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Shengjie Wu, Zuhao Zhang, Dandan Wu, Hongling Chen, Xixi Qian, Xuerong Wang & Wenbin Huang. (2019) AEG-1 promotes the growth of gastric cancer through the upregulation of eIF4E expression. OncoTargets and Therapy 12, pages 5887-5895.
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Hai Xu, Yuan Sun, Lan Zeng, Ying Li, Shan Hu, Shuping He, Haixia Chen, Qing Zou & Baoping Luo. (2019) Inhibition of cytosolic phospholipase A2 alpha increases chemosensitivity in cervical carcinoma through suppressing β-catenin signaling. Cancer Biology & Therapy 20:6, pages 912-921.
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Jianling Xie, James E. Merrett, Kirk B. Jensen & Christopher G. Proud. (2019) The MAP kinase-interacting kinases (MNKs) as targets in oncology. Expert Opinion on Therapeutic Targets 23:3, pages 187-199.
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Kankan Chen, Yue Chen, Zhi Chen, Yuye Shi, Zhengmei He, Banghe Ding, Chunling Wang & Liang Yu. (2018) miR-134 increases the antitumor effects of cytarabine by targeting Mnks in acute myeloid leukemia cells. OncoTargets and Therapy 11, pages 3141-3147.
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Yoko Tabe, Agostino Tafuri, Kazumasa Sekihara, Haeun Yang & Marina Konopleva. (2017) Inhibition of mTOR kinase as a therapeutic target for acute myeloid leukemia. Expert Opinion on Therapeutic Targets 21:7, pages 705-714.
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Zhuo Ma, Lingjun Zhu, Xuan Luo, Sulan Zhai, Ping Li & Xuerong Wang. (2012) Perifosine enhances mTORC1-targeted cancer therapy by activation of GSK3β in NSCLC cells. Cancer Biology & Therapy 13:11, pages 1009-1017.
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Rosalie Fisher, Lisa Pickering & James Larkin. (2011) New targeted therapies for renal cell carcinoma. Expert Opinion on Investigational Drugs 20:7, pages 933-945.
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Xuerong Wang & Shi-Yong Sun. (2009) Enhancing mTOR-targeted cancer therapy. Expert Opinion on Therapeutic Targets 13:10, pages 1193-1203.
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Articles from other publishers (106)
Xin Xu, Zuliyaer Talifu, Chun-Jia Zhang, Feng Gao, Han Ke, Yun-Zhu Pan, Han Gong, Hua-Yong Du, Yan Yu, Ying-Li Jing, Liang-Jie Du, Jian-Jun Li & De-Gang Yang. (2023) Mechanism of skeletal muscle atrophy after spinal cord injury: A narrative review. Frontiers in Nutrition 10.
Crossref
Crossref
Jayalakshmi Sridhar, Rajesh Komati & Satyendra Kumar. 2022. Breast Cancer. Breast Cancer
163
178
.
Amy L. Adamson, Dana Jeffus, Alexis Davis & Eva Greengrove. (2022) Epstein-Barr virus lytic replication activates and is dependent upon MAPK-interacting kinase 1/2 in a cell-type dependent manner.. Virology 572, pages 72-85.
Crossref
Crossref
Yaoxiang Tang, Jiadi Luo, Yang Yang, Sile Liu, Hongmei Zheng, Yuting Zhan, Songqing Fan & Qiuyuan Wen. (2022) Overexpression of p-4EBP1 associates with p-eIF4E and predicts poor prognosis for non-small cell lung cancer patients with resection. PLOS ONE 17:6, pages e0265465.
Crossref
Crossref
Thao N.D. Pham, Christina Spaulding, Mario A. Shields, Anastasia E. Metropulos, Dhavan N. Shah, Mahmoud G. Khalafalla, Daniel R. Principe, David J. Bentrem & Hidayatullah G. Munshi. (2022) Inhibition of MNKs promotes macrophage immunosuppressive phenotype to limit CD8+ T cell antitumor immunity. JCI Insight 7:9.
Crossref
Crossref
Jordan B. Metz, Nicholas J. Hornstein, Sohani Das Sharma, Jeremy Worley, Christian Gonzalez & Peter A. Sims. (2022) High-throughput translational profiling with riboPLATE-seq. Scientific Reports 12:1.
Crossref
Crossref
Honami Yonezawa, Akari Ikeda, Ryo Takahashi, Haruka Endo, Yasuyo Sugawara, Mikako Goto, Mirute Kanno, Sosuke Ogawa, Karin Nakamura, Haruki Ujiie, Masato Iwatsuki, Tomoyasu Hirose, Toshiaki Sunazuka, Yoshimasa Uehara & Naoyuki Nishiya. (2022) Ivermectin represses Wnt/β-catenin signaling by binding to TELO2, a regulator of phosphatidylinositol 3-kinase-related kinases. iScience 25:3, pages 103912.
