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Autophagy Volume 11, 2015 - Issue 8
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Basic Research Paper

Export-deficient monoubiquitinated PEX5 triggers peroxisome removal in SV40 large T antigen-transformed mouse embryonic fibroblasts

Marcus NordgrenLaboratory of Lipid Biochemistry and Protein Interactions; Department of Cellular and Molecular Medicine; University of Leuven – KU Leuven; Leuven, Belgium
,
Tânia FranciscoInstituto de Biologia Molecular e Celular; Universidade do Porto; Porto, Portugal
,
Celien LismontLaboratory of Lipid Biochemistry and Protein Interactions; Department of Cellular and Molecular Medicine; University of Leuven – KU Leuven; Leuven, Belgium
,
Lore HennebelLaboratory of Lipid Biochemistry and Protein Interactions; Department of Cellular and Molecular Medicine; University of Leuven – KU Leuven; Leuven, Belgium
,
Chantal BreesLaboratory of Lipid Biochemistry and Protein Interactions; Department of Cellular and Molecular Medicine; University of Leuven – KU Leuven; Leuven, Belgium
,
Bo WangLaboratory of Lipid Biochemistry and Protein Interactions; Department of Cellular and Molecular Medicine; University of Leuven – KU Leuven; Leuven, Belgium
,
Paul P Van VeldhovenLaboratory of Lipid Biochemistry and Protein Interactions; Department of Cellular and Molecular Medicine; University of Leuven – KU Leuven; Leuven, Belgium
,
Jorge E AzevedoInstituto de Biologia Molecular e Celular; Universidade do Porto; Porto, Portugal;Instituto de Ciências Biomédicas Abel Salazar; Universidade do Porto; Porto, Portugal
&
Marc FransenLaboratory of Lipid Biochemistry and Protein Interactions; Department of Cellular and Molecular Medicine; University of Leuven – KU Leuven; Leuven, BelgiumCorrespondence[email protected]
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Pages 1326-1340 | Received 18 Sep 2015, Accepted 08 Jun 2015, Published online: 14 Aug 2015

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Nicholas D. Demers, Victoria Riccio, Doo Sin Jo, Sushil Bhandari, Kelsey B. Law, Weifang Liao, Choy Kim, G. Angus McQuibban, Seong-Kyu Choe, Dong-Hyung Cho & Peter K. Kim. (2023) PEX13 prevents pexophagy by regulating ubiquitinated PEX5 and peroxisomal ROS. Autophagy 19:6, pages 1781-1802.
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Ren-Qi Yao, Chao Ren, Zhao-Fan Xia & Yong-Ming Yao. (2021) Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles. Autophagy 17:2, pages 385-401.
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Wei Wang & Suresh Subramani. (2017) Role of PEX5 ubiquitination in maintaining peroxisome dynamics and homeostasis. Cell Cycle 16:21, pages 2037-2045.
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Taras Y. Nazarko. (2017) Pexophagy is responsible for 65% of cases of peroxisome biogenesis disorders. Autophagy 13:5, pages 991-994.
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Kelsey B. Law, Dana Bronte-Tinkew, Erminia Di Pietro, Ann Snowden, Richard O. Jones, Ann Moser, John H. Brumell, Nancy Braverman & Peter K. Kim. (2017) The peroxisomal AAA ATPase complex prevents pexophagy and development of peroxisome biogenesis disorders. Autophagy 13:5, pages 868-884.
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Kazi Md Mahmudul Hasan & Md Anwarul Haque. (2023) Autophagy and Its Lineage-Specific Roles in the Hematopoietic System. Oxidative Medicine and Cellular Longevity 2023, pages 1-25.
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Ana G. Pedrosa, Tânia Francisco, Tony A. Rodrigues, Maria J. Ferreira, Gerbrand J. van der Heden van Noort & Jorge E. Azevedo. (2023) The Extraction Mechanism of Monoubiquitinated PEX5 from the Peroxisomal Membrane. Journal of Molecular Biology 435:2, pages 167896.
