Advanced search
Publication Cover
Journal of Enzyme Inhibition and Medicinal Chemistry Volume 35, 2020 - Issue 1
Submit an article Journal homepage
2,983
Views
56
CrossRef citations to date
0
Altmetric
Short Communication

Antitumor properties of certain spirooxindoles towards hepatocellular carcinoma endowed with antioxidant activity

Sara T. Al-Rashooda Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi ArabiaView further author information
,
Ahmed R. Hamedb Department of Chemistry of Medicinal Plants, National Research Centre, Dokki, Egypt;c Biology Unit, Central Laboratory of the Pharmaceutical & Drug Industries Research Division, National Research Centre, Dokki, EgyptView further author information
,
Ghada S. Hassand Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, EgyptView further author information
,
Hamad M. Alkahtania Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi ArabiaView further author information
,
Abdulrahman A. Almehiziaa Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi ArabiaORCID Iconhttps://orcid.org/0000-0001-8711-3873View further author information
ORCID Icon,
Amal Alharbia Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi ArabiaView further author information
,
Mohammad M. Al-Saneae Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka, Saudi ArabiaView further author information
&
Wagdy M. Eldehnaf Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafr El-Sheikh, EgyptCorrespondence[email protected] [email protected]
View further author information
 show all
Pages 831-839 | Received 31 Dec 2019, Accepted 10 Mar 2020, Published online: 25 Mar 2020

Citations (56)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (15)

Eman A. Sobh, Mohammed A. Dahab, Eslam B. Elkaeed, Aisha A. Alsfouk, Ibrahim M. Ibrahim, Ahmed M. Metwaly & Ibrahim H. Eissa. (2023) Design, synthesis, docking, MD simulations, and anti-proliferative evaluation of thieno[2,3-d]pyrimidine derivatives as new EGFR inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1.
Read now
Mohammed A. Dahab, Hazem A. Mahdy, Hazem Elkady, Mohammed S. Taghour, Alaa Elwan, Mohamed A. Elkady, Elsayed G. E. Elsakka, Eslam B. Elkaeed, Aisha A. Alsfouk, Ibrahim M. Ibrahim, Ahmed M. Metwaly & Ibrahim H. Eissa. (2023) Semi-synthesized anticancer theobromine derivatives targeting VEGFR-2: in silico and in vitro evaluations. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-20.
Read now
Eman A. Sobh, Mohammed A. Dahab, Eslam B. Elkaeed, Aisha A. Alsfouk, Ibrahim M. Ibrahim, Ahmed M. Metwaly & Ibrahim H. Eissa. (2023) Computer aided drug discovery (CADD) of a thieno[2,3-d]pyrimidine derivative as a new EGFR inhibitor targeting the ribose pocket. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-23.
Read now
Tarfah Al-Warhi, Ahmed M El Kerdawy, Mohamed A Said, Amgad Albohy, Zainab M Elsayed, Nada Aljaeed, Eslam B Elkaeed, Wagdy M Eldehna, Hatem A Abdel-Aziz & Miral A Abdelmoaz. (2022) Novel 2-(5-Aryl-4,5-Dihydropyrazol-1-yl)thiazol-4-One as EGFR Inhibitors: Synthesis, Biological Assessment and Molecular Docking Insights. Drug Design, Development and Therapy 16, pages 1457-1471.
Read now
Ahmed A. Gaber, Mohamed Sobhy, Abdallah Turky, Hanan Gaber Abdulwahab, Ahmed A. Al-Karmalawy, Mostafa. A. Elhendawy, Mohamed. M. Radwan, Eslam B. Elkaeed, Ibrahim M. Ibrahim, Heba S. A. Elzahabi & Ibrahim H. Eissa. (2022) Discovery of new 1H-pyrazolo[3,4-d]pyrimidine derivatives as anticancer agents targeting EGFRWT and EGFRT790M. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 2283-2303.
Read now
Mohammed S. Taghour, Hazem A. Mahdy, Maher H. Gomaa, Ahmed Aglan, Mahmoud Gomaa Eldeib, Alaa Elwan, Mohammed A. Dahab, Eslam B. Elkaeed, Aisha A. Alsfouk, Mohamed M. Khalifa, Ibrahim H. Eissa & Hazem Elkady. (2022) Benzoxazole derivatives as new VEGFR-2 inhibitors and apoptosis inducers: design, synthesis, in silico studies, and antiproliferative evaluation. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 2063-2077.
