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Review

Non-canonical functions of claudin proteins: Beyond the regulation of cell-cell adhesions

Article: e1327839 | Received 17 Feb 2017, Accepted 03 May 2017, Published online: 26 May 2017

Keep up to date with the latest research on this topic with citation updates for this article.

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Daisuke Kyuno, Akira Takasawa, Kumi Takasawa, Yusuke Ono, Tomoyuki Aoyama, Kazufumi Magara, Yuna Nakamori, Ichiro Takemasa & Makoto Osanai. (2022) Claudin-18.2 as a therapeutic target in cancers: cumulative findings from basic research and clinical trials. Tissue Barriers 10:1.
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Anna Agata Scalise, Nikolaos Kakogiannos, Federica Zanardi, Fabio Iannelli & Monica Giannotta. (2021) The blood–brain and gut–vascular barriers: from the perspective of claudins. Tissue Barriers 9:3.
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Sara Cherradi, Pierre Martineau, Céline Gongora & Maguy Del Rio. (2019) Claudin gene expression profiles and clinical value in colorectal tumors classified according to their molecular subtype. Cancer Management and Research 11, pages 1337-1348.
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Wenjing Li, Chang Xu, Kun Wang, Yuhan Ding & Lei Ding. (2019) Non-tight junction-related function of claudin-7 in interacting with integrinβ1 to suppress colorectal cancer cell proliferation and migration. Cancer Management and Research 11, pages 1443-1451.
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Kun Wang, Chang Xu, Wenjing Li & Lei Ding. (2018) Emerging clinical significance of claudin-7 in colorectal cancer: a review. Cancer Management and Research 10, pages 3741-3752.
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Tania Rodrigues, Linda Dib, Émilie Bréthaut, Michel M. Matter, Lidia Matter-Sadzinski & Jean-Marc Matter. (2023) Increased neuron density in the midbrain of a foveate bird, pigeon, results from profound change in tissue morphogenesis. Developmental Biology 502, pages 77-98.
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Aihua Hou, Safiah Mohamed Ali, Evelyn Png, Walter Hunziker & Louis Tong. (2023) Transglutaminase-2 is critical for corneal epithelial barrier function via positive regulation of Claudin-1. The Ocular Surface 28, pages 155-164.
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Nora Brunner, Laura Stein & Salah Amasheh. (2022) Cellular Distribution Pattern of tjp1 (ZO-1) in Xenopus laevis Oocytes Heterologously Expressing Claudins. The Journal of Membrane Biology 256:1, pages 51-61.
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Tania Rodrigues, Linda Dib, Emilie Bréthaut, Michel Marc Matter, Lidia Matter-Sadzinski & Jean-Marc Matter. (2023) Increased Neuron Density in the Midbrain of Foveate Birds Results from Profound Change in Tissue Morphogenesis. SSRN Electronic Journal.
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Xiuzhen Du, Yanjiao Hu, Xiaoyu Ji, Lei Sui, Qingmei Zheng, Kejuan Song, Teng Lv, Yulong Chen, Han Zhao, Shuzhen Dai, Peng Zhao & Qin Yao. (2022) Membranous and nuclear staining of CLDN18 in HPV ‐independent and HPV ‐associated endocervical adenocarcinomas . Cancer Medicine 12:2, pages 1441-1450.
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Catarina Quintanova, Nina Himmerkus, Samuel L. Svendsen, Otto von Schwerdtner, Cosima Merkel, Lennart Pinckert, Kerim Mutig, Tilman Breiderhoff, Dominik Müller, Dorothee Günzel & Markus Bleich. (2022) Unrecognized role of claudin‐10b in basolateral membrane infoldings of the thick ascending limb. Annals of the New York Academy of Sciences 1517:1, pages 266-278.
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Lorena Suarez-Artiles, Tilman Breiderhoff, Rossana Girardello, Hannes Gonschior, Sophie Rodius, Antoine Lesur, Ulf Reimer, Evelyn Ramberger, Daniel Perez-Hernandez, Dominik Müller, Philipp Mertins & Gunnar Dittmar. (2022) Pan-claudin family interactome analysis reveals shared and specific interactions. Cell Reports 41:6, pages 111588.
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Weirong Xing, Sheila Pourteymoor, Yian Chen & Subburaman Mohan. (2022) Targeted Deletion of the Claudin12 Gene in Mice Increases Articular Cartilage and Inhibits Chondrocyte Differentiation. Frontiers in Endocrinology 13.
