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Review Article

Metabolic syndrome: Clinical concept and molecular basis

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Pages 482-494 | Published online: 08 Jul 2009

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Xi Yang, Yi Lin, Guo-dong Xu, Yan-shu Chen, Ye Zhou, Jing Sun & Li Li. (2021) Optimal Cut-Off Values of Visceral Fat Area for Predicting Metabolic Syndrome Among Type 2 Diabetes Patients in Ningbo, China. Diabetes, Metabolic Syndrome and Obesity 14, pages 1375-1383.
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Irene Coll-Risco, Virginia A. Aparicio, Elena Nebot, Daniel Camiletti-Moirón, Rosario Martínez, Garyfallia Kapravelou, María López-Jurado, Jesús M. Porres & Pilar Aranda. (2016) Effects of interval aerobic training combined with strength exercise on body composition, glycaemic and lipid profile and aerobic capacity of obese rats. Journal of Sports Sciences 34:15, pages 1452-1460.
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Iwona Rotter, Danuta Kosik-Bogacka, Barbara Dołęgowska, Karolina Skonieczna-Żydecka, Wioletta Pawlukowska & Maria Laszczyńska. (2015) Analysis of relationships between the concentrations of total testosterone and dehydroepiandrosterone sulfate and the occurrence of selected metabolic disorders in aging men. The Aging Male 18:4, pages 249-255.
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Ken Kishida, Tohru Funahashi, Yuji Matsuzawa & Iichiro Shimomura. (2012) Visceral adiposity as a target for the management of the metabolic syndrome. Annals of Medicine 44:3, pages 233-241.
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Anna Alisi, Stefano Cianfarani, Melania Manco, Carlo Agostoni & Valerio Nobili. (2012) Non-alcoholic fatty liver disease and metabolic syndrome in adolescents: Pathogenetic role of genetic background and intrauterine environment. Annals of Medicine 44:1, pages 29-40.
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Aki Hiuge-Shimizu, Ken Kishida, Tohru Funahashi, Yuko Ishizaka, Rie Oka, Minoru Okada, Shizu Suzuki, Norihide Takaya, Tohru Nakagawa, Toshiki Fukui, Hiroshi Fukuda, Naoya Watanabe, Tohru Yoshizumi, Tadashi Nakamura, Yuji Matsuzawa, Minoru Yamakado & Iichiro Shimomura. (2012) Absolute value of visceral fat area measured on computed tomography scans and obesity-related cardiovascular risk factors in large-scale Japanese general population (the VACATION-J study). Annals of Medicine 44:1, pages 82-92.
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Alberto Jiménez-Maldonado, Patricia C. García-Suárez, Iván Rentería, José Moncada-Jiménez & Eric P. Plaisance. (2020) Impact of high-intensity interval training and sprint interval training on peripheral markers of glycemic control in metabolic syndrome and type 2 diabetes. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1866:8, pages 165820.
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Yumiko Oishi & Ichiro Manabe. (2020) Organ System Crosstalk in Cardiometabolic Disease in the Age of Multimorbidity. Frontiers in Cardiovascular Medicine 7.
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Sushil K. Dubey, Vivek K. Chaturvedi, Divya Mishra, Anand Bajpeyee, Aprajita Tiwari & M. P. Singh. (2019) Role of edible mushroom as a potent therapeutics for the diabetes and obesity. 3 Biotech 9:12.
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Jaana van Gastel, Jan Boddaert, Areta Jushaj, Richard T. Premont, Louis M. Luttrell, Jonathan Janssens, Bronwen Martin & Stuart Maudsley. (2018) GIT2—A keystone in ageing and age-related disease. Ageing Research Reviews 43, pages 46-63.
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Kazuyo Tsushita, Akiko S Hosler, Katsuyuki Miura, Yukiko Ito, Takashi Fukuda, Akihiko Kitamura & Kozo Tatara. (2018) Rationale and Descriptive Analysis of Specific Health Guidance: the Nationwide Lifestyle Intervention Program Targeting Metabolic Syndrome in Japan. Journal of Atherosclerosis and Thrombosis 25:4, pages 308-322.
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Ming-Ling Chang, Chia-Jung Kuo, Hsin-Chih Huang, Yin-Yi Chu & Cheng-Tang Chiu. (2016) Association between Leptin and Complement in Hepatitis C Patients with Viral Clearance: Homeostasis of Metabolism and Immunity. PLOS ONE 11:11, pages e0166712.
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Hong-Ming Hsu, Wen-Ying Chen, Pin-Ho Pan & Frank Chiahung Mao. (2014) Vitis thunbergii supplementation demonstrates an anti-obesity effect in developing obese mice. European Journal of Integrative Medicine 6:5, pages 581-587.
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Yin Xueyao, Zhang Saifei, Yu Dan, Pan Qianqian, Dong Xuehong, Zhou Jiaqiang, Zheng Fenping & Li Hong. (2014) Circulating Fractalkine Levels Predict the Development of the Metabolic Syndrome. International Journal of Endocrinology 2014, pages 1-9.
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Manuela Cabiati, Serena Raucci, Tiziana Liistro, Eugenia Belcastro, Tommaso Prescimone, Chiara Caselli, Marco Matteucci, Patricia Iozzo, Letizia Mattii, Daniela Giannessi & Silvia Del Ry. (2013) Impact of Obesity on the Expression Profile of Natriuretic Peptide System in a Rat Experimental Model. PLoS ONE 8:8, pages e72959.