Crossref
Crossref
Sile Liu, Weiyuan Wang, Yue Ning, Hongmei Zheng, Yuting Zhan, Haihua Wang, Yang Yang, Jiadi Luo, Qiuyuan Wen, Hongjing Zang, Jinwu Peng, Jian Ma & Songqing Fan. (2022) Exosome-mediated miR-7-5p delivery enhances the anticancer effect of Everolimus via blocking MNK/eIF4E axis in non-small cell lung cancer. Cell Death & Disease 13:2.
Crossref
Crossref
Shi-Yong Sun. (2020) mTOR-targeted cancer therapy: great target but disappointing clinical outcomes, why?. Frontiers of Medicine 15:2, pages 221-231.
Crossref
Crossref
Muhammad Saad Yousuf, Stephanie I. Shiers, James J. Sahn & Theodore J. Price. (2020) Pharmacological Manipulation of Translation as a Therapeutic Target for Chronic Pain. Pharmacological Reviews 73:1, pages 59-88.
Crossref
Crossref
Jianling Xie, Kaikai Shen, Ashley T. Jones, Jian Yang, Andrew R. Tee, Ming Hong Shen, Mengyuan Yu, Swati Irani, Derick Wong, James E. Merrett, Roman V. Lenchine, Stuart De Poi, Kirk B. Jensen, Paul J. Trim, Marten F. Snel, Makoto Kamei, Sally Kim Martin, Stephen Fitter, Shuye Tian, Xuemin Wang, Lisa M. Butler, Andrew C. W. Zannettino & Christopher G. Proud. (2020) Reciprocal signaling between mTORC1 and MNK2 controls cell growth and oncogenesis. Cellular and Molecular Life Sciences 78:1, pages 249-270.
Crossref
Crossref
Pauline Martin, Vilas Wagh, Surya A. Reis, Serkan Erdin, Roberta L. Beauchamp, Ghalib Shaikh, Michael Talkowski, Elizabeth Thiele, Steven D. Sheridan, Stephen J. Haggarty & Vijaya Ramesh. (2020) TSC patient-derived isogenic neural progenitor cells reveal altered early neurodevelopmental phenotypes and rapamycin-induced MNK-eIF4E signaling. Molecular Autism 11:1.
Crossref
Crossref
Anil Kumar Yadav & Byeong-Churl Jang. (2020) Anti-Survival and Pro-Apoptotic Effects of 6-Shogaol on SW872 Human Liposarcoma Cells via Control of the Intrinsic Caspase Pathway, STAT-3, AMPK, and ER Stress. Biomolecules 10:10, pages 1380.
Crossref
Crossref
Zita Bognar, Anna Maria Cseh, Katalin Fekete, Csenge Antus, Rita Bognar, Antal Tapodi, Fadi H. J. Ramadan, Balazs Sumegi & Ferenc Gallyas. (2020) Amiodarone’s major metabolite, desethylamiodarone inhibits proliferation of B16-F10 melanoma cells and limits lung metastasis formation in an in vivo experimental model. PLOS ONE 15:9, pages e0239088.
Crossref
Crossref
Thao N.D. Pham, Christina Spaulding & Hidayatullah G. Munshi. (2020) Controlling TIME: How MNK Kinases Function to Shape Tumor Immunity. Cancers 12:8, pages 2096.
Crossref
Crossref
Taofeek K. Owonikoko, R. Donald Harvey, Bradley Carthon, Zhengjia Chen, Colleen Lewis, Hanna Collins, Chao Zhang, David H. Lawson, Olatunji B. Alese, Mehmet Asim Bilen, Gabriel L. Sica, Conor E. Steuer, Walid L. Shaib, Christina Wu, Wayne B. Harris, Mehmet Akce, Ragini R. Kudchagkar, Bassel F. El-Rayes, Sagar Lonial, Suresh S. Ramalingam & Fadlo Raja Khuri. (2020) A Phase I Study of Safety, Pharmacokinetics, and Pharmacodynamics of Concurrent Everolimus and Buparlisib Treatment in Advanced Solid Tumors. Clinical Cancer Research 26:11, pages 2497-2505.
Crossref
Crossref
Celia Pinto-Díez, Raquel Ferreras-Martín, Rebeca Carrión-Marchante, Víctor M. González & María Elena Martín. (2020) Deeping in the Role of the MAP-Kinases Interacting Kinases (MNKs) in Cancer. International Journal of Molecular Sciences 21:8, pages 2967.
Crossref
Crossref
Asiya Batool, Sheikh Tahir Majeed, Sabreena Aashaq, Rabiya Majeed, Nadiem Nazir Bhat & Khurshid Iqbal Andrabi. (2019) Eukaryotic initiation factor 4E is a novel effector of mTORC1 signaling pathway in cross talk with Mnk1. Molecular and Cellular Biochemistry 465:1-2, pages 13-26.
Crossref
Crossref
Anna Prossomariti, Giulia Piazzi, Chiara Alquati & Luigi Ricciardiello. (2020) Are Wnt/β-Catenin and PI3K/AKT/mTORC1 Distinct Pathways in Colorectal Cancer?. Cellular and Molecular Gastroenterology and Hepatology 10:3, pages 491-506.
Crossref
Crossref
Hui Hua, Qingbin Kong, Hongying Zhang, Jiao Wang, Ting Luo & Yangfu Jiang. (2019) Targeting mTOR for cancer therapy. Journal of Hematology & Oncology 12:1.
Crossref
Crossref
Asiya Batool, Sabreena Aashaq & Khurshid I. Andrabi. (2019) Eukaryotic initiation factor 4E (eIF4E): A recap of the cap‐binding protein. Journal of Cellular Biochemistry 120:9, pages 14201-14212.
Crossref
Crossref
Sheikh Tahir Majeed, Rabiya Majeed, Ghazia Shah & Khurshid I Andrabi. 2019. Homeostasis - An Integrated Vision. Homeostasis - An Integrated Vision.
Anil Yadav, Vinoth Kumar, David Bailey & Byeong-Churl Jang. (2019) AZD1208, a Pan-Pim Kinase Inhibitor, Has Anti-Growth Effect on 93T449 Human Liposarcoma Cells via Control of the Expression and Phosphorylation of Pim-3, mTOR, 4EBP-1, S6, STAT-3 and AMPK. International Journal of Molecular Sciences 20:2, pages 363.
Crossref
Crossref
Xian-bo Huang, Chun-mei Yang, Qing-mei Han, Xiu-jin Ye, Wen Lei & Wen-bin Qian. (2018) MNK1 inhibitor CGP57380 overcomes mTOR inhibitor-induced activation of eIF4E: the mechanism of synergic killing of human T-ALL cells. Acta Pharmacologica Sinica 39:12, pages 1894-1901.
Crossref
Crossref
Leandro S. D'Abronzo & Paramita M. Ghosh. (2018) eIF4E Phosphorylation in Prostate Cancer. Neoplasia 20:6, pages 563-573.
Crossref
Crossref
Kenji Tanabe, Ayane Inagaki, Yuji Henmi & Masanobu Satake. (2018) Image-Based Profiling Can Discriminate the Effects of Inhibitors on Signaling Pathways under Differential Ligand Stimulation. SLAS Discovery 23:4, pages 330-340.
Crossref
Crossref
Shengjie Wu, Li Yang, Dandan Wu, Zhongyuan Gao, Ping Li, Wenbin Huang & Xuerong Wang. (2017) AEG-1 induces gastric cancer metastasis by upregulation of eIF4E expression. Journal of Cellular and Molecular Medicine 21:12, pages 3481-3493.
Crossref
Crossref
L S D'Abronzo, S Bose, M E Crapuchettes, R E Beggs, R L Vinall, C G Tepper, S Siddiqui, M Mudryj, F U Melgoza, B P Durbin-Johnson, R W deVere White & P M Ghosh. (2017) The androgen receptor is a negative regulator of eIF4E phosphorylation at S209: implications for the use of mTOR inhibitors in advanced prostate cancer. Oncogene 36:46, pages 6359-6373.
Crossref
Crossref
Zhihua Guo, Guilin Peng, Ermao Li, Shaoyan Xi, Yu Zhang, Yong Li, Xiaodong Lin, Guangqiu Li, Qinian Wu & Jianxing He. (2017) MAP kinase-interacting serine/threonine kinase 2 promotes proliferation, metastasis, and predicts poor prognosis in non-small cell lung cancer. Scientific Reports 7:1.
Crossref
Crossref
Ella Lineham, John Spencer & Simon J Morley. (2017) Dual abrogation of MNK and mTOR: a novel therapeutic approach for the treatment of aggressive cancers. Future Medicinal Chemistry 9:13, pages 1539-1555.
Crossref
Crossref
Xuerong Wang, Ping Yue, Hui Tao & Shi-Yong Sun. (2017) Inhibition of p70S6K does not mimic the enhancement of Akt phosphorylation by rapamycin. Heliyon 3:8, pages e00378.
Crossref
Crossref
Michael C. Brown & Matthias Gromeier. (2017) MNK Controls mTORC1:Substrate Association through Regulation of TELO2 Binding with mTORC1. Cell Reports 18:6, pages 1444-1457.
Crossref
Crossref
Myria Galazi, Gregory Weitsman, James Monypenny, Oana Coban, Hanna Milewicz, Valenti Gomez, Francesca Ciccarelli & Tony Ng. 2017. Mechanisms of Molecular Carcinogenesis – Volume 2. Mechanisms of Molecular Carcinogenesis – Volume 2
315
358
.
Nuria Eritja, Andree Yeramian, Bo-Juen Chen, David Llobet-Navas, Eugenia Ortega, Eva Colas, Miguel Abal, Xavier Dolcet, Jaume Reventos & Xavier Matias-Guiu. 2017. Molecular Genetics of Endometrial Carcinoma. Molecular Genetics of Endometrial Carcinoma
149
207
.
Katherine Shives, Aaron Massey, Nicholas May, Thomas Morrison & J. Beckham. (2016) 4EBP-Dependent Signaling Supports West Nile Virus Growth and Protein Expression. Viruses 8:10, pages 287.
