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Molecular and Cellular Biology Volume 31, 2011 - Issue 9
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Article

Calmodulin Antagonizes a Calcium-Activated SCF Ubiquitin E3 Ligase Subunit, FBXL2, To Regulate Surfactant Homeostasis

Bill B. Chen1 Department of Medicine, Acute Lung Injury Center of Excellence, The University of Pittsburgh, Pittsburgh, Pennsylvania15213
,
Tiffany A. Coon1 Department of Medicine, Acute Lung Injury Center of Excellence, The University of Pittsburgh, Pittsburgh, Pennsylvania15213
,
Jennifer R. Glasser1 Department of Medicine, Acute Lung Injury Center of Excellence, The University of Pittsburgh, Pittsburgh, Pennsylvania15213
&
Rama K. Mallampalli1 Department of Medicine, Acute Lung Injury Center of Excellence, The University of Pittsburgh, Pittsburgh, Pennsylvania15213;2 Department of Cell Biology and Physiology, The University of Pittsburgh, Pittsburgh, Pennsylvania15213;3 Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PennsylvaniaCorrespondence[email protected]
Pages 1905-1920 | Received 22 Jun 2010, Accepted 18 Oct 2010, Published online: 20 Mar 2023

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Sung-Moon Kim & Sue-Yun Hwang. (2017) CFL-1, a novel F-box protein with leucine-rich repeat may interact with UNC-10 for the regulation of defecation and daumone response in Caenorhabditis elegans . Animal Cells and Systems 21:3, pages 185-189.
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Wei Chen, Sheng Xiong, Jin Li, Xiuying Li, Yuan Liu, Chunbin Zou & Rama K. Mallampalli. (2015) The Ubiquitin E3 Ligase SCF-FBXO24 Recognizes Deacetylated Nucleoside Diphosphate Kinase A To Enhance Its Degradation. Molecular and Cellular Biology 35:6, pages 1001-1013.
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Bill B. Chen & Rama K. Mallampalli. (2013) F-box protein substrate recognition. Cell Cycle 12:7, pages 1009-1010.
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Rama K. Mallampalli, Jennifer R. Glasser, Tiffany A. Coon & Bill B. Chen. (2013) Calmodulin protects Aurora B on the midbody to regulate the fidelity of cytokinesis. Cell Cycle 12:4, pages 663-673.
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Sung-Moon Kim, Sang-Ho Jang, Narae Son, Ching-Tack Han, Kwan-sik Min, Hakkyo Lee & Sue-Yun Hwang. (2012) A novel F-box protein with leucine-rich repeats affects defecation frequency and daumone response in Caenorhabditis elegans . Animal Cells and Systems 16:4, pages 280-288.
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Bill B. Chen, Jennifer R. Glasser, Tiffany A. Coon & Rama K. Mallampalli. (2011) FBXL2 is a ubiquitin E3 ligase subunit that triggers mitotic arrest. Cell Cycle 10:20, pages 3487-3494.
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Xueren Li, Chunjing Feng & Shouchun Peng. (2022) Epigenetics alternation in lung fibrosis and lung cancer. Frontiers in Cell and Developmental Biology 10.
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Bethany Mason & Heike Laman. (2020) The FBXL family of F-box proteins: variations on a theme. Open Biology 10:11.
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Yuan Liu, Travis B. Lear, Manish Verma, Kent Z.Q. Wang, P. Anthony Otero, Alison C. McKelvey, Sarah R. Dunn, Erin Steer, Nicholas W. Bateman, Christine Wu, Yu Jiang, Nathaniel M. Weathington, Mauricio Rojas, Charleen T. Chu, Bill B. Chen & Rama K. Mallampalli. (2020) Chemical inhibition of FBXO7 reduces inflammation and confers neuroprotection by stabilizing the mitochondrial kinase PINK1. JCI Insight 5:11.
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Nicolas Rosa, Flore Sneyers, Jan B. Parys & Geert Bultynck. 2020. Cell Death Regulation in Health and Disease - Part A. Cell Death Regulation in Health and Disease - Part A 101 148 .
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Rukmini Mukherjee, Anshu Bhattacharya, Abhishek Sau, Samita Basil, Saikat Chakrabarti & Oishee Chakrabarti. (2018) Calmodulin regulates MGRN1‐GP78 interaction mediated ubiquitin proteasomal degradation system. The FASEB Journal 33:2, pages 1927-1945.
