Advanced search
Publication Cover
Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 34, 2004 - Issue 1
Submit an article Journal homepage
350
Views
57
CrossRef citations to date
0
Altmetric
Original Articles

A Facile and Efficient One‐Pot Synthesis of Dihydropyrimidinones Catalyzed by Magnesium Bromide Under Solvent‐Free Conditions

Hojatollah Salehi Department of Chemistry, University of Science and Technology of China, 96 JinZhai Road, Hefei, 230026, China
&
Qing‐Xiang Guo Department of Chemistry, University of Science and Technology of China, 96 JinZhai Road, Hefei, 230026, ChinaCorrespondence[email protected]
Pages 171-179 | Received 27 May 2003, Published online: 16 Aug 2006

Citations (57)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (8)

Min Wang, Hongxu Jiang, Shun Zhang & He Pan. (2018) Cerous p-Toluenesulfonate as an Efficient and Recyclable Catalyst for the Synthesis of N1-Substituted-4-aryl-3,4-dihydropyrimidin-2(1H)-ones. Organic Preparations and Procedures International 50:5, pages 482-492.
Read now
Haixin Yuan, Kehua Zhang, Jingjing Xia, Xianhai Hu & Shizhen Yuan. (2017) Gallium (III) chloride-catalyzed synthesis of 3,4-dihydropyrimidinones for Biginelli reaction under solvent-free conditions. Cogent Chemistry 3:1.
Read now
SunilS. Chavan, YogeshO. Sharma & MariamS. Degani. (2009) Cost-effective ionic liquid for environmentally friendly synthesis of 3,4-dihydropyrimidin-2(1H)-ones. Green Chemistry Letters and Reviews 2:3, pages 175-179.
Read now
M. Syamala. (2009) Recent Progress in Three-Component Reactions. An Update. Organic Preparations and Procedures International 41:1, pages 1-68.
Read now
Haixia Zhou, Miao He, Chunsheng Liu, Heng Jiang & Genxiang Luo. (2006) One‐Pot Synthesis of 3,4‐Dihydropyrimidin‐2(1 )‐ones using CuBr2 as Catalyst. Preparative Biochemistry & Biotechnology 36:4, pages 375-381.
Read now
Renwei Zheng, Xiaoxia Wang, Hui Xu & Jingxing Du. (2006) Brønsted Acidic Ionic Liquid: An Efficient and Reusable Catalyst for the Synthesis of 3,4‐Dihydropyrimidin‐2(1H)‐ones. Synthetic Communications 36:11, pages 1503-1513.
Read now
Adrienn Hegedüs, Zoltán Hell & Ilona Vígh. (2006) Convenient One‐Pot Heterogeneous Catalytic Method for the Preparation of 3,4‐Dihydropyrimidin‐2(1H)‐ones. Synthetic Communications 36:1, pages 129-136.
Read now
Y. Thirupathi Reddy, B. Rajitha, P. Narsimha Reddy, B. Sunil Kumar & V. P. Rao$suffix/text()$suffix/text(). (2004) Bismuth Subnitrate Catalyzed Efficient Synthesis of 3,4‐Dihydropyrimidin‐2(1H)‐Ones: An Improved Protocol for the Biginelli Reaction. Synthetic Communications 34:20, pages 3821-3825.
Read now

Articles from other publishers (49)

Nastaran Ghanbari & Hossein Ghafuri. (2023) Pyromellitic acid grafted to cross-linked LDH by dendritic units: An efficient and recyclable heterogeneous catalyst for green synthesis of 2,3-dihydro quinazoline and dihydropyrimidinones derivatives. Heliyon 9:11, pages e20978.
Crossref
Bhushan B. Popatkar, Nitin A. Sasane & Gangadhar A. Meshram. (2023) [ EMIM ] AlCl 4 ‐ionic liquid catalyzed mechanochemically assisted synthesis of 3,4‐dihydropyrimidin‐2‐( 1H )‐one and thione derivatives . Journal of Heterocyclic Chemistry 60:7, pages 1199-1209.