Read now
Moustafa O. Aboelez, Amany Belal, Guangya Xiang & Xiang Ma. (2022) Design, synthesis, and molecular docking studies of novel pomalidomide-based PROTACs as potential anti-cancer agents targeting EGFRWT and EGFRT790M. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 1196-1211.
Read now
Wagdy M. Eldehna, Mohammed S. Taghour, Tarfah Al-Warhi, Alessio Nocentini, Mostafa M. Elbadawi, Hazem A. Mahdy, Mohamed A. Abdelrahman, Ohoud J. Alotaibi, Nada Aljaeed, Diaaeldin M. Elimam, Kamyar Afarinkia, Hatem A. Abdel-Aziz & Claudiu T. Supuran. (2022) Discovery of 2,4-thiazolidinedione-tethered coumarins as novel selective inhibitors for carbonic anhydrase IX and XII isoforms. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 531-541.
Read now
Hazem Elkady, Alaa Elwan, Hesham A. El-Mahdy, Ahmed S. Doghish, Ahmed Ismail, Mohammed S. Taghour, Eslam B. Elkaeed, Ibrahim H. Eissa, Mohammed A. Dahab, Hazem A. Mahdy & Mohamed M. Khalifa. (2022) New benzoxazole derivatives as potential VEGFR-2 inhibitors and apoptosis inducers: design, synthesis, anti-proliferative evaluation, flowcytometric analysis, and in silico studies. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 403-416.
Read now
Mohamed Hagras, Marwa A. Saleh, Rogy R. Ezz Eldin, Abdelrahman A. Abuelkhir, Emad Gamil Khidr, Ahmed A. El-Husseiny, Hesham A. El-Mahdy, Eslam B. Elkaeed & Ibrahim H. Eissa. (2022) 1,3,4-Oxadiazole-naphthalene hybrids as potential VEGFR-2 inhibitors: design, synthesis, antiproliferative activity, apoptotic effect, and in silico studies. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 386-402.
Read now
Diaaeldin M. Elimam, Abdullah A. Elgazar, Fardous F. El-Senduny, Ramadan A. El-Domany, Farid A Badria & Wagdy M. Eldehna. (2022) Natural inspired piperine-based ureas and amides as novel antitumor agents towards breast cancer. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 39-50.
Read now
Mohammed M. Alanazi, Ibrahim H. Eissa, Nawaf A. Alsaif, Ahmad J. Obaidullah, Wael A. Alanazi, Abdullah F. Alasmari, Hussam Albassam, Hazem Elkady & Alaa Elwan. (2021) Design, synthesis, docking, ADMET studies, and anticancer evaluation of new 3-methylquinoxaline derivatives as VEGFR-2 inhibitors and apoptosis inducers. Journal of Enzyme Inhibition and Medicinal Chemistry 36:1, pages 1760-1782.
Read now
Mohammed M. Alanazi, Alaa Elwan, Nawaf A. Alsaif, Ahmad J. Obaidullah, Hamad M. Alkahtani, Abdulrahman A. Al-Mehizia, Sultan M. Alsubaie, Mohammed S. Taghour & Ibrahim H. Eissa. (2021) Discovery of new 3-methylquinoxalines as potential anti-cancer agents and apoptosis inducers targeting VEGFR-2: design, synthesis, and in silico studies. Journal of Enzyme Inhibition and Medicinal Chemistry 36:1, pages 1732-1750.
Read now
Wagdy M. Eldehna, Rofaida Salem, Zainab M. Elsayed, Tarfah Al-Warhi, Hamada R. Knany, Rezk R. Ayyad, Thamer Bin Traiki, Maha-Hamadien Abdulla, Rehan Ahmad, Hatem A. Abdel-Aziz & Radwan El-Haggar. (2021) Development of novel benzofuran-isatin conjugates as potential antiproliferative agents with apoptosis inducing mechanism in Colon cancer. Journal of Enzyme Inhibition and Medicinal Chemistry 36:1, pages 1423-1434.
Read now
Nawaf A. Alsaif, Mohammed S. Taghour, Mohammed M. Alanazi, Ahmad J. Obaidullah, Abdulrahman A. Al-Mehizia, Manal M. Alanazi, Saleh Aldawas, Alaa Elwan & Hazem Elkady. (2021) Discovery of new VEGFR-2 inhibitors based on bis([1, 2, 4]triazolo)[4,3-a:3',4'-c]quinoxaline derivatives as anticancer agents and apoptosis inducers. Journal of Enzyme Inhibition and Medicinal Chemistry 36:1, pages 1093-1114.
