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Article

Activation of the RalGEF/Ral Pathway Promotes Prostate Cancer Metastasis to Bone

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Pages 7538-7550 | Received 30 May 2007, Accepted 13 Aug 2007, Published online: 27 Mar 2023

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Wei-Yu Chen, Tao Zeng, Yu-Chng Wen, Hsiu-Lien Yeh, Kuo-Ching Jiang, Wei-Hao Chen, Qingfu Zhang, Jiaoti Huang & Yen-Nien Liu. (2019) Androgen deprivation-induced ZBTB46-PTGS1 signaling promotes neuroendocrine differentiation of prostate cancer. Cancer Letters 440-441, pages 35-46.
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Yuan-Chin Tsai, Tao Zeng, Wassim Abou-Kheir, Hsiu-Lien Yeh, Juan Juan Yin, Yi-Chao Lee, Wei-Yu Chen & Yen-Nien Liu. (2018) Disruption of ETV6 leads to TWIST1-dependent progression and resistance to epidermal growth factor receptor tyrosine kinase inhibitors in prostate cancer. Molecular Cancer 17:1.
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Hongjiao Liu, Xiaomian Lin, Tao Huang, Li Song, Cairong Zhu, Hongmin Ma, Tianzhu Long, Huixuan Zeng, Rongzhen Li, Heng Wang, Yishan Huang, Liankuai Chen & Xiaoping Wu. (2018) A short peptide reverses the aggressive phenotype of prostate cancer cells. European Journal of Pharmacology 838, pages 129-137.
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Kendra A. Williams, Minnkyong Lee, Jean M. Winter, Derek E. Gildea, Carla Calagua, Natasha L. Curry, Jens Lichtenberg, Huihui Ye & Nigel P.S. Crawford. (2018) Prostate cancer susceptibility gene HIST1H1A is a modulator of androgen receptor signaling and epithelial to mesenchymal transition . Oncotarget 9:47, pages 28532-28546.
Crossref
Yvona Ward, Ross Lake, Farhoud Faraji, Jamie Sperger, Philip Martin, Cameron Gilliard, Kimberly P. Ku, Tamara Rodems, David Niles, Heather Tillman, JuanJuan Yin, Kent Hunter, Adam G. Sowalsky, Joshua Lang & Kathleen Kelly. (2018) Platelets Promote Metastasis via Binding Tumor CD97 Leading to Bidirectional Signaling that Coordinates Transendothelial Migration. Cell Reports 23:3, pages 808-822.
Crossref
Chao Yan & Dan Theodorescu. (2017) RAL GTPases: Biology and Potential as Therapeutic Targets in Cancer. Pharmacological Reviews 70:1, pages 1-11.
Crossref
Sarah R. Pollock & David F. Kashatus. 2018. Encyclopedia of Signaling Molecules. Encyclopedia of Signaling Molecules 4424 4433 .
Liwei Lang, Chloe Shay, Xiangdong Zhao & Yong Teng. (2017) Combined targeting of Arf1 and Ras potentiates anticancer activity for prostate cancer therapeutics. Journal of Experimental & Clinical Cancer Research 36:1.
Crossref
Adel Rezaei Moghadam, Elham Patrad, Elham Tafsiri, Warner Peng, Benjamin Fangman, Timothy J Pluard, Anthony Accurso, Michael Salacz, Kushal Shah, Brandon Ricke, Danse Bi, Kyle Kimura, Leland Graves, Marzieh Khajoie Najad, Roya Dolatkhah, Zohreh Sanaat, Mina Yazdi, Naeimeh Tavakolinia, Mohammad Mazani, Mojtaba Amani, Saeid Ghavami, Robyn Gartell, Colleen Reilly, Zaid Naima, Tuba Esfandyari & Faris Farassati. (2017) Ral signaling pathway in health and cancer. Cancer Medicine 6:12, pages 2998-3013.
Crossref
W-Y Chen, Y-C Tsai, M K Siu, H-L Yeh, C-L Chen, J J Yin, J Huang & Y-N Liu. (2017) Inhibition of the androgen receptor induces a novel tumor promoter, ZBTB46, for prostate cancer metastasis. Oncogene 36:45, pages 6213-6224.
Crossref
M K Siu, W-Y Chen, H-Y Tsai, H-Y Chen, J J Yin, C-L Chen, Y-C Tsai & Y-N Liu. (2017) TCF7 is suppressed by the androgen receptor via microRNA-1-mediated downregulation and is involved in the development of resistance to androgen deprivation in prostate cancer. Prostate Cancer and Prostatic Diseases 20:2, pages 172-178.
