Citations (165)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (9)
Charli B. Fant & Dylan J. Taatjes. (2019) Regulatory functions of the Mediator kinases CDK8 and CDK19. Transcription 10:2, pages 76-90.
Read now
Read now
Thaleia Papadopoulou, Aysegül Kaymak, Sergi Sayols & Holger Richly. (2016) Dual role of Med12 in PRC1-dependent gene repression and ncRNA-mediated transcriptional activation. Cell Cycle 15:11, pages 1479-1493.
Read now
Read now
Alison D. Clark, Marieke Oldenbroek & Thomas G. Boyer. (2015) Mediator kinase module and human tumorigenesis. Critical Reviews in Biochemistry and Molecular Biology 50:5, pages 393-426.
Read now
Read now
Zachary C. Poss, Christopher C. Ebmeier & Dylan J. Taatjes. (2013) The Mediator complex and transcription regulation. Critical Reviews in Biochemistry and Molecular Biology 48:6, pages 575-608.
Read now
Read now
Weiting Gu, Chenguang Wang, Weihua Li, Fu-Ning Hsu, Lifeng Tian, Jie Zhou, Cunzhong Yuan, Xiao-Jun Xie, Tao Jiang, Sankar Addya, Yanhong Tai, Beihua Kong & Jun-Yuan Ji. (2013) Tumor-suppressive effects of CDK8 in endometrial cancer cells. Cell Cycle 12:6, pages 987-999.
Read now
Read now
Matthew T. Knuesel & Dylan J. Taatjes. (2011) Mediator and post-recruitment regulation of RNA polymerase II. Transcription 2:1, pages 28-31.
Read now
Read now
Matthew D. Galbraith, Aaron J. Donner & Joaquín M. Espinosa. (2010) CDK8. Transcription 1:1, pages 4-12.
Read now
Read now
Vanessa Gobert, Dani Osman, Stéphanie Bras, Benoit Augé, Muriel Boube, Henri-Marc Bourbon, Thomas Horn, Michael Boutros, Marc Haenlin & Lucas Waltzer. (2010) A Genome-Wide RNA Interference Screen Identifies a Differential Role of the Mediator CDK8 Module Subunits for GATA/ RUNX-Activated Transcription in Drosophila. Molecular and Cellular Biology 30:11, pages 2837-2848.
Read now
Read now
Madesh Belakavadi & Joseph D. Fondell. (2010) Cyclin-Dependent Kinase 8 Positively Cooperates with Mediator To Promote Thyroid Hormone Receptor-Dependent Transcriptional Activation. Molecular and Cellular Biology 30:10, pages 2437-2448.
Read now
Read now
Articles from other publishers (156)
Susana Prieto, Geronimo Dubra, Alain Camasses, Ana Bella Aznar, Christina Begon‐Pescia, Elisabeth Simboeck, Nelly Pirot, François Gerbe, Lucie Angevin, Philippe Jay, Liliana Krasinska & Daniel Fisher. (2022) CDK8 and CDK19 act redundantly to control the CFTR pathway in the intestinal epithelium. EMBO reports 24:2.
Crossref
Crossref
Yinuo Li, Xiuhua Xu, Huma Asif, Yue Feng, Brendan F. Kohrn, Scott R. Kennedy, J. Julie Kim & Jian-Jun Wei. (2022) Myometrial oxidative stress drives MED12 mutations in leiomyoma. Cell & Bioscience 12:1.
Crossref
Crossref
Junling Mo, Guangyao Fan, Toshifumi Tsukahara & Matomo Sakari. (2022) The Role of the Exonic lncRNA PRKDC-210 in Transcription Regulation. International Journal of Molecular Sciences 23:22, pages 13783.
Crossref
Crossref
William F. Richter, Shraddha Nayak, Janet Iwasa & Dylan J. Taatjes. (2022) The Mediator complex as a master regulator of transcription by RNA polymerase II. Nature Reviews Molecular Cell Biology 23:11, pages 732-749.
Crossref
Crossref
Marius V. Dannappel, Danxi Zhu, Xin Sun, Hui Kheng Chua, Marle Poppelaars, Monica Suehiro, Subash Khadka, Terry C.C. Lim Kam Sian, Dhanya Sooraj, Melissa Loi, Hugh Gao, Daniel Croagh, Roger J. Daly, Pouya Faridi, Thomas G. Boyer & Ron Firestein. (2022) CDK8 and CDK19 regulate intestinal differentiation and homeostasis via the chromatin remodeling complex SWI/SNF. Journal of Clinical Investigation 132:20.
