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Research Article

Arsenic trioxide therapy in acute promyelocytic leukemia and beyond: from bench to bedside

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Pages 2387-2401 | Published online: 01 Jul 2009

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Read on this site (4)

Jingli Liu, Tonia Hermon, Xiaohua Gao, Darlene Dixon & Hang Xiao. (2023) Arsenic and diabetes mellitus: a putative role for the immune system. All Life 16:1.
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Seyed H. Ghaffari, Majid Momeny, Davood Bashash, Roohollah Mirzaei, Ardeshir Ghavamzadeh & Kamran Alimoghaddam. (2012) Cytotoxic effect of arsenic trioxide on acute promyelocytic leukemia cells through suppression of NFkβ-dependent induction of hTERT due to down-regulation of Pin1 transcription. Hematology 17:4, pages 198-206.
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Yu Su, XiaoMin Wang, WanHai Xu, Li Xue, ChunBo He, DeJun Yang & RuiHua An. (2012) Arsenic Trioxide Increases the Sensitivity of 786–0 Renal Carcinoma Cells to Radiotherapy. Cancer Investigation 30:2, pages 114-118.
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Philip G Board. (2007) The use of glutathione transferase-knockout mice as pharmacological and toxicological models. Expert Opinion on Drug Metabolism & Toxicology 3:3, pages 421-433.
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Articles from other publishers (34)