Crossref
Yuan-Chin Tsai, Wei-Yu Chen, Man Kit Siu, Hong-Yuan Tsai, Juan Juan Yin, Jiaoti Huang & Yen-Nien Liu. (2017) Epidermal growth factor receptor signaling promotes metastatic prostate cancer through microRNA-96-mediated downregulation of the tumor suppressor ETV6. Cancer Letters 384, pages 1-8.
Crossref
M-K Siu, F Suau, W-Y Chen, Y-C Tsai, H-Y Tsai, H-L Yeh & Y-N Liu. (2016) KLF4 functions as an activator of the androgen receptor through reciprocal feedback. Oncogenesis 5:12, pages e282-e282.
Crossref
Chao Yan, Dan Theodorescu, Bettina Miller, Amit Kumar, Vijay Kumar, David Ross & Michael F. Wempe. (2016) Synthesis of novel Ral inhibitors: An in vitro and in vivo study. Bioorganic & Medicinal Chemistry Letters 26:23, pages 5815-5818.
Crossref
Takashi Kobayashi. (2016) Understanding the biology of urothelial cancer metastasis. Asian Journal of Urology 3:4, pages 211-222.
Crossref
Jitian Li, Liping Dai, Ningjing Lei, Mengtao Xing, Pei Li, Chenglin Luo, Carlos A. Casiano & Jian-Ying Zhang. (2016) Evaluation and characterization of anti-RalA autoantibody as a potential serum biomarker in human prostate cancer. Oncotarget 7:28, pages 43546-43556.
Crossref
CHEN CHEN, HONG SHEN, LI-GUO ZHANG, JIAN LIU, XIAO-GE CAO, AN-LIANG YAO, SHAO-SAN KANG, WEI-XING GAO, HUI HAN, FENG-HONG CAO & ZHI-GUO LI. (2016) Construction and analysis of protein-protein interaction networks based on proteomics data of prostate cancer. International Journal of Molecular Medicine 37:6, pages 1576-1586.
Crossref
Man Kit Siu, Wei-Yu Chen, Hong-Yuan Tsai, Hsiu-Lien Yeh, Juan Juan Yin, Shih-Yang Liu & Yen-Nien Liu. (2016) Androgen receptor regulates SRC expression through microRNA-203. Oncotarget 7:18, pages 25726-25741.
Crossref
Jinlu Dai, Janine Hensel, Ning Wang, Marianna Kruithof-de Julio & Yusuke Shiozawa. (2016) Mouse models for studying prostate cancer bone metastasis. BoneKEy Reports 5.
Crossref
Sarah R. Pollock & David F. Kashatus. 2016. Encyclopedia of Signaling Molecules. Encyclopedia of Signaling Molecules 1 10 .
Z Wang, Y Zhou, X Hu, W Chen, X Lin, L Sun, X Xu, W Hong & T Wang. (2015) RILP suppresses invasion of breast cancer cells by modulating the activity of RalA through interaction with RalGDS. Cell Death & Disease 6:10, pages e1923-e1923.
Crossref
M K Siu, Y-C Tsai, Y-S Chang, J J Yin, F Suau, W-Y Chen & Y-N Liu. (2014) Transforming growth factor-β promotes prostate bone metastasis through induction of microRNA-96 and activation of the mTOR pathway. Oncogene 34:36, pages 4767-4776.
Crossref
Yung-Sheng Chang, Wei-Yu Chen, Juan Juan Yin, Heather Sheppard-Tillman, Jiaoti Huang & Yen-Nien Liu. (2015) EGF Receptor Promotes Prostate Cancer Bone Metastasis by Downregulating miR-1 and Activating TWIST1. Cancer Research 75:15, pages 3077-3086.
Crossref
R. Shirakawa & H. Horiuchi. (2015) Ral GTPases: crucial mediators of exocytosis and tumourigenesis. Journal of Biochemistry 157:5, pages 285-299.
Crossref
Sunny Guin & Dan Theodorescu. (2015) The RAS-RAL axis in cancer: evidence for mutation-specific selectivity in non-small cell lung cancer. Acta Pharmacologica Sinica 36:3, pages 291-297.
Crossref
Wei-Yu Chen, Shih-Yang Liu, Yung-Sheng Chang, Juan Juan Yin, Hsiu-lien Yeh, Tarek H. Mouhieddine, Ola Hadadeh, Wassim Abou-Kheir & Yen-Nien Liu. (2014) MicroRNA-34a regulates WNT/TCF7 signaling and inhibits bone metastasis in Ras-activated prostate cancer. Oncotarget 6:1, pages 441-457.