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Jiayi Wei, Liangjing Wu, Shuai Yang, Conghui Zhang, Le Feng, Minli Wang, Hui Li & Fang Wang. (2022) E-cadherin to N-cadherin switching in the TGF-β1 mediated retinal pigment epithelial to mesenchymal transition. Experimental Eye Research 220, pages 109085.
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Andrea D. Rivera, Kasum Azim, Veronica Macchi, Andrea Porzionato, Arthur M. Butt & Raffaele De Caro. (2022) Epidermal Growth Factor Pathway in the Age-Related Decline of Oligodendrocyte Regeneration. Frontiers in Cellular Neuroscience 16.
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Amna N. Naser, Tiaosi Xing, Qun Lu & Yan-Hua Chen. 2022. Tight Junctions. Tight Junctions 199 215 .
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Snježana Čužić, Maja Antolić, Anja Ognjenović, Darija Stupin-Polančec, Adriana Petrinić Grba, Boška Hrvačić, Miroslava Dominis Kramarić, Sanja Musladin, Lidija Požgaj, Ivo Zlatar, Denis Polančec, Gorana Aralica, Marko Banić, Marija Urek, Brankica Mijandrušić Sinčić, Aleksandar Čubranić, Ines Glojnarić, Martina Bosnar & Vesna Eraković Haber. (2021) Claudins: Beyond Tight Junctions in Human IBD and Murine Models. Frontiers in Pharmacology 12.
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Olga P. Popova, Alla V. Kuznetsova, Svetlana Yu Bogomazova & Alexey A. Ivanov. (2021) Claudins as biomarkers of differential diagnosis and prognosis of tumors. Journal of Cancer Research and Clinical Oncology 147:10, pages 2803-2817.
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Prasoon Kumar, Dhaval Kedaria, Chinmaya Mahapatra, Monisha Mohandas & Kaushik Chatterjee. (2021) A designer cell culture insert with a nanofibrous membrane toward engineering an epithelial tissue model validated by cellular nanomechanics. Nanoscale Advances 3:16, pages 4714-4725.
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Jian Li. (2021) Dysregulated expression of claudins in cancer (Review). Oncology Letters 22:3.
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Mary C. Moran, Radha P. Pandya, Kimberly A. Leffler, Takeshi Yoshida, Lisa A. Beck & Matthew G. Brewer. (2021) Characterization of Human Keratinocyte Cell Lines for Barrier Studies. JID Innovations 1:2, pages 100018.
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Andrea D. Rivera, Francesca Pieropan, Irene Chacon‐De‐La‐Rocha, Davide Lecca, Maria P. Abbracchio, Kasum Azim & Arthur M. Butt. (2021) Functional genomic analyses highlight a shift in Gpr17 ‐regulated cellular processes in oligodendrocyte progenitor cells and underlying myelin dysregulation in the aged mouse cerebrum . Aging Cell 20:4.
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Daisuke Kyuno, Akira Takasawa, Shin Kikuchi, Ichiro Takemasa, Makoto Osanai & Takashi Kojima. (2021) Role of tight junctions in the epithelial-to-mesenchymal transition of cancer cells. Biochimica et Biophysica Acta (BBA) - Biomembranes 1863:3, pages 183503.
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Carolin Schilpp, Robin Lochbaum, Peter Braubach, Danny Jonigk, Manfred Frick, Paul Dietl & Oliver H. Wittekindt. (2021) TGF-β1 increases permeability of ciliated airway epithelia via redistribution of claudin 3 from tight junction into cell nuclei. Pflügers Archiv - European Journal of Physiology 473:2, pages 287-311.
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Tyler J. Caron, Kathleen E. Scott, Nishita Sinha, Sureshkumar Muthupalani, Mahnoor Baqai, Lay-Hong Ang, Yue Li, Jerrold R. Turner, James G. Fox & Susan J. Hagen. (2021) Claudin-18 Loss Alters Transcellular Chloride Flux but not Tight Junction Ion Selectivity in Gastric Epithelial Cells. Cellular and Molecular Gastroenterology and Hepatology 11:3, pages 783-801.
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Xin Wang, Yuta Chiba, Lingling Jia, Keigo Yoshizaki, Kan Saito, Aya Yamada, Man Qin & Satoshi Fukumoto. (2020) Expression Patterns of Claudin Family Members During Tooth Development and the Role of Claudin-10 (Cldn10) in Cytodifferentiation of Stratum Intermedium. Frontiers in Cell and Developmental Biology 8.
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Florian Rouaud, Sophie Sluysmans, Arielle Flinois, Jimit Shah, Ekaterina Vasileva & Sandra Citi. (2020) Scaffolding proteins of vertebrate apical junctions: structure, functions and biophysics. Biochimica et Biophysica Acta (BBA) - Biomembranes 1862:10, pages 183399.
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Luca Meoli & Dorothee Günzel. (2020) Channel functions of claudins in the organization of biological systems. Biochimica et Biophysica Acta (BBA) - Biomembranes 1862:9, pages 183344.
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Chiara Romani, Valentina Zizioli, Marco Silvestri, Laura Ardighieri, Mattia Bugatti, Michela Corsini, Paola Todeschini, Sergio Marchini, Maurizio D'Incalci, Laura Zanotti, Antonella Ravaggi, Fabio Facchetti, Angela Gambino, Franco Odicino, Enrico Sartori, Alessandro Davide Santin, Stefania Mitola, Eliana Bignotti & Stefano Calza. (2020) Low Expression of Claudin-7 as Potential Predictor of Distant Metastases in High-Grade Serous Ovarian Carcinoma Patients. Frontiers in Oncology 10.
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Nicole Thornton, Vanja Karamatic Crew, Louise Tilley, Carole A. Green, Chwen Ling Tay, Rebecca E. Griffiths, Belinda K. Singleton, Frances Spring, Piers Walser, Abdul Ghani Alattar, Benjamin Jones, Rosalind Laundy, Jill R. Storry, Mattias Möller, Lorna Wall, Richard Charlewood, Connie M. Westhoff, Christine Lomas-Francis, Vered Yahalom, Ute Feick, Axel Seltsam, Beate Mayer, Martin L. Olsson & David J. Anstee. (2020) Disruption of the tumour-associated EMP3 enhances erythroid proliferation and causes the MAM-negative phenotype. Nature Communications 11:1.
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Yu Takahashi, Yutaka Tsutsumi, Chihiro Takeuchi, Kazuya Shiogama, Yasuyoshi Mizutani, Ken‐ichi Inada, Nobutake Yamamichi & Kazuhiko Koike. (2020) Nuclear staining of claudin‐18 is a new immunohistochemical marker for diagnosing intramucosal well‐differentiated gastric adenocarcinoma. Pathology International.
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Josh Lewis Stern, Grace Hibshman, Kevin Hu, Sarah E. Ferrara, James C. Costello, William Kim, Pablo Tamayo, Thomas R. Cech & Franklin W. Huang. (2020) Mesenchymal and MAPK Expression Signatures Associate with Telomerase Promoter Mutations in Multiple Cancers. Molecular Cancer Research 18:7, pages 1050-1062.
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Tomohiro Kohmoto, Kiyoshi Masuda, Katsutoshi Shoda, Rizu Takahashi, Sae Ujiro, Shoichiro Tange, Daisuke Ichikawa, Eigo Otsuji & Issei Imoto. (2019) Claudin-6 is a single prognostic marker and functions as a tumor-promoting gene in a subgroup of intestinal type gastric cancer. Gastric Cancer 23:3, pages 403-417.
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Elja M.M. Louer, Dorothee Günzel, Rita Rosenthal, Claudia Carmone, Guoqiang Yi, Henk G. Stunnenberg, Anneke I. den Hollander & Peter M.T. Deen. (2020) Differential day-night expression of tight junction components in murine retinal pigment epithelium. Experimental Eye Research 193, pages 107985.
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Jian-Nan Li, Zhan Zhang, Guang-Zhi Wu, Deng-Bing Yao & Shu-Sen Cui. (2020) Claudin-15 overexpression inhibits proliferation and promotes apoptosis of Schwann cells in vitro. Neural Regeneration Research 15:1, pages 169.
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Sandra Citi. (2020) Cell Biology: Tight Junctions as Biomolecular Condensates. Current Biology 30:2, pages R83-R86.
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Hidenori Kage, Per Flodby, Beiyun Zhou & Zea Borok. (2019) Dichotomous roles of claudins as tumor promoters or suppressors: lessons from knockout mice. Cellular and Molecular Life Sciences 76:23, pages 4663-4672.
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Richard C Lindsey, Weirong Xing, Sheila Pourteymoor, Catrina Godwin, Alexander Gow & Subburaman Mohan. (2019) Novel Role for Claudin‐11 in the Regulation of Osteoblasts via Modulation of ADAM10‐Mediated Notch Signaling. Journal of Bone and Mineral Research 34:10, pages 1910-1922.
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Alice L. Buddle, Michael B. Thompson, Laura A. Lindsay, Christopher R. Murphy, Camilla M. Whittington & Bronwyn M. McAllan. (2019) Dynamic changes to claudins in the uterine epithelial cells of the marsupial Sminthopsis crassicaudata (Dasyuridae) during pregnancy . Molecular Reproduction and Development 86:6, pages 639-649.
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