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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 32, 2017 - Issue 1
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Research Article

A new nitrobenzoxadiazole-based GSTP1-1 inhibitor with a previously unheard of mechanism of action and high stability

Chiara FulciDepartment of Experimental Medicine and Surgery, University of Tor Vergata, Rome, Italy; View further author information
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Dante RotiliDepartment of Drug Chemistry and Technologies, University of Rome “Sapienza”, Rome, Italy; ORCID Iconhttp://orcid.org/0000-0002-8428-8763View further author information
ORCID Icon,
Anastasia De LucaDepartment of Experimental Medicine and Surgery, University of Tor Vergata, Rome, Italy; View further author information
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Lorenzo StellaDepartment of Chemical Sciences and Technologies; ORCID Iconhttp://orcid.org/0000-0002-5489-7381View further author information
ORCID Icon,
Blasco Morozzo della RoccaDepartment of Biology, University of Tor Vergata, Rome, Italy; View further author information
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Mariantonietta ForgioneDepartment of Drug Chemistry and Technologies, University of Rome “Sapienza”, Rome, Italy; View further author information
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Veronica Di PaoloDepartment of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy; View further author information
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Antonello MaiDepartment of Drug Chemistry and Technologies, University of Rome “Sapienza”, Rome, Italy; ;Pasteur Institute, Cenci Bolognetti Foundation, University of Rome “La Sapienza”, Rome, Italy; View further author information
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Mattia FalconiDepartment of Biology, University of Tor Vergata, Rome, Italy; View further author information
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Luigi QuintieriDepartment of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy; View further author information
&
Anna M. CaccuriDepartment of Experimental Medicine and Surgery, University of Tor Vergata, Rome, Italy; ;The NAST Centre for Nanoscience & Nanotechnology & Innovative Instrumentation, University of Tor Vergata, Rome, ItalyCorrespondence[email protected]
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Pages 240-247 | Received 28 Jul 2016, Accepted 20 Sep 2016, Published online: 18 Jan 2017

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Sarah A. P. Pereira, A. Catarina Baptista L, Lorenzo Biancalana, Fabio Marchetti, Paul J. Dyson & M. Lúcia M. F. S. Saraiva. (2022) Automated approach for the evaluation of glutathione-S-transferase P1-1 inhibition by organometallic anticancer compounds. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 1527-1536.
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Francesco Fiorentino, Marta De Angelis, Martina Menna, Annarita Rovere, Anna Maria Caccuri, Francesca D’Acunzo, Anna Teresa Palamara, Lucia Nencioni, Dante Rotili & Antonello Mai. (2021) Anti-influenza A virus activity and structure–activity relationship of a series of nitrobenzoxadiazole derivatives. Journal of Enzyme Inhibition and Medicinal Chemistry 36:1, pages 2128-2138.
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Patrick E. Hanna & M. W. Anders. (2019) The mercapturic acid pathway. Critical Reviews in Toxicology 49:10, pages 819-929.
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Veronica Di Paolo, Chiara Fulci, Dante Rotili, Francesca Sciarretta, Alessia Lucidi, Blasco Morozzo della Rocca, Anastasia De Luca, Antonio Rosato, Luigi Quintieri & Anna Maria Caccuri. (2019) Synthesis and characterisation of a new benzamide-containing nitrobenzoxadiazole as a GSTP1-1 inhibitor endowed with high stability to metabolic hydrolysis. Journal of Enzyme Inhibition and Medicinal Chemistry 34:1, pages 1131-1139.
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Shu-Chen Dong, Huan-Huan Sha, Xiao-Yue Xu, Tian-Mu Hu, Rui Lou, Huizi Li, Jian-Zhong Wu, Chen Dan & Jifeng Feng. (2018) Glutathione S-transferase π: a potential role in antitumor therapy. Drug Design, Development and Therapy 12, pages 3535-3547.
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Articles from other publishers (11)

