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Inhibition of CD73 AMP hydrolysis by a therapeutic antibody with a dual, non-competitive mechanism of action

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Pages 454-467 | Received 13 Nov 2015, Accepted 12 Jan 2016, Published online: 16 Mar 2016

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Alessio Nocentini, Clemente Capasso & Claudiu T. Supuran. (2021) Small-molecule CD73 inhibitors for the immunotherapy of cancer: a patent and literature review (2017–present). Expert Opinion on Therapeutic Patents 31:10, pages 867-876.
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Bradley N. Spatola, Alana G. Lerner, Clifford Wong, Tracy dela Cruz, Megan Welch, Wanchi Fung, Maria Kovalenko, Karolina Losenkova, Gennady G. Yegutkin, Courtney Beers, John Corbin & Vanessa B. Soros. (2020) Fully human anti-CD39 antibody potently inhibits ATPase activity in cancer cells via uncompetitive allosteric mechanism. mAbs 12:1.
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Ghasem Ghalamfarsa, Mohammad Hossein Kazemi, Sahar Raoofi Mohseni, Ali Masjedi, Mohammad Hojjat-Farsangi, Gholamreza Azizi, Mehdi Yousefi & Farhad Jadidi-Niaragh. (2019) CD73 as a potential opportunity for cancer immunotherapy. Expert Opinion on Therapeutic Targets 23:2, pages 127-142.
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Marta Tomczyk, Paulina Mierzejewska, Ewa M. Slominska & Ryszard T. Smolenski. (2018) The metabolism of ecto-5’-nucleotidase (CD73) inhibitor-α,β-methylene adenosine diphosphate in BALB/c mice. Nucleosides, Nucleotides & Nucleic Acids 37:12, pages 709-716.
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Luca Antonioli, Corrado Blandizzi, Fabio Malavasi, Davide Ferrari & György Haskó. (2016) Anti-CD73 immunotherapy: A viable way to reprogram the tumor microenvironment. OncoImmunology 5:9.
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Carl M. Hay, Erin Sult, Qihui Huang, Kathy Mulgrew, Stacy R. Fuhrmann, Kelly A. McGlinchey, Scott A. Hammond, Raymond Rothstein, Jonathan Rios-Doria, Edmund Poon, Nick Holoweckyj, Nicholas M. Durham, Ching Ching Leow, Gundo Diedrich, Melissa Damschroder, Ronald Herbst, Robert E. Hollingsworth & Kris F. Sachsenmeier. (2016) Targeting CD73 in the tumor microenvironment with MEDI9447. OncoImmunology 5:8.
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