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mAbs Volume 7, 2015 - Issue 2
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Protein design of IgG/TCR chimeras for the co-expression of Fab-like moieties within bispecific antibodies

Xiufeng WuEli Lilly Biotechnology Center; San Diego, CAUSA
,
Arlene J SerenoEli Lilly Biotechnology Center; San Diego, CAUSA
,
Flora HuangEli Lilly Biotechnology Center; San Diego, CAUSA
,
Kai ZhangEli Lilly Biotechnology Center; San Diego, CAUSA
,
Micheal BattEli Lilly Biotechnology Center; San Diego, CAUSA
,
Jonathan R FitchettEli Lilly Biotechnology Center; San Diego, CAUSA
,
Dongmei HeEli Lilly Biotechnology Center; San Diego, CAUSA
,
Heather L RickEli Lilly Biotechnology Center; San Diego, CAUSA
,
Elaine M ConnerEli Lilly Biotechnology Center; San Diego, CAUSA
&
Stephen J DemarestEli Lilly Biotechnology Center; San Diego, CAUSACorrespondence[email protected]
 show all
Pages 364-376 | Received 27 Oct 2014, Accepted 09 Dec 2014, Published online: 11 Mar 2015

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Lennart Kühl, Nadine Aschmoneit, Roland E. Kontermann & Oliver Seifert. (2022) The eIg technology to generate Ig-like bispecific antibodies. mAbs 14:1.
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Oliver Seifert, Alexander Rau, Nadine Beha, Fabian Richter & Roland E. Kontermann. (2019) Diabody-Ig: a novel platform for the generation of multivalent and multispecific antibody molecules. mAbs 11:5, pages 919-929.
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Ulrich Brinkmann & Roland E. Kontermann. (2017) The making of bispecific antibodies. mAbs 9:2, pages 182-212.
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Raheleh Toughiri, Xiufeng Wu, Diana Ruiz, Flora Huang, John W. Crissman, Mark Dickey, Karen Froning, Elaine M. Conner, Thomas P. Cujec & Stephen J. Demarest. (2016) Comparing domain interactions within antibody Fabs with kappa and lambda light chains. mAbs 8:7, pages 1276-1285.
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Anke Steinmetz, François Vallée, Christian Beil, Christian Lange, Nicolas Baurin, Jochen Beninga, Cécile Capdevila, Carsten Corvey, Alain Dupuy, Paul Ferrari, Alexey Rak, Peter Wonerow, Jochen Kruip, Vincent Mikol & Ercole Rao. (2016) CODV-Ig, a universal bispecific tetravalent and multifunctional immunoglobulin format for medical applications. mAbs 8:5, pages 867-878.
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Xiufeng Wu, Arlene J Sereno, Flora Huang, Steven M Lewis, Ricky L Lieu, Caroline Weldon, Carina Torres, Cody Fine, Micheal A Batt, Jonathan R Fitchett, Andrew L Glasebrook, Brian Kuhlman & Stephen J Demarest. (2015) Fab-based bispecific antibody formats with robust biophysical properties and biological activity. mAbs 7:3, pages 470-482.
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Articles from other publishers (14)

Yordkhwan W. Iwasaki, Kannan Tharakaraman, Vidya Subramanian, Amnart Khongmanee, Andrew Hatas, Eduardo Fleischer, Troy T. Rurak, Patchara Ngok-ngam, Phanthakarn Tit-oon, Mathuros Ruchirawat, Jutamaad Satayavivad, Mayuree Fuangthong & Ram Sasisekharan. (2023) Generation of bispecific antibodies by structure-guided redesign of IgG constant regions. Frontiers in Immunology 13.
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Guanghui Xu, Yuting Luo, Hanbing Wang, Yue Wang, Baorui Liu & Jia Wei. (2022) Therapeutic bispecific antibodies against intracellular tumor antigens. Cancer Letters 538, pages 215699.
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Caizhi Zhao, Wei Zhang, Guihua Gong, Liping Xie, Ming-Wei Wang & Youjia Hu. (2021) A new approach to produce IgG4-like bispecific antibodies. Scientific Reports 11:1.
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Wen-Bin Zhao, Ying Shen, Wen-Hui Liu, Yi-Ming Li, Shi-Jie Jin, Ying-Chun Xu, Li-Qiang Pan, Zhan Zhou & Shu-Qing Chen. (2021) Soluble Expression of Fc-Fused T Cell Receptors Allows Yielding Novel Bispecific T Cell Engagers. Biomedicines 9:7, pages 790.
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Xiaotian Zhong & Aaron M. D’Antona. (2021) Recent Advances in the Molecular Design and Applications of Multispecific Biotherapeutics. Antibodies 10:2, pages 13.
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Karen Froning, Jack Maguire, Arlene Sereno, Flora Huang, Shawn Chang, Kenneth Weichert, Anton J. Frommelt, Jessica Dong, Xiufeng Wu, Heather Austin, Elaine M. Conner, Jonathan R. Fitchett, Aik Roy Heng, Deepa Balasubramaniam, Mark T. Hilgers, Brian Kuhlman & Stephen J. Demarest. (2020) Computational stabilization of T cell receptors allows pairing with antibodies to form bispecifics. Nature Communications 11:1.
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Aran F. Labrijn, Maarten L. Janmaat, Janice M. Reichert & Paul W. H. I. Parren. (2019) Bispecific antibodies: a mechanistic review of the pipeline. Nature Reviews Drug Discovery 18:8, pages 585-608.
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Netra Unni Rajesh & Anam Qudrat. (2019) Protein Chimera-based Ca2+ Rewiring as a Treatment Modality for Neurodegeneration. Current Psychopharmacology 8:1, pages 27-40.
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Xiufeng Wu & Stephen J. Demarest. (2019) Building blocks for bispecific and trispecific antibodies. Methods 154, pages 3-9.
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Simon Krah, Harald Kolmar, Stefan Becker & Stefan Zielonka. (2018) Engineering IgG-Like Bispecific Antibodies—An Overview. Antibodies 7:3, pages 28.
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Petra Verdino, Shane Atwell & Stephen J Demarest. (2018) Emerging trends in bispecific antibody and scaffold protein therapeutics. Current Opinion in Chemical Engineering 19, pages 107-123.
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Jijie Gu, Andrew McCluskey & Tariq Ghayur. 2017. Protein Therapeutics. Protein Therapeutics 229 270 .
Simon Krah, Carolin Sellmann, Laura Rhiel, Christian Schröter, Stephan Dickgiesser, Jan Beck, Stefan Zielonka, Lars Toleikis, Björn Hock, Harald Kolmar & Stefan Becker. (2017) Engineering bispecific antibodies with defined chain pairing. New Biotechnology 39, pages 167-173.
Crossref
Kai Zhang, Stephen J. Demarest, Xiufeng Wu & Jonathan R. Fitchett. 2017. Synthetic Antibodies. Synthetic Antibodies 197 213 .

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