5,579
Views
624
CrossRef citations to date
0
Altmetric
Research Article

Summary of information on human CYP enzymes: human P450 metabolism data

Pages 83-448 | Published online: 15 Apr 2002

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (78)

Jian-Chang Qian, Jian-Ping Cai & Guo-Xin Hu. (2021) Han Chinese specific cytochrome P450 polymorphisms and their impact on the metabolism of anti-hypertensive drugs with adrenoreceptor blocking properties. Expert Opinion on Drug Metabolism & Toxicology 17:6, pages 707-716.
Read now
Mariana Babayeva & Zvi Loewy. (2020) Repurposing Drugs for COVID-19: Pharmacokinetics and Pharmacogenomics of Chloroquine and Hydroxychloroquine. Pharmacogenomics and Personalized Medicine 13, pages 531-542.
Read now
Jinglin Gao, Huan Ren, Zhangying Feng, Shanshan Chen, Yu Liang, Wanqiu Liu, Qian Zhou & Mingxia Wang. (2020) Effects of multidose simvastatin co-administration on pharmacokinetic profile of apatinib in rats by UPLC-MS/MS. Xenobiotica 50:9, pages 1115-1120.
Read now
Min Chen, Cui Zhou, Tianpeng Zhang & Baojian Wu. (2020) Identification of rhythmic human CYPs and their circadian regulators using synchronized hepatoma cells. Xenobiotica 50:9, pages 1052-1063.
Read now
Kai Wang, Qing Gao, Tingting Zhang, Jinqiu Rao, Liqin Ding & Feng Qiu. (2020) Inhibition of CYP2C9 by natural products: insight into the potential risk of herb-drug interactions. Drug Metabolism Reviews 52:2, pages 235-257.
Read now
Vadim Tseilikman, Eliyahu Dremencov, Olga Tseilikman, Michaela Pavlovicova, Lubica Lacinova & Daniela Jezova. (2020) Role of glucocorticoid- and monoamine-metabolizing enzymes in stress-related psychopathological processes. Stress 23:1, pages 1-12.
Read now
Laith N AL-Eitan, Ayah Y Almasri & Sahar O Al-Habahbeh. (2019) Impact of a variable number tandem repeat in the CYP2C9 promoter on warfarin sensitivity and responsiveness in Jordanians with cardiovascular disease. Pharmacogenomics and Personalized Medicine 12, pages 15-22.
Read now
Risto O. Juvonen, Mira Ahinko, Juhani Huuskonen, Hannu Raunio & Olli T. Pentikäinen. (2019) Development of new Coumarin-based profluorescent substrates for human cytochrome P450 enzymes. Xenobiotica 49:9, pages 1015-1024.
Read now
Cheng-Cheng Yang, Xiang Zheng, Teng-Hui Liu, Chen-Chen Wang, Peng-Fei Tang, Zhe Chen, Bo-Wen Zhang, Ping Fang, Guo-Xin Hu & Jian-Ping Cai. (2019) Functional characterization of 21 CYP3A4 variants on amiodarone metabolism in vitro. Xenobiotica 49:1, pages 120-126.
Read now
Masataka Nakano & Miki Nakajima. (2018) Current knowledge of microRNA-mediated regulation of drug metabolism in humans. Expert Opinion on Drug Metabolism & Toxicology 14:5, pages 493-504.
Read now
Davide Seripa, Madia Lozupone, Eleonora Stella, Giulia Paroni, Paola Bisceglia, Maddalena La Montagna, Grazia D’onofrio, Carolina Gravina, Maria Urbano, Maria Giovanna Priore, Angela Lamanna, Antonio Daniele, Antonello Bellomo, Giancarlo Logroscino, Antonio Greco & Francesco Panza. (2017) Psychotropic drugs and CYP2D6 in late-life psychiatric and neurological disorders. What do we know?. Expert Opinion on Drug Safety 16:12, pages 1373-1385.
Read now
Lilly Aswathy, Radhakrishnan S. Jisha, Vijay H. Masand, Jayant M. Gajbhiye & Indira G. Shibi. (2017) Computational strategies to explore antimalarial thiazine alkaloid lead compounds based on an Australian marine sponge Plakortis Lita. Journal of Biomolecular Structure and Dynamics 35:11, pages 2407-2429.
Read now
Gaku Okamatsu, Tetsuya Komatsu, Yuka Ono, Hiroki Inoue, Tsuyoshi Uchide, Takenori Onaga, Daiji Endoh, Takio Kitazawa, Takeo Hiraga, Yasuhiro Uno & Hiroki Teraoka. (2017) Characterization of feline cytochrome P450 2B6. Xenobiotica 47:2, pages 93-102.
Read now
Qinghua Weng, Bingqing Liang, Yali Zhou, Xiangyu Li, Hao Wang, Yunyun Zhan, Dapeng Dai, JianPing Cai & Guoxin Hu. (2016) Effect of 24 cytochrome P450 2D6 variants found in the Chinese population on the N-demethylation of amitriptyline in vitro. Pharmaceutical Biology 54:11, pages 2475-2479.
Read now
Kevin A. Ford, Gregory Ryslik, Jasleen Sodhi, Jason Halladay, Dolo Diaz, Donna Dambach & Melisa Masuda. (2015) Computational predictions of the site of metabolism of cytochrome P450 2D6 substrates: comparative analysis, molecular docking, bioactivation and toxicological implications. Drug Metabolism Reviews 47:3, pages 291-319.
Read now
Danyi Lu, Dong Dong, Zhong Liu, Yifei Wang & Baojian Wu. (2015) Metabolism elucidation of BJ-B11 (a heat shock protein 90 inhibitor) by human liver microsomes: identification of main contributing enzymes. Expert Opinion on Drug Metabolism & Toxicology 11:7, pages 1029-1040.
Read now
Davide Seripa, Francesco Panza, Julia Daragjati, Giulia Paroni & Alberto Pilotto. (2015) Measuring pharmacogenetics in special groups: geriatrics. Expert Opinion on Drug Metabolism & Toxicology 11:7, pages 1073-1088.
Read now
Toshiro Niwa, Norie Murayama, Yurie Imagawa & Hiroshi Yamazaki. (2015) Regioselective hydroxylation of steroid hormones by human cytochromes P450. Drug Metabolism Reviews 47:2, pages 89-110.
Read now
Qiaoli Wang, Xiaotong Han, Jian Li, Xinghui Gao, Yan Wang, Mingzhou Liu, Guicheng Dong & Jiang Yue. (2015) Regulation of cerebral CYP2D alters tramadol metabolism in the brain: interactions of tramadol with propranolol and nicotine. Xenobiotica 45:4, pages 335-344.
Read now
Yan-Ying Wang, Jun Yang, Hang Liu, Feng-Qin Lin, Jing-Shan Shi & Feng Zhang. (2015) Effects of tetrahydroxystilbene glucoside on mouse liver cytochrome P450 enzyme expressions. Xenobiotica 45:4, pages 279-285.
Read now
Swati Jaiswal, Abhisheak Sharma, Mahendra Shukla, Kalpesh Vaghasiya, Nagarjun Rangaraj & Jawahar Lal. (2014) Novel pre-clinical methodologies for pharmacokinetic drug–drug interaction studies: spotlight on “humanized” animal models. Drug Metabolism Reviews 46:4, pages 475-493.
Read now
L. M. Tormoehlen, K. J. Tekulve & K. A. Nañagas. (2014) Hydrocarbon toxicity: A review. Clinical Toxicology 52:5, pages 479-489.
Read now
Qiang You, Linling Cheng, Dingzhou Li, Jessica Whritenour, Thomas T. Kawabata & Cynthia Ju. (2014) Development of a screening assay to evaluate the potential of drugs to cause immune-mediated hypersensitivity reactions. Journal of Immunotoxicology 11:2, pages 110-115.