Crossref
Crossref
Emilia Dimitrova, Angelika Feldmann, Robin H. van der Weide, Koen D. Flach, Anna Lastuvkova, Elzo de Wit & Robert J. Klose. (2022) Distinct roles for CKM–Mediator in controlling Polycomb-dependent chromosomal interactions and priming genes for induction. Nature Structural & Molecular Biology 29:10, pages 1000-1010.
Crossref
Crossref
Kevin C. Clopper & Dylan J. Taatjes. (2022) Chemical inhibitors of transcription-associated kinases. Current Opinion in Chemical Biology 70, pages 102186.
Crossref
Crossref
Qiwei Yang, Michal Ciebiera, Maria Victoria Bariani, Mohamed Ali, Hoda Elkafas, Thomas G Boyer & Ayman Al-Hendy. (2022) Comprehensive Review of Uterine Fibroids: Developmental Origin, Pathogenesis, and Treatment. Endocrine Reviews 43:4, pages 678-719.
Crossref
Crossref
Joel Rovnak & Sandra L. Quackenbush. (2022) Exploitation of the Mediator complex by viruses. PLOS Pathogens 18:4, pages e1010422.
Crossref
Crossref
Yingchao Zhou, Lingfeng Zha, Jianfei Wu, Mengru Wang, Mengchen Zhou, Gang Wu, Xiang Cheng, Zhengrong Huang, Qiang Xie & Xin Tu. (2022) MED12 Regulates Smooth Muscle Cell Functions and Participates in the Development of Aortic Dissection. Genes 13:4, pages 692.
Crossref
Crossref
Sribalasubashini Muralimanoharan, Ross Shamby, Nicholas Stansbury, Robert Schenken, Barbara de la Pena Avalos, Samin Javanmardi, Eloise Dray, Patrick Sung & Thomas G. Boyer. (2022) Aberrant R-loop-induced replication stress in MED12-mutant uterine fibroids. Scientific Reports 12:1.
Crossref
Crossref
Olivia Luyties & Dylan J. Taatjes. (2022) The Mediator kinase module: an interface between cell signaling and transcription. Trends in Biochemical Sciences 47:4, pages 314-327.
Crossref
Crossref
Genevieve V. Dall, Anne Hamilton, Gayanie Ratnayake, Clare Scott & Holly Barker. (2022) Interrogating the Genomic Landscape of Uterine Leiomyosarcoma: A Potential for Patient Benefit. Cancers 14:6, pages 1561.
Crossref
Crossref
Li Zhang, Chen Cheng, Jing Li, Lili Wang, Alexander A. Chumanevich, Donald C. Porter, Aleksei Mindich, Svetlana Gorbunova, Igor B. Roninson, Mengqian Chen & Campbell McInnes. (2022) A Selective and Orally Bioavailable Quinoline-6-Carbonitrile-Based Inhibitor of CDK8/19 Mediator Kinase with Tumor-Enriched Pharmacokinetics. Journal of Medicinal Chemistry 65:4, pages 3420-3433.
Crossref
Crossref
Judith H. I. Haarhuis, Robin H. van der Weide, Vincent A. Blomen, Koen D. Flach, Hans Teunissen, Laureen Willems, Thijn R. Brummelkamp, Benjamin D. Rowland & Elzo de Wit. (2022) A Mediator-cohesin axis controls heterochromatin domain formation. Nature Communications 13:1.
Crossref
Crossref
Cristian Gonzalez, Shivani Akula & Marieke Burleson. (2022) The role of mediator subunit 12 in tumorigenesis and cancer therapeutics (Review). Oncology Letters 23:3.
Crossref
Crossref
Dhanya Sooraj, Claire Sun, Anh Doan, Daniel J. Garama, Marius V. Dannappel, Danxi Zhu, Hui K. Chua, Sylvia Mahara, Wan Amir Wan Hassan, Yeng Kwang Tay, Aleks Guanizo, Daniel Croagh, Zdenka Prodanovic, Daniel J. Gough, Chunhua Wan & Ron Firestein. (2022) MED12 and BRD4 cooperate to sustain cancer growth upon loss of mediator kinase. Molecular Cell 82:1, pages 123-139.e7.
Crossref
Crossref
Lindsey Barron, Subash Khadka, Robert Schenken, Long He, John Blenis, Julian Blagg, Shin-Fu Chen, Kuang-Lei Tsai & Thomas G. Boyer. (2021) Identification and characterization of the mediator kinase-dependent myometrial stem cell phosphoproteome. F&S Science 2:4, pages 383-395.