Judith A. Carrall, Wilford Lie, Jacob M. Lambert, Hugh H. Harris, Barry Lai & Carolyn T. Dillon. (2023) Optimizing Arsenic Therapy by Selectively Targeting Leukemia Cells. Journal of Medicinal Chemistry 66:17, pages 12101-12114.
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Wanbin Fu, Gelan Zhu, Lan Xu, Jia Liu, Xiaofeng Han, Junying Wang, Xinpeng Wang, Jian Hou, Huanbin Zhao & Hua Zhong. (2022) G-CSF upregulates the expression of aquaporin-9 through CEBPB to enhance the cytotoxic activity of arsenic trioxide to acute myeloid leukemia cells. Cancer Cell International 22:1.
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Xiaoniao Cai, Leilei Yu, Zhen Chen, Fangpeng Ye, Zonghai Ren & Peisheng Jin. (2020) Arsenic trioxide-induced upregulation of miR-1294 suppresses tumor growth in hepatocellular carcinoma by targeting TEAD1 and PIM1. Cancer Biomarkers 28:2, pages 221-230.
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Mengyuan Zhang, Xiaoguo Ma, Jing Li, Renfeng Huang, Lihui Guo, Xiaofeng Zhang, Yinming Fan, Xiaowen Xie & Guolong Zeng. (2019) Enhanced removal of As(Ⅲ) and As(Ⅴ) from aqueous solution using ionic liquid-modified magnetic graphene oxide. Chemosphere 234, pages 196-203.
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Yuxue Zhao, Kenji Onda, Bo Yuan, Sachiko Tanaka, Anna Kiyomi, Kentaro Sugiyama, Munetoshi Sugiura, Norio Takagi & Toshihiko Hirano. (2018) Arsenic disulfide‑induced apoptosis and its potential mechanism in two‑ and three‑dimensionally cultured human breast cancer MCF‑7 cells. International Journal of Oncology.
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Leanne Lee Leung, Sze-Kwan Lam, Yuan-Yuan Li & James Chung-Man Ho. (2017) Tumour growth-suppressive effect of arsenic trioxide in squamous cell lung carcinoma. Oncology Letters 14:3, pages 3748-3754.
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Elaheh Nooshinfar, Davood Bashash, Ava Safaroghli-Azar, Samaneh Bayati, Mostafa Rezaei-Tavirani, Seyed H. Ghaffari & Mohammad Esmaeil Akbari. (2016) Melatonin promotes ATO-induced apoptosis in MCF-7 cells: Proposing novel therapeutic potential for breast cancer. Biomedicine & Pharmacotherapy 83, pages 456-465.
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Yingjian Zeng, Guangyang Weng, Jiaxin Fan, Zhangqiu Li, Jianwei Wu, Yuanming Li, Rong Zheng, Pingfang Xia & Kunyuan Guo. (2016) Curcumin reduces the expression of survivin, leading to enhancement of arsenic trioxide-induced apoptosis in myelodysplastic syndrome and leukemia stem-like cells. Oncology Reports 36:3, pages 1233-1242.
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SUIJING WU, LING XU, XIN HUANG, SUXIA GENG, YAN XU, SHAOHUA CHEN, LIJIAN YANG, XIULI WU, JANYU WENG, XIN DU & YANGQIU LI. (2016) Arsenic induced complete remission in a refractory T-ALL patient with a distinct T-cell clonal evolution without molecular complete remission: A case report. Oncology Letters 11:6, pages 4123-4130.
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Xin Zhang, Xin-Rong Yang, Chao Sun, Bo Hu, Yun-Fan Sun, Xiao-Wu Huang, Zheng Wang, Yi-Feng He, Hai-Ying Zeng, Shuang-Jian Qiu, Ya Cao, Jia Fan & Jian Zhou. (2015) Promyelocytic leukemia protein induces arsenic trioxide resistance through regulation of aldehyde dehydrogenase 3 family member A1 in hepatocellular carcinoma. Cancer Letters 366:1, pages 112-122.
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Joanna Roszak, Anna Smok-Pieniążek, Marek Nocuń & Maciej Stępnik. (2013) Characterization of arsenic trioxide resistant clones derived from Jurkat leukemia T cell line: Focus on PI3K/Akt signaling pathway. Chemico-Biological Interactions 205:3, pages 198-211.
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Saeed Hassani, Seyed H. Ghaffari, Farhad Zaker, Rohellah Mirzaee, Hajar Mardani, Davood Bashash, Ali Zekri, Meysam Yousefi, Azam Zaghal, Kamran Alimoghaddam & Ardeshir Ghavamzadeh. (2013) Azidothymidine hinders arsenic trioxide-induced apoptosis in acute promyelocytic leukemia cells by induction of p21 and attenuation of G2/M arrest. Annals of Hematology 92:9, pages 1207-1220.
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Bin He, Chungang Yuan, Jing Sun & Guibin Jiang. 2012. Analytical Techniques for Clinical Chemistry. Analytical Techniques for Clinical Chemistry 409 453 .
Roya Mahinpour, Gholamhossein Riazi, Mohammad A. Shokrgozar, Mohammad N. Sarbolouki, Shahin Ahmadian, Masoumeh Douraghi, Hamid Hadi Alijanvand, Kayhan Azadmanesh, Maryam Heidari, Zahra Naghdi Gheshlaghi & Ali A. Moosavi‐Movahedi. (2013) Disruption of tubulin polymerization and cell proliferation by 1‐naphthylarsonic acid. Cell Biology International 36:4, pages 403-408.
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Shengpeng Wang, Xu Wu, Miao Tan, Jian Gong, Wen Tan, Baolin Bian, Meiwan Chen & Yitao Wang. (2012) Fighting fire with fire: Poisonous Chinese herbal medicine for cancer therapy. Journal of Ethnopharmacology 140:1, pages 33-45.
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Gail J. Roboz, Ellen K. Ritchie, Tania Curcio, Michael Samuel, Juliette Provenzano, Javier Segovia, Paul J. Christos, Susan Mathew, Sandra Allen-Bard & Eric J. Feldman. (2011) Arsenic trioxide and low-dose cytarabine for patients with intermediate-2 and high-risk myelodysplastic syndrome. Leukemia Research 35:4, pages 522-525.