Read now
C. Desbans, C. Hilgendorf, M. Lutz, P. Bachellier, T. Zacharias, J. C. Weber, H. Dolgos, L. Richert & A.-L. Ungell. (2014) Prediction of fraction metabolized via CYP3A in humans utilizing cryopreserved human hepatocytes from a set of 12 single donors. Xenobiotica 44:1, pages 17-27.
Read now
David C Lamb, Michael R Waterman & Bin Zhao. (2013) Streptomyces cytochromes P450: applications in drug metabolism. Expert Opinion on Drug Metabolism & Toxicology 9:10, pages 1279-1294.
Read now
Wanda Baer-Dubowska & Hanna Szaefer. (2013) Modulation of carcinogen-metabolizing cytochromes P450 by phytochemicals in humans. Expert Opinion on Drug Metabolism & Toxicology 9:8, pages 927-941.
Read now
Kristi L Helke & Marvin Michael Swindle. (2013) Animal models of toxicology testing: the role of pigs. Expert Opinion on Drug Metabolism & Toxicology 9:2, pages 127-139.
Read now
Noriaki Yoda, Chie Emoto, Shoichi Date, Satoshi Kondo, Masateru Miyake, Satoru Nakazato, Ken Umehara & Eiji Kashiyama. (2012) Characterization of intestinal and hepatic P450 enzymes in cynomolgus monkeys with typical substrates and inhibitors for human P450 enzymes. Xenobiotica 42:8, pages 719-730.
Read now
Dong Dong, Baojian Wu, Diana Chow & Ming Hu. (2012) Substrate selectivity of drug-metabolizing cytochrome P450s predicted from crystal structures and in silico modeling. Drug Metabolism Reviews 44:2, pages 192-208.
Read now
Joseph McGraw & Donald Waller. (2012) Cytochrome P450 variations in different ethnic populations. Expert Opinion on Drug Metabolism & Toxicology 8:3, pages 371-382.
Read now
Araceli Vences-Mejía, Josefina Gómez-Garduño, Heriberto Caballero-Ortega, Víctor Dorado-González, Rosario Nosti-Palacios, Norma Labra-Ruíz & J. Javier Espinosa-Aguirre. (2012) Effect of mosquito mats (pyrethroid-based) vapor inhalation on rat brain cytochrome P450s. Toxicology Mechanisms and Methods 22:1, pages 41-46.
Read now
Juhyun Kim, Concepcion Peraire, Josep Solà, Karla M. Johanning, James T. Dalton & Karen A. Veverka. (2011) Drug interaction potential of toremifene and N-desmethyltoremifene with multiple cytochrome P450 isoforms. Xenobiotica 41:10, pages 851-862.
Read now
David FV Lewis & Yuko Ito. (2010) Human CYPs involved in drug metabolism: structures, substrates and binding affinities. Expert Opinion on Drug Metabolism & Toxicology 6:6, pages 661-674.
Read now
Partha Pratim Roy & Kunal Roy. (2010) Classical and 3D-QSAR studies of cytochrome 17 inhibitor imidazole-substituted biphenyls. Molecular Simulation 36:4, pages 311-325.
Read now
K. Murai, H. Yamazaki, K. Nakagawa, R. Kawai & T. Kamataki. (2009) Deactivation of anti-cancer drug letrozole to a carbinol metabolite by polymorphic cytochrome P450 2A6 in human liver microsomes. Xenobiotica 39:11, pages 795-802.
Read now
Bo Wang, Li-Ping Yang, Xiao-Zhuang Zhang, Shui-Qing Huang, Mark Bartlam & Shu-Feng Zhou. (2009) New insights into the structural characteristics and functional relevance of the human cytochrome P450 2D6 enzyme. Drug Metabolism Reviews 41:4, pages 573-643.
Read now
Kunal Roy & Partha Pratim Roy. (2009) QSAR of cytochrome inhibitors. Expert Opinion on Drug Metabolism & Toxicology 5:10, pages 1245-1266.
Read now
T. Ringsted, N. Nikolov, G.E. Jensen, E.B. Wedebye & J. Niemelä. (2009) QSAR models for P450 (2D6) substrate activity. SAR and QSAR in Environmental Research 20:3-4, pages 309-325.
Read now
S. Kurosawa, S. Uchida, Y. Ito,S. Yamada. (2009) Effect of ursodeoxycholic acid on the pharmacokinetics of midazolam and CYP3A in the liver and intestine of rats. Xenobiotica 39:2, pages 162-170.
Read now
David FV Lewis & Yuko Ito. (2008) Human cytochromes P450 in the metabolism of drugs: new molecular models of enzyme–substrate interactions. Expert Opinion on Drug Metabolism & Toxicology 4:9, pages 1181-1186.
Read now
Grover P Miller. (2008) Advances in the interpretation and prediction of CYP2E1 metabolism from a biochemical perspective. Expert Opinion on Drug Metabolism & Toxicology 4:8, pages 1053-1064.
Read now
Y. Deng, H.-C. Bi, L.-Z. Zhao, F. He, Y.-Q. Liu, J.-J. Yu, Z.-M. Ou, L. Ding, X. Chen, Z.-Y. Huang, M. Huang & S.-F. Zhou. (2008) Induction of cytochrome P450s by terpene trilactones and flavonoids of the extract EGb 761 in rats. Xenobiotica 38:5, pages 465-481.
Read now
C. Emoto, Y. Yamato, Y. Sato, H. Ohshita, M. Katoh, C. Tateno, T. Yokoi, K. Yoshizato & K. Iwasaki. (2008) Non-invasive method to detect induction of CYP3A4 in chimeric mice with a humanized liver. Xenobiotica 38:3, pages 239-248.
Read now
Rainer Cermak. (2008) Effect of dietary flavonoids on pathways involved in drug metabolism. Expert Opinion on Drug Metabolism & Toxicology 4:1, pages 17-35.
Read now
William W. Johnson. (2008) Cytochrome P450 Inactivation by Pharmaceuticals and Phytochemicals: Therapeutic Relevance. Drug Metabolism Reviews 40:1, pages 101-147.
Read now
Caitlin M. Brown, Brad Reisfeld & Arthur N. Mayeno. (2008) Cytochromes P450: A Structure-Based Summary of Biotransformations Using Representative Substrates. Drug Metabolism Reviews 40:1, pages 1-100.
Read now
C. Emoto, H. Nishida, H. Hirai & K. Iwasaki. (2007) CYP3A4 and CYP3A5 catalyse the conversion of the -methyl-D-aspartate (NMDA) antagonist CJ-036878 to two novel dimers. Xenobiotica 37:12, pages 1408-1420.
Read now
Michael Michael & Margaret M Doherty. (2007) Drug metabolism by tumours: its nature, relevance and therapeutic implications. Expert Opinion on Drug Metabolism & Toxicology 3:6, pages 783-803.
Read now
G. Tournel, C. Cauffiez, J. Leclerc, I. Billaut-Laden, D. Allorge, D. Chevalier, F. Migot-Nabias, A. Kenani, F. Broly & J.-M. Lo-Guidice. (2007) CYP2F1 genetic polymorphism: Identification of interethnic variations. Xenobiotica 37:12, pages 1433-1438.
Read now
Bitna Yi, Ji-Yeon Yang & Mihi Yang. (2007) Past and Future Applications of CYP450-Genetic Polymorphisms for Biomonitoring of Environmental Toxicants. Journal of Environmental Science and Health, Part C 25:4, pages 353-377.
Read now
C. Emoto & K. Iwasaki. (2007) Relative roles of CYP2C19 and CYP3A4/5 in midazolam 1′-hydroxylation. Xenobiotica 37:6, pages 592-603.
Read now
Yi-Tong Liu, Hai-Ping Hao, Chang-Xiao Liu, Guang-Ji Wang & Hong-Guang Xie. (2007) Drugs as CYP3A Probes, Inducers, and Inhibitors. Drug Metabolism Reviews 39:4, pages 699-721.
Read now
MAREN BODE, MATTHIAS HAAS, TANYA FAYMONVILLE, BRIGITTE THIEDE, INGOLF SCHUPHAN & BURKHARD SCHMIDT. (2006) Biotransformation of Metamitron by Human P450 Expressed in Transgenic Tobacco Cell Cultures. Journal of Environmental Science and Health, Part B 41:3, pages 201-222.
Read now
David E. Amacher. (2006) A Toxicologist's Guide to the Preclinical Assessment of Hepatic Microsomal Enzyme Induction. Toxicology Mechanisms and Methods 16:7, pages 385-394.
Read now
David F.V. Lewis, Brian G. Lake, Yuko Ito & Maurice Dickins. (2006) Lipophilicity Relationships in Inhibitors of CYP2C9 and CYP2C19 Enzymes. Journal of Enzyme Inhibition and Medicinal Chemistry 21:4, pages 385-389.
Read now
David F.V. Lewis, Brian G. Lake & Maurice Dickins. (2006) Quantitative structure–activity relationships (QSARs) in CYP3A4 inhibitors: The importance of lipophilic character and hydrogen bonding. Journal of Enzyme Inhibition and Medicinal Chemistry 21:2, pages 127-132.
Read now
H. Yamazaki, A. Okayama, N. Imai, F. P. Guengerich & M. Shimizu. (2006) Inter-individual variation of cytochrome P4502J2 expression and catalytic activities in liver microsomes from Japanese and Caucasian populations. Xenobiotica 36:12, pages 1201-1209.
Read now
Shufeng Zhou, Eli Chan, Xiaotian Li & Min Huang. (2005) Clinical outcomes and management of mechanism-based inhibition of cytochrome P450 3A4. Therapeutics and Clinical Risk Management 1:1, pages 3-13.
Read now
C. Cauffiez, N. Pottier, G. Tournel, J.-M. Lo-Guidice, D. Allorge, D. Chevalier, F. Migot-Nabias, A. Kenani & F. Broly. (2005) CYP2A13 genetic polymorphism in French Caucasian, Gabonese and Tunisian populations. Xenobiotica 35:7, pages 661-669.
Read now
David FV Lewis. (2005) Human P450s in the metabolism of drugs: molecular modelling of enzyme–substrate interactions. Expert Opinion on Drug Metabolism & Toxicology 1:1, pages 5-8.
Read now
Yihuai Gao, He Gao, Eli Chan, Wenbo Tang, Xiaotian Li, Jun Liang & Shufeng Zhou. (2005) Protective Effect of Ganoderma (a Mushroom with Medicinal Properties) Against Various Liver Injuries. Food Reviews International 21:1, pages 27-52.
Read now
Balram Chowbay, Shufeng Zhou & Edmund J. D. Lee. (2005) An Interethnic Comparison of Polymorphisms of the Genes Encoding Drug-Metabolizing Enzymes and Drug Transporters: Experience in Singapore. Drug Metabolism Reviews 37:2, pages 327-378.
Read now
Shufeng Zhou, Eli Chan, Wei Duan, Min Huang & Yu-Zong Chen. (2005) Drug Bioactivation Covalent Binding to Target Proteins and Toxicity Relevance. Drug Metabolism Reviews 37:1, pages 41-213.
Read now
D. F. V. Lewis, B. G. Lake, M. Dickins & P. S. Goldfarb. (2004) Homology modelling of CYP3A4 from the CYP2C5 crystallographic template: analysis of typical CYP3A4 substrate interactions. Xenobiotica 34:6, pages 549-569.
Read now
S. L. Boye, O. Kerdpin, D. J. Elliot, J. O. Miners, L. Kelly, R. A. Mckinnon, C. R. Bhasker, K. Yoovathaworn & D. J. Birkett. (2004) Optimizing bacterial expression of catalytically active human cytochromes P450: comparison of CYP2C8 and CYP2C9. Xenobiotica 34:1, pages 49-60.
Read now
T. Niwa, T. Shiraga, S. Yamasaki, K. Ishibashi, Y. Ohno & A. Kagayama. (2003) In vitro activation of 7-benzyloxyresorufin O-debenzylation and nifedipine oxidation in human liver microsomes. Xenobiotica 33:7, pages 717-729.
Read now
David F. V. Lewis & Maruice Dickins. (2003) Baseline Lipophilicity Relationships in Human Cytochromes P450 Associated with Drug Metabolism. Drug Metabolism Reviews 35:1, pages 1-18.
Read now
Eric F. Johnson, Michael R. Wester & C. David Stout. (2002) THE STRUCTURE OF MICROSOMAL CYTOCHROME P450 2C5: A STEROID AND DRUG METABOLIZING ENZYME. Endocrine Research 28:4, pages 435-441.
Read now
David R. Nelson. (2002) Introductory remarks on human CYPs. Drug Metabolism Reviews 34:1-2, pages 1-5.
Read now
M. Rypka, J. Veselý, Z. Chmela, D. Riegrová, K. Červenková, L. Havlíček, K. Lemr, J. Hanuš, B. Černý, J. Lukeš & K. Michalíková. (2002) In vitro biotransformation of 2,6,9-trisubstituted purine-derived cyclin-dependent kinase inhibitor bohemine by mouse liver microsomes. Xenobiotica 32:11, pages 1017-1031.
Read now

Articles from other publishers (546)

Ziru Dai, Yue Wu, Yuan Xiong, Jingjing Wu, Min Wang, Xiao Sun, Xinxin Ding, Ling Yang, Xiaobo Sun & Guangbo Ge. (2023) CYP1A inhibitors: Recent progress, current challenges, and future perspectives. Medicinal Research Reviews 44:1, pages 169-234.
Crossref
Mohammad Amin Valizadeh Osalu, Hossein Soltanzadeh & Zahra Hojjati Bonab. (2023) Association of CYP1A2 Gene rs17861162 Polymorphism and Breast Cancer Risk in Iranian Women: A Case-Control Study. Gene, Cell and Tissue 11:1.
Crossref
Francisca Pinheiro, Nathalia Varejão, Adrià Sánchez-Morales, Filipa Bezerra, Susanna Navarro, Adrián Velázquez-Campoy, Félix Busqué, Maria Rosário Almeida, Ramon Alibés, David Reverter, Irantzu Pallarès & Salvador Ventura. (2023) PITB: A high affinity transthyretin aggregation inhibitor with optimal pharmacokinetic properties. European Journal of Medicinal Chemistry 261, pages 115837.
Crossref
Yasuhiro Uno, Shotaro Uehara, Genki Ushirozako, Tatsunori Masatani & Hiroshi Yamazaki. (2023) Chronic Toxoplasma infection affects gene expression of drug-metabolizing enzymes in mouse liver . Xenobiotica, pages 1-11.
Crossref
Alberto Boretti. (2023) Imiquimod tópico para tratar la micosis fungoide en fase tumoral con pocos nódulos o nódulos aislados. Piel.
Crossref
Qing Zhao, Yao Chen, Weihua Huang, Honghao Zhou & Wei Zhang. (2023) Drug-microbiota interactions: an emerging priority for precision medicine. Signal Transduction and Targeted Therapy 8:1.
Crossref
Polina I. Koroleva, Tatiana V. Bulko, Lyubov’ E. Agafonova & Victoria V. Shumyantseva. (2023) Catalytic and Electrocatalytic Mechanisms of Cytochromes P450 in the Development of Biosensors and Bioreactors. Biochemistry (Moscow) 88:10, pages 1645-1657.
Crossref
David Tyler Sweeney, Francisco Zárate-Pérez, Kamila Stokowa-Sołtys & John C. Hackett. (2023) Induced Fit Describes Ligand Binding to Membrane-Associated Cytochrome P450 3A4. Molecular Pharmacology 104:4, pages 154-163.