Crossref
Crossref
Brittany Friedson & Katrina F. Cooper. (2021) Cdk8 Kinase Module: A Mediator of Life and Death Decisions in Times of Stress. Microorganisms 9:10, pages 2152.
Crossref
Crossref
S. V. Shtykalova, A. A. Egorova, M. A. Maretina, S. A. Freund, V. S. Baranov & A. V. Kiselev. (2021) Molecular Genetic Basis and Prospects of Gene Therapy of Uterine Leiomyoma. Russian Journal of Genetics 57:9, pages 1002-1016.
Crossref
Crossref
Pratibha Srivastava, Ryosuke Takii, Mariko Okada, Mitsuaki Fujimoto & Akira Nakai. (2021) MED12 interacts with the heat‐shock transcription factor HSF1 and recruits CDK8 to promote the heat‐shock response in mammalian cells. FEBS Letters 595:14, pages 1933-1948.
Crossref
Crossref
Dou Yeon Youn, Alus M. Xiaoli, Haihong Zong, Junichi Okada, Li Liu, Jacob Pessin, Jeffrey E. Pessin & Fajun Yang. (2021) The Mediator complex kinase module is necessary for fructose regulation of liver glycogen levels through induction of glucose-6-phosphatase catalytic subunit (G6pc). Molecular Metabolism 48, pages 101227.
Crossref
Crossref
Srishti Srivastava & Ritu Kulshreshtha. (2020) Insights into the regulatory role and clinical relevance of mediator subunit, MED12, in human diseases. Journal of Cellular Physiology 236:5, pages 3163-3177.
Crossref
Crossref
Kazuya Fukasawa, Takuya Kadota, Tetsuhiro Horie, Kazuya Tokumura, Ryuichi Terada, Yuka Kitaguchi, Gyujin Park, Shinsuke Ochiai, Sayuki Iwahashi, Yasuka Okayama, Manami Hiraiwa, Takanori Yamada, Takashi Iezaki, Katsuyuki Kaneda, Megumi Yamamoto, Tatsuya Kitao, Hiroaki Shirahase, Masaharu Hazawa, Richard W. Wong, Tomoki Todo, Atsushi Hirao & Eiichi Hinoi. (2021) CDK8 maintains stemness and tumorigenicity of glioma stem cells by regulating the c-MYC pathway. Oncogene 40:15, pages 2803-2815.
Crossref
Crossref
Ana Martinez-Val, Cian J. Lynch, Isabel Calvo, Pilar Ximénez-Embún, Fernando Garcia, Eduardo Zarzuela, Manuel Serrano & Javier Munoz. (2021) Dissection of two routes to naïve pluripotency using different kinase inhibitors. Nature Communications 12:1.
Crossref
Crossref
Dan Wu, Zhaoyan Zhang, Xing Chen, Yaoyao Yan & Xinhua Liu. (2021) Angel or Devil ? - CDK8 as the new drug target. European Journal of Medicinal Chemistry 213, pages 113043.
Crossref
Crossref
Rekha Agrawal, Fajkus Jiří & Jitendra K Thakur. (2021) The kinase module of the Mediator complex: an important signalling processor for the development and survival of plants. Journal of Experimental Botany 72:2, pages 224-240.
Crossref
Crossref
Yi-Chuan Li, Ti-Chun Chao, Hee Jong Kim, Timothy Cholko, Shin-Fu Chen, Guojie Li, Laura SnyderKotaro Nakanishi, Chia-en Chang, Kenji Murakami, Benjamin A. GarciaThomas G. Boyer & Kuang-Lei Tsai. (2021) Structure and noncanonical Cdk8 activation mechanism within an Argonaute-containing Mediator kinase module. Science Advances 7:3.
Crossref
Crossref
Sara Osman, Eusra Mohammad, Michael Lidschreiber, Alexandra Stuetzer, Fanni Laura Bazsó, Kerstin C. Maier, Henning Urlaub & Patrick Cramer. (2021) The Cdk8 kinase module regulates interaction of the mediator complex with RNA polymerase II. Journal of Biological Chemistry 296, pages 100734.
Crossref
Crossref
Joseph StraubSree VenigallaJamie J. Newman. (2020) Mediator's Kinase Module: A Modular Regulator of Cell Fate. Stem Cells and Development 29:24, pages 1535-1551.