Read now

Articles from other publishers (41)

Eman A. Sobh, Mohammed A. Dahab, Eslam B. Elkaeed, Bshra A. Alsfouk, Ibrahim M. Ibrahim, Ahmed M. Metwaly & Ibrahim H. Eissa. (2023) New thieno[2,3‐ d ]pyrimidine derivatives as EGFR WT and EGFR T790M inhibitors: Design, synthesis, antiproliferative activities, docking studies, ADMET , toxicity, MD simulation studies . Journal of Heterocyclic Chemistry.
Crossref
Hua Zhao & Yufen Zhao. (2023) Engaging Isatins and Amino Acids in Multicomponent One-Pot 1,3-Dipolar Cycloaddition Reactions—Easy Access to Structural Diversity. Molecules 28:18, pages 6488.
Crossref
Eman A. Sobh, Mohammed A. Dahab, Eslam B. Elkaeed, Bshra A. Alsfouk, Ibrahim M. Ibrahim, Ahmed M. Metwaly & Ibrahim H. Eissa. (2023) A novel thieno[2,3‐ d ]pyrimidine derivative inhibiting vascular endothelial growth factor receptor‐2: A story of computer‐aided drug discovery . Drug Development Research 84:6, pages 1247-1265.
Crossref
Eman A Sobh, Mohammed A Dahab, Eslam B Elkaeed, Aisha A Alsfouk, Ibrahim M Ibrahim, Ahmed M Metwaly & Ibrahim H Eissa. (2023) Discovery of new thieno[2,3- d ]pyrimidines as EGFR tyrosine kinase inhibitors for cancer treatment . Future Medicinal Chemistry.
Crossref
Agus Rimus Liandi, Antonius Herry Cahyana, Diva Naufal Alfariza, Rahma Nuraini, Renita Wulan Sari & Tio Putra Wendari. (2023) Spirooxindoles: Recent report of green synthesis approach. Green Synthesis and Catalysis.
Crossref
Hazem A Mahdy, Hazem Elkady, Mohammed S Taghour, Alaa Elwan, Mohammed A Dahab, Mohamed A Elkady, Elsayed GE Elsakka, Eslam B Elkaeed, Bshra A Alsfouk, Ibrahim M Ibrahim, Ibrahim H Eissa & Ahmed M Metwaly. (2023) New theobromine derivatives inhibiting VEGFR-2: design, synthesis, antiproliferative, docking and molecular dynamics simulations. Future Medicinal Chemistry.
Crossref
Omnia R. Elbatrawy, Mohamed Hagras, Moshira A. El Deeb, Fatimah Agili, Maghawry Hegazy, Ahmed A. El-Husseiny, Mahmoud Mohamed Mokhtar, Samy Y. Elkhawaga, Ibrahim H. Eissa & Samar El-Kalyoubi. (2023) Discovery of New Uracil and Thiouracil Derivatives as Potential HDAC Inhibitors. Pharmaceuticals 16:7, pages 966.
Crossref
Omnia R Elbatrawy, Moshira A El Deeb, Mohamed Hagras, Fatimah Agili, Maghawry Hegazy, Ahmed A El-Husseiny, Mohamed A Elkady, Ibrahim H Eissa & Samar El-Kalyoubi. (2023) New thiouracil derivatives as histone deacetylase inhibitors and apoptosis inducers: design, synthesis and anticancer evaluation. Future Medicinal Chemistry 15:12, pages 1019-1035.
Crossref
Bhargava Sai Allaka, Srinivas Basavoju, Estharla Madhu Rekha, Dharmarajan Sriram & Gamidi Rama Krishna. (2022) Design and synthesis of novel quinazolinyl-bisspirooxindoles as potent anti-tubercular agents: an ultrasound-promoted methodology. Molecular Diversity 27:3, pages 1427-1436.
Crossref
Mohd Asif, Farrukh Aqil, Fatmah Ali Alasmary, Amani salem almalki, Abdul Rahman Khan & Malik Nasibullah. (2023) Lewis base-catalyzed synthesis of highly functionalized spirooxindole-pyranopyrazoles and their in vitro anticancer studies. Medicinal Chemistry Research 32:5, pages 1001-1015.
Crossref
Mohd Asif, Sahir Sultan Alvi, Tazeen Azaz, Abdul Rahman Khan, Bhoopendra Tiwari, Bilal Bin Hafeez & Malik Nasibullah. (2023) Novel Functionalized Spiro [Indoline-3,5′-pyrroline]-2,2′dione Derivatives: Synthesis, Characterization, Drug-Likeness, ADME, and Anticancer Potential. International Journal of Molecular Sciences 24:8, pages 7336.