Crossref
Irina A. Pikuleva. (2023) Challenges and Opportunities in P450 Research on the Eye. Drug Metabolism and Disposition 51:10, pages 1295-1307.
Crossref
Yongjin Hao, Jiawan Ma, Jin Wang, Xiaoliang Yu, Zhanhui Li, Shuwei Wu, Sheng Tian, Haikuo Ma, Sudan He & Xiaohu Zhang. (2023) Synthesis and evaluation of dihydrofuro[2,3-b]pyridine derivatives as potent IRAK4 inhibitors. European Journal of Medicinal Chemistry 258, pages 115616.
Crossref
Wei Pan, Lei Feng, Cheng-Peng Sun, Xiang-Ge Tian, Chao Shi, Chao Wang, Xia Lv, Yan Wang, Shan-Shan Huang, Bao-Jing Zhang, Jing Ning & Xiao-Chi Ma. (2023) Tetracyclic triterpenoids as inhibitors of cytochrome P450 3A4 and their quantitative structure activity relationship analysis. Arabian Journal of Chemistry 16:10, pages 105156.
Crossref
Joanna Hajdys, Piotr Fularski, Klaudia Leszto, Gabriela Majchrowicz, Magdalena Stabrawa, Ewelina Młynarska, Jacek Rysz & Beata Franczyk. (2023) New Insights into the Nephroprotective Potential of Lercanidipine. International Journal of Molecular Sciences 24:18, pages 14048.
Crossref
Han Kang, Sebastian Hasselbeck, Katerina Taškova, Nessa Wang, Luuk N.van Oosten, Ralf Mrowka, Jochen Utikal, Miguel A. Andrade-Navarro, Jichang Wang, Stefan Wölfl & Xinlai Cheng. (2023) Development of a next-generation endogenous OCT4 inducer and its anti-aging effect in vivo. European Journal of Medicinal Chemistry 257, pages 115513.
Crossref
Longqiang Li, Zhou Lu, Guixia Liu, Yun Tang & Weihua Li. (2023) Machine Learning Models to Predict Cytochrome P450 2B6 Inhibitors and Substrates. Chemical Research in Toxicology 36:8, pages 1332-1344.
Crossref
Jeonghyeon Gu, Dongmin Bang, Jungseob Yi, Sangseon Lee, Dong Kyu Kim & Sun Kim. (2023) A model-agnostic framework to enhance knowledge graph-based drug combination prediction with drug–drug interaction data and supervised contrastive learning. Briefings in Bioinformatics.
Crossref
Hiromi Sato, Rika Marutani, Ryota Takaoka, Daniel Mori‐Fegan, Xinying Wang, Kazuya Maeda, Hiroyuki Kusuhara, Hiroshi Suzuki, Hideki Yoshioka & Akihiro Hisaka. (2023) Model‐based meta‐analysis of ethnic differences and their variabilities in clearance of oral drugs classified by clearance mechanism. CPT: Pharmacometrics & Systems Pharmacology 12:8, pages 1132-1142.
Crossref
Nadezhda Y. Davydova, David A. Hutner, Kari A. Gaither, Dilip Kumar Singh, Bhagwat Prasad & Dmitri R. Davydov. (2023) High-Throughput Assay of Cytochrome P450-Dependent Drug Demethylation Reactions and Its Use to Re-Evaluate the Pathways of Ketamine Metabolism. Biology 12:8, pages 1055.
Crossref
Juan Cai & Rongwei Shi. (2023) Exploration of the binding of antifungal drugs to human P450 2C9 based on docking and molecular dynamics simulation . International Journal of Quantum Chemistry 123:14.
Crossref
Toshiro Niwa, Misaki Tani, Anna Suzuki & Mizuho Murakami. (2023) Stimulatory and Inhibitory Effects of Steroid Hormones and Human Cytochrome P450 (CYP) 3A Inhibitors on Cortisol 6β-Hydroxylation Catalyzed by CYP3A Subfamilies. Drug Metabolism and Bioanalysis Letters 16:2, pages 73-80.
Crossref
Ngoc Tran, William E. Fantegrossi, Keith R. McCain, Xinwen Wang & Ryoichi Fujiwara. (2023) Identification of Cytochrome P450 Enzymes Responsible for Oxidative Metabolism of Synthetic Cannabinoid (1-Hexyl-1H-Indol-3-yl)-1-naphthalenyl-methanone (JWH-019). Catalysts 13:6, pages 1008.
Crossref
Chiatali O. DokeRanjit S. TiwariVijay B. TodekarAbhijeet P. ManeViraj S. SawantGanesh V. Sawant. (2023) Herb Drug Interaction in Antibiotic Drug, Antiulcer Drug, Antihypertensive Drug, Antidiabetic Drug, Anticancer Drug. Research Journal of Science and Technology, pages 119-126.
Crossref
Manzhen Zhou, Junda Li, Jinyi Xu, Lufeng Zheng & Shengtao Xu. (2023) Exploring human CYP4 enzymes: Physiological roles, function in diseases and focus on inhibitors. Drug Discovery Today 28:5, pages 103560.
Crossref
Lukas Gebauer, Christof Dücker, Ole Jensen & Jürgen Brockmöller. (2023) Combined and independent effects of OCT1 and CYP2D6 on the cellular disposition of drugs. Biomedicine & Pharmacotherapy 161, pages 114454.
Crossref
Qing Zhang, Yuying Qi, Shuanghu Wang, Fangling Zhao, Lili Zou, Quan Zhou, Peiwu Geng, Yun Hong, Hang Yang, Qingfeng Luo, Jianping Cai, Hualan Wu, Dongxu Wang, Hao Chen, Jiefu Yang & Dapeng Dai. (2023) Identification and in vitro functional assessment of 10 CYP2C9 variants found in Chinese Han subjects. Frontiers in Endocrinology 14.
Crossref
Samiksha Kukal, Sarita Thakran, Neha Kanojia, Saroj Yadav, Manish Kumar Mishra, Debleena Guin, Pooja Singh & Ritushree Kukreti. (2023) Genic-intergenic polymorphisms of CYP1A genes and their clinical impact. Gene 857, pages 147171.
Crossref
Evangelia Eirini Tsermpini, Alessandro Serretti & Vita Dolžan. 2023. Precision Medicine. Precision Medicine 131 186 .
José Fernando Rinaldi de Alvarenga, Caroline Lei Preti, Lara Santos Martins, Guilherme Noronha Hernandez, Brunna Genaro, Bruna Lamesa Costa, Caroline Gieseler Dias, Eduardo Purgatto & Jarlei Fiamoncini. (2022) Identification of D-Limonene Metabolites by LC-HRMS: An Exploratory Metabolic Switching Approach in a Mouse Model of Diet-Induced Obesity. Metabolites 12:12, pages 1246.
Crossref
Ning-Ning Wang, Xiang-Gui Wang, Guo-Li Xiong, Zi-Yi Yang, Ai-Ping Lu, Xiang Chen, Shao Liu, Ting-Jun Hou & Dong-Sheng Cao. (2022) Machine learning to predict metabolic drug interactions related to cytochrome P450 isozymes. Journal of Cheminformatics 14:1.
Crossref
Kevin F. dos Santos, Elsa M. Materón & Osvaldo N. OliveiraJr.Jr.. (2022) Influence of cytochrome P450 3A4 and membrane lipid composition on doxorubicin activity. Colloids and Surfaces B: Biointerfaces 220, pages 112886.
Crossref
Alina A. Bagdasaryan, Vladimir N. Chubarev, Elena A. Smolyarchuk, Vladimir N. Drozdov, Ivan I. Krasnyuk, Junqi Liu, Ruitai Fan, Edmund Tse, Evgenia V. Shikh & Olga A. Sukocheva. (2022) Pharmacogenetics of Drug Metabolism: The Role of Gene Polymorphism in the Regulation of Doxorubicin Safety and Efficacy. Cancers 14:21, pages 5436.