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Nilanjana Ph. D.S Sivasankaran. 2013. Cardiovascular Diseases. Cardiovascular Diseases 277 308 .
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Akira Tsujimura. (2013) The Relationship between Testosterone Deficiency and Men's Health. The World Journal of Men's Health 31:2, pages 126.
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Norikazu Maeda, Tohru Funahashi & Iichiro Shimomura. (2013) Cardiovascular-metabolic impact of adiponectin and aquaporin [Review]. Endocrine Journal 60:3, pages 251-259.
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Tomoki Nagata, Daisuke Sugiyama, Takako Kise, Satomi Tsuji, Hideo Ohira, Itsuko Sato, Mari Yamamoto, Hitomi Kohsaka, Seiji Kawano, Shizuya Yamashita, Yuichi Ishikawa & Yoshio Fujioka. (2012) Fasting remnant lipoproteins can predict postprandial hyperlipidemia. Lipids in Health and Disease 11:1.
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Jeong-Ah Lee, Jong-Won Kim & Do-Yeon Kim. (2012) Effects of yoga exercise on serum adiponectin and metabolic syndrome factors in obese postmenopausal women. Menopause 19:3, pages 296-301.
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Shigeko Hara, Hiroshi Tsuji, Yuki Ohmoto, Kazuhisa Amakawa, Shiun Dong Hsieh, Yasuji Arase & Hiromu Nakajima. (2012) High serum uric acid level and low urine pH as predictors of metabolic syndrome: a retrospective cohort study in a Japanese urban population. Metabolism 61:2, pages 281-288.
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Aki Hiuge-Shimizu, Ken Kishida, Tohru Funahashi, Yuko Ishizaka, Rie Oka, Minoru Okada, Shizu Suzuki, Norihide Takaya, Tohru Nakagawa, Toshiki Fukui, Hiroshi Fukuda, Naoya Watanabe, Tohru Yoshizumi, Tetsuya Ohira, Tadashi Nakamura, Yuji Matsuzawa, Minoru Yamakado & Iichiro Shimomura. (2012) Reduction of Visceral Fat Correlates with the Decrease in the Number of Obesity-Related Cardiovascular Risk Factors in Japanese with Abdominal Obesity (VACATION-J Study). Journal of Atherosclerosis and Thrombosis 19:11, pages 1006-1018.
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Yoichi Ohno, Satomi Shibazaki, Ryuichiro Araki, Takashi Miyazaki, Mayuko Hanyu, Makiko Satoh, Tsuneo Takenaka, Hirokazu Okada & Hiromichi Suzuki. (2011) Antihypertensive medication versus health promotion for improving metabolic syndrome in preventing cardiovascular events: a success rate-oriented simulation study. BMC Medical Informatics and Decision Making 11:1.
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Akira Tsujimura & Norio Nonomura. (2011) Recent topics related to testosterone deficiency syndrome in Japan. Asian Journal of Andrology 13:4, pages 558-562.
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Susumu Kashine, Ken Kishida, Tohru Funahashi, Tetsuyuki Yasuda, Kohei Okita, Yuji Matsuzawa & Iichiro Shimomura. (2011) Selective Contribution of Waist Circumference Reduction on the Improvement of Sleep-disordered Breathing in Patients Hospitalized with Type 2 Diabetes Mellitus. Internal Medicine 50:18, pages 1895-1903.
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Michio Otsuki, Tetsuhiro Kitamura, Kayoko Goya, Hiroshi Saito, Mikio Mukai, Soji Kasayama, Iichiro Shimomura & Masafumi Koga. (2011) Association of urine acidification with visceral obesity and the metabolic syndrome. Endocrine Journal 58:5, pages 363-367.
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Junji Kozawa, Hiromi Iwahashi, Kohei Okita, Yukiyoshi Okauchi, Akihisa Imagawa & Iichiro Shimomura. (2011) Insulin tolerance test predicts the effectiveness of insulin sensitizers in japanese type 2 diabetic patients. Diabetes Therapy 1:2, pages 121-130.
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Sachiko Tamba, Hideaki Nakatsuji, Ken Kishida, Midori Noguchi, Tomoko Ogawa, Yukiyoshi Okauchi, Hitoshi Nishizawa, Akihisa Imagawa, Tadashi Nakamura, Yuji Matsuzawa, Tohru Funahashi & Iichiro Shimomura. (2010) Relationship between visceral fat accumulation and urinary albumin-creatinine ratio in middle-aged Japanese men. Atherosclerosis 211:2, pages 601-605.
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Christoph Oberlinner, Andreas Zober, Peter P. Nawroth, Per M. Humpert & Michael Morcos. (2009) Alanine-aminotransferase levels predict impaired glucose tolerance in a worksite population. Acta Diabetologica 47:2, pages 161-165.
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Mark J. Nesbitt, Mark A. Reynolds, Harlan Shiau, Kyong Choe, Eleanor M. Simonsick & Luigi Ferrucci. (2013) Association of periodontitis and metabolic syndrome in the Baltimore Longitudinal Study of Aging. Aging Clinical and Experimental Research 22:3, pages 238-242.
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Hideaki Nakatsuji, Ken Kishida, Teruo Kitamura, Chika Nakajima, Tohru Funahashi & Iichiro Shimomura. (2010) Dysregulation of glucose, insulin, triglyceride, blood pressure, and oxidative stress after an oral glucose tolerance test in men with abdominal obesity. Metabolism 59:4, pages 520-526.
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Noriko Tamei, Tetsuya Ogawa, Hideki Ishida, Yoshitaka Ando & Kosaku Nitta. (2010) Relationship of High-Molecular-Weight Adiponectin Levels to Visceral Fat Accumulation in Hemodialysis Patients. Internal Medicine 49:4, pages 299-305.
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