Crossref
Moustafa O. Aboelez, Moumen S. Kamel, Amany Belal, Ahmed El Badry Abdel-Aziz, Mohammed A. S. Abourehab, H. Abdel-Ghany, Mohamed A. El Hamd & Mahmoud Abd El Aleem Ali El-Remaily. (2022) Microwave-assisted synthesis, spectroscopic characterization, and biological evaluation of fused thieno[2,3-d]pyrimidines as potential anti-cancer agents targeting EGFRWT and EGFRT790M. Molecular Diversity 27:2, pages 901-917.
Crossref
Meenakshi Duhan, Rahul Singh, Meena Devi, Jayant Sindhu, Parvin Kumar, Sudhir Kumar, Ramesh Kataria, Ashwani Kumar, Sohan Lal & Devender Singh. (2023) Thiazolidine-2,4-dione framework containing spiropyrrolidine-oxindole and 1,2,3-triazole scaffold: synthesis, in vitro α-amylase inhibition and in silico studies . New Journal of Chemistry 47:11, pages 5399-5412.
Crossref
Yongchao Wang, Lijun Yan, Yuxin Yan, Sujin Li, Hongying Lu, Jia Liu & Jianwei Dong. (2023) Dipolarophile-Controlled Regioselective 1,3-Dipolar Cycloaddition: A Switchable Divergent Access to Functionalized N-Fused Pyrrolidinyl Spirooxindoles. International Journal of Molecular Sciences 24:4, pages 3771.
Crossref
Ahmed A. Gaber, Mohamed Sobhy, Abdallah Turky, Wagdy M. Eldehna, Samiha A. El-Sebaey, Souad A. El-Metwally, Abeer M. El-Naggar, Ibrahim M. Ibrahim, Eslam B. Elkaeed, Ahmed M. Metwaly & Ibrahim H. Eissa. (2023) New [1,2,4]triazolo[4,3-c]quinazolines as intercalative Topo II inhibitors: Design, synthesis, biological evaluation, and in silico studies. PLOS ONE 18:1, pages e0274081.
Crossref
Siva S. Panda, Adel S. Girgis, Marian N. Aziz & Mohamed S. Bekheit. (2023) Spirooxindole: A Versatile Biologically Active Heterocyclic Scaffold. Molecules 28:2, pages 618.
Crossref
Faezeh Mataji, Leila Youseftabar-Miri, Marjan Jebeli Javan, Elham Rajabbeigi & Sara Hallajian. (2022) Regioselective synthesis of spirooxindole-pyrolidine via (GAP) chemistry process: Experimental and DFT study. Journal of Molecular Structure 1270, pages 133891.
Crossref
Zahra M. Alamshany, Nada Y. Tashkandi, Ismail M.M. Othman, Manal M. Anwar & Eman S. Nossier. (2022) New thiophene, thienopyridine and thiazoline-based derivatives: Design, synthesis and biological evaluation as antiproliferative agents and multitargeting kinase inhibitors. Bioorganic Chemistry 127, pages 105964.
Crossref
Rania B. Bakr & Nadia A.A. Elkanzi. (2022) Novel 1,2-Thiazine-Pyridine Hybrid: Design, Synthesis, Antioxidant Activity and Molecular Docking Study. Letters in Drug Design & Discovery 19:8, pages 675-690.
Crossref
Nawaf A. Alsaif, Hazem A. Mahdy, Mohammed M. Alanazi, Ahmad J. Obaidullah, Hamad M. Alkahtani, Abdullah M. Al‐Hossaini, Abdulrahman A. Al‐Mehizi, Alaa Elwan & Mohammed S. Taghour. (2021) Targeting VEGFR‐2 by new quinoxaline derivatives: Design, synthesis, antiproliferative assay, apoptosis induction, and in silico studies. Archiv der Pharmazie 355:2.
Crossref
Aya A. Farahat, Eman M. Samir, Mayssoune Y. Zaki, Rabah A. T. Serya & Hatem A. Abdel‐Aziz. (2021) Synthesis and in vitro antiproliferative activity of certain novel pyrazolo[3,4‐ b ]pyridines with potential p38α MAPK‐inhibitory activity . Archiv der Pharmazie 355:2.