Crossref
Crossref
Jensen M. Spear, Zhixin Lu & Wade A. Russu. (2020) Pharmacological Inhibition of CDK8 in Triple-Negative Breast Cancer Cell Line MDA-MB-468 Increases E2F1 Protein, Induces Phosphorylation of STAT3 and Apoptosis. Molecules 25:23, pages 5728.
Crossref
Crossref
Dorota Komar & Przemyslaw Juszczynski. (2020) Rebelled epigenome: histone H3S10 phosphorylation and H3S10 kinases in cancer biology and therapy. Clinical Epigenetics 12:1.
Crossref
Crossref
Yingfang Zhu, Pengcheng Huang, Pengcheng Guo, Leelyn Chong, Gaobo Yu, Xiaoli Sun, Tao Hu, Yuan Li, Chuan‐Chih Hsu, Kai Tang, Yun Zhou, Chunzhao Zhao, Wei Gao, W. Andy Tao, Tesfaye Mengiste & Jian‐Kang Zhu. (2020)
CDK8 is associated with RAP2.6 and SnRK2.6 and positively modulates abscisic acid signaling and drought response in
Arabidopsis
. New Phytologist 228:5, pages 1573-1590.
Crossref
Crossref
Jenna K. Rimel, Zachary C. Poss, Benjamin Erickson, Zachary L. Maas, Christopher C. Ebmeier, Jared L. Johnson, Tim-Michael Decker, Tomer M. Yaron, Michael J. Bradley, Kristin B. Hamman, Shanhu Hu, Goran Malojcic, Jason J. Marineau, Peter W. White, Martine Brault, Limei Tao, Patrick DeRoy, Christian Clavette, Shraddha Nayak, Leah J. Damon, Ines H. Kaltheuner, Heeyoun Bunch, Lewis C. Cantley, Matthias Geyer, Janet Iwasa, Robin D. Dowell, David L. Bentley, William M. Old & Dylan J. Taatjes. (2020) Selective inhibition of CDK7 reveals high-confidence targets and new models for TFIIH function in transcription. Genes & Development 34:21-22, pages 1452-1473.
Crossref
Crossref
David C. Stieg, Katrina F. Cooper & Randy Strich. (2020) The extent of cyclin C promoter occupancy directs changes in stress-dependent transcription. Journal of Biological Chemistry 295:48, pages 16280-16291.
Crossref
Crossref
Diego Martínez-Alonso & Marcos Malumbres. (2020) Mammalian cell cycle cyclins. Seminars in Cell & Developmental Biology 107, pages 28-35.
Crossref
Crossref
Emilie Lebraud, Guillaume Pinna, Capucine Siberchicot, Jordane Depagne, Didier Busso, Damiano Fantini, Lamya Irbah, Elena Robeska, Gueorgui Kratassiouk, Jean-Luc Ravanat, Bernd Epe, J Pablo Radicella & Anna Campalans. (2020) Chromatin recruitment of OGG1 requires cohesin and mediator and is essential for efficient 8-oxoG removal. Nucleic Acids Research 48:16, pages 9082-9097.
Crossref
Crossref
Christina Schoenherr, Adam Byron, Billie Griffith, Alexander Loftus, Jimi C. Wills, Alison F. Munro, Alex von Kriegsheim & Margaret C. Frame. (2020) The autophagy protein Ambra1 regulates gene expression by supporting novel transcriptional complexes. Journal of Biological Chemistry 295:34, pages 12045-12057.
Crossref
Crossref
Bin Chen, Pengbo Wen, Guanshuo Hu, Yang Gao, Xiaojing Qi, Kaili Zhu, Shaopeng Chen, Lijun Wu, An Xu & Guoping Zhao. (2020) Antagonizing CDK8 Sensitizes Colorectal Cancer to Radiation Through Potentiating the Transcription of e2f1 Target Gene apaf1. Frontiers in Cell and Developmental Biology 8.
Crossref
Crossref
Hiromi Yamazaki, Shuya Kasai, Junsei Mimura, Peng Ye, Atsushi Inose-Maruyama, Kunikazu Tanji, Koichi Wakabayashi, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Tsubasa Sato, Taku Ozaki, Douglas R. Cavener, Masayuki Yamamoto & Ken Itoh. (2020) Ribosome binding protein GCN1 regulates the cell cycle and cell proliferation and is essential for the embryonic development of mice. PLOS Genetics 16:4, pages e1008693.
Crossref
Crossref
Yi Kuang, