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Biomanufacturing evolution from conventional to intensified processes for productivity improvement: a case study

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Michael A. MacDonald, Matthias Nöbel, Verónica S. Martínez, Kym Baker, Evan Shave, Peter P. Gray, Stephen Mahler, Trent Munro, Lars K. Nielsen & Esteban Marcellin. (2022) Engineering death resistance in CHO cells for improved perfusion culture. mAbs 14:1.
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Ying Gao & David Gervais. (2021) Overcoming challenges of improving legacy biopharmaceutical processes. Journal of Chemical Technology & Biotechnology 96:5, pages 1141-1150.
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Natascha Gödecke, Sabrina Herrmann, Hansjörg Hauser, Anke Mayer-Bartschmid, Mark Trautwein & Dagmar Wirth. (2020) Rational Design of Single Copy Expression Cassettes in Defined Chromosomal Sites Overcomes Intraclonal Cell-to-Cell Expression Heterogeneity and Ensures Robust Antibody Production. ACS Synthetic Biology 10:1, pages 145-157.
Crossref
Jan Müller, Misha Teale, Sandra Steiner, Stefan Junne, Peter Neubauer, Dieter Eibl & Regine Eibl. 2021. Cell Culture Engineering and Technology. Cell Culture Engineering and Technology 401 429 .
Ashish Kumar, Isuru A. Udugama, Carina L. Gargalo & Krist V. Gernaey. (2020) Why Is Batch Processing Still Dominating the Biologics Landscape? Towards an Integrated Continuous Bioprocessing Alternative. Processes 8:12, pages 1641.
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