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Cancer Biology & Therapy Volume 23, 2022 - Issue 1
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Research Paper

BRD4 PROTAC degrader MZ1 exerts anticancer effects in acute myeloid leukemia by targeting c-Myc and ANP32B genes

Li Maa Department of Hematology, Children’s Hospital of Soochow University, Suzhou, China;b Department of Pediatrics, The Affiliated Huaian No. 1 People’s Hospital of Nanjing Medical University, Huaian, ChinaView further author information
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Jianwei Wangc Institute of Pediatric Research, Children’s Hospital of Soochow University, Suzhou, ChinaView further author information
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Yongping Zhanga Department of Hematology, Children’s Hospital of Soochow University, Suzhou, ChinaView further author information
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Fang Fangc Institute of Pediatric Research, Children’s Hospital of Soochow University, Suzhou, ChinaView further author information
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Jing Linga Department of Hematology, Children’s Hospital of Soochow University, Suzhou, ChinaView further author information
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Xinran Chua Department of Hematology, Children’s Hospital of Soochow University, Suzhou, ChinaView further author information
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Zimu Zhangc Institute of Pediatric Research, Children’s Hospital of Soochow University, Suzhou, ChinaView further author information
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Yanfang Taoc Institute of Pediatric Research, Children’s Hospital of Soochow University, Suzhou, ChinaView further author information
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Xiaolu Lic Institute of Pediatric Research, Children’s Hospital of Soochow University, Suzhou, ChinaView further author information
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Yuanyuan Tianc Institute of Pediatric Research, Children’s Hospital of Soochow University, Suzhou, China;a Department of Hematology, Children’s Hospital of Soochow University, Suzhou, ChinaView further author information
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Zhiheng Lia Department of Hematology, Children’s Hospital of Soochow University, Suzhou, ChinaView further author information
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Xu Sanga Department of Hematology, Children’s Hospital of Soochow University, Suzhou, ChinaView further author information
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Kunlong Zhanga Department of Hematology, Children’s Hospital of Soochow University, Suzhou, ChinaView further author information
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Lihui Lua Department of Hematology, Children’s Hospital of Soochow University, Suzhou, ChinaView further author information
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Xiaomei Wana Department of Hematology, Children’s Hospital of Soochow University, Suzhou, ChinaView further author information
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Yanling Chena Department of Hematology, Children’s Hospital of Soochow University, Suzhou, ChinaView further author information
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Juanjuan Yua Department of Hematology, Children’s Hospital of Soochow University, Suzhou, ChinaView further author information
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Ran Zhuoa Department of Hematology, Children’s Hospital of Soochow University, Suzhou, ChinaView further author information
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Shuiyan Wud Intensive Care Unit, Children’s Hospital of Soochow University, Suzhou, ChinaView further author information
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Jun Lua Department of Hematology, Children’s Hospital of Soochow University, Suzhou, ChinaView further author information
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Jian Panc Institute of Pediatric Research, Children’s Hospital of Soochow University, Suzhou, ChinaORCID Iconhttps://orcid.org/0000-0002-0292-5141View further author information
ORCID Icon &
Shaoyan Hua Department of Hematology, Children’s Hospital of Soochow University, Suzhou, ChinaCorrespondence[email protected]
[email protected]
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Pages 1-15 | Received 23 May 2022, Accepted 06 Sep 2022, Published online: 28 Sep 2022

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Li Ma, Jianwei Wang, Yang Yang, Jun Lu, Jing Ling, Xinran Chu, Zimu Zhang, Yanfang Tao, Xiaolu Li, Yuanyuan Tian, Zhiheng Li, Yongping Zhang, Xu Sang, Lihui Lu, Xiaomei Wan, Kunlong Zhang, Yanling Chen, Juanjuan Yu, Ran Zhuo, Shuiyan Wu, Jian Pan, Xiuxia Zhou, Yixin Hu & Shaoyan Hu. (2023) BRD4 PROTAC degrader MZ1 exhibits anti-B-cell acute lymphoblastic leukemia effects via targeting CCND3. Hematology 28:1.
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Yinglin Xia. (2023) Statistical normalization methods in microbiome data with application to microbiome cancer research. Gut Microbes 15:2.
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Articles from other publishers (2)

Bryony G. Kennedy, Jonathan J. Morgan & Lisa J. Crawford. (2023) Ubiquitin‐dependent regulation of MYC: A promising therapeutic target. Clinical and Translational Discovery 3:2.
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Lara J. Bou Malhab, Habiba Alsafar, Saleh Ibrahim & Mohamed Rahmani. (2023) PROTACs: Walking through hematological malignancies. Frontiers in Pharmacology 14.
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