Crossref
Saurav Lahiri & R Thangavel. (2023) Investigation of electronic and magnetic properties in vacancy incorporated monolayer magnesium bromide for spintronics application: an ab-initio study. Physica Scripta 98:5, pages 055937.
Crossref
Yasser M. Zohny, Samir M. Awad, Maha A. Rabie & Omar A. Al-Saidan. (2023) Synthesis of Dihydropyrimidines: Isosteres of Nifedipine and Evaluation of Their Calcium Channel Blocking Efficiency. Molecules 28:2, pages 784.
Crossref
Netra Prasad Neupane, Yuan-Seng Wu & Amita Verma. 2023. Dihydropyrimidinones as Potent Anticancer Agents. Dihydropyrimidinones as Potent Anticancer Agents 1 15 .
Fatemeh Rajabi, Mika Sillanpää, Christophe Len & Rafael Luque. (2022) Efficient Synthesis of Dihydropyrimidines Using a Highly Ordered Mesoporous Functionalized Pyridinium Organosilica. Catalysts 12:3, pages 350.
Crossref
Nilesh S. Pawar, Pramod N. Patil & Rajashri N. Pachpande. (2022) An Efficient Synthesis and Antibacterial Activity of Some Novel 3,4–Dihydropyrimidin-2-(1H)-Ones. An Efficient Synthesis and Antibacterial Activity of Some Novel 3,4–Dihydropyrimidin-2-(1H)-Ones.
Ashish Patel, Karan Gandhi, Sweta Shah, Darshan Patel, Shreyas Chhatbar, Drashti ShahStuti Patel, Harnisha Patel & Tushar Bambharoliya. (2022) In silico Study and Solvent-free one-pot Synthesis of Tetrahydropyrimidine derivatives by Mechanochemistry Approach for Targeting Human Neutrophil Elastase against Lung Cancer. Current Computer-Aided Drug Design 18:4, pages 293-306.
Crossref
K. Shenbagam & G. Sivasankari. (2022) Laccase Enzyme Catalyst Mediated Synthesis of Pyrimidines and its Antibacterial, Antifungal, Molecular Docking Studies. Asian Journal of Chemistry 34:8, pages 2105-2112.
Crossref
Nandkishor D. Gawhale, Mahendra N. Lokhande, Santosh J. Uke, Satish P. Mardikar, Vikram U. Pandit & Manisha M. Kodape. (2022) An expedient synthesis of 3,4-dihydropyrimidin-2(1H)-ones derivatives under solvent free condition using titanium dioxide as a catalyst. Materials Today: Proceedings 53, pages 191-195.
Crossref
Syed Faizan, B.R. Prashantha Kumar, Namburu Lalitha Naishima, T. Ashok, Antony Justin, Merugumolu Vijay Kumar, Revanasiddappa Bistuvalli Chandrashekarappa, Nulgumnalli Manjunathaiah Raghavendra, Pradeep Kabadi & Laxmi Adhikary. (2021) Design, parallel synthesis of Biginelli 1,4-dihydropyrimidines using PTSA as a catalyst, evaluation of anticancer activity and structure activity relationships via 3D QSAR studies. Bioorganic Chemistry 117, pages 105462.
Crossref
Navjeet Kaur. 2020. Metal and Nonmetal Assisted Synthesis of Six-Membered Heterocycles. Metal and Nonmetal Assisted Synthesis of Six-Membered Heterocycles 183 241 .
Vasant Chabukswar, Digamber Pawar, Kalpana Handore, Suresh Shisodia, Balasaheb Diwate, Pravin Adhav, Swati Jagdale, Anuruddha Chabukswar, Vishwas Gaikwad & Sabrina Dallavalle. (2019) Biopolymer Catalysed Synthesis of 6-methyl-4-phenylcarbamoyl-1, 2, 3, 4- Tetrahydropyrimidine-2-ones and Evaluation of their Anti-bacterial and Anti-tubercular Activities. Current Bioactive Compounds 15:4, pages 408-414.
