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Research Article

Cytotoxic activity of 4′-hydroxychalcone derivatives against Jurkat cells and their effects on mammalian DNA topoisomerase I

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Pages 804-807 | Received 07 Feb 2008, Accepted 09 Jul 2008, Published online: 01 Jun 2009

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Read on this site (7)

Sinan Bilginer, Halise Inci Gul, Feyza Sena Erdal, Hiroshi Sakagami, Serkan Levent, Ilhami Gulcin & Claudiu T. Supuran. (2019) Synthesis, cytotoxicities, and carbonic anhydrase inhibition potential of 6-(3-aryl-2-propenoyl)-2(3H)-benzoxazolones. Journal of Enzyme Inhibition and Medicinal Chemistry 34:1, pages 1722-1729.
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Cem Yamali, Halise Inci Gul, Hiroshi Sakagami & Claudiu T. Supuran. (2016) Synthesis and bioactivities of halogen bearing phenolic chalcones and their corresponding bis Mannich bases. Journal of Enzyme Inhibition and Medicinal Chemistry 31:sup4, pages 125-131.
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Halise Inci Gul, Mehtap Tugrak, Hiroshi Sakagami, Parham Taslimi, Ilhami Gulcin & Claudiu T. Supuran. (2016) Synthesis and bioactivity studies on new 4-(3-(4-Substitutedphenyl)-3a,4-dihydro-3H-indeno[1,2-c]pyrazol-2-yl) benzenesulfonamides. Journal of Enzyme Inhibition and Medicinal Chemistry 31:6, pages 1619-1624.
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Halise Inci Gul, Cem Yamali, Asiye Tugce Yasa, Elif Unluer, Hiroshi Sakagami, Muhammet Tanc & Claudiu T. Supuran. (2016) Carbonic anhydrase inhibition and cytotoxicity studies of Mannich base derivatives of thymol. Journal of Enzyme Inhibition and Medicinal Chemistry 31:6, pages 1375-1380.
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Cem Yamali, Mehtap Tugrak, Halise Inci Gul, Muhammet Tanc & Claudiu T. Supuran. (2016) The inhibitory effects of phenolic Mannich bases on carbonic anhydrase I and II isoenzymes. Journal of Enzyme Inhibition and Medicinal Chemistry 31:6, pages 1678-1681.
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Mehtap Tugrak, Cem Yamali, Hiroshi Sakagami & Halise Inci Gul. (2016) Synthesis of mono Mannich bases of 2-(4-hydroxybenzylidene)-2,3-dihydroinden-1-one and evaluation of their cytotoxicities. Journal of Enzyme Inhibition and Medicinal Chemistry 31:5, pages 818-823.
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Sinan Bilginer, Halise Inci Gul, Ebru Mete, Umashankar Das, Hiroshi Sakagami, Naoki Umemura & Jonathan Richard Dimmock. (2013) 1-(3-Aminomethyl-4-hydroxyphenyl)-3-pyridinyl-2-propen-1-ones: A novel group of tumour-selective cytotoxins. Journal of Enzyme Inhibition and Medicinal Chemistry 28:5, pages 974-980.
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Articles from other publishers (12)