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Ryan M. Judy, Connor J. Sheedy & Brooke M. Gardner. (2022) Insights into the Structure and Function of the Pex1/Pex6 AAA-ATPase in Peroxisome Homeostasis. Cells 11:13, pages 2067.
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Houqing Yu, Roarke A Kamber & Vladimir Denic. (2022) The peroxisomal exportomer directly inhibits phosphoactivation of the pexophagy receptor Atg36 to suppress pexophagy in yeast. eLife 11.
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Jun Zheng, Xi Chen, Qiang Liu, Guisheng Zhong & Min Zhuang. (2022) Ubiquitin ligase MARCH5 localizes to peroxisomes to regulate pexophagy. Journal of Cell Biology 221:1.
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Hongli Li, Celien Lismont, Iulia Revenco, Mohamed A. F. Hussein, Cláudio F. Costa & Marc Fransen. (2021) The Peroxisome-Autophagy Redox Connection: A Double-Edged Sword?. Frontiers in Cell and Developmental Biology 9.
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Jing Li & Wei Wang. (2021) Mechanisms and Functions of Pexophagy in Mammalian Cells. Cells 10:5, pages 1094.
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Shanmuga S. Mahalingam, Nandini Shukla, Jean-Claude Farré, Katarzyna Zientara-Rytter & Suresh Subramani. (2021) Balancing the Opposing Principles That Govern Peroxisome Homeostasis. Trends in Biochemical Sciences 46:3, pages 200-212.
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Anna Vainshtein & Paolo Grumati. (2020) Selective Autophagy by Close Encounters of the Ubiquitin Kind. Cells 9:11, pages 2349.
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Ndidi-Ese Uzor, Louise D. McCullough & Andrey S. Tsvetkov. (2020) Peroxisomal Dysfunction in Neurological Diseases and Brain Aging. Frontiers in Cellular Neuroscience 14.
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Jin Rui Liang, Emily Lingeman, Thao Luong, Saba Ahmed, Matthias Muhar, Truc Nguyen, James A. Olzmann & Jacob E. Corn. (2020) A Genome-wide ER-phagy Screen Highlights Key Roles of Mitochondrial Metabolism and ER-Resident UFMylation. Cell 180:6, pages 1160-1177.e20.
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Rong Hua & Peter K. Kim. 2020. The Liver. The Liver 137 150 .
Markus Kunze. (2020) The type-2 peroxisomal targeting signal. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1867:2, pages 118609.
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Kyla Germain & Peter K. Kim. (2020) Pexophagy: A Model for Selective Autophagy. International Journal of Molecular Sciences 21:2, pages 578.
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Lauren L. Daniele, Jennifer Caughey, Stefanie Volland, Rachel C. Sharp, Anuradha Dhingra, David S. Williams, Nancy J. Philp & Kathleen Boesze-Battaglia. (2019) Peroxisome turnover and diurnal modulation of antioxidant activity in retinal pigment epithelia utilizes microtubule-associated protein 1 light chain 3B (LC3B). American Journal of Physiology-Cell Physiology 317:6, pages C1194-C1204.
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Ana G. Pedrosa, Tânia Francisco, Maria J. Ferreira, Tony A. Rodrigues, Aurora Barros-Barbosa & Jorge E. Azevedo. (2019) A Mechanistic Perspective on PEX1 and PEX6, Two AAA+ Proteins of the Peroxisomal Protein Import Machinery. International Journal of Molecular Sciences 20:21, pages 5246.
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Celien Lismont, Janet Koster, Sarah Provost, Myriam Baes, Paul P. Van Veldhoven, Hans R. Waterham & Marc Fransen. (2019) Deciphering the potential involvement of PXMP2 and PEX11B in hydrogen peroxide permeation across the peroxisomal membrane reveals a role for PEX11B in protein sorting. Biochimica et Biophysica Acta (BBA) - Biomembranes 1861:10, pages 182991.