Crossref
Crossref
H. Marcus, O. Attar-Schneider, M. Dabbah, V. Zismanov, S. Tartakover-Matalon, M. Lishner & L. Drucker. (2016) Mesenchymal stem cells secretomes' affect multiple myeloma translation initiation. Cellular Signalling 28:6, pages 620-630.
Crossref
Crossref
Qiuyuan Wen, Weiyuan Wang, Jiadi Luo, Shuzhou Chu, Lingjiao Chen, Lina Xu, Hongjing Zang, Mohannad Ma Alnemah, Jian Ma & Songqing Fan. (2016) CGP57380 enhances efficacy of RAD001 in non-small cell lung cancer through abrogating mTOR inhibition-induced phosphorylation of eIF4E and activating mitochondrial apoptotic pathway. Oncotarget 7:19, pages 27787-27801.
Crossref
Crossref
Kenji Tanabe. (2016) Image-based compound profiling reveals a dual inhibitor of tyrosine kinase and microtubule polymerization. Scientific Reports 6:1.
Crossref
Crossref
Eva M García-Recio, Celia Pinto-Díez, M Isabel Pérez-Morgado, Marta García-Hernández, Gerónimo Fernández, M Elena Martín & Víctor M González. (2016) Characterization of MNK1b DNA Aptamers That Inhibit Proliferation in MDA-MB231 Breast Cancer Cells. Molecular Therapy - Nucleic Acids 5, pages e275.
Crossref
Crossref
Chunwan Lu, Levi Makala, Daqing Wu & Yafei Cai. (2016) Targeting translation: eIF4E as an emerging anticancer drug target. Expert Reviews in Molecular Medicine 18.
Crossref
Crossref
Marco Breinig, Felix A Klein, Wolfgang Huber & Michael Boutros. (2015) A chemical–genetic interaction map of small molecules using high‐throughput imaging in cancer cells. Molecular Systems Biology 11:12.
Crossref
Crossref
Mark A. Feitelson, Alla Arzumanyan, Rob J. Kulathinal, Stacy W. Blain, Randall F. Holcombe, Jamal Mahajna, Maria Marino, Maria L. Martinez-Chantar, Roman Nawroth, Isidro Sanchez-Garcia, Dipali Sharma, Neeraj K. Saxena, Neetu Singh, Panagiotis J. Vlachostergios, Shanchun Guo, Kanya Honoki, Hiromasa Fujii, Alexandros G. Georgakilas, Alan Bilsland, Amedeo Amedei, Elena Niccolai, Amr Amin, S. Salman Ashraf, Chandra S. Boosani, Gunjan Guha, Maria Rosa Ciriolo, Katia Aquilano, Sophie Chen, Sulma I. Mohammed, Asfar S. Azmi, Dipita Bhakta, Dorota Halicka, W. Nicol Keith & Somaira Nowsheen. (2015) Sustained proliferation in cancer: Mechanisms and novel therapeutic targets. Seminars in Cancer Biology 35, pages S25-S54.
Crossref
Crossref
Pierre-Emmanuel Joubert, Kenneth Stapleford, Florence Guivel-Benhassine, Marco Vignuzzi, Olivier Schwartz & Matthew L. Albert. (2015) Inhibition of mTORC1 Enhances the Translation of Chikungunya Proteins via the Activation of the MnK/eIF4E Pathway. PLOS Pathogens 11:8, pages e1005091.
Crossref
Crossref
Christopher G. Proud. (2015) Mnks, eIF4E phosphorylation and cancer. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1849:7, pages 766-773.
Crossref
Crossref
Alba Martínez, Marta Sesé, Javier Hernandez Losa, Nathaniel Robichaud, Nahum Sonenberg, Trond Aasen & Santiago Ramón y Cajal. (2015) Phosphorylation of eIF4E Confers Resistance to Cellular Stress and DNA-Damaging Agents through an Interaction with 4E-T: A Rationale for Novel Therapeutic Approaches. PLOS ONE 10:4, pages e0123352.
Crossref
Crossref
VICTORIA ZISMANOV, OSHRAT ATTAR-SCHNEIDER, MICHAEL LISHNER, RACHEL HEFFEZ AIZENFELD, SHELLY TARTAKOVER MATALON & LIAT DRUCKER. (2015) Multiple myeloma proteostasis can be targeted via translation initiation factor eIF4E. International Journal of Oncology 46:2, pages 860-870.
Crossref
Crossref
Theodosia Teo, Mingfeng Yu, Yuchao Yang, Todd Gillam, Frankie Lam, Matthew J. Sykes & Shudong Wang. (2015) Pharmacologic co-inhibition of Mnks and mTORC1 synergistically suppresses proliferation and perturbs cell cycle progression in blast crisis-chronic myeloid leukemia cells. Cancer Letters 357:2, pages 612-623.
