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Research Articles

In vitro human helper T-cell assay to screen antibody drug candidates for immunogenicity

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Pages 125-132 | Received 20 Nov 2018, Accepted 03 Apr 2019, Published online: 08 Jun 2019

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Yoshiyuki Arata, Shigeki Motoyama, Mariko Yano, Tatsuya Ikuno, Shunsuke Ito, Tomochika Matsushita, Akira Takeiri, Yukari Nishito, Nami Yabuki, Hideaki Mizuno, Zenjiro Sampei, Masayuki Mishima, Masaki Honda, Jumpei Kiyokawa, Hiromi Suzuki, Shuichi Chiba, Mitsuyasu Tabo & Chiyomi Kubo. (2023) Rapid in vitro assessment of the immunogenicity potential of engineered antibody therapeutics through detection of CD4+ T cell interleukin-2 secretion. mAbs 15:1.
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Sivan Cohen, Shan Chung, Christoph Spiess, Victor Lundin, Eric Stefanich, Steven T. Laing, Vanessa Clark, Jochen Brumm, Ying Zhou, Catherine Huang, Joyce Guerrero, Srividya Myneni, Rajbharan Yadav, Ketevan Siradze & Kun Peng. (2021) An integrated approach for characterizing immunogenic responses toward a bispecific antibody. mAbs 13:1.
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Sivan Cohen, Srividya Myneni, Anna Batt, Joyce Guerrero, Jochen Brumm & Shan Chung. (2021) Immunogenicity risk assessment for biotherapeutics through in vitro detection of CD134 and CD137 on T helper cells. mAbs 13:1.
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Robin E. Walsh, Megan Lannan, Yi Wen, Xiaoli Wang, Christopher A. Moreland, Jill Willency, Michael D. Knierman, Laura Spindler, Ling Liu, Wei Zeng, Guilherme V. Rocha, Victor Obungu, Jirong Lu, Arunan Kaliyaperumal, Andrea Ferrante, Robert Siegel & Laurent P. Malherbe. (2020) Post-hoc assessment of the immunogenicity of three antibodies reveals distinct immune stimulatory mechanisms. mAbs 12:1.
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Articles from other publishers (7)

Yale S. Michaels, Cara F. Buchanan, Nikolche Gjorevski & Annie Moisan. (2023) Bioengineering translational models of lymphoid tissues. Nature Reviews Bioengineering.
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Sivan Cohen & Shan Chung. (2021) In vitro immunogenicity prediction: bridging between innate and adaptive immunity . Bioanalysis 13:13, pages 1071-1081.
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Dilki Wickramarachchi, Gregory Steeno, Zhiping You, Saleem Shaik, Christopher Lepsy & Li Xue. (2020) Fit-for-Purpose Validation and Establishment of Assay Acceptance and Reporting Criteria of Dendritic Cell Activation Assay Contributing to the Assessment of Immunogenicity Risk. The AAPS Journal 22:5.
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Shide Liang & Chi Zhang. (2020) Prediction of immunogenicity for humanized and full human therapeutic antibodies. PLOS ONE 15:8, pages e0238150.
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Jing Zhang, Jizu Yi & Pengfei Zhou. (2020) Development of bispecific antibodies in China: overview and prospects. Antibody Therapeutics 3:2, pages 126-145.
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