clearance using fresh human hepatocytes: Comparison with cryopreserved hepatocytes and hepatic microsomes for five benzodiazepines. Xenobiotica 38:4, pages 353-367.
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Ping Zhao. (2008) The use of hepatocytes in evaluating time-dependent inactivation of P450 in vivo. Expert Opinion on Drug Metabolism & Toxicology 4:2, pages 151-164.
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Alejandro Soto-Gutierrez, Hesham Basma, Nalu Navarro-Alvarez, Basak
E. Uygun, Martin
L. Yarmush, Naoya Kobayashi & Ira
J. Fox. (2008) Differentiating Stem Cells into Liver. Biotechnology and Genetic Engineering Reviews 25:1, pages 149-164.
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M. Baker & T. Parton. (2007) Kinetic determinants of hepatic clearance: Plasma protein binding and hepatic uptake. Xenobiotica 37:10-11, pages 1110-1134.
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O. Pelkonen & M. Turpeinen. (2007) extrapolation of hepatic clearance: Biological tools, scaling factors, model assumptions and correct concentrations. Xenobiotica 37:10-11, pages 1066-1089.
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N. J. Hewitt, E. L. Lecluyse & S. S. Ferguson. (2007) Induction of hepatic cytochrome P450 enzymes: methods, mechanisms, recommendations, and correlations. Xenobiotica 37:10-11, pages 1196-1224.
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Hongjian Zhang, Carl D Davis, Michael W Sinz & A David Rodrigues. (2007) Cytochrome P450 reaction-phenotyping: an industrial perspective. Expert Opinion on Drug Metabolism & Toxicology 3:5, pages 667-687.
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G. I. Somers, M. K. Bayliss & J. B. Houston. (2007) The metabolism of the 5HT3 antagonists, ondansetron, alosetron and GR87442 II: Investigation into the in vitro methods used to predict the in vivo hepatic clearance of ondansetron, alosetron and GR87442 in the rat, dog and human. Xenobiotica 37:8, pages 855-869.
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