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mAbs Volume 14, 2022 - Issue 1
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Short Communication

Epitope mapping of anti-drug antibodies to a clinical candidate bispecific antibody

Arthur J. Schick IIIa Protein Analytical Chemistry, Genentech Inc, South San Francisco, California, USAView further author information
,
Victor Lundina Protein Analytical Chemistry, Genentech Inc, South San Francisco, California, USAView further author information
,
Justin Lowb BioAnalytical Sciences, Genentech Inc, South San Francisco, California, USAView further author information
,
Kun Pengb BioAnalytical Sciences, Genentech Inc, South San Francisco, California, USAView further author information
,
Richard Vandlenc Protein Chemistry, Genentech Inc. South San Francisco, California, USAView further author information
&
Aaron T. Weckslera Protein Analytical Chemistry, Genentech Inc, South San Francisco, California, USACorrespondence[email protected]
View further author information
Article: 2028337 | Received 07 Dec 2021, Accepted 09 Jan 2022, Published online: 24 Jan 2022

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Wen-Ting K. Tsai, Yinyin Li, Zhaojun Yin, Peter Tran, Qui Phung, Zhenru Zhou, Kun Peng, Dan Qin, Sien Tam, Christoph Spiess, Jochen Brumm, Manda Wong, Zhengmao Ye, Patrick Wu, Sivan Cohen & Paul J. Carter. (2024) Nonclinical immunogenicity risk assessment for knobs-into-holes bispecific IgG1 antibodies. mAbs 16:1.
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Ruoxuan Sun, Mark G. Qian & Xiaobin Zhang. (2024) T and B cell epitope analysis for the immunogenicity evaluation and mitigation of antibody-based therapeutics. mAbs 16:1.
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Elizabeth Sara Hecht, Shrenik Mehta, Aaron T. Wecksler, Ben Aguilar, Nathaniel Swanson, Wilson Phung, Ananya Dubey Kelsoe, W. Henry Benner, Devin Tesar, Robert F. Kelley, Wendy Sandoval & Alavattam Sreedhara. (2022) Insights into ultra-low affinity lipase-antibody noncovalent complex binding mechanisms. mAbs 14:1.
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Md Harunur Rashid. (2022) Full-length recombinant antibodies from Escherichia coli: production, characterization, effector function (Fc) engineering, and clinical evaluation. mAbs 14:1.
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Articles from other publishers (4)

Daniel Nyberg Larsen, Jakub Zbigniew Kaczmarek, Yaseelan Palarasah, Jonas Heilskov Graversen & Peter Højrup. (2024) Epitope mapping of SARS-CoV-2 RBDs by hydroxyl radical protein footprinting reveals the importance of including negative antibody controls. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1872:4, pages 141011.
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Arnik Shah, Dipanwita Batabyal, Dayong Qiu, Weidong Cui, John Harrahy & Alexander R. Ivanov. (2024) Mapping conformational changes on bispecific antigen-binding biotherapeutic by covalent labeling and mass spectrometry. Journal of Pharmaceutical Analysis, pages 100966.
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Jérôme Castel, Sarah Delaux, Oscar Hernandez-Alba & Sarah Cianférani. (2023) Recent advances in structural mass spectrometry methods in the context of biosimilarity assessment: from sequence heterogeneities to higher order structures. Journal of Pharmaceutical and Biomedical Analysis 236, pages 115696.
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Corie Y. Ralston & Joshua S. Sharp. (2022) Structural Investigation of Therapeutic Antibodies Using Hydroxyl Radical Protein Footprinting Methods. Antibodies 11:4, pages 71.
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