Crossref
Crossref
Maja Genheden, Justin W. Kenney, Harvey E. Johnston, Antigoni Manousopoulou, Spiros D. Garbis & Christopher G. Proud. (2015) BDNF Stimulation of Protein Synthesis in Cortical Neurons Requires the MAP Kinase-Interacting Kinase MNK1. The Journal of Neuroscience 35:3, pages 972-984.
Crossref
Crossref
Daniel C. Cho & James W. Mier. 2015. Renal Cell Carcinoma. Renal Cell Carcinoma
253
262
.
Michael C. Brown, Mikhail I. Dobrikov & Matthias Gromeier. (2014) Mitogen-Activated Protein Kinase-Interacting Kinase Regulates mTOR/AKT Signaling and Controls the Serine/Arginine-Rich Protein Kinase-Responsive Type 1 Internal Ribosome Entry Site-Mediated Translation and Viral Oncolysis. Journal of Virology 88:22, pages 13149-13160.
Crossref
Crossref
Jui-Ling Hsu, Shih-Ping Liu, Chia-Chung Lee, Lih-Ching Hsu, Yunn-Fang Ho, Hsu-Shan Huang & Jih-Hwa Guh. (2014) A unique amidoanthraquinone derivative displays antiproliferative activity against human hormone-refractory metastatic prostate cancers through activation of LKB1-AMPK-mTOR signaling pathway. Naunyn-Schmiedeberg's Archives of Pharmacology 387:10, pages 979-990.
Crossref
Crossref
Frank Eckerdt, Elspeth Beauchamp, Jonathan Bell, Asneha Iqbal, Bing Su, Rikiro Fukunaga, Rishi R. Lulla, Stewart Goldman & Leonidas C. Platanias. (2014) Regulatory effects of a Mnk2-eIF4E feedback loop during mTORC1 targeting of human medulloblastoma cells. Oncotarget 5:18, pages 8442-8451.
Crossref
Crossref
Toby A. Eyre, Graham P. Collins, Anthony H. Goldstone & Kate Cwynarski. (2014) Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies. British Journal of Haematology 166:3, pages 336-351.
Crossref
Crossref
JUAN MA, LI ZHUO HAN, HE LIANG, CHUNLIU MI, HUI SHI, JUNG JOON LEE & XUEJUN JIN. (2014) Celastrol inhibits the HIF-1α pathway by inhibition of mTOR/p70S6K/eIF4E and ERK1/2 phosphorylation in human hepatoma cells. Oncology Reports 32:1, pages 235-242.
Crossref
Crossref
Joanna Kaplon, Cornelia Hömig-Hölzel, Linda Gao, Katrin Meissl, Els M. E. Verdegaal, Sjoerd H. van der Burg, Remco van Doorn & Daniel S. Peeper. (2014)
Near-genomewide RNAi screening for regulators of BRAF
V
600E
-induced senescence identifies
RASEF
, a gene epigenetically silenced in melanoma
. Pigment Cell & Melanoma Research 27:4, pages 640-652.
Crossref
Crossref
Michal Grzmil, Roland M. Huber, Daniel Hess, Stephan Frank, Debby Hynx, Gerald Moncayo, Dominique Klein, Adrian Merlo & Brian A. Hemmings. (2014) MNK1 pathway activity maintains protein synthesis in rapalog-treated gliomas. Journal of Clinical Investigation 124:2, pages 742-754.
Crossref
Crossref
David A. Fruman & Christian Rommel. (2014) PI3K and cancer: lessons, challenges and opportunities. Nature Reviews Drug Discovery 13:2, pages 140-156.
Crossref
Crossref
Athanasia Pavlidou & Nikos F. Vlahos. (2014) Molecular Alterations of PI3K/Akt/mTOR Pathway: A Therapeutic Target in Endometrial Cancer. The Scientific World Journal 2014, pages 1-9.
Crossref
Crossref
Luc Furic, Emma Beardsley & Ivan Topisirovic. 2014. Translation and Its Regulation in Cancer Biology and Medicine. Translation and Its Regulation in Cancer Biology and Medicine
363
374
.
Shuai Wu, Shui-Di Zheng, Hong-Ling Huang, Li-Chong Yan, Xiao-Fei Yin, Hai-Neng Xu, Kang-Jian Zhang, Jing-Hua Gui, Liang Chu & Xin-Yuan Liu. (2013) Lithium Down-regulates Histone Deacetylase 1 (HDAC1) and Induces Degradation of Mutant Huntingtin. Journal of Biological Chemistry 288:49, pages 35500-35510.
Crossref
Crossref
E M Beauchamp & L C Platanias. (2012) The evolution of the TOR pathway and its role in cancer. Oncogene 32:34, pages 3923-3932.
Crossref
Crossref
Rebecca L. Stead & Christopher G. Proud. (2013) Rapamycin enhances eIF4E phosphorylation by activating MAP kinase-interacting kinase 2a (Mnk2a). FEBS Letters 587:16, pages 2623-2628.
Crossref
Crossref
Daniel Cho. (2013) Novel Targeting of Phosphatidylinositol 3-Kinase and Mammalian Target of Rapamycin in Renal Cell Carcinoma. The Cancer Journal 19:4, pages 311-315.
