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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 35, 2020 - Issue 1
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Short Communication

Combining carbonic anhydrase and thioredoxin reductase inhibitory motifs within a single molecule dramatically increases its cytotoxicity

Mikhail Krasavina Saint Petersburg State University, Saint Petersburg, Russian FederationCorrespondence[email protected] [email protected]
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,
Tatiana Sharonovaa Saint Petersburg State University, Saint Petersburg, Russian FederationView further author information
,
Vladimir Sharoykoa Saint Petersburg State University, Saint Petersburg, Russian FederationView further author information
,
Daniil Zhukovskya Saint Petersburg State University, Saint Petersburg, Russian FederationView further author information
,
Stanislav Kalinina Saint Petersburg State University, Saint Petersburg, Russian FederationView further author information
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Raivis Žalubovskisb Latvian Institute of Organic Synthesis, Riga, Latvia;c Faculty of Materials Science and Applied Chemistry, Institute of Technology of Organic Chemistry, Riga Technical University, Riga, LatviaView further author information
,
Tatiana Tennikovaa Saint Petersburg State University, Saint Petersburg, Russian FederationView further author information
&
Claudiu T. Supurand Neurofarba Department, Universita degli Studi di Firenze, Florence, ItalyCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-4262-0323View further author information
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Pages 665-671 | Received 27 Jan 2020, Accepted 19 Feb 2020, Published online: 05 Mar 2020

Citations (20)

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Morteza Abdoli, Alessandro Bonardi, Claudiu T. Supuran & Raivis Žalubovskis. (2023) Investigation of novel alkyl/benzyl (4-sulphamoylphenyl)carbamimidothioates as carbonic anhydrase inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1.
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Jekaterina Ivanova, Morteza Abdoli, Alessio Nocentini, Raivis Žalubovskis & Claudiu T. Supuran. (2023) 1,2,3-Benzoxathiazine-2,2-dioxides – effective inhibitors of human carbonic anhydrases. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1, pages 225-238.
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Morteza Abdoli, Alessandro Bonardi, Claudiu T. Supuran & Raivis Žalubovskis. (2023) 4-Cyanamidobenzenesulfonamide derivatives: a novel class of human and bacterial carbonic anhydrase inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1, pages 156-165.
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Morteza Abdoli, Simone Giovannuzzi, Claudiu T. Supuran & Raivis Žalubovskis. (2022) 4-(3-Alkyl/benzyl-guanidino)benzenesulfonamides as selective carbonic anhydrase VII inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 1568-1576.
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Qianhe Xu & Junmin Zhang. (2022) Novel strategies for targeting the thioredoxin system for cancer therapy. Expert Opinion on Drug Discovery 17:5, pages 437-442.
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Claudiu T. Supuran. (2021) Carbonic anhydrase inhibitors: an update on experimental agents for the treatment and imaging of hypoxic tumors. Expert Opinion on Investigational Drugs 30:12, pages 1197-1208.
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Evgeny Chupakhin & Mikhail Krasavin. (2021) Thioredoxin reductase inhibitors: updated patent review (2017-present). Expert Opinion on Therapeutic Patents 31:8, pages 745-758.
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Claudiu T. Supuran. (2021) Multitargeting approaches involving carbonic anhydrase inhibitors: hybrid drugs against a variety of disorders. Journal of Enzyme Inhibition and Medicinal Chemistry 36:1, pages 1702-1714.
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Anna Jastrząb & Elżbieta Skrzydlewska. (2021) Thioredoxin-dependent system. Application of inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 36:1, pages 362-371.
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Claudiu T. Supuran. (2020) Exploring the multiple binding modes of inhibitors to carbonic anhydrases for novel drug discovery. Expert Opinion on Drug Discovery 15:6, pages 671-686.
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Articles from other publishers (10)

Morteza Abdoli, Alessandro Bonardi, Niccolò Paoletti, Ashok Aspatwar, Seppo Parkkila, Paola Gratteri, Claudiu T. Supuran & Raivis Žalubovskis. (2023) Inhibition Studies on Human and Mycobacterial Carbonic Anhydrases with N-((4-Sulfamoylphenyl)carbamothioyl) Amides. Molecules 28:10, pages 4020.
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Jekateri̅na Ivanova, Alessio Nocentini, Kaspars Ta̅rs, Ja̅nis Leita̅ns, Elviss Dvinskis, Andris Kazaks, Ilona Domračeva, Claudiu T. Supuran & Raivis Žalubovskis. (2023) Atropo/Tropo Flexibility: A Tool for Design and Synthesis of Self-Adaptable Inhibitors of Carbonic Anhydrases and Their Antiproliferative Effect. Journal of Medicinal Chemistry 66:8, pages 5703-5718.
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Sergey V. Baykov, Anton A. Shetnev, Artem V. Semenov, Svetlana O. Baykova & Vadim P. Boyarskiy. (2023) Room Temperature Synthesis of Bioactive 1,2,4-Oxadiazoles. International Journal of Molecular Sciences 24:6, pages 5406.
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A. Nikitjuka, M. Ozola, L. Jackevica, R. Bobrovs & R. Žalubovskis. (2023) Exploration of 3,4-unsubstituted coumarins as thioredoxin reductase 1 inhibitors for cancer therapy. Organic & Biomolecular Chemistry.
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Claudiu T. Supuran. 2022. Flavonoids and Phenolics. Flavonoids and Phenolics 298 329 .
Morteza Abdoli, Viviana De Luca, Clemente Capasso, Claudiu T. Supuran & Raivis Žalubovskis. (2022) Benzenesulfonamides Incorporating Hydantoin Moieties Effectively Inhibit Eukaryoticand Human Carbonic Anhydrases. International Journal of Molecular Sciences 23:22, pages 14115.
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Camelia Bhattacharyya, Surupa Chakraborty & Rajib Sengupta. (2022) NO news: S-(de)nitrosylation of cathepsins and their relationship with cancer. Analytical Biochemistry 655, pages 114872.
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Laura T. Ferguson, Elizabeth D. Hood, Tea Shuvaeva, Vladimir V. Shuvaev, Maria C. Basil, Zhicheng Wang, Jia Nong, Xiaonan Ma, Jichuan Wu, Jacob W. Myerson, Oscar A. Marcos-Contreras, Jeremy Katzen, Justine M. Carl, Edward E. Morrisey, Edward Cantu, Carlos H. Villa, Samir Mitragotri, Vladimir R. Muzykantov & Jacob S. Brenner. (2022) Dual Affinity to RBCs and Target Cells (DART) Enhances Both Organ- and Cell Type-Targeting of Intravascular Nanocarriers. ACS Nano 16:3, pages 4666-4683.
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Polina Paramonova, Tatiana Sharonova, Stanislav Kalinin, Evgeny Chupakhin, Alexander Bunev & Mikhail Krasavin. (2022) (E)-3-Arylidene-4-diazopyrrolidine-2,5-diones conveniently elaborated into cytotoxic compounds bearing primary sulfonamide and Michael acceptor moieties. Mendeleev Communications 32:2, pages 176-177.
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Sizhu Ren, Ruixue Chen, Zhangfei Wu, Shan Su, Jiaxi Hou & Yanlin Yuan. (2021) Enzymatic characteristics of immobilized carbonic anhydrase and its applications in CO2 conversion. Colloids and Surfaces B: Biointerfaces 204, pages 111779.
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