Crossref
Elshaymaa I. Elmongy, Najla Altwaijry, Nashwah G. M. Attallah, Manal Mubarak AlKahtani & Hanan Ali Henidi. (2022) In-Silico Screening of Novel Synthesized Thienopyrimidines Targeting Fms Related Receptor Tyrosine Kinase-3 and Their In-Vitro Biological Evaluation. Pharmaceuticals 15:2, pages 170.
Crossref
Diaaeldin M. Elimam, Wagdy M. Eldehna, Rofaida Salem, Alessandro Bonardi, Alessio Nocentini, Sara T. Al-Rashood, Mahmoud M. Elaasser, Paola Gratteri, Claudiu T. Supuran & Heba Abdelrasheed Allam. (2022) Natural inspired ligustrazine-based SLC-0111 analogues as novel carbonic anhydrase inhibitors. European Journal of Medicinal Chemistry 228, pages 114008.
Crossref
Reham F. Barghash, Wagdy M. Eldehna, Markéta Kovalová, Veronika Vojáčková, Vladimír Kryštof & Hatem A. Abdel-Aziz. (2022) One-pot three-component synthesis of novel pyrazolo[3,4-b]pyridines as potent antileukemic agents. European Journal of Medicinal Chemistry 227, pages 113952.
Crossref
Diaaeldin M. Elimam, Abdullah A. Elgazar, Alessandro Bonardi, Mohamed Abdelfadil, Alessio Nocentini, Ramadan A. El-Domany, Hatem A. Abdel-Aziz, Farid A. Badria, Claudiu T. Supuran & Wagdy M. Eldehna. (2021) Natural inspired piperine-based sulfonamides and carboxylic acids as carbonic anhydrase inhibitors: Design, synthesis and biological evaluation. European Journal of Medicinal Chemistry 225, pages 113800.
Crossref
Moataz Shaldam, Alessio Nocentini, Zainab M. Elsayed, Tamer M. Ibrahim, Rofaida Salem, Ramadan A. El-Domany, Clemente Capasso, Claudiu T. Supuran & Wagdy M. Eldehna. (2021) Development of Novel Quinoline-Based Sulfonamides as Selective Cancer-Associated Carbonic Anhydrase Isoform IX Inhibitors. International Journal of Molecular Sciences 22:20, pages 11119.
Crossref
Seyyed Mohammad Ebrahimi, Ali Kareem Abbas, Hossein Shahbazi-Alavi, Javad Safaei-Ghomi, Atefeh Bakhtiari & Raheleh Teymuri. (2021) Sonosynthesis of spiroindolines using functionalized SBA-15. Research on Chemical Intermediates 47:10, pages 3963-3978.
Crossref
Chao Ma, Mohammed S. Taghour, Amany Belal, Ahmed B. M. Mehany, Naglaa Mostafa, Ahmed Nabeeh, Ibrahim H. Eissa & Ahmed A. Al-Karmalawy. (2021) Design and Synthesis of New Quinoxaline Derivatives as Potential Histone Deacetylase Inhibitors Targeting Hepatocellular Carcinoma: In Silico, In Vitro, and SAR Studies. Frontiers in Chemistry 9.
Crossref
Reda G. Yousef, Helmy M. Sakr, Ibrahim H. Eissa, Ahmed. B. M. Mehany, Ahmed M. Metwaly, Mostafa A. Elhendawy, Mohamed M. Radwan, Mahmoud A. ElSohly, Hamada S. Abulkhair & Khaled. El-Adl. (2021) New quinoxaline-2(1 H )-ones as potential VEGFR-2 inhibitors: design, synthesis, molecular docking, ADMET profile and anti-proliferative evaluations . New Journal of Chemistry 45:36, pages 16949-16964.
Crossref
Mohammed M. Alanazi, Hazem Elkady, Nawaf A. Alsaif, Ahmad J. Obaidullah, Hamad M. Alkahtani, Manal M. Alanazi, Madhawi A. Alharbi, Ibrahim H. Eissa & Mohammed A. Dahab. (2021) New quinoxaline-based VEGFR-2 inhibitors: design, synthesis, and antiproliferative evaluation with in silico docking, ADMET, toxicity, and DFT studies . RSC Advances 11:48, pages 30315-30328.
Crossref
Khaled El-Adl, Helmy M. Sakr, Reda G. Yousef, Ahmed B.M. Mehany, Ahmed M. Metwaly, Mostafa A. Elhendawy, Mohamed M. Radwan, Mahmoud A. ElSohly, Hamada S. Abulkhair & Ibrahim H. Eissa. (2021) Discovery of new quinoxaline-2(1H)-one-based anticancer agents targeting VEGFR-2 as inhibitors: Design, synthesis, and anti-proliferative evaluation. Bioorganic Chemistry 114, pages 105105.