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Se-Jin JeongXiangyu ZhangAstrid Rodriguez-VelezTrent D. EvansBabak Razani. (2019) p62/ SQSTM1 and Selective Autophagy in Cardiometabolic Diseases . Antioxidants & Redox Signaling 31:6, pages 458-471.
Crossref
Nan Liang, Qiao He, Xiaodong Liu & Hui Sun. (2019) Multifaceted roles of ATM in autophagy: From nonselective autophagy to selective autophagy. Cell Biochemistry and Function 37:3, pages 177-184.
Crossref
Victoria Riccio, Nicholas Demers, Rong Hua, Miluska Vissa, Derrick T. Cheng, Amy Wong Strilchuk, Yuqing Wang, G. Angus McQuibban & Peter Kijun Kim. (2019) Deubiquitinating enzyme USP30 maintains basal peroxisome abundance by regulating pexophagy. Journal of Cell Biology 218:3, pages 798-807.
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Jean‐Claude Farré, Shanmuga S Mahalingam, Marco Proietto & Suresh Subramani. (2018) Peroxisome biogenesis, membrane contact sites, and quality control. EMBO reports 20:1.
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Marc FransenCelien Lismont. (2019) Redox Signaling from and to Peroxisomes: Progress, Challenges, and Prospects. Antioxidants & Redox Signaling 30:1, pages 95-112.
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Celien LismontMarcus NordgrenChantal BreesBernard KnoopsPaul P. Van VeldhovenMarc Fransen. (2019) Peroxisomes as Modulators of Cellular Protein Thiol Oxidation: A New Model System. Antioxidants & Redox Signaling 30:1, pages 22-39.
Crossref
Masahide Oku & Yasuyoshi Sakai. 2019. Peroxisomes: Biogenesis, Function, and Role in Human Disease. Peroxisomes: Biogenesis, Function, and Role in Human Disease 43 58 .
Tanja Eberhart & Werner J. Kovacs. (2018) Pexophagy in yeast and mammals: an update on mysteries. Histochemistry and Cell Biology 150:5, pages 473-488.
Crossref
Daniel Schwerter, Immanuel Grimm, Wolfgang Girzalsky & Ralf Erdmann. (2018) Receptor recognition by the peroxisomal AAA complex depends on the presence of the ubiquitin moiety and is mediated by Pex1p. Journal of Biological Chemistry 293:40, pages 15458-15470.
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Elena Marcassa, Andreas Kallinos, Jane Jardine, Emma V Rusilowicz‐Jones, Aitor Martinez, Sandra Kuehl, Markus Islinger, Michael J Clague & Sylvie Urbé. (2018) Dual role of USP 30 in controlling basal pexophagy and mitophagy . EMBO reports 19:7.
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Ana G. Pedrosa, Tânia Francisco, Diana Bicho, Ana F. Dias, Aurora Barros-Barbosa, Vera Hagmann, Gabriele Dodt, Tony A. Rodrigues & Jorge E. Azevedo. (2018) Peroxisomal monoubiquitinated PEX5 interacts with the AAA ATPases PEX1 and PEX6 and is unfolded during its dislocation into the cytosol. Journal of Biological Chemistry 293:29, pages 11553-11563.
Crossref
Joon No Lee, Raghbendra Kumar Dutta, Yunash Maharjan, Zhi-qiang Liu, Jae-Young Lim, Se-Jin Kim, Dong-Hyung Cho, Hong-Seob So, Seong-Kyu Choe & Raekil Park. (2018) Catalase inhibition induces pexophagy through ROS accumulation. Biochemical and Biophysical Research Communications 501:3, pages 696-702.
Crossref
So Young Eun, Joon No Lee, In-Koo Nam, Zhi-qiang Liu, Hong-Seob So, Seong-Kyu Choe & RaeKil Park. (2018) PEX5 regulates autophagy via the mTORC1-TFEB axis during starvation. Experimental & Molecular Medicine 50:4, pages 1-12.