Crossref
Crossref
Michal Grzmil & Brian A. Hemmings. (2013) Overcoming resistance to rapalogs in gliomas by combinatory therapies. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1834:7, pages 1371-1380.
Crossref
Crossref
L Adesso, S Calabretta, F Barbagallo, G Capurso, E Pilozzi, R Geremia, G Delle Fave & C Sette. (2012) Gemcitabine triggers a pro-survival response in pancreatic cancer cells through activation of the MNK2/eIF4E pathway. Oncogene 32:23, pages 2848-2857.
Crossref
Crossref
Moïse Coëffier, Sophie Claeyssens, Christine Bôle-Feysot, Charlène Guérin, Brigitte Maurer, Stéphane Lecleire, Alain Lavoinne, Nathalie Donnadieu, Anne-Françoise Cailleux & Pierre Déchelotte. (2013) Enteral delivery of proteins stimulates protein synthesis in human duodenal mucosa in the fed state through a mammalian target of rapamycin–independent pathway. The American Journal of Clinical Nutrition 97:2, pages 286-294.
Crossref
Crossref
Samy A. F. Morad, Maximilian Schmid, Berthold Büchele, Hans-Ullrich Siehl, Menna El Gaafary, Oleg Lunov, Tatiana Syrovets & Thomas Simmet. (2013) A Novel Semisynthetic Inhibitor of the FRB Domain of Mammalian Target of Rapamycin Blocks Proliferation and Triggers Apoptosis in Chemoresistant Prostate Cancer Cells. Molecular Pharmacology 83:2, pages 531-541.
Crossref
Crossref
Rosalie Fisher, Martin Gore & James Larkin. (2013) Current and future systemic treatments for renal cell carcinoma. Seminars in Cancer Biology 23:1, pages 38-45.
Crossref
Crossref
Y Shi, P Frost, B Hoang, Y Yang, R Fukunaga, J Gera & A Lichtenstein. (2012) MNK kinases facilitate c-myc IRES activity in rapamycin-treated multiple myeloma cells. Oncogene 32:2, pages 190-197.
Crossref
Crossref
Emmanouil Fokas, Michio Yoshimura, Remko Prevo, Geoff Higgins, Wolfgang Hackl, Sauveur-Michel Maira, Eric J Bernhard, WGillies McKenna & Ruth J Muschel. (2012) NVP-BEZ235 and NVP-BGT226, dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitors, enhance tumor and endothelial cell radiosensitivity. Radiation Oncology 7:1.
Crossref
Crossref
Yu-Ting Chen, Karen AL Tan, Lisa Y Pang & David J Argyle. (2012) The class I PI3K/Akt pathway is critical for cancer cell survival in dogs and offers an opportunity for therapeutic intervention. BMC Veterinary Research 8:1.
Crossref
Crossref
Hui Ren, Mingwei Chen, Ping Yue, Hui Tao, Taofeek K. Owonikoko, Suresh S. Ramalingam, Fadlo R. Khuri & Shi-Yong Sun. (2012) The combination of RAD001 and NVP-BKM120 synergistically inhibits the growth of lung cancer in vitro and in vivo. Cancer Letters 325:2, pages 139-146.
Crossref
Crossref
Michalis V. Karamouzis & Athanasios G. Papavassiliou. (2012) Targeting insulin-like growth factor in breast cancer therapeutics. Critical Reviews in Oncology/Hematology 84:1, pages 8-17.
Crossref
Crossref
Blake B. Rasmussen & Elena Volpi. 2012. Sarcopenia. Sarcopenia
20
40
.
Michal Grzmil & Brian A. Hemmings. (2012) Translation Regulation as a Therapeutic Target in Cancer. Cancer Research 72:16, pages 3891-3900.
Crossref
Crossref
Jinqiang Hou, Frankie Lam, Christopher Proud & Shudong Wang. (2012) Targeting Mnks for Cancer Therapy. Oncotarget 3:2, pages 118-131.
Crossref
Crossref
Micah J. Drummond & Blake B. Rasmussen. 2012. Muscle Aging, Inclusion‐Body Myositis and Myopathies. Muscle Aging, Inclusion‐Body Myositis and Myopathies
97
108
.
Matthew G. Fury, Marija Drobnjak, Camelia S. Sima, Marina Asher, Jatin Shah, Nancy Lee, Diane Carlson, H. Guido Wendel & David G. Pfister. (2011) Tissue microarray evidence of association between p16 and phosphorylated eIF4E in tonsillar squamous cell carcinoma. Head & Neck 33:9, pages 1340-1345.
Crossref
Crossref
Marco Mazzoletti, Francesca Bortolin, Laura Brunelli, Roberta Pastorelli, Silvana Di Giandomenico, Eugenio Erba, Paolo Ubezio & Massimo Broggini. (2011) Combination of PI3K/mTOR Inhibitors: Antitumor Activity and Molecular Correlates. Cancer Research 71:13, pages 4573-4584.