Crossref
Leanna R. Gentry, Timothy D. Martin, David J. Reiner & Channing J. Der. (2014) Ral small GTPase signaling and oncogenesis: More than just 15minutes of fame. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1843:12, pages 2976-2988.
Crossref
Chao Yan, Degang Liu, Liwei Li, Michael F. Wempe, Sunny Guin, May Khanna, Jeremy Meier, Brenton Hoffman, Charles Owens, Christina L. Wysoczynski, Matthew D. Nitz, William E. Knabe, Mansoor Ahmed, David L. Brautigan, Bryce M. Paschal, Martin A. Schwartz, David N. M. Jones, David Ross, Samy O. Meroueh & Dan Theodorescu. (2014) Discovery and characterization of small molecules that target the GTPase Ral. Nature 515:7527, pages 443-447.
Crossref
JuanJuan Yin, Yen-Nien Liu, Heather Tillman, Ben Barrett, Stephen Hewitt, Kris Ylaya, Lei Fang, Ross Lake, Eva Corey, Colm Morrissey, Robert Vessella & Kathleen Kelly. (2014) AR-Regulated TWEAK-FN14 Pathway Promotes Prostate Cancer Bone Metastasis. Cancer Research 74:16, pages 4306-4317.
Crossref
Jessica Tome-Garcia, Dan Li, Seda Ghazaryan, Limin Shu & Lizhao Wu. (2014) ERBB2 Increases Metastatic Potentials Specifically in Androgen-Insensitive Prostate Cancer Cells. PLoS ONE 9:6, pages e99525.
Crossref
Man Kit Siu, Wassim Abou-Kheir, Juan Juan Yin, Yung-Sheng Chang, Ben Barrett, Florent Suau, Orla Casey, Wei-Yu Chen, Lei Fang, Paul Hynes, Yao-Yu Hsieh, Yen-Nien Liu, Jiaoti Huang & Kathleen Kelly. (2014) Loss of EGFR signaling-regulated miR-203 promotes prostate cancer bone metastasis and tyrosine kinase inhibitors resistance. Oncotarget 5:11, pages 3770-3784.
Crossref
Brian O. Bodemann & Michael A. White. 2014. Ras Superfamily Small G Proteins: Biology and Mechanisms 1. Ras Superfamily Small G Proteins: Biology and Mechanisms 1 257 279 .
Sunny Guin, Yuanbin Ru, Murry W. Wynes, Rangnath Mishra, Xian Lu, Charles Owens, Anna E. Barόn, Vihas T. Vasu, Fred R. Hirsch, Jeffrey A. Kern & Dan Theodorescu. (2013) Contributions of KRAS and RAL in Non–Small-Cell Lung Cancer Growth and Progression. Journal of Thoracic Oncology 8:12, pages 1492-1501.
Crossref
David F. Kashatus. (2013) Ral GTPases in tumorigenesis: Emerging from the shadows. Experimental Cell Research 319:15, pages 2337-2342.
Crossref
Qingxin Liu, Mike R. Russell, Kristina Shahriari, Danielle L. Jernigan, Mercedes I. Lioni, Fernando U. Garcia & Alessandro Fatatis. (2013) Interleukin-1β Promotes Skeletal Colonization and Progression of Metastatic Prostate Cancer Cells with Neuroendocrine Features. Cancer Research 73:11, pages 3297-3305.
Crossref
Z Li, Y Zhang, W J Kim & Y Daaka. (2012) PGE2 promotes renal carcinoma cell invasion through activated RalA. Oncogene 32:11, pages 1408-1415.
Crossref
Y-N Liu, J J Yin, W Abou-Kheir, P G Hynes, O M Casey, L Fang, M Yi, R M Stephens, V Seng, H Sheppard-Tillman, P Martin & K Kelly. (2012) MiR-1 and miR-200 inhibit EMT via Slug-dependent and tumorigenesis via Slug-independent mechanisms. Oncogene 32:3, pages 296-306.
Crossref
Jonathan M. Cooper, Brian O. Bodemann & Michael A. White. 2013. Inhibitors of the Ras superfamily G-proteins, Part B. Inhibitors of the Ras superfamily G-proteins, Part B 137 156 .
Steven C. Smith, Alexander S. Baras, Charles R. Owens, Garrett Dancik & Dan Theodorescu. (2012) Transcriptional Signatures of Ral GTPase Are Associated with Aggressive Clinicopathologic Characteristics in Human Cancer. Cancer Research 72:14, pages 3480-3491.