Crossref
Damián Gatica, Vikramjit Lahiri & Daniel J. Klionsky. (2018) Cargo recognition and degradation by selective autophagy. Nature Cell Biology 20:3, pages 233-242.
Crossref
Cheryl L. Walker, Laura C. D. Pomatto, Durga Nand Tripathi & Kelvin J. A. Davies. (2018) Redox Regulation of Homeostasis and Proteostasis in Peroxisomes. Physiological Reviews 98:1, pages 89-115.
Crossref
Marc Fransen & Celien Lismont. 2018. Proteomics of Peroxisomes. Proteomics of Peroxisomes 435 461 .
Yong Tae Kwon & Aaron Ciechanover. (2017) The Ubiquitin Code in the Ubiquitin-Proteasome System and Autophagy. Trends in Biochemical Sciences 42:11, pages 873-886.
Crossref
Kim L. Gonzalez, Wendell A. Fleming, Yun‐Ting Kao, Zachary J. Wright, Savina V. Venkova, Meredith J. Ventura & Bonnie Bartel. (2017) Disparate peroxisome‐related defects in Arabidopsis pex6 and pex26 mutants link peroxisomal retrotranslocation and oil body utilization . The Plant Journal 92:1, pages 110-128.
Crossref
Paul A. Walton, Chantal Brees, Celien Lismont, Oksana Apanasets & Marc Fransen. (2017) The peroxisomal import receptor PEX5 functions as a stress sensor, retaining catalase in the cytosol in times of oxidative stress. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1864:10, pages 1833-1843.
Crossref
Tânia Francisco, Tony A. Rodrigues, Ana F. Dias, Aurora Barros-Barbosa, Diana Bicho & Jorge E. Azevedo. (2017) Protein transport into peroxisomes: Knowns and unknowns. BioEssays 39:10, pages 1700047.
Crossref
Laura L. Cross, Rupesh Paudyal, Yasuko Kamisugi, Alan Berry, Andrew C. Cuming, Alison Baker & Stuart L. Warriner. (2017) Towards designer organelles by subverting the peroxisomal import pathway. Nature Communications 8:1.
Crossref
Xu Li, Han Han, Mao-Tian Zhou, Bing Yang, Albert Paul Ta, Nan Li, Junjie Chen & Wenqi Wang. (2017) Proteomic Analysis of the Human Tankyrase Protein Interaction Network Reveals Its Role in Pexophagy. Cell Reports 20:3, pages 737-749.
Crossref
Cynthia M. Cipolla & Irfan J. Lodhi. (2017) Peroxisomal Dysfunction in Age-Related Diseases. Trends in Endocrinology & Metabolism 28:4, pages 297-308.
Crossref
Allyson L. Anding & Eric H. Baehrecke. (2017) Cleaning House: Selective Autophagy of Organelles. Developmental Cell 41:1, pages 10-22.
Crossref
Trent D. Evans, Ismail SerginXiangyu ZhangBabak Razani. (2017) Target acquired: Selective autophagy in cardiometabolic disease. Science Signaling 10:468.
Crossref
Rathi Prasad, Irene Hadjidemetriou, Avinaash Maharaj, Eirini Meimaridou, Federica Buonocore, Moin Saleem, Jenny Hurcombe, Agnieszka Bierzynska, Eliana Barbagelata, Ignacio Bergadá, Hamilton Cassinelli, Urmi Das, Ruth Krone, Bulent Hacihamdioglu, Erkan Sari, Ediz Yesilkaya, Helen L. Storr, Maria Clemente, Monica Fernandez-Cancio, Nuria Camats, Nanik Ram, John C. Achermann, Paul P. Van Veldhoven, Leonardo Guasti, Debora Braslavsky, Tulay Guran & Louise A. Metherell. (2017) Sphingosine-1-phosphate lyase mutations cause primary adrenal insufficiency and steroid-resistant nephrotic syndrome. Journal of Clinical Investigation 127:3, pages 942-953.