Crossref
Crossref
Marc Dufour, Anne Dormond-Meuwly, Nicolas Demartines & Olivier Dormond. (2011) Targeting the Mammalian Target of Rapamycin (mTOR) in Cancer Therapy: Lessons from Past and Future Perspectives. Cancers 3:2, pages 2478-2500.
Crossref
Crossref
Sarah P. Blagden & Anne E. Willis. (2011) The biological and therapeutic relevance of mRNA translation in cancer. Nature Reviews Clinical Oncology 8:5, pages 280-291.
Crossref
Crossref
Sung-Hsin Kuo, Chih-Hung Hsu, Li-Tzong Chen, Yen-Sen Lu, Ching-Huang Lin, Pei-Yen Yeh, Huei-Jiuan Jeng, Ming Gao, Kun-Huei Yeh & Ann-Lii Cheng. (2011) Lack of compensatory pAKT activation and eIF4E phosphorylation of lymphoma cells towards mTOR inhibitor, RAD001. European Journal of Cancer 47:8, pages 1244-1257.
Crossref
Crossref
Michal Grzmil, Pier MorinJrJr, Maria Maddalena Lino, Adrian Merlo, Stephan Frank, Yuhua Wang, Gerald Moncayo & Brian A. Hemmings. (2011) MAP Kinase-Interacting Kinase 1 Regulates SMAD2-Dependent TGF-β Signaling Pathway in Human Glioblastoma. Cancer Research 71:6, pages 2392-2402.
Crossref
Crossref
Jennifer S. Carew, Kevin R. Kelly & Steffan T. Nawrocki. (2011) Mechanisms of mTOR inhibitor resistance in cancer therapy. Targeted Oncology 6:1, pages 17-27.
Crossref
Crossref
Alexa S. GreenNicolas ChapuisThiago Trovati MacielLise WillemsMireille LambertChristophe ArnoultOlivier BoyerValerie BardetSophie ParkMarc ForetzBenoit ViolletNorbert Ifrah, François DreyfusOlivier Hermine, Ivan Cruz MouraCatherine LacombePatrick MayeuxDidier BouscaryJerome Tamburini. (2010) The LKB1/AMPK signaling pathway has tumor suppressor activity in acute myeloid leukemia through the repression of mTOR-dependent oncogenic mRNA translation. Blood 116:20, pages 4262-4273.
Crossref
Crossref
Nicolas Chapuis, Jerome Tamburini, Alexa S. Green, Christine Vignon, Valerie Bardet, Aymeric Neyret, Melanie Pannetier, Lise Willems, Sophie Park, Alexandre Macone, Sauveur-Michel Maira, Norbert Ifrah, François Dreyfus, Olivier Herault, Catherine Lacombe, Patrick Mayeux & Didier Bouscary. (2010) Dual Inhibition of PI3K and mTORC1/2 Signaling by NVP-BEZ235 as a New Therapeutic Strategy for Acute Myeloid Leukemia. Clinical Cancer Research 16:22, pages 5424-5435.
Crossref
Crossref
Yikun Li, Ping Yue, Xingming Deng, Takeshi Ueda, Rikiro Fukunaga, Fadlo R. Khuri & Shi-Yong Sun. (2010) Protein Phosphatase 2A Negatively Regulates Eukaryotic Initiation Factor 4E Phosphorylation and eIF4F Assembly through Direct Dephosphorylation of Mnk and eIF4E. Neoplasia 12:10, pages 848-855.
Crossref
Crossref
N Chapuis, J Tamburini, A S Green, L Willems, V Bardet, S Park, C Lacombe, P Mayeux & D Bouscary. (2010) Perspectives on inhibiting mTOR as a future treatment strategy for hematological malignancies. Leukemia 24:10, pages 1686-1699.
Crossref
Crossref
Takeshi UedaMasato SasakiAndrew J. EliaIok In Christine ChioKoichi Hamada, Rikiro Fukunaga & Tak W. Mak. (2010) Combined deficiency for MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) delays tumor development. Proceedings of the National Academy of Sciences 107:32, pages 13984-13990.
Crossref
Crossref
Daniel C. Cho, Matthew B. Cohen, David J. Panka, Michael Collins, Musie Ghebremichael, Michael B. Atkins, Sabina Signoretti & James W. Mier. (2010) The Efficacy of the Novel Dual PI3-Kinase/mTOR Inhibitor NVP-BEZ235 Compared with Rapamycin in Renal Cell Carcinoma. Clinical Cancer Research 16:14, pages 3628-3638.
Crossref
Crossref
Patrick R. HagnerAbraham Schneider & Ronald B. Gartenhaus. (2010) Targeting the translational machinery as a novel treatment strategy for hematologic malignancies. Blood 115:11, pages 2127-2135.
Crossref
Crossref
Wenge Li, Nehal Thakor, Eugenia Y. Xu, Ying Huang, Chi Chen, Rong Yu, Martin Holcik & Ah-Ng Kong. (2010) An internal ribosomal entry site mediates redox-sensitive translation of Nrf2. Nucleic Acids Research 38:3, pages 778-788.