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Rukmini Mukherjee, Aneesha Das, Saikat Chakrabarti & Oishee Chakrabarti. (2017) Calcium dependent regulation of protein ubiquitination – Interplay between E3 ligases and calcium binding proteins. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1864:7, pages 1227-1235.
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Xiang Zhao, Gangsheng Zhao, Zhongli Shi, Chenhe Zhou, Yunlin Chen, Bin Hu & Shigui Yan. (2017) Low-intensity pulsed ultrasound (LIPUS) prevents periprosthetic inflammatory loosening through FBXL2-TRAF6 ubiquitination pathway. Scientific Reports 7:1.
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Andrea Braganza, Jianfeng Li, Xuemei Zeng, Nathan A. Yates, Nupur B. Dey, Joel Andrews, Jennifer Clark, Leila Zamani, Xiao-hong Wang, Claudette St. Croix, Roderick O'Sullivan, Laura Garcia-Exposito, Jeffrey L. Brodsky & Robert W. Sobol. (2017) UBE3B Is a Calmodulin-regulated, Mitochondrion-associated E3 Ubiquitin Ligase. Journal of Biological Chemistry 292:6, pages 2470-2484.
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Yuan Liu & Rama K. Mallampalli. (2016) Small molecule therapeutics targeting F-box proteins in cancer. Seminars in Cancer Biology 36, pages 105-119.
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James D. Londino, Dexter Gulick, Jeffrey S. Isenberg & Rama K. Mallampalli. (2015) Cleavage of Signal Regulatory Protein α (SIRPα) Enhances Inflammatory Signaling. Journal of Biological Chemistry 290:52, pages 31113-31125.
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Jianmin Xie & Jieruo Gu. (2015) Identification of C‐terminal Hsp70‐interacting protein as a mediator of tumour necrosis factor action in osteoblast differentiation by targeting osterix for degradation. Journal of Cellular and Molecular Medicine 19:8, pages 1814-1824.
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Tiffany A. CoonAlison C. McKelveyTravis LearShristi RajbhandariSarah R. DunnWilliam ConnellyJoe Y. ZhaoSeungHye HanYuan LiuNathaniel M. WeathingtonBryan J. McVerryYingze ZhangBill B. Chen. (2015) The proinflammatory role of HECTD2 in innate immunity and experimental lung injury. Science Translational Medicine 7:295.
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Y Liu, T Lear, Y Zhao, J Zhao, C Zou, B B Chen & R K Mallampalli. (2015) F-box protein Fbxl18 mediates polyubiquitylation and proteasomal degradation of the pro-apoptotic SCF subunit Fbxl7. Cell Death & Disease 6:2, pages e1630-e1630.
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Chunbin Zou, Matthew J. Synan, Jin Li, Sheng Xiong, Michelle Manni, Yuan Liu, Bill B. Chen, Yutong Zhao, Sruti Shiva, Yulia Y. Tyurina, Jianfei Jiang, Janet S. Lee, Sudipta Das, Anuradha Ray, Prabir Ray, Valerian E. Kagan & Rama K. Mallampalli. (2015) LPS impairs oxygen utilization in epithelia by triggering degradation of the mitochondrial enzyme Alcat1. Journal of Cell Science.
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Jeffrey R. Skaar, Julia K. Pagan & Michele Pagano. (2014) SCF ubiquitin ligase-targeted therapies. Nature Reviews Drug Discovery 13:12, pages 889-903.
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Albert Lu & Suzanne R. Pfeffer. (2014) A CULLINary ride across the secretory pathway: more than just secretion. Trends in Cell Biology 24:7, pages 389-399.
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Bill B. Chen, Tiffany A. Coon, Jennifer R. Glasser, Chunbin Zou, Bryon Ellis, Tuhin Das, Alison C. McKelvey, Shristi Rajbhandari, Travis Lear, Christelle Kamga, Sruti Shiva, Chenjian Li, Joseph M. Pilewski, Jason Callio, Charleen T. Chu, Anuradha Ray, Prabir Ray, Yulia Y. Tyurina, Valerian E. Kagan & Rama K. Mallampalli. (2014) E3 Ligase Subunit Fbxo15 and PINK1 Kinase Regulate Cardiolipin Synthase 1 Stability and Mitochondrial Function in Pneumonia. Cell Reports 7:2, pages 476-487.