Crossref
Amparo Pascual-Ahuir, Sara Manzanares-Estreder & Markus Proft. (2017) Pro- and Antioxidant Functions of the Peroxisome-Mitochondria Connection and Its Impact on Aging and Disease. Oxidative Medicine and Cellular Longevity 2017, pages 1-17.
Crossref
Shun-ichi Yamashita & Yukio Fujiki. 2017. Peroxisomes. Peroxisomes 243 248 .
Tony A Rodrigues, Tânia Francisco, Ana F Dias, Ana G Pedrosa, Cláudia P Grou & Jorge E Azevedo. (2016) A cell-free organelle-based in vitro system for studying the peroxisomal protein import machinery. Nature Protocols 11:12, pages 2454-2469.
Crossref
Katarzyna Zientara-Rytter & Agnieszka Sirko. (2016) To deliver or to degrade - an interplay of the ubiquitin-proteasome system, autophagy and vesicular transport in plants. The FEBS Journal 283:19, pages 3534-3555.
Crossref
Graeme Sargent, Tim van Zutphen, Tatiana Shatseva, Ling Zhang, Valeria Di Giovanni, Robert Bandsma & Peter Kijun Kim. (2016) PEX2 is the E3 ubiquitin ligase required for pexophagy during starvation. Journal of Cell Biology 214:6, pages 677-690.
Crossref
Alison BakerThomas Lanyon HoggStuart L. Warriner. (2016) Peroxisome protein import: a complex journey. Biochemical Society Transactions 44:3, pages 783-789.
Crossref
Silke Oeljeklaus, Andreas Schummer, Thomas Mastalski, Harald W. Platta & Bettina Warscheid. (2016) Regulation of peroxisome dynamics by phosphorylation. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1863:5, pages 1027-1037.
Crossref
Masanori Honsho, Shun-ichi Yamashita & Yukio Fujiki. (2016) Peroxisome homeostasis: Mechanisms of division and selective degradation of peroxisomes in mammals. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1863:5, pages 984-991.
Crossref
Harald W. Platta, Rebecca Brinkmeier, Christina Reidick, Silvia Galiani, Mathias P. Clausen & Christian Eggeling. (2016) Regulation of peroxisomal matrix protein import by ubiquitination. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1863:5, pages 838-849.
Crossref
Pierce G. Young & Bonnie Bartel. (2016) Pexophagy and peroxisomal protein turnover in plants. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1863:5, pages 999-1005.
Crossref
Rebecca L. Farr, Celien Lismont, Stanley R. Terlecky & Marc Fransen. (2016) Peroxisome biogenesis in mammalian cells: The impact of genes and environment. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1863:5, pages 1049-1060.
Crossref
Katarzyna Zientara-RytterSuresh Subramani. (2016) Autophagic degradation of peroxisomes in mammals. Biochemical Society Transactions 44:2, pages 431-440.
Crossref
Yukio FUJIKI. (2016) Peroxisome biogenesis and human peroxisome-deficiency disorders. Proceedings of the Japan Academy, Series B 92:10, pages 463-477.
Crossref
Moninder S. Bhogal, Thomas Lanyon-Hogg, Katherine A. Johnston, Stuart L. Warriner & Alison Baker. (2016) Covalent Label Transfer between Peroxisomal Importomer Components Reveals Export-driven Import Interactions. Journal of Biological Chemistry 291:5, pages 2460-2468.
Crossref
AiLin Jin, Joon No Lee, Min Soo Kim, SeongAe Kwak, Se-Jin Kim, Kyung Song, Seong-Kyu Choe & Raekil Park. (2016) 2,2′-dipyridyl induces pexophagy. Biochemical and Biophysical Research Communications 469:4, pages 941-947.
Crossref
Suresh Subramani. (2015) A mammalian pexophagy target. Nature Cell Biology 17:11, pages 1371-1373.
Crossref

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