Crossref
Veronica Di Paolo, Francesco Maria Ferrari, Italo Poggesi & Luigi Quintieri. (2022) Quantitative Prediction of Drug Interactions Caused by Cytochrome P450 2B6 Inhibition or Induction. Clinical Pharmacokinetics 61:9, pages 1297-1306.
Crossref
Toshiro Niwa, Shoko Sasaki, Yuka Yamamoto & Mayu Tanaka. (2022) Effect of Human Cytochrome P450 2D6 Polymorphism on Progesterone Hydroxylation. European Journal of Drug Metabolism and Pharmacokinetics 47:5, pages 741-747.
Crossref
Nancy H. C. Loos, Jos H. Beijnen & Alfred H. Schinkel. (2022) The Mechanism-Based Inactivation of CYP3A4 by Ritonavir: What Mechanism?. International Journal of Molecular Sciences 23:17, pages 9866.
Crossref
Natalie Jakobs, Esra Yilmaz & Jürgen Krücken. (2022) Transgenic Expression of Haemonchus contortus Cytochrome P450 Hco-cyp-13A11 Decreases Susceptibility to Particular but Not All Macrocyclic Lactones in the Model Organism Caenorhabditis elegans. International Journal of Molecular Sciences 23:16, pages 9155.
Crossref
Longji HUANG, Xiaojing ZHANG, Lin LUO, Hongfang MU, Wenbin LI & Rong WANG. (2022) Effects of high-altitude environment on pharmacokinetic parameters of gliquidone in rats. Journal of Zhejiang University (Medical Sciences) 51:4, pages 389-396.
Crossref
Xie Meinan, Wang Yimeng, Wang Chao, Tang Tianli, Jianjun Li, Ying Peng & Nie Xiangping. (2022) Response of the Sirtuin/PXR signaling pathway in Mugilogobius chulae exposed to environmentally relevant concentration Paracetamol. Aquatic Toxicology 249, pages 106222.
Crossref
Slobodan P. Rendić, Rachel D. Crouch & F. Peter Guengerich. (2022) Roles of selected non-P450 human oxidoreductase enzymes in protective and toxic effects of chemicals: review and compilation of reactions. Archives of Toxicology 96:8, pages 2145-2246.
Crossref
Toshiro Niwa & Risa Ishii. (2022) Mechanism-Based Inhibition of CYP3A Subfamilies by Macrolide Antibiotics and Piperine. Drug Metabolism and Bioanalysis Letters 15:2, pages 75-80.
Crossref
Poonam Giri, Lakshmikant Gupta, Anil Rathod, Vipul Joshi, Shyamkumar Giri, Nirmal Patel, Sameer Agarwal & Mukul R Jain. (2022) ZY12201: A Potent TGR5 Agonist: Identification of a Novel Pan CYP450 Inhibitor Tool Compound for In-Vitro Assessment. Drug Metabolism and Bioanalysis Letters 15:2, pages 116-132.
Crossref
Qinglian Zhai, Maaike van der Lee, Teun van Gelder & Jesse J. Swen. (2022) Why We Need to Take a Closer Look at Genetic Contributions to CYP3A Activity. Frontiers in Pharmacology 13.
Crossref
Jean-Pierre Valentin, Peter Hoffmann, Catherine Ortemann-Renon, John Koerner, Jennifer Pierson, Gary Gintant, James Willard, Christine Garnett, Matthew Skinner, Hugo M Vargas, Todd Wisialowski & Michael K Pugsley. (2022) The Challenges of Predicting Drug-Induced QTc Prolongation in Humans. Toxicological Sciences 187:1, pages 3-24.
Crossref
Kohei Ihara, Ami Oguro & Hiromasa Imaishi. (2022) Diagnosis of Parkinson's disease by investigating the inhibitory effect of serum components on P450 inhibition assay. Scientific Reports 12:1.
Crossref
Meijuan Xu, Ying Chen, Xiaoyun Xi, Chao Jiang, Qian Zhang, Ting Wu, Jihong Chu, Guoliang Dai, Yongtao Bai, Qian Yu, Jiandong Zou & Wenzheng Ju. (2022) In vitro inhibitory effects of components from Salvia miltiorrhiza on catalytic activity of three human Arachidonic acid ω-hydroxylases. Drug Metabolism and Pharmacokinetics 43, pages 100402.
Crossref
Celso Muller Bandeira, Adriana Ávila Almeida, Mônica Ghislaine Oliveira Alves, Maria Beatriz Nogueira Pascoal, José Francisco Sales Chagas, Morun Bernardino Neto, Patrícia Pimentel de Barros, Fábio Daumas Nunes, Celina Faig Lima Carta & Janete Dias Almeida. (2022) The Fagerström and AUDIT Tests as Probable Screening Tools in Oral Cancer and Their Correlation with CYP1A1, GSTM1, GSTP1, and GSTT1 Gene Expression. International Journal of Environmental Research and Public Health 19:7, pages 3991.
Crossref
Nizwa Itrat, Sumbal Rasheed, Kanwal Rehman, Hira Amjad & Muhammad Sajid Hamid Akash. 2022. Biochemistry of Drug Metabolizing Enzymes. Biochemistry of Drug Metabolizing Enzymes 455 476 .
Xiao‐fang Ma, Qi Zhao, Yan Cheng, Dong‐Mei Yan, Wei‐Feng Zhu & Fei Li. (2021) Metabolomics reveals the role of isopentenyl group in coumarins metabolism. Biomedical Chromatography 36:1.
Crossref
André Fischer & Martin Smieško. (2021) A Conserved Allosteric Site on Drug-Metabolizing CYPs: A Systematic Computational Assessment. International Journal of Molecular Sciences 22:24, pages 13215.
Crossref
Vedanjali Gogineni, Manal A. Nael, Narayan D. Chaurasiya, Khaled M. Elokely, Christopher R. McCurdy, John M. Rimoldi, Stephen J. Cutler, Babu L. Tekwani & Francisco León. (2021) Computationally Assisted Lead Optimization of Novel Potent and Selective MAO-B Inhibitors. Biomedicines 9:10, pages 1304.
Crossref
Koichi Kato, Tomoki Nakayoshi, Rika Nokura, Hiroki Hosono, Masahiro Hiratsuka, Yoshinobu Ishikawa, Eiji Kurimoto & Akifumi Oda. (2021) Deciphering Structural Alterations Associated with Activity Reductions of Genetic Polymorphisms in Cytochrome P450 2A6 Using Molecular Dynamics Simulations. International Journal of Molecular Sciences 22:18, pages 10119.
Crossref
Bikash Dangi, Nadezhda Y. Davydova, Marc A. Maldonado, Deepak Ahire, Bhagwat Prasad & Dmitri R. Davydov. (2021) Probing functional interactions between cytochromes P450 with principal component analysis of substrate saturation profiles and targeted proteomics. Archives of Biochemistry and Biophysics 708, pages 108937.
Crossref
Sherif M. Shoieb, Rambabu Dakarapu, John R. Falck & Ayman O. S. El-Kadi. (2021) Novel Synthetic Analogues of 19(S/R)-Hydroxyeicosatetraenoic Acid Exhibit Noncompetitive Inhibitory Effect on the Activity of Cytochrome P450 1A1 and 1B1. European Journal of Drug Metabolism and Pharmacokinetics 46:5, pages 613-624.
Crossref
Albert P. Li. 2021. Transporters and Drug‐Metabolizing Enzymes in Drug Toxicity. Transporters and Drug‐Metabolizing Enzymes in Drug Toxicity 79 137 .
Yining Xu, Neha Shrestha, Véronique Préat & Ana Beloqui. (2021) An overview of in vitro, ex vivo and in vivo models for studying the transport of drugs across intestinal barriers. Advanced Drug Delivery Reviews 175, pages 113795.