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Rama K. Mallampalli, Tiffany A. Coon, Jennifer R. Glasser, Claire Wang, Sarah R. Dunn, Nathaniel M. Weathington, Jing Zhao, Chunbin Zou, Yutong Zhao & Bill B. Chen. (2013) Targeting F Box Protein Fbxo3 To Control Cytokine-Driven Inflammation. The Journal of Immunology 191:10, pages 5247-5255.
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David E. Nelson, Suzanne J. Randle & Heike Laman. (2013) Beyond ubiquitination: the atypical functions of Fbxo7 and other F-box proteins. Open Biology 3:10, pages 130131.
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Nathaniel M. Weathington, Jacob I. Sznajder & Rama K. Mallampalli. (2013) The Emerging Role of the Ubiquitin Proteasome in Pulmonary Biology and Disease. American Journal of Respiratory and Critical Care Medicine 188:5, pages 530-537.
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Nathaniel M. Weathington & Rama K. Mallampalli. (2013) New insights on the function of SCF ubiquitin E3 ligases in the lung. Cellular Signalling 25:9, pages 1792-1798.
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Jing Zhao, Rachel K. Mialki, Jianxin Wei, Tiffany A. Coon, Chunbin Zou, Bill B. Chen, Rama K. Mallampalli & Yutong Zhao. (2013) SCF E3 ligase F‐box protein complex SCF FBXL19 regulates cell migration by mediating Rac1 ubiquitination and degradation . The FASEB Journal 27:7, pages 2611-2619.
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Bill B Chen, Tiffany A Coon, Jennifer R Glasser, Bryan J McVerry, Jing Zhao, Yutong Zhao, Chunbin Zou, Bryon Ellis, Frank C Sciurba, Yingze Zhang & Rama K Mallampalli. (2013) A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation. Nature Immunology 14:5, pages 470-479.
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Shafi Kuchay, Shanshan Duan, Emily Schenkein, Angelo Peschiaroli, Anita Saraf, Laurence Florens, Michael P. Washburn & Michele Pagano. (2013) FBXL2- and PTPL1-mediated degradation of p110-free p85β regulatory subunit controls the PI(3)K signalling cascade. Nature Cell Biology 15:5, pages 472-480.
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Chunbin Zou, Yan Chen, Rebecca M. Smith, Courtney Snavely, Jin Li, Tiffany A. Coon, Bill B. Chen, Yutong Zhao & Rama K. Mallampalli. (2013) SCFFbxw15 Mediates Histone Acetyltransferase Binding to Origin Recognition Complex (HBO1) Ubiquitin-Proteasomal Degradation to Regulate Cell Proliferation *. Journal of Biological Chemistry 288:9, pages 6306-6316.
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Kyle LeggettJulie MaylorClark UndemNing Lai, Wenju LuKelly SchweitzerLandon S. KingAllen C. Myers, J. T. SylvesterVenkataramana SidhayeLarissa A. Shimoda. (2012) Hypoxia-induced migration in pulmonary arterial smooth muscle cells requires calcium-dependent upregulation of aquaporin 1. American Journal of Physiology-Lung Cellular and Molecular Physiology 303:4, pages L343-L353.
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Bill B. Chen, Jennifer R. Glasser, Tiffany A. Coon, Chunbin Zou, Hannah L. Miller, Moon Fenton, John F. McDyer, Michael Boyiadzis & Rama K. Mallampalli. (2012) F-box protein FBXL2 targets cyclin D2 for ubiquitination and degradation to inhibit leukemic cell proliferation. Blood 119:13, pages 3132-3141.
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István Vadász, Curtis H. Weiss & Jacob I. Sznajder. (2012) Ubiquitination and Proteolysis in Acute Lung Injury. Chest 141:3, pages 763-771.
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Surinder M. Soond & Andrew Chantry. (2011) How ubiquitination regulates the TGF-β signalling pathway: New insights and new players. BioEssays 33:10, pages 749-758.
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Elisabet Sarri, Adrià Sicart, Francisco Lázaro-Diéguez & Gustavo Egea. (2011) Phospholipid Synthesis Participates in the Regulation of Diacylglycerol Required for Membrane Trafficking at the Golgi Complex. Journal of Biological Chemistry 286:32, pages 28632-28643.
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Chunbin Zou, Bryon M. Ellis, Rebecca M. Smith, Bill B. Chen, Yutong Zhao & Rama K. Mallampalli. (2011) Acyl-CoA:Lysophosphatidylcholine Acyltransferase I (Lpcat1) Catalyzes Histone Protein O-Palmitoylation to Regulate mRNA Synthesis. Journal of Biological Chemistry 286:32, pages 28019-28025.
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