Crossref
Hossein Mohammad Zaheri, Shahrzad Javanshir, Behnaz Hemmati, Zahra Dolatkhah & Maryam Fardpour. (2018) Magnetic core–shell Carrageenan moss/Fe3O4: a polysaccharide-based metallic nanoparticles for synthesis of pyrimidinone derivatives via Biginelli reaction. Chemistry Central Journal 12:1.
Crossref
Şirin Gülten. (2017) Nickel Chloride Hexahydrate Catalyzed Multicomponent Biginelli's Synthesis of 3,4-Dihydropyrimidin-2(1 H )-Ones and Thiones . Journal of Heterocyclic Chemistry 54:2, pages 1252-1260.
Crossref
Akbar Mobinikhaledi, Atisa Yazdanipour & Majid Ghashang. (2016) A green one-pot Biginelli synthesis of 3,4-dihydropyrimidin-2-(1H)-ones catalyzed by novel Aurivillius nanostructures under solvent-free conditions. Reaction Kinetics, Mechanisms and Catalysis 119:2, pages 511-522.
Crossref
Jingjing Xia & Kehua Zhang. (2015) Ga(OTf)3 Catalyzed Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones. HETEROCYCLES 91:1, pages 105.
Crossref
Rajesh H. Vekariya, Kinjal D. Patel & Hitesh D. Patel. (2015) Melamine trisulfonic acid (MTSA): an efficient and recyclable heterogeneous catalyst in green organic synthesis. RSC Advances 5:110, pages 90819-90837.
Crossref
Tilak Raj, Beant Kaur Billing, Navneet Kaur & Narinder Singh. (2015) Design, synthesis and antimicrobial evaluation of dihydropyrimidone based organic–inorganic nano-hybrids. RSC Advances 5:58, pages 46654-46661.
Crossref
Muhammad Yar, Marek Bajda, Lubna Shahzadi, Sohail Anjum Shahzad, Maqsood Ahmed, Muhammad Ashraf, Umber Alam, Islam Ullah Khan & Ather Farooq Khan. (2014) Novel synthesis of dihydropyrimidines for α-glucosidase inhibition to treat type 2 diabetes: In vitro biological evaluation and in silico docking. Bioorganic Chemistry 54, pages 96-104.
Crossref
K. Venkatesan, V. S. V. Satyanarayana & A. Sivakumar. (2014) Ultrasound‐Assisted Synthesis of 6‐Methyl‐1,2,3,4‐tetrahydro‐ N ‐aryl‐2‐oxo/thio‐4‐arylpyrimidine‐5‐carboxamides Catalyzed by Uranyl Nitrate Hexahydrate . Journal of the Chinese Chemical Society 61:6, pages 624-630.
Crossref
Chandrashekhar Arunrao Ladole, Nilesh Govindrao Salunkhe, Ravindra Sakharam Bhaskar & Anand Shankarrao Aswar. (2014) A microwave-assisted synthesis of 3,4-dihydropyrimidin-2(1H)-one/thione derivatives using nanocrystalline MgFe2O4 as catalyst. European Journal of Chemistry 5:1, pages 122-126.
Crossref
Rsuini U. Gutiérrez, Hans C. Correa, Rafael Bautista, José Luis Vargas, Alberto V. Jerezano, Francisco Delgado & Joaquín Tamariz. (2013) Regioselective Synthesis of 1,2-Dihydroquinolines by a Solvent-Free MgBr 2 -Catalyzed Multicomponent Reaction . The Journal of Organic Chemistry 78:19, pages 9614-9626.
Crossref
Şirin Gülten. (2013) Magnesium Bromide and Magnesium Chloride Hexahydrate Catalyzed One-Pot Synthesis of Dihydropyrimidines via Biginelli Reaction under Solvent-Free Conditions . Journal of Heterocyclic Chemistry 50:2, pages 391-395.