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Qian Liu, Hao Zhang, Lisa Smeester, Fei Zou, Matt Kesic, Ilona Jaspers, Jingbo Pi & Rebecca C Fry. (2010) The NRF2-mediated oxidative stress response pathway is associated with tumor cell resistance to arsenic trioxide across the NCI-60 panel. BMC Medical Genomics 3:1.
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Ashkan Emadi & Steven D. Gore. (2010) Arsenic trioxide — An old drug rediscovered. Blood Reviews 24:4-5, pages 191-199.
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Kristie L. Munro, Keith R. Bambery, Elizabeth A. Carter, Ljiljana Puskar, Mark J. Tobin, Bayden R. Wood & Carolyn T. Dillon. (2010) Synchrotron radiation infrared microspectroscopy of arsenic-induced changes to intracellular biomolecules in live leukemia cells. Vibrational Spectroscopy 53:1, pages 39-44.
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Susan Lösler, Sarah Schlief, Christiane Kneifel, Eckhard Thiel, Hubert Schrezenmeier & Markus T. Rojewski. (2009) Antimony-trioxide- and arsenic-trioxide-induced apoptosis in myelogenic and lymphatic cell lines, recruitment of caspases, and loss of mitochondrial membrane potential are enhanced by modulators of the cellular glutathione redox system. Annals of Hematology 88:11, pages 1047-1058.
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JE Chang, PM Voorhees, JM Kolesar, HG Ahuja, FA Sanchez, GA Rodriguez, K Kim, J Werndli, HH Bailey & BS Kahl. (2008) Phase II study of arsenic trioxide and ascorbic acid for relapsed or refractory lymphoid malignancies: a Wisconsin Oncology Network study. Hematological Oncology 27:1, pages 11-16.
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Helen M. Pettersson, Alexander Pietras, Matilda Munksgaard Persson, Jenny Karlsson, Leif Johansson, Maria C. Shoshan & Sven Påhlman. (2009) Arsenic trioxide is highly cytotoxic to small cell lung carcinoma cells. Molecular Cancer Therapeutics 8:1, pages 160-170.
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Gail J. Roboz, Ellen K. Ritchie, Tania Curcio, Juliette Provenzano, Rebecca Carlin, Michael Samuel, Beth Wittenberg, Madhu Mazumdar, Paul J. Christos, Susan Mathew, Sandra Allen‐Bard & Eric J. Feldman. (2008) Arsenic trioxide and low‐dose cytarabine in older patients with untreated acute myeloid leukemia, excluding acute promyelocytic leukemia. Cancer 113:9, pages 2504-2511.
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Kristie L. Munro, Anna Mariana, Andrejs I. Klavins, Amalanie J. Foster, Barry Lai, Stefan Vogt, ZhongHou Cai, Hugh H. Harris & Carolyn T. Dillon. (2008) Microprobe XRF Mapping and XAS Investigations of the Intracellular Metabolism of Arsenic for Understanding Arsenic-Induced Toxicity. Chemical Research in Toxicology 21:9, pages 1760-1769.
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Gail J. Roboz. (2008) Arsenic and Old Lace: Novel Approaches in Elderly Patients With Acute Myeloid Leukemia. Seminars in Hematology 45, pages S22-S24.
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Elizabeth FoxBassem I. RazzoukBrigitte C. WidemannShaun XiaoMichelle O'BrienWendy GoodspeedGregory H. ReamanSusan M. BlaneyAnthony J. Murgo, Frank M. BalisPeter C. Adamson. (2008) Phase 1 trial and pharmacokinetic study of arsenic trioxide in children and adolescents with refractory or relapsed acute leukemia, including acute promyelocytic leukemia or lymphoma. Blood 111:2, pages 566-573.
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Hong Zhang, George Duncan, Lixin Wang, Ping Liu, Hao Cui, John R. Reddan, Bao-Feng Yang & I. Michael Wormstone. (2007) Arsenic trioxide initiates ER stress responses, perturbs calcium signalling and promotes apoptosis in human lens epithelial cells. Experimental Eye Research 85:6, pages 825-835.
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Guo-qiang CHEN, Li-shun WANG, Ying-li WU & Yun YU. (2007) Leukemia, an effective model for chemical biology and target therapy. Acta Pharmacologica Sinica 28:9, pages 1316-1324.
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Helen M. Pettersson, Jenny Karlsson, Alexander Pietras, Ingrid Øra & Sven Påhlman. (2007) Arsenic trioxide and neuroblastoma cytotoxicity. Journal of Bioenergetics and Biomembranes 39:1, pages 35-41.
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Chae Hyeong Lee, Yong‐Tark Jeon, Su‐Hyeong Kim & Yong‐Sang Song. (2008) NF‐κB as a potential molecular target for cancer therapy. BioFactors 29:1, pages 19-35.
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. (2006) Pharmacokinetics of Arsenic Hexaoxide, a Anticancer Compound, in Rats. Journal of Korean Pharmaceutical Sciences 36:6, pages 377-383.
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Shoucheng Ning & Susan J. Knox. (2006) Optimization of combination therapy of arsenic trioxide and fractionated radiotherapy for malignant glioma. International Journal of Radiation Oncology*Biology*Physics 65:2, pages 493-498.
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E Maquarre, C Artus, Z Gadhoum, C Jasmin, F Smadja-Joffe & J Robert-Lézénès. (2005) CD44 ligation induces apoptosis via caspase- and serine protease-dependent pathways in acute promyelocytic leukemia cells. Leukemia 19:12, pages 2296-2303.
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