Ning Lv, Chunyan Huang, Haoyan Huang, Zhiqiang Dong, Xijing Chen, Chengcan Lu & Yongjie Zhang. (2023) Overexpression of Glutathione S-Transferases in Human Diseases: Drug Targets and Therapeutic Implications. Antioxidants 12:11, pages 1970.
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Oleksii Kupreienko, Fotini Pouliou, Konstantinos Konstandinidis, Irene Axarli, Eleni Douni, Anastassios C. Papageorgiou & Nikolaos E. Labrou. (2023) Inhibition Analysis and High-Resolution Crystal Structure of Mus musculus Glutathione Transferase P1-1. Biomolecules 13:4, pages 613.
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Sasmita Das, Mohammed Adil Shareef & Bhaskar C. Das. (2023) Design and Synthesis of New Boron-Based Benzo[c][1,2,5]oxadiazoles and Benzo[c][1,2,5]thiadiazoles as Potential Hypoxia Inhibitors. Inorganics 11:1, pages 34.
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Panagiota Pantiora, Veronika Furlan, Dimitris Matiadis, Barbara Mavroidi, Fereniki Perperopoulou, Anastassios C. Papageorgiou, Marina Sagnou, Urban Bren, Maria Pelecanou & Nikolaos E. Labrou. (2022) Monocarbonyl Curcumin Analogues as Potent Inhibitors against Human Glutathione Transferase P1-1. Antioxidants 12:1, pages 63.
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Debojit Bhattacherjee, Khyati Raina, Tapas K. Mandal, Rajkumar P. Thummer & Krishna P. Bhabak. (2022) Targeting Wnt/β-catenin signaling pathway in triple-negative breast cancer by benzylic organotrisulfides: Contribution of the released hydrogen sulfide towards potent anti-cancer activity. Free Radical Biology and Medicine 191, pages 82-96.
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Tiffany M. Russell & Des R. Richardson. (2022) Glutathione-S-Transferases as Potential Targets for Modulation of Nitric Oxide-Mediated Vasodilation. Biomolecules 12:9, pages 1292.
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Silvia Cerantola, Sofia Faggin, Valentina Caputi, Annalisa Bosi, Davide Banfi, Anna Rambaldo, Andrea Porzionato, Rosa Di Liddo, Raffaele De Caro, Edoardo V. Savarino, Cristina Giaroni & Maria Cecilia Giron. (2022) Small intestine neuromuscular dysfunction in a mouse model of dextran sulfate sodium-induced ileitis: Involvement of dopaminergic neurotransmission. Life Sciences 301, pages 120562.
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Giulia Siciliano, Veronica Di Paolo, Dante Rotili, Rossella Migale, Francesca Pedini, Marialuisa Casella, Serena Camerini, Daniele Dalzoppo, Rob Henderson, Tonnie Huijs, Koen J. Dechering, Antonello Mai, Anna Maria Caccuri, Marco Lalle, Luigi Quintieri & Pietro Alano. (2022) The Nitrobenzoxadiazole Derivative NBDHEX Behaves as Plasmodium falciparum Gametocyte Selective Inhibitor with Malaria Parasite Transmission Blocking Activity. Pharmaceuticals 15:2, pages 168.
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Imane Almi, Salah Belaidi, Enfale Zerroug, Mebarka Alloui, Ridha Ben Said, Roberto Linguerri & Majdi Hochlaf. (2020) QSAR investigations and structure-based virtual screening on a series of nitrobenzoxadiazole derivatives targeting human glutathione-S-transferases. Journal of Molecular Structure 1211, pages 128015.
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Marija Pljesa-Ercegovac, Ana Savic-Radojevic, Marija Matic, Vesna Coric, Tatjana Djukic, Tanja Radic & Tatjana Simic. (2018) Glutathione Transferases: Potential Targets to Overcome Chemoresistance in Solid Tumors. International Journal of Molecular Sciences 19:12, pages 3785.
Crossref
Huan-huan Sha, Zhen Wang, Shu-chen Dong, Tian-mu HuSi-wen Liu, Jun-ying Zhang, Yang Wu, Rong Ma, Jian-zhong Wu, Dan Chen & Ji-feng Feng. (2018) 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio) hexanol: a promising new anticancer compound. Bioscience Reports 38:1.
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