Crossref
Mohammed M. Alanazi, Hazem A. Mahdy, Nawaf A. Alsaif, Ahmad J. Obaidullah, Hamad M. Alkahtani, Abdulrahman A. Al-Mehizia, Sultan M. Alsubaie, Mohammed A. Dahab & Ibrahim H. Eissa. (2021) New bis([1,2,4]triazolo)[4,3-a:3′,4′-c]quinoxaline derivatives as VEGFR-2 inhibitors and apoptosis inducers: Design, synthesis, in silico studies, and anticancer evaluation. Bioorganic Chemistry 112, pages 104949.
Crossref
Souad A. El-Metwally, Mohsen M. Abou-El-Regal, Ibrahim H. Eissa, Ahmed B.M. Mehany, Hazem A. Mahdy, Hazem Elkady, Alaa Elwan & Eslam B. Elkaeed. (2021) Discovery of thieno[2,3-d]pyrimidine-based derivatives as potent VEGFR-2 kinase inhibitors and anti-cancer agents. Bioorganic Chemistry 112, pages 104947.
Crossref
Karen Acosta-Quiroga, Cristian Rojas-Peña, Luz Stella Nerio, Margarita Gutiérrez & Efraín Polo-Cuadrado. (2021) Spirocyclic derivatives as antioxidants: a review. RSC Advances 11:36, pages 21926-21954.
Crossref
Nawaf A. Alsaif, Mohammed A. Dahab, Mohammed M. Alanazi, Ahmad J. Obaidullah, Abdulrahman A. Al-Mehizia, Manal M. Alanazi, Saleh Aldawas, Hazem A. Mahdy & Hazem Elkady. (2021) New quinoxaline derivatives as VEGFR-2 inhibitors with anticancer and apoptotic activity: Design, molecular modeling, and synthesis. Bioorganic Chemistry 110, pages 104807.
Crossref
Moataz Shaldam, Wagdy M. Eldehna, Alessio Nocentini, Zainab M. Elsayed, Tamer M. Ibrahim, Rofaida Salem, Ramadan A. El-Domany, Clemente Capasso, Hatem A. Abdel-Aziz & Claudiu T. Supuran. (2021) Development of novel benzofuran-based SLC-0111 analogs as selective cancer-associated carbonic anhydrase isoform IX inhibitors. European Journal of Medicinal Chemistry 216, pages 113283.
Crossref
P. V. Saranya, Mohan Neetha, Thaipparambil Aneeja & Gopinathan Anilkumar. (2021) Transition metal-catalyzed synthesis of spirooxindoles. RSC Advances 11:13, pages 7146-7179.
Crossref
Saeed Nazari, Fatemeh Safari, Mohammad Barasm Mamaghani & Ayoob Bazgir. (2020) Synthesis and evaluation of in vitro cytotoxic effects of triazol/spiroindolinequinazolinedione, triazol/indolin-3-thiosemicarbazone and triazol/thiazol-indolin-2-one conjugates. DARU Journal of Pharmaceutical Sciences 28:2, pages 591-601.
Crossref
Aleksandra L. Predeina, Marina S. Dukhinova & Vladimir V. Vinogradov. (2020) Bioreactivity of decellularized animal, plant, and fungal scaffolds: perspectives for medical applications. Journal of Materials Chemistry B 8:44, pages 10010-10022.
Crossref
Eslam M. Abbass, Ali Kh. Khalil, Mohamed M. Mohamed, Ibrahim H. Eissa & Abeer M. El-Naggar. (2020) Design, efficient synthesis, docking studies, and anticancer evaluation of new quinoxalines as potential intercalative Topo II inhibitors and apoptosis inducers. Bioorganic Chemistry 104, pages 104255.
Crossref
Ahmed A. Nasser, Ibrahim H. Eissa, Mohamed R. Oun, Mohamed A. El-Zahabi, Mohammed S. Taghour, Amany Belal, Abdulrahman M. Saleh, Ahmed B. M. Mehany, Hendrik Luesch, Ahmad E. Mostafa, Wael M. Afifi, James R. Rocca & Hazem A. Mahdy. (2020) Discovery of new pyrimidine-5-carbonitrile derivatives as anticancer agents targeting EGFR WT and EGFR T790M . Organic & Biomolecular Chemistry 18:38, pages 7608-7634.
Crossref

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.