Crossref
Immaculate M. Langmia, Katja S. Just, Sabrina Yamoune, Jürgen Brockmöller, Collen Masimirembwa & Julia C. Stingl. (2021) CYP2B6 Functional Variability in Drug Metabolism and Exposure Across Populations—Implication for Drug Safety, Dosing, and Individualized Therapy. Frontiers in Genetics 12.
Crossref
Yanrong Ma, Mingyan Xin, Yuanjie Wen, Huan Wang, Guoqiang Zhang, Jianye Dai & Xin-An Wu. (2021) The utility of endogenous glycochenodeoxycholate-3-sulfate and 4β-hydroxycholesterol to evaluate the hepatic disposition of atorvastatin in rats. Asian Journal of Pharmaceutical Sciences 16:4, pages 519-529.
Crossref
Siyang Tian, Xuan Cao, Russell Greiner, Carin Li, AnChi Guo & David S. Wishart. (2021) CyProduct: A Software Tool for Accurately Predicting the Byproducts of Human Cytochrome P450 Metabolism. Journal of Chemical Information and Modeling 61:6, pages 3128-3140.
Crossref
Shogo Ozawa, Toshitaka Miura, Jun Terashima, Wataru Habano & Seiichi Ishida. (2021) Recent Progress in Prediction Systems for Drug-induced Liver Injury Using In vitro Cell Culture. Drug Metabolism Letters 14:1, pages 25-40.
Crossref
Risto O. Juvonen, Mira Ahinko, Elmeri M. Jokinen, Juhani Huuskonen, Hannu Raunio & Olli T. Pentikäinen. (2021) Substrate Selectivity of Coumarin Derivatives by Human CYP1 Enzymes: In Vitro Enzyme Kinetics and In Silico Modeling. ACS Omega 6:17, pages 11286-11296.
Crossref
R. Donald Harvey, Kathryn F. Mileham, Vishal Bhatnagar, Jamie R. Brewer, Atiqur Rahman, Cassadie Moravek, Andrew S. Kennedy, Elizabeth A. Ness, E. Claire Dees, S. Percy Ivy, Scot W. Ebbinghaus, Caroline Schenkel & Thomas S. Uldrick. (2021) Modernizing Clinical Trial Eligibility Criteria: Recommendations of the ASCO-Friends of Cancer Research Washout Period and Concomitant Medication Work Group. Clinical Cancer Research 27:9, pages 2400-2407.
Crossref
Rui-jing Liu, Yong-jian He, Huan Liu, Dong-dong Zheng, Shao-wen Huang & Chun-hong Liu. (2021) Protective effect of Lycium barbarum polysaccharide on di-(2-ethylhexyl) phthalate-induced toxicity in rat liver. Environmental Science and Pollution Research 28:18, pages 23501-23509.
Crossref
Slobodan P. Rendic. (2021) Metabolism and interactions of Ivermectin with human cytochrome P450 enzymes and drug transporters, possible adverse and toxic effects. Archives of Toxicology 95:5, pages 1535-1546.
Crossref
Donald J. AbrahamDeepak K. Dalvie & Bernard Testa. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 1 139 .
Hye Ran Kim, Jin Cheol Kim, Seok Young Kang, Hye One Kim, Chun Wook Park & Bo Young Chung. (2021) Rapamycin Alleviates 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Induced Aggravated Dermatitis in Mice with Imiquimod-Induced Psoriasis-Like Dermatitis by Inducing Autophagy. International Journal of Molecular Sciences 22:8, pages 3968.
Crossref
Toshiro Niwa, Manami Toyota, Hinako Kawasaki, Risa Ishii & Shoko Sasaki. (2021) Comparison of the Stimulatory and Inhibitory Effects of Steroid Hormones and α-Naphthoflavone on Steroid Hormone Hydroxylation Catalyzed by Human Cytochrome P450 3A Subfamilies. Biological and Pharmaceutical Bulletin 44:4, pages 579-584.
Crossref
Fanny Moreau, Nicolas Simon, Julia Walther, Mathilde Dambrine, Gaetan Kosmalski, Stéphanie Genay, Maxime Perez, Dominique Lecoutre, Stéphanie Belaiche, Chloé Rousselière, Michel Tod, Bertrand Décaudin & Pascal Odou. (2021) Does DDI-Predictor Help Pharmacists to Detect Drug-Drug Interactions and Resolve Medication Issues More Effectively?. Metabolites 11:3, pages 173.
Crossref
Saraswathisreeram Pranush Kumar, Deeki Doma Sherpa, Amit Kumar Sahu, Tarang Jadav, Rakesh Kumar Tekade & Pinaki Sengupta. (2021) Innovation in bioanalytical strategies and in vitro drug–drug interaction study approaches in drug discovery . Bioanalysis 13:6, pages 513-532.
Crossref
Yanpeng Dai, Tianzi Xue, Hefang Ji, Pan Zhang, Dongdong Zhang & Zhengjian Qi. (2021) In situ target enzyme-activated near-infrared fluorescent probe: A case study of CYP2J2 using three-fragmentary molecular assembly engineering. Sensors and Actuators B: Chemical 328, pages 129034.
Crossref
Slobodan P. Rendic & F. Peter Guengerich. (2021) Human Family 1–4 cytochrome P450 enzymes involved in the metabolic activation of xenobiotic and physiological chemicals: an update. Archives of Toxicology 95:2, pages 395-472.
Crossref
Song Gao, Edward C. Bell, Yun Zhang & Dong Liang. (2021) Racial Disparity in Drug Disposition in the Digestive Tract. International Journal of Molecular Sciences 22:3, pages 1038.
Crossref
Manuel Sellner, André Fischer, Charleen G. Don & Martin Smieško. (2021) Conformational Landscape of Cytochrome P450 Reductase Interactions. International Journal of Molecular Sciences 22:3, pages 1023.
Crossref
Sabrina T. Wiebe, Andreas Huennemeyer, Werner Kadus, Markus Goettel, Alen Jambrecina, Armin Schultz, Richard Vinisko, Laura Schlieker, Lena Herich & Gerd Mikus. (2020) Midazolam microdosing applied in early clinical development for drug–drug interaction assessment. British Journal of Clinical Pharmacology 87:1, pages 178-188.
Crossref
Julia Carolin Stingl. 2021. Principles of Translational Science in Medicine. Principles of Translational Science in Medicine 71 83 .
Ashok Singh. 2021. Neurobiology of Alcohol and the Brain. Neurobiology of Alcohol and the Brain 75 140 .
Melvin D. Lobo. 2021. Postural Tachycardia Syndrome. Postural Tachycardia Syndrome 229 230 .
D. Fernando Estrada, Amit Kumar, Christopher S. Campomizzi & Natalie Jay. 2021. Enzyme Kinetics in Drug Metabolism. Enzyme Kinetics in Drug Metabolism 171 192 .
Kun Hu, Qian Xiang, Zhe Wang, Xiaoyan Sheng, Li'e Li, Yan Liang, Xia Zhao, Xia Ye & Yimin Cui. (2020) Effects of Vitamin D Receptor, Cytochrome P450 3A, and Cytochrome P450 Oxidoreductase Genetic Polymorphisms on the Pharmacokinetics of Remimazolam in Healthy Chinese Volunteers. Clinical Pharmacology in Drug Development 10:1, pages 22-29.
Crossref
Arda AYDIN, Anıl ÇAY, Burak POLAT & Aykut OR. (2020) Çanakkale İli Ticari Süt Çiftliklerinde Aydınlatma Koşullarının Değerlendirilmesi. ÇOMÜ Ziraat Fakültesi Dergisi 8:2, pages 289-299.
Crossref
Rozalia-Maria Anastasiadi, Federico Berti, Silvia Colomban, Claudio Tavagnacco, Luciano Navarini & Marina Resmini. (2020) Simultaneous Quantification of Antioxidants Paraxanthine and Caffeine in Human Saliva by Electrochemical Sensing for CYP1A2 Phenotyping. Antioxidants 10:1, pages 10.
Crossref
Yutao Liu, Chang Liu, Yamei Liu, Quanli Ge & Chen Sun. (2020) Cytochrome P450 Mediated Bioactivation of Rutaevin, a Bioactive and Potentially Hepatotoxic Component of Evodia Rutaecarpa . Chemical Research in Toxicology 33:12, pages 3054-3064.
Crossref
Huajun Li, Yubo Zhang, Jing Zhang, Chaoran Zhao, Yizi Zhu & Mei Han. (2020) A quantitative proteomics analysis for small molecule Stemazole’s effect on human neural stem cells. Proteome Science 18:1.
Crossref
Parimal Pande, Xiao-bo Zhong & Warren W. Ku. (2020) Histone Methyltransferase G9a Regulates Expression of Nuclear Receptors and Cytochrome P450 Enzymes in HepaRG Cells at Basal Level and in Fatty Acid Induced Steatosis. Drug Metabolism and Disposition 48:12, pages 1321-1329.
Crossref
Sarika Daripally & Kiranmayi Peddi. (2020) Polymorphic variants of drug-metabolizing enzymes alter the risk and survival of oral cancer patients. 3 Biotech 10:12.
Crossref
Sabrina T. Wiebe, Andreas D. Meid & Gerd Mikus. (2020) Composite midazolam and 1′-OH midazolam population pharmacokinetic model for constitutive, inhibited and induced CYP3A activity. Journal of Pharmacokinetics and Pharmacodynamics 47:6, pages 527-542.
Crossref
Joshua F. Robinson, Emily G. Hamilton, Juleen Lam, Hao Chen & Tracey J. Woodruff. (2020) Differences in cytochrome p450 enzyme expression and activity in fetal and adult tissues. Placenta 100, pages 35-44.
Crossref
Shuang Zhou, Xue Li, Meilin Zhu, Hongyang Yu, Runxuan Chu, Wei Chen, Bing Wang, Meng Wang, Lingna Zheng, Zhifang Chai, Hanqing Chen & Weiyue Feng. (2020) Hepatic impacts of gold nanoparticles with different surface coatings as revealed by assessing the hepatic drug-metabolizing enzyme and lipid homeostasis in mice. NanoImpact 20, pages 100259.
Crossref
Yunfang Zhou, Yingying Tu, Quan Zhou, Ailian Hua, Peiwu Geng, Feifei Chen, Aixia Han, Jin Liu, Dapeng Dai, Shuanghu Wang, Junlu Wang & Congcong Wen. (2020) Evaluation of acacetin inhibition potential against cytochrome P450 in vitro and in vivo. Chemico-Biological Interactions 329, pages 109147.
Crossref
Lorela Paço, Francisco Zarate-Perez, Amanda F. Clouser, William M. Atkins & John C. Hackett. (2020) Dynamics and Mechanism of Binding of Androstenedione to Membrane-Associated Aromatase. Biochemistry 59:33, pages 2999-3009.
Crossref
Francisco Zárate-Pérez & John C. Hackett. (2020) Conformational selection is present in ligand binding to cytochrome P450 19A1 lipoprotein nanodiscs. Journal of Inorganic Biochemistry 209, pages 111120.
Crossref
Hannu Raunio, Olli Pentikäinen & Risto O. Juvonen. (2020) Coumarin-Based Profluorescent and Fluorescent Substrates for Determining Xenobiotic-Metabolizing Enzyme Activities In Vitro. International Journal of Molecular Sciences 21:13, pages 4708.
Crossref
Nokulunga Hlengwa, Christo J. F. Muller, Albertus K. Basson, Sandra Bowles, Johan Louw & Charles Awortwe. (2020) Herbal supplements interactions with oral oestrogen‐based contraceptive metabolism and transport. Phytotherapy Research 34:7, pages 1519-1529.
Crossref
Rita Romskaug, Torgeir Bruun Wyller, Jørund Straand, Hege Kersten & Espen Molden. (2020) Prescribed Doses of CYP2D6-Metabolized Drugs and Hemodynamic Responses in Relation to CYP2D6 Genotype Among Older Patients Exposed to Polypharmacy. Drugs & Aging 37:6, pages 425-433.
Crossref
Andrea Fanelli, Chiara Palazzo, Eleonora Balzani, Alessandra Iuvaro, Susi Pelotti & Rita Maria Melotti. (2020) An Explorative Study of CYP2D6’s Polymorphism in a Sample of Chronic Pain Patients. Pain Medicine 21:5, pages 1010-1017.
Crossref
Fang Yu, Yeek Teck Goh, Huan Li, Narmada Balakrishnan Chakrapani, Ming Ni, Guo Lin Xu, Tseng-Ming Hsieh, Yi-Chin Toh, Christine Cheung, Ciprian Iliescu & Hanry Yu. (2020) A vascular-liver chip for sensitive detection of nutraceutical metabolites from human pluripotent stem cell derivatives. Biomicrofluidics 14:3.
Crossref
Rob C. van Wijk, Rami Ayoun Alsoud, Hans Lennernäs & Ulrika S. H. Simonsson. (2020) Model-Informed Drug Discovery and Development Strategy for the Rapid Development of Anti-Tuberculosis Drug Combinations. Applied Sciences 10:7, pages 2376.
Crossref
Wenjuan Ma, Wei Wang, Xuhua Huang, Guangzhe Yao, Qi Jia, Jiayuan Shen, Huizi Ouyang, Yanxu Chang & Jun He. (2020) HPLC-MS/MS Analysis of Aconiti Lateralis Radix Praeparata and Its Combination with Red Ginseng Effect on Rat CYP450 Activities Using the Cocktail Approach . Evidence-Based Complementary and Alternative Medicine 2020, pages 1-12.
Crossref
Toshiro Niwa, Ayaka Okamoto, Kanae Narita, Manami Toyota, Kyoko Kato, Kyoko Kobayashi & Shoko Sasaki. (2020) Comparison of steroid hormone hydroxylation mediated by cytochrome P450 3A subfamilies. Archives of Biochemistry and Biophysics 682, pages 108283.
Crossref
Sharmila Das, Dong Guo, Xiaohui Jiang, Wenlei Jiang, Yan Shu, Tricia Y. Ting & James E. Polli. (2020) Lack of Association of Generic Brittle Status with Genetics and Physiologic Measures in Patients with Epilepsy. Pharmaceutical Research 37:3.
Crossref
Xinlai Cheng, Stefanie Haeberle, Iart Luca Shytaj, Rodrigo. A. Gama-Brambila, Jannick Theobald, Shahrouz Ghafoory, Jessica Wölker, Uttara Basu, Claudia Schmidt, Annika Timm, Katerina Taškova, Andrea S. Bauer, Jörg Hoheisel, Nikolaos Tsopoulidis, Oliver T. Fackler, Andrea Savarino, Miguel A. Andrade-Navarro, Ingo Ott, Marina Lusic, Eva N. Hadaschik & Stefan. Wölfl. (2020) NHC-gold compounds mediate immune suppression through induction of AHR-TGFβ1 signalling in vitro and in scurfy mice. Communications Biology 3:1.
Crossref
Jian Lu, Xuyang Shang, Weiguo Zhong, Yuan Xu, Rong Shi & Xin Wang. (2020) New insights of CYP1A in endogenous metabolism: a focus on single nucleotide polymorphisms and diseases. Acta Pharmaceutica Sinica B 10:1, pages 91-104.
Crossref
Nadezhda Y. DavydovaBikash DangiMarc A. MaldonadoNikita E. Vavilov, Victor G. Zgoda & Dmitri R. Davydov. (2019) Toward a systems approach to cytochrome P450 ensemble: interactions of CYP2E1 with other P450 species and their impact on CYP1A2. Biochemical Journal 476:23, pages 3661-3685.