Crossref
Sami Sajjadifar, Eshagh Rezaee Nezhad & Ghasem Darvishi. (2013) 1-Methyl-3-(2-(sulfooxy)ethyl)-1H-imidazol-3-ium Chloride as a New and Green Ionic Liquid Catalyst for One-Pot Synthesis of Dihydropyrimidinones under Solvent-Free Condition. Journal of Chemistry 2013, pages 1-6.
Crossref
Samad Khaksar, Seyed Mohammad Vahdat & Roshanak Najafi Moghaddamnejad. (2012) Pentafluorophenylammonium triflate: an efficient, practical, and cost-effective organocatalyst for the Biginelli reaction. Monatshefte für Chemie - Chemical Monthly 143:12, pages 1671-1674.
Crossref
Mahmood TAJBAKHSH, Yousef RANJBAR, Abdolhosein MASUODI & Samad KHAKSAR. (2012) A Simple and Environmentally Benign Protocol for Biginelli Reactions Catalyzed by Silica-Bonded S-Sulfonic Acid. Chinese Journal of Catalysis 33:9-10, pages 1542-1545.
Crossref
Ricardo F. Affeldt, Edilson V. Benvenutti & Dennis Russowsky. (2012) A new In–SiO2 composite catalyst in the solvent-free multicomponent synthesis of Ca2+ channel blockers nifedipine and nemadipine B. New Journal of Chemistry 36:7, pages 1502.
Crossref
Kawaljit Singh & Kamaljit Singh. 2012. 223 308 .
Chandran Raju, R. Uma, Kalaipriya Madhaiyan, Radhakrishnan Sridhar & Seeram Ramakrishna. (2011) Ammonium Trifluoroacetate-Mediated Synthesis of 3,4-dihydropyrimidin-2(1 H )-ones . ISRN Organic Chemistry 2011, pages 1-5.
Crossref
Farhad Shirini, Mohammad Ali Zolfigol & Jalal Albadi. (2011) Melamine trisulfonic acid: A new, efficient and recyclable catalyst for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones in the absence of solvent. Chinese Chemical Letters 22:3, pages 318-321.
Crossref
Pengfei Zhang, Wanmei Li, Guobin Zhou, Yifeng Lai & Shifu Xu. (2011) One-Pot Synthesis of Dihydropyrimidiones via Environmentally Friendly Enzyme-Catalyzed Biginelli Reaction. HETEROCYCLES 83:9, pages 2067.
Crossref
Hemant S. Chandak, Nitin P. Lad & Pravin P. Upare. (2009) Recyclable Amberlyst-70 as a Catalyst for Biginelli Reaction: An Efficient One-Pot Green Protocol for the Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones. Catalysis Letters 131:3-4, pages 469-473.
Crossref
Maksim A. Kolosov, Valeriy D. Orlov, Dmitriy A. Beloborodov & Victor V. Dotsenko. (2008) A chemical placebo: NaCl as an effective, cheapest, non-acidic and greener catalyst for Biginelli-type 3,4-dihydropyrimidin-2(1H)-ones (-thiones) synthesis. Molecular Diversity 13:1, pages 5-25.
Crossref
Dailei Song, Runxia Wang, Yongli Chen, Shaohua Zhang, Chunsheng Liu & Genxiang Luo. (2008) Copper(II) trifluoroacetate catalyzed synthesis of 3,4- dihydropyrimidin-2(1H)-ones under solvent-free conditions. Reaction Kinetics and Catalysis Letters 95:2, pages 385-390.
Crossref
Sandeep V. Shinde, Wamanrao N. Jadhav, Machindra K. Lande, Laxman S. Gadekar, Balasaheb R. Arbad, Jeevan M. Kondre & Nandkishor N. Karade. (2008) Scolecite as a Novel Heterogeneous Acid Catalyst for an Efficient Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Via Multi-component Biginelli Reaction. Catalysis Letters 125:1-2, pages 57-61.
Crossref
Hadi Adibi, Heshmat Allah Samimi & Mojtaba Beygzadeh. (2007) Iron(III) trifluoroacetate and trifluoromethanesulfonate: Recyclable Lewis acid catalysts for one-pot synthesis of 3,4-dihydropyrimidinones or their sulfur analogues and 1,4-dihydropyridines via solvent-free Biginelli and Hantzsch condensation protocols. Catalysis Communications 8:12, pages 2119-2124.
Crossref
Fang Dong, Luo Jun, Zhou Xinli, Ye Zhiwen & Liu Zuliang. (2007) One-pot green procedure for Biginelli reaction catalyzed by novel task-specific room-temperature ionic liquids. Journal of Molecular Catalysis A: Chemical 274:1-2, pages 208-211.
Crossref
Atul Kumar & Ram Awatar Maurya. (2007) Synthesis of 3,4-dihydropyrimidin-2(1H)-ones using Ziegler–Natta catalyst system under solvent free conditions. Journal of Molecular Catalysis A: Chemical 272:1-2, pages 53-56.
Crossref
Atul Kumar & Ram Awatar Maurya. (2007) An efficient bakers’ yeast catalyzed synthesis of 3,4-dihydropyrimidin-2-(1H)-ones. Tetrahedron Letters 48:26, pages 4569-4571.
Crossref
Cheng Jiang & Qi Dong You. (2007) An efficient and solvent-free one-pot synthesis of dihydropyrimidinones under microwave irradiation. Chinese Chemical Letters 18:6, pages 647-650.
Crossref
Yang Yu, Di Liu, Chunsheng Liu & Genxiang Luo. (2007) One-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones using chloroacetic acid as catalyst. Bioorganic & Medicinal Chemistry Letters 17:12, pages 3508-3510.
Crossref
Javad Azizian, Ali A. Mohammadi, M. Kohshari, Ali R. Karimi & Mohammad R. Mohammadizadeh. (2009) Biginelli‐like three component reaction: Synthesis of some new ethyl 6‐ethoxycarbonylmethyl‐4‐aryl‐2‐oxo‐1,2,3,4‐tetrahydropyrimidine‐5‐carboxylate derivatives. Journal of Heterocyclic Chemistry 44:2, pages 455-458.
Crossref
Ichiro Suzuki, Yuko Suzumura & Kei Takeda. (2006) Metal triflimide as a Lewis acid catalyst for Biginelli reactions in water. Tetrahedron Letters 47:45, pages 7861-7864.
Crossref
Hojatollah Salehi, Qian-rong Li & Qing-xiang Guo. (2006) One-pot Synthesis and Characterization of 13-Acetyl-9-methyl-11-oxo-8-oxa-10,12-diazatricyclo[7.3.1.0 2,7 ]trideca-2,4,6-triene . Chinese Journal of Chemical Physics 19:1, pages 84-88.
Crossref
Weike Su, Jianjun Li, Zhiguo Zheng & Yinchu Shen. (2005) One-pot synthesis of dihydropyrimidiones catalyzed by strontium(II) triflate under solvent-free conditions. Tetrahedron Letters 46:36, pages 6037-6040.
Crossref
V. Naveen Kumar, P. Someshwar, P. Narsimha Reddy, Y. Thirupathi Reddy & B. Rajitha. (2009) Copper dipyridine dichloride as a mild and efficient catalyst for a one pot condensation bigenelli reaction. Journal of Heterocyclic Chemistry 42:5, pages 1017-1019.
Crossref
Hojatollah Salehi & Qing-Xiang Guo. (2005) Efficient Magnesium Bromide-Catalyzed One-pot Synthesis of Substituted 1,2,3,4-Tetrahydropyrimidin-2-ones Under Solvent-free Conditions. Chinese Journal of Chemistry 23:1, pages 91-97.
Crossref
Hojatollah Salehi & Qing‐Xiang Guo. (2004) A Facile and Efficient One‐Pot Synthesis of Dihydropyrimidinones Catalyzed by Magnesium Bromide under Solvent‐Free Conditions.. ChemInform 35:27.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.