Sinan Bilginer, Halise I. Gul, Feyza S. Erdal, Hiroshi Sakagami & Ilhami Gulcin. (2020) New halogenated chalcones with cytotoxic and carbonic anhydrase inhibitory properties: 6‐(3‐Halogenated phenyl‐2‐propen‐1‐oyl)‐2(3 H )‐benzoxazolones . Archiv der Pharmazie 353:6, pages 1900384.
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Sinan BİLGİNER. (2020) Benzoksazolon Türevi Şalkon Bileşiklerinin Sentezi ve Biyoaktivitelerinin AraştırılmasıSynthesis and Bioactivities of Benzoxazolone Derivative Chalcone Compounds. Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi 13:1, pages 334-347.
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Ihsan Ikhtiarudin, Nesa Agistia, Neni Frimayanti, Tria Harlianti & Jasril Jasril. (2020) Microwave-assisted synthesis of 1-(4-hydroxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one and its activities as an antioxidant, sunscreen, and antibacterial. Jurnal Kimia Sains dan Aplikasi 23:2, pages 51-60.
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M. Kuskucu, V. Akyildiz, Á. Kulmány, Y. Ergün, S. Zencir, I. Zupko, S. Durdagi, M. Zaka, K. Sahin, H. Orhan & Z. Topcu. (2019) Structural modification of ellipticine derivatives with alkyl groups of varying length is influential on their effects on human DNA topoisomerase II: a combined experimental and computational study. Medicinal Chemistry Research 29:2, pages 189-198.
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Maris A. Cinelli. (2018) Topoisomerase 1B poisons: Over a half‐century of drug leads, clinical candidates, and serendipitous discoveries. Medicinal Research Reviews 39:4, pages 1294-1337.
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Halise Inci Gul, Cem Yamali, Gulsen Gunesacar, Hiroshi Sakagami, Noriyuki Okudaira, Yoshihiro Uesawa & Hajime Kagaya. (2018) Cytotoxicity, apoptosis, and QSAR studies of phenothiazine derived methoxylated chalcones as anticancer drug candidates. Medicinal Chemistry Research 27:10, pages 2366-2378.
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Hidehiko Kikuchi, Futoshi Kuribayashi & Harishkumar Madhyastha. (2018) Positions and numbers of hydroxyl groups in hydroxychalcone derivatives are involved in cytotoxicity against human monoblastic U937 cells. Fundamental Toxicological Sciences 5:4, pages 149-152.
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Fatma Yesilyurt, Abdullah Aydin, Halise Inci Gul, Mehmet Akkurt & Nefise Dilek Ozcelik. (2018) Crystal structure and theoretical study of (2 E )-1-[4-hydroxy-3-(morpholin-4-ylmethyl)phenyl]-3-(thiophen-2-yl)prop-2-en-1-one . Acta Crystallographica Section E Crystallographic Communications 74:7, pages 960-963.
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Nilufer Bulut, Umit M. Kocyigit, Ibrahim H. Gecibesler, Taner Dastan, Huseyin Karci, Parham Taslimi, Sevgi Durna Dastan, Ilhami Gulcin & Ahmet Cetin. (2018) Synthesis of some novel pyridine compounds containing bis-1,2,4-triazole/thiosemicarbazide moiety and investigation of their antioxidant properties, carbonic anhydrase, and acetylcholinesterase enzymes inhibition profiles. Journal of Biochemical and Molecular Toxicology 32:1, pages e22006.
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Taner Dastan, Umit M. Kocyigit, Sevgi Durna Dastan, Pakize Canturk Kilickaya, Parham Taslimi, Ozge Cevik, Metin Koparir, Cahit Orek, İlhami Gulçin & Ahmet Cetin. (2017) Investigation of acetylcholinesterase and mammalian DNA topoisomerases, carbonic anhydrase inhibition profiles, and cytotoxic activity of novel bis(α‐aminoalkyl)phosphinic acid derivatives against human breast cancer. Journal of Biochemical and Molecular Toxicology 31:11.
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Cem Yamali, Dilan Ozmen Ozgun, Halise Inci Gul, Hiroshi Sakagami, Cavit Kazaz & Noriyuki Okudaira. (2017) Synthesis and structure elucidation of 1-(2,5/3,5-difluorophenyl)-3-(2,3/2,4/2,5/3,4-dimethoxyphenyl)-2-propen-1-ones as anticancer agents. Medicinal Chemistry Research 26:9, pages 2015-2023.
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Abdullah Aydın, Mehmet Akkurt, Halise Inci Gul, Kadir Ozden Yerdelen & Raziye Catak Celik. (2016) Crystal structure of 1-{4-hydroxy-3-[(pyrrolidin-1-yl)methyl]phenyl}-3-phenylprop-2-en-1-one. Acta Crystallographica Section E Crystallographic Communications 72:5, pages 696-698.
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