Crossref
Crossref
Yi-Jiun Chen, Bertrand Chin-Ming Tan, Ya-Yun Cheng, Jin-Shin Chen & Sheng-Chung Lee. (2010) Differential regulation of CHOP translation by phosphorylated eIF4E under stress conditions. Nucleic Acids Research 38:3, pages 764-777.
Crossref
Crossref
Gabriele Capurso, Nicola Fazio, Stefano Festa, Francesco Panzuto, Filippo De Braud & Gianfranco Delle Fave. (2009) Molecular target therapy for gastroenteropancreatic endocrine tumours: Biological rationale and clinical perspectives. Critical Reviews in Oncology/Hematology 72:2, pages 110-124.
Crossref
Crossref
Daniela Katz, Alexander Lazar & Dina Lev. (2009) Malignant peripheral nerve sheath tumour (MPNST): the clinical implications of cellular signalling pathways. Expert Reviews in Molecular Medicine 11.
Crossref
Crossref
Emma Puighermanal, Giovanni Marsicano, Arnau Busquets-Garcia, Beat Lutz, Rafael Maldonado & Andrés Ozaita. (2009) Cannabinoid modulation of hippocampal long-term memory is mediated by mTOR signaling. Nature Neuroscience 12:9, pages 1152-1158.
Crossref
Crossref
Rongshi Li, Alan Pourpak & Stephan W. Morris. (2009) Inhibition of the Insulin-like Growth Factor-1 Receptor (IGF1R) Tyrosine Kinase as a Novel Cancer Therapy Approach. Journal of Medicinal Chemistry 52:16, pages 4981-5004.
Crossref
Crossref
Jerome TamburiniAlexa S. GreenValerie BardetNicolas ChapuisSophie ParkLise WillemsMadalina Uzunov, Norbert Ifrah, François DreyfusCatherine LacombePatrick MayeuxDidier Bouscary. (2009) Protein synthesis is resistant to rapamycin and constitutes a promising therapeutic target in acute myeloid leukemia. Blood 114:8, pages 1618-1627.
Crossref
Crossref
Hasan Korkaya, Amanda Paulson, Emmanuelle Charafe-Jauffret, Christophe Ginestier, Marty Brown, Julie Dutcher, Shawn G. Clouthier & Max S. Wicha. (2009) Regulation of Mammary Stem/Progenitor Cells by PTEN/Akt/β-Catenin Signaling. PLoS Biology 7:6, pages e1000121.
Crossref
Crossref
Changye Y. Zou, Kerrington D. Smith, Quan-Sheng Zhu, Jun Liu, Ian E. McCutcheon, John M. Slopis, Funda Meric-Bernstam, Zhenghong Peng, William G. Bornmann, Gordon B. Mills, Alexander J. Lazar, Raphael E. Pollock & Dina Lev. (2009) Dual targeting of AKT and mammalian target of rapamycin: A potential therapeutic approach for malignant peripheral nerve sheath tumor. Molecular Cancer Therapeutics 8:5, pages 1157-1168.
Crossref
Crossref
Romina Marone, Dominik Erhart, Ann C. Mertz, Thomas Bohnacker, Christian Schnell, Vladimir Cmiljanovic, Frédéric Stauffer, Carlos Garcia-Echeverria, Bernd Giese, Sauveur-Michel Maira & Matthias P. Wymann. (2009) Targeting Melanoma with Dual Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitors. Molecular Cancer Research 7:4, pages 601-613.
Crossref
Crossref
Micah J. Drummond, Hans C. Dreyer, Christopher S. Fry, Erin L. Glynn & Blake B. Rasmussen. (2009) Nutritional and contractile regulation of human skeletal muscle protein synthesis and mTORC1 signaling. Journal of Applied Physiology 106:4, pages 1374-1384.
Crossref
Crossref
Heidi A Lane & Madlaina Breuleux. (2009) Optimal targeting of the mTORC1 kinase in human cancer. Current Opinion in Cell Biology 21:2, pages 219-229.
Crossref
Crossref
Diansheng Zhong, Xiuju Liu, Fadlo R. Khuri, Shi-Yong Sun, Paula M. Vertino & Wei Zhou. (2008) LKB1 Is Necessary for Akt-Mediated Phosphorylation of Proapoptotic Proteins. Cancer Research 68:18, pages 7270-7277.
Crossref
Crossref
Xuejun Jin, Hong Ri Jin, Dongho Lee, Jeong-Hyung Lee, Sang Kyum Kim & Jung Joon Lee. (2008) A quassinoid 6α-tigloyloxychaparrinone inhibits hypoxia-inducible factor-1 pathway by inhibition of eukaryotic translation initiation factor 4E phosphorylation. European Journal of Pharmacology 592:1-3, pages 41-47.
Crossref
Crossref
Ying Zhang, Yan Li & Da-Qing Yang. (2008) Phosphorylation of eIF-4E positively regulates formation of the eIF-4F translation initiation complex following DNA damage. Biochemical and Biophysical Research Communications 367:1, pages 54-59.
Crossref
Crossref