Crossref
Kraisiri Khidkhan, Hazuki Mizukawa, Yoshinori Ikenaka, Shouta M.M. Nakayama, Kei Nomiyama, Nozomu Yokoyama, Osamu Ichii, Wageh Sobhy Darwish, Mitsuyoshi Takiguchi, Shinsuke Tanabe & Mayumi Ishizuka. (2019) Tissue distribution and characterization of feline cytochrome P450 genes related to polychlorinated biphenyl exposure. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 226, pages 108613.
Crossref
Sophie Gravel, Jean‐Louis Chiasson, Jacques Turgeon, Alexia Grangeon & Veronique Michaud. (2019) Modulation of CYP 450 Activities in Patients With Type 2 Diabetes . Clinical Pharmacology & Therapeutics 106:6, pages 1280-1289.
Crossref
Jeffrey G. Scott & Nicolas Buchon. (2019) Drosophila melanogaster as a powerful tool for studying insect toxicology. Pesticide Biochemistry and Physiology 161, pages 95-103.
Crossref
Bryan Mackowiak, Linhao Li, Caitlin Lynch, Andrew Ziman, Scott Heyward, Menghang Xia & Hongbing Wang. (2019) High-content analysis of constitutive androstane receptor (CAR) translocation identifies mosapride citrate as a CAR agonist that represses gluconeogenesis. Biochemical Pharmacology 168, pages 224-236.
Crossref
Kazuma Kaitoh, Masaaki Kotera & Kimito Funatsu. (2019) Novel Electrotopological Atomic Descriptors for the Prediction of Xenobiotic Cytochrome P450 Reactions. Molecular Informatics 38:10.
Crossref
Maya Okamura, Ryota Shizu, Takuomi Hosaka, Takamitsu Sasaki & Kouichi Yoshinari. (2019) Possible involvement of the competition for the transcriptional coactivator glucocorticoid receptor-interacting protein 1 in the inflammatory signal-dependent suppression of PXR-mediated CYP3A induction in vitro. Drug Metabolism and Pharmacokinetics 34:4, pages 272-279.
Crossref
Hsien-Tsung Yao, Yu-Hsuan Yang & Mei-Ling Li. (2019) Intake of Molecular Hydrogen in Drinking Water Increases Membrane Transporters, p-Glycoprotein, and Multidrug Resistance-Associated Protein 2 without Affecting Xenobiotic-Metabolizing Enzymes in Rat Liver. Molecules 24:14, pages 2627.
Crossref
Brett M. Reid, Jennifer B. Permuth, Y. Ann Chen, Brooke L. Fridley, Edwin S. Iversen, Zhihua Chen, Heather Jim, Robert A. Vierkant, Julie M. Cunningham, Jill S. Barnholtz-Sloan, Steven Narod, Harvey Risch, Joellen M. Schildkraut, Ellen L. Goode, Alvaro N. Monteiro & Thomas A. Sellers. (2019) Genome-wide Analysis of Common Copy Number Variation and Epithelial Ovarian Cancer Risk. Cancer Epidemiology, Biomarkers & Prevention 28:7, pages 1117-1126.
Crossref
Petra Zehetner, Martina Höferl & Gerhard Buchbauer. (2019) Essential oil components and cytochrome P450 enzymes: a review. Flavour and Fragrance Journal 34:4, pages 223-240.
Crossref
Yuko Tousen, Jun Takebayashi, Takashi Kondo, Hiroyuki Fuchino, Noriaki Kawano, Takayuki Inui, Kayo Yoshimatsu, Nobuo Kawahara & Yoshiko Ishimi. (2019) Safety and Efficacy Assessment of Isoflavones from Pueraria (Kudzu) Flower Extract in Ovariectomised Mice: A Comparison with Soy Isoflavones. International Journal of Molecular Sciences 20:12, pages 2867.
Crossref
Xiao-Yang Zhou, Xiao-Xia Hu, Chen-Chen Wang, Xiang-Ran Lu, Zhe Chen, Qian Liu, Guo-Xin Hu & Jian-Ping Cai. (2019) Enzymatic Activities of CYP3A4 Allelic Variants on Quinine 3-Hydroxylation In Vitro. Frontiers in Pharmacology 10.
Crossref
Yongbin Tong, Peng Zeng, Tianpeng Zhang, Mengjing Zhao, Pei Yu & Baojian Wu. (2019) The transcription factor E4bp4 regulates the expression and activity of Cyp3a11 in mice. Biochemical Pharmacology 163, pages 215-224.
Crossref
Laura J Henze, Niklas J Koehl, Joseph P O'Shea, Edmund S Kostewicz, René Holm & Brendan T Griffin. (2019) The pig as a preclinical model for predicting oral bioavailability and in vivo performance of pharmaceutical oral dosage forms: a PEARRL review. Journal of Pharmacy and Pharmacology 71:4, pages 581-602.
Crossref
Felix Hammann, Verena Schöning & Jürgen Drewe. (2018) Prediction of clinically relevant drug‐induced liver injury from structure using machine learning. Journal of Applied Toxicology 39:3, pages 412-419.
Crossref
Lydia Benkaidali, François André, Gautier Moroy, Bahoueddine Tangour, François Maurel & Michel Petitjean. (2019) Four Major Channels Detected in the Cytochrome P450 3A4: A Step toward Understanding Its Multispecificity. International Journal of Molecular Sciences 20:4, pages 987.
Crossref
Laura N. Jeffreys, Harshwardhan Poddar, Marina Golovanova, Colin W. Levy, Hazel M. Girvan, Kirsty J. McLean, Michael W. Voice, David Leys & Andrew W. Munro. (2019) Novel insights into P450 BM3 interactions with FDA-approved antifungal azole drugs. Scientific Reports 9:1.
Crossref
Sayed M. Derayea, Hirofumi Tsujino, Yukiko Oyama, Yoshinobu Ishikawa, Taku Yamashita & Tadayuki Uno. (2019) Investigation on drug-binding in heme pocket of CYP2C19 with UV–visible and resonance Raman spectroscopies. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 209, pages 209-216.
Crossref
Chen Cheng, Jianchang Qian, Zhe Wang, Wanshu Li, Chengke Huang, Mengchun Chen, Yaoyao Dong, Lejing Lian & Wei Sun. (2019) Influences of Corydalis decumbens on the Activities of CYP450 Enzymes in Rats with a Cocktail Approach . BioMed Research International 2019, pages 1-9.
Crossref
Erica N. Bozeman & Lily Yang. 2019. Nanotheranostics for Cancer Applications. Nanotheranostics for Cancer Applications 13 31 .
Yasuhiro Uno, Shotaro Uehara, Norie Murayama & Hiroshi Yamazaki. (2018) Cytochrome P450 1A1 , 2C9 , 2C19 , and 3A4 Polymorphisms Account for Interindividual Variability of Toxicological Drug Metabolism in Cynomolgus Macaques . Chemical Research in Toxicology 31:12, pages 1373-1381.
Crossref
Laith AL-Eitan, Ayah Almasri & Rame Khasawneh. (2018) Impact of CYP2C9 and VKORC1 Polymorphisms on Warfarin Sensitivity and Responsiveness in Jordanian Cardiovascular Patients during the Initiation Therapy. Genes 9:12, pages 578.
Crossref
Yuriy V. Sheludko, Iryna M. Gerasymenko & Heribert Warzecha. (2018) Transient Expression of Human Cytochrome P450s 2D6 and 3A4 in Nicotiana benthamiana Provides a Possibility for Rapid Substrate Testing and Production of Novel Compounds . Biotechnology Journal 13:11, pages 1700696.
Crossref

Displaying 200 of 624 citing articles. Use the download link below to view the full list of citing articles.

Download full citations list

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.