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Cancer Biology & Therapy Volume 16, 2015 - Issue 4
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Research Paper

Small molecule schweinfurthins selectively inhibit cancer cell proliferation and mTOR/AKT signaling by interfering with trans-Golgi-network trafficking

Xingfeng BaoEisai Inc.; Andover, MA, USACorrespondence[email protected]
,
Wanjun ZhengEisai Inc.; Andover, MA, USA
,
Naoko Hata SugiTsukuba Research Laboratory; Eisai Co.; Ibaraki,Japan
,
Kishan L AgarwalaTsukuba Research Laboratory; Eisai Co.; Ibaraki,Japan
,
Qunli XuEisai Inc.; Andover, MA, USA;Takeda Oncology; Cambridge, MA, USA
,
Zichun WangEisai Inc.; Andover, MA, USA
,
Karen TendykeEisai Inc.; Andover, MA, USA
,
Winnie LeeEisai Inc.; Andover, MA, USA;Mersana Therapeutics; Cambridge, MA, USA
,
Lana ParentEisai Inc.; Andover, MA, USA;Norvartis Institutes for Biomedical Research; Cambridge, MA, USA
,
Wei LiEisai Inc.; Andover, MA, USA
,
Hongsheng ChengEisai Inc.; Andover, MA, USA
,
Yongchun ShenEisai Inc.; Andover, MA, USA
,
Noel TaylorEisai Inc.; Andover, MA, USA
,
Zoltan DezsoEisai Inc.; Andover, MA, USA
,
Hong DuEisai Inc.; Andover, MA, USA
,
Yoshihiko KotakeTsukuba Research Laboratory; Eisai Co.; Ibaraki,Japan
,
Nanding ZhaoEisai Inc.; Andover, MA, USA
,
John WangEisai Inc.; Andover, MA, USA;H3 Biomedicine Inc.; Cambridge, MA, USA
,
Maarten PostemaEisai Inc.; Andover, MA, USA
,
Mary Woodall-JappeEisai Inc.; Andover, MA, USA
,
Yasutaka TakaseTsukuba Research Laboratory; Eisai Co.; Ibaraki,Japan
,
Toshimitsu UenakaEisai Inc.; Andover, MA, USA;Morphotek Inc.; Exton, PA, USA
,
David G I KingstonDepartment of Chemistry and Virginia Tech Center for Drug Discovery; Virginia Tech; Blacksburg, VA, USA
&
Kenichi NomotoEisai Inc.; Andover, MA, USA
 show all
Pages 589-601 | Received 01 Dec 2014, Accepted 09 Feb 2015, Published online: 13 Apr 2015

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Ruoheng Zhang, J.D. Neighbors, T.D. Schell & R.J. Hohl. (2022) Schweinfurthin induces ICD without ER stress and caspase activation. OncoImmunology 11:1.
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Kathleen M. Kokolus, Jeremy S. Haley, Emily J. Koubek, Raghavendra Gowda, Saketh S. Dinavahi, Arati Sharma, David F. Claxton, Klaus F. Helm, Joseph J. Drabick, Gavin P. Robertson, Jeffrey D. Neighbors, Raymond J. Hohl & Todd D. Schell. (2019) Schweinfurthin natural products induce regression of murine melanoma and pair with anti-PD-1 therapy to facilitate durable tumor immunity. OncoImmunology 8:2.
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Ryan M Sheehy, Craig H Kuder, Zoe Bachman & Raymond J Hohl. (2015) Calcium and P-glycoprotein independent synergism between schweinfurthins and verapamil. Cancer Biology & Therapy 16:8, pages 1259-1268.
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Emily J. Koubek, Jillian S. Weissenrieder, Luz E. Ortiz, Nnenna Nwogu, Alexander M. Pham, J. Dylan Weissenkampen, Jessie L. Reed, Jeffrey D. Neighbors, Raymond J. Hohl & Hyun Jin Kwun. (2022) Therapeutic Potential of 5′-Methylschweinfurthin G in Merkel Cell Polyomavirus-Positive Merkel Cell Carcinoma. Viruses 14:9, pages 1848.
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Barbara Manfredi, Jeffrey D. Neighbors & Raymond J. Hohl. (2022) Cytotoxic Effects of the Schweinfurthin Analog 5′-Methylschweinfurthin G in Malignant Plasma Cells. Pharmacology 107:9-10, pages 510-523.
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Chloe M. Schroeder, Patrick N. Dey, John A. Beutler & David F. Wiemer. (2021) Synthesis of a Coumarin-Based Analogue of Schweinfurthin F. The Journal of Organic Chemistry 86:23, pages 16824-16833.
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Dominika Roos & Martin E. Maier. (2020) Approach to the Core Structure of Schweinfurthin B. ChemistrySelect 5:46, pages 14747-14752.
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Yongmin Cho, Moon Nyeo Park, Seungjin Noh, Seog Young Kang & Bonglee Kim. (2020) Review of Natural Compounds for the Management and Prevention of Lymphoma. Processes 8:9, pages 1164.
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Lucia Biasutto, Andrea Mattarei, Martina La Spina, Michele Azzolini, Sofia Parrasia, Ildikò Szabò & Mario Zoratti. (2019) Strategies to target bioactive molecules to subcellular compartments. Focus on natural compounds. European Journal of Medicinal Chemistry 181, pages 111557.
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Brett L. Roberts, Zachary C. Severance, Ryan C. Bensen, Anh T. Le, Cori A. Malinky, Evan M. Mettenbrink, Juan I. Nuñez, William J. Reddig, Earl L. Blewett & Anthony W.G. Burgett. (2019) Differing activities of oxysterol-binding protein (OSBP) targeting anti-viral compounds. Antiviral Research, pages 104548.
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Francesca Zappa, Mario Failli & Maria Antonietta De Matteis. (2018) The Golgi complex in disease and therapy. Current Opinion in Cell Biology 50, pages 102-116.
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Jeff W. Stevens, David K. Meyerholz, Jeffery D. Neighbors & José A. Morcuende. (2017) 5′-methylschweinfurthin G reduces chondrosarcoma tumor growth . Journal of Orthopaedic Research.
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Bruno Mesmin, Joëlle Bigay, Joël Polidori, Denisa Jamecna, Sandra Lacas‐Gervais & Bruno Antonny. (2017) Sterol transfer, PI 4P consumption, and control of membrane lipid order by endogenous OSBP . The EMBO Journal 36:21, pages 3156-3174.
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David P. Stockdale, John A. Beutler & David F. Wiemer. (2017) Synthesis of amide isosteres of schweinfurthin-based stilbenes. Bioorganic & Medicinal Chemistry 25:20, pages 5483-5489.
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