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Indrajit Ghosh, Hiten Gutka, Mary E. Krause, Ryan Clemens & Ramesh S. Kashi. (2023) A systematic review of commercial high concentration antibody drug products approved in the US: formulation composition, dosage form design and primary packaging considerations. mAbs 15:1.
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Xuan Han, James Shih, Yuhao Lin, Qing Chai & Steven M. Cramer. (2022) Development of QSAR models for in silico screening of antibody solubility. mAbs 14:1.
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Yu Tang, Paul Cain, Victor Anguiano, James J. Shih, Qing Chai & Yiqing Feng. (2021) Impact of IgG subclass on molecular properties of monoclonal antibodies. mAbs 13:1.
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Emily K. Makowski, Lina Wu, Priyanka Gupta & Peter M. Tessier. (2021) Discovery-stage identification of drug-like antibodies using emerging experimental and computational methods. mAbs 13:1.
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Allesandra Stratigakis, Dylan Paty, Peng Zou, Zhongyuan Zhao, Yanyan Li & Tao Zhang. (2023) A regression approach for assessing large molecular drug concentration in breast milk. Reproduction and Breeding 3:4, pages 199-207.
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Mohammad Abdallah, Lihuan Lin, Ian K. Styles, Alexander Mörsdorf, James L. Grace, Gracia Gracia, Cameron Nowell, John F. Quinn, Cornelia B. Landersdorfer, Michael R. Whittaker & Natalie L. Trevaskis. (2023) Functionalisation of brush polyethylene glycol polymers with specific lipids extends their elimination half-life through association with natural lipid trafficking pathways. Acta Biomaterialia.
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Vineeth Chandran Suja, Qin M Qi, Kevin Halloran, Jifeng Zhang, Suyog Shaha, Supriya Prakash, Ninad Kumbhojkar, Antoine Deslandes, Sylvain Huille, Yatin R Gokarn & Samir Mitragotri. (2023) A biomimetic chip to assess subcutaneous bioavailability of monoclonal antibodies in humans. PNAS Nexus 2:10.
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Adrian D. Hobson, Jianwen Xu, Dennie S. Welch, Christopher C. Marvin, Michael J. McPherson, Bradley Gates, Xiaoli Liao, Markus Hollmann, Michael J. Gattner, Kristina Dzeyk, Hetal Sarvaiya, Vikram M. Shenoy, Margaret M. Fettis, Agnieszka K. Bischoff, Lu Wang, Ling C. Santora, Lu Wang, Julia Fitzgibbons, Paulin Salomon, Axel HernandezJr.Jr., Ying Jia, Christian A. Goess, Suzanne L. Mathieu, Shaughn H. Bryant, Mary E. Larsen, Baoliang Cui & Yu Tian. (2023) Discovery of ABBV-154, an anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody-Drug Conjugate (iADC). Journal of Medicinal Chemistry 66:17, pages 12544-12558.
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Adrian D. Hobson, Jianwen Xu, Christopher C. Marvin, Michael J. McPherson, Markus Hollmann, Michael Gattner, Kristina Dzeyk, Margaret M. Fettis, Agnieszka K. Bischoff, Lu Wang, Julia Fitzgibbons, Lu Wang, Paulin Salomon, Axel HernandezJr.Jr., Ying Jia, Hetal Sarvaiya, Christian A. Goess, Suzanne L. Mathieu & Ling C. Santora. (2023) Optimization of Drug-Linker to Enable Long-term Storage of Antibody–Drug Conjugate for Subcutaneous Dosing. Journal of Medicinal Chemistry 66:13, pages 9161-9173.
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Yuhong Zeng, Subhashchandra Naik, Timothy Tran, Philip Wuthrich, Neal Muni & Robert P. Mahoney. (2023) Preclinical Pharmacokinetic Study on Caffeine as an Excipient for Monoclonal Antibody Formulations. Journal of Pharmaceutical Sciences.
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David Li, Poh Yee Chow, Tzu Ping Lin, Celine Cheow, Zhuoxuan Li & Matthias G. Wacker. (2023) Simulate SubQ: The Methods and the Media. Journal of Pharmaceutical Sciences 112:6, pages 1492-1508.
