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mAbs Volume 11, 2019 - Issue 6
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Tetravalent biepitopic targeting enables intrinsic antibody agonism of tumor necrosis factor receptor superfamily members

Yanli YangDepartments of Antibody Engineering, Genentech Inc., South San Francisco, CA, USAView further author information
,
Sherry H. YehBiochemical and Cellular Pharmacology, Genentech Inc., South San Francisco, CA, USAORCID Iconhttps://orcid.org/0000-0002-2015-4563View further author information
ORCID Icon,
Shravan MadireddiCancer Immunology, Genentech Inc., South San Francisco, CA, USAORCID Iconhttps://orcid.org/0000-0002-7069-1252View further author information
ORCID Icon,
Wadim L. MatochkoDepartments of Antibody Engineering, Genentech Inc., South San Francisco, CA, USAORCID Iconhttps://orcid.org/0000-0001-7387-9106View further author information
ORCID Icon,
Chen GuProtein Chemistry, Genentech Inc., South San Francisco, CA, USAView further author information
,
Patricia Pacheco SanchezTranslational Oncology, Genentech Inc., South San Francisco, CA, USAView further author information
,
Mark UltschStructural Biology, Genentech Inc., South San Francisco, CA, USAORCID Iconhttps://orcid.org/0000-0002-8290-5908View further author information
ORCID Icon,
Gladys De Leon BoenigStructural Biology, Genentech Inc., South San Francisco, CA, USAORCID Iconhttps://orcid.org/0000-0002-8314-1188View further author information
ORCID Icon,
Seth F. HarrisStructural Biology, Genentech Inc., South San Francisco, CA, USAView further author information
,
Brandon LeonardDepartments of Antibody Engineering, Genentech Inc., South San Francisco, CA, USAView further author information
,
Suzie J. ScalesMolecular Biology, Genentech Inc., South San Francisco, CA, USAORCID Iconhttps://orcid.org/0000-0003-2544-0283View further author information
ORCID Icon,
Jing W. ZhuCancer Immunology, Genentech Inc., South San Francisco, CA, USAView further author information
,
Erin ChristensenProtein Chemistry, Genentech Inc., South San Francisco, CA, USAView further author information
,
Julie Q. HangProtein Chemistry, Genentech Inc., South San Francisco, CA, USAView further author information
,
Randall J. BrezskiDepartments of Antibody Engineering, Genentech Inc., South San Francisco, CA, USAView further author information
,
Scot MarstersCancer Immunology, Genentech Inc., South San Francisco, CA, USAORCID Iconhttps://orcid.org/0000-0002-8517-0994View further author information
ORCID Icon,
Avi AshkenaziCancer Immunology, Genentech Inc., South San Francisco, CA, USAView further author information
,
Siddharth SukumaranPre-Clinical and Translational Pharmacokinetics, Genentech Inc., South San Francisco, CA, USAView further author information
,
Henry ChiuBiochemical and Cellular Pharmacology, Genentech Inc., South San Francisco, CA, USAView further author information
,
Rafael CubasTranslational Oncology, Genentech Inc., South San Francisco, CA, USAORCID Iconhttps://orcid.org/0000-0002-3450-9054View further author information
ORCID Icon,
Jeong M. KimCancer Immunology, Genentech Inc., South San Francisco, CA, USAView further author information
&
Greg A. LazarDepartments of Antibody Engineering, Genentech Inc., South San Francisco, CA, USACorrespondence[email protected]
View further author information
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Pages 996-1011 | Received 08 Jan 2019, Accepted 18 May 2019, Published online: 20 Jun 2019

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