Crossref
David J. Mulholland, Naoko Kobayashi, Marcus Ruscetti, Allen Zhi, Linh M. Tran, Jiaoti Huang, Martin Gleave & Hong Wu. (2012) Pten Loss and RAS/MAPK Activation Cooperate to Promote EMT and Metastasis Initiated from Prostate Cancer Stem/Progenitor Cells . Cancer Research 72:7, pages 1878-1889.
Crossref
KETAO JIN, WEILI GAO, YANYAN LU, HUANRONG LAN, LISONG TENG & FEILIN CAO. (2012) Mechanisms regulating colorectal cancer cell metastasis into liver (Review). Oncology Letters 3:1, pages 11-15.
Crossref
Yvona Ward, Ross Lake, Juan Juan Yin, Christopher D. Heger, Mark Raffeld, Paul K. Goldsmith, Maria Merino & Kathleen Kelly. (2011) LPA Receptor Heterodimerizes with CD97 to Amplify LPA-Initiated RHO-Dependent Signaling and Invasion in Prostate Cancer Cells. Cancer Research 71:23, pages 7301-7311.
Crossref
Antonio T Baines, Dapeng Xu & Channing J Der. (2011) Inhibition of Ras for cancer treatment: the search continues. Future Medicinal Chemistry 3:14, pages 1787-1808.
Crossref
Masakazu Hamada, Tetsuei Miki, Soichi Iwai, Hidetaka Shimizu & Yoshiaki Yura. (2010) Involvement of RhoA and RalB in geranylgeranyltransferase I inhibitor-mediated inhibition of proliferation and migration of human oral squamous cell carcinoma cells. Cancer Chemotherapy and Pharmacology 68:3, pages 559-569.
Crossref
Philip Martin, Yen-Nien Liu, Rachel Pierce, Wassim Abou-Kheir, Orla Casey, Victoria Seng, Daniel Camacho, R. Mark Simpson & Kathleen Kelly. (2011) Prostate Epithelial Pten/TP53 Loss Leads to Transformation of Multipotential Progenitors and Epithelial to Mesenchymal Transition. The American Journal of Pathology 179:1, pages 422-435.
Crossref
A. V. Knizhnik, O. V. Kovaleva, K. K. Laktionov, V. V. Mochalnikova, A. V. Komelkov, E. M. Tchevkina & I. B. Zborovskaya. (2011) Arf6, RalA, and BIRC5 protein expression in nonsmall cell lung cancer. Molecular Biology 45:2, pages 275-282.
Crossref
Olga Zolochevska & Marxa L. Figueiredo. (2011) Cell-cycle regulators cdk2ap1 and bicalutamide suppress malignant biological interactions between prostate cancer and bone cells. The Prostate 71:4, pages 353-367.
Crossref
Megan N. Thobe, Robert J. Clark, Russell O. Bainer, Sandip M. Prasad & Carrie W. Rinker-Schaeffer. (2011) From Prostate to Bone: Key Players in Prostate Cancer Bone Metastasis. Cancers 3:1, pages 478-493.
Crossref
Timothy D. Martin, Jonathan C. Samuel, Elizabeth D. Routh, Channing J. Der & Jen Jen Yeh. (2011) Activation and Involvement of Ral GTPases in Colorectal Cancer. Cancer Research 71:1, pages 206-215.
Crossref
Suzanne A. Eccles. 2011. Tumor Models in Cancer Research. Tumor Models in Cancer Research 447 495 .
Zhong Wu, Charles Owens, Nidhi Chandra, Kay Popovic, Mark Conaway & Dan Theodorescu. (2010) RalBP1 Is Necessary for Metastasis of Human Cancer Cell Lines. Neoplasia 12:12, pages 1003-1012.
Crossref
Dominico Vigil, Jacqueline Cherfils, Kent L. Rossman & Channing J. Der. (2010) Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?. Nature Reviews Cancer 10:12, pages 842-857.
Crossref
Elisa Ferro & Lorenza Trabalzini. (2010) RalGDS family members couple Ras to Ral signalling and that's not all. Cellular Signalling 22:12, pages 1804-1810.
Crossref
Juan Juan Yin, Luhua Zhang, Jeeva Munasinghe, R. Ilona Linnoila & Kathleen Kelly. (2010) Cediranib/AZD2171 Inhibits Bone and Brain Metastasis in a Preclinical Model of Advanced Prostate Cancer. Cancer Research 70:21, pages 8662-8673.
Crossref
Hong Wang, Charles Owens, Nidhi Chandra, Mark R. Conaway, David L. Brautigan & Dan Theodorescu. (2010) Phosphorylation of RalB Is Important for Bladder Cancer Cell Growth and Metastasis. Cancer Research 70:21, pages 8760-8769.
Crossref
Dominico Vigil, Timothy D. Martin, Falina Williams, Jen Jen Yeh, Sharon L. Campbell & Channing J. Der. (2010) Aberrant Overexpression of the Rgl2 Ral Small GTPase-specific Guanine Nucleotide Exchange Factor Promotes Pancreatic Cancer Growth through Ral-dependent and Ral-independent Mechanisms. Journal of Biological Chemistry 285:45, pages 34729-34740.
Crossref
P A Zipfel, D C Brady, D F Kashatus, B D Ancrile, D S Tyler & C M Counter. (2010) Ral activation promotes melanomagenesis. Oncogene 29:34, pages 4859-4864.
Crossref
P J Mishra, L Ha, J Rieker, E V Sviderskaya, D C Bennett, M D Oberst, K Kelly & G Merlino. (2010) Dissection of RAS downstream pathways in melanomagenesis: a role for Ral in transformation. Oncogene 29:16, pages 2449-2456.
Crossref
Jose Luis Luque-García, Jorge Luis Martínez-Torrecuadrada, Carolina Epifano, Marta Cañamero, Ingrid Babel & J. Ignacio Casal. (2010) Differential protein expression on the cell surface of colorectal cancer cells associated to tumor metastasis. PROTEOMICS 10:5, pages 940-952.
Crossref
Jen Jen Yeh, James P. Madigan, Paul M. Campbell, Patrick J. Roberts, Lanika DeGraffenreid & Channing J. Der. 2010. Handbook of Cell Signaling. Handbook of Cell Signaling 2837 2857 .
Wen-Sheng Wu & Jia-Ru Wu. 2010. Signal Transduction in Cancer Metastasis. Signal Transduction in Cancer Metastasis 1 8 .
Ryutaro Shirakawa, Shuya Fukai, Mitsunori Kawato, Tomohito Higashi, Hirokazu Kondo, Tomoyuki Ikeda, Ei Nakayama, Katsuya Okawa, Osamu Nureki, Takeshi Kimura, Toru Kita & Hisanori Horiuchi. (2009) Tuberous Sclerosis Tumor Suppressor Complex-like Complexes Act as GTPase-activating Proteins for Ral GTPases. Journal of Biological Chemistry 284:32, pages 21580-21588.
Crossref
Timothy T. Li, Mistre Alemayehu, Adel I. Aziziyeh, Cynthia Pape, Macarena Pampillo, Lynne-Marie Postovit, Gordon B. Mills, Andy V. Babwah & Moshmi Bhattacharya. (2009) β-Arrestin/Ral Signaling Regulates Lysophosphatidic Acid–Mediated Migration and Invasion of Human Breast Tumor Cells. Molecular Cancer Research 7:7, pages 1064-1077.
Crossref
Juan JuanYin, Kirsten Tracy, Luhua Zhang, Jeeva Munasinghe, Erik Shapiro, Alan Koretsky & Kathleen Kelly. (2009) Noninvasive imaging of the functional effects of anti-VEGF therapy on tumor cell extravasation and regional blood volume in an experimental brain metastasis model. Clinical & Experimental Metastasis 26:5, pages 403-414.
Crossref
Steven Christopher Smith & Dan Theodorescu. (2009) The Ral GTPase pathway in metastatic bladder cancer: Key mediator and therapeutic target. Urologic Oncology: Seminars and Original Investigations 27:1, pages 42-47.
Crossref
Michael D Oberst, Stacey J Beberman, Liu Zhao, Juan Juan Yin, Yvona Ward & Kathleen Kelly. (2008) TDAG51 is an ERK signaling target that opposes ERK-mediated HME16C mammary epithelial cell transformation. BMC Cancer 8:1.
Crossref
Ira Skvortsova, Sergej Skvortsov, Taras Stasyk, Uma Raju, Bela-Andre Popper, Bernhard Schiestl, Elisabeth von Guggenberg, Andreas Neher, Guenther K. Bonn, Lukas A. Huber & Peter Lukas. (2008) Intracellular signaling pathways regulating radioresistance of human prostate carcinoma cells. PROTEOMICS 8:21, pages 4521-4533.
Crossref
Brian O. Bodemann & Michael A. White. (2008) Ral GTPases and cancer: linchpin support of the tumorigenic platform. Nature Reviews Cancer 8:2, pages 133-140.
Crossref

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