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Peng Zou. (2023) Predicting Human Bioavailability of Subcutaneously Administered Fusion Proteins and Monoclonal Antibodies Using Human Intravenous Clearance or Antibody Isoelectric Point. The AAPS Journal 25:3.
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Amita Datta-Mannan, Bruce A. Molitoris, Yiqing Feng, Michelle M. Martinez, Ruben M. Sandoval, Robin M. Brown, Daniel Merkel, Johnny E. Croy & Kenneth W. Dunn. (2023) Intravital Microscopy Reveals Unforeseen Biodistribution Within the Liver and Kidney Mechanistically Connected to the Clearance of a Bifunctional Antibody. Drug Metabolism and Disposition 51:3, pages 403-412.
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Andreas Evers, Shipra Malhotra, Wolf-Guido Bolick, Ahmad Najafian, Maria Borisovska, Shira Warszawski, Yves Fomekong Nanfack, Daniel Kuhn, Friedrich Rippmann, Alejandro Crespo & Vanita Sood. 2023. Genotype Phenotype Coupling. Genotype Phenotype Coupling
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Shihao Hu, Amita Datta-Mannan & David Z. D’Argenio. (2022) Monoclonal Antibody Pharmacokinetics in Cynomolgus Monkeys Following Subcutaneous Administration: Physiologically Based Model Predictions from Physiochemical Properties. The AAPS Journal 25:1.
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Hannes Ausserwöger, Matthias M. Schneider, Therese W. Herling, Paolo Arosio, Gaetano Invernizzi, Tuomas P. J. Knowles & Nikolai Lorenzen. (2022) Non-specificity as the sticky problem in therapeutic antibody development. Nature Reviews Chemistry 6:12, pages 844-861.
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Christian Bender, Sabine Eichling, Lutz Franzen, Viktoria Herzog, Ludger M. Ickenstein, Dhananjay Jere, Lara Nonis, Gregoire Schwach, Philipp Stoll, Marta Venczel & Shalin Zenk. (2022) Evaluation of In Vitro Tools to Predict the In Vivo Absorption of Biopharmaceuticals Following Subcutaneous Administration. Journal of Pharmaceutical Sciences 111:9, pages 2514-2524.
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Busra Gurel, Melike Berksoz, Eda Capkin, Ayhan Parlar, Meltem Corbacioglu Pala, Aylin Ozkan, Yılmaz Capan, Duygu Emine Daglikoca & Meral Yuce. (2022) Structural and Functional Analysis of CEX Fractions Collected from a Novel Avastin® Biosimilar Candidate and Its Innovator: A Comparative Study. Pharmaceutics 14:8, pages 1571.
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Paul J. Carter & Arvind Rajpal. (2022) Designing antibodies as therapeutics. Cell 185:15, pages 2789-2805.
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Priyanka Gupta, Emily K. Makowski, Sandeep Kumar, Yulei Zhang, Justin M. Scheer & Peter M. Tessier. (2022) Antibodies with Weakly Basic Isoelectric Points Minimize Trade-offs between Formulation and Physiological Colloidal Properties. Molecular Pharmaceutics 19:3, pages 775-787.
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Amita Datta-Mannan, Robin Brown, Stephanie Key, Paul Cain & Yiqing Feng. (2021) Pharmacokinetic Developability and Disposition Profiles of Bispecific Antibodies: A Case Study with Two Molecules. Antibodies 11:1, pages 2.
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Lucky Ahmed, Priyanka Gupta, Kyle P. Martin, Justin M. Scheer, Andrew E. Nixon & Sandeep Kumar. (2021) Intrinsic physicochemical profile of marketed antibody-based biotherapeutics. Proceedings of the National Academy of Sciences 118:37.
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Peng Hou, Fudan Zheng, Clairissa D. Corpstein, Lei Xing & Tonglei Li. (2021) Multiphysics Modeling and Simulation of Subcutaneous Injection and Absorption of Biotherapeutics: Sensitivity Analysis. Pharmaceutical Research 38:6, pages 1011-1030.
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Hao Lou & Michael J. Hageman. (2021) Machine Learning Attempts for Predicting Human Subcutaneous Bioavailability of Monoclonal Antibodies. Pharmaceutical Research 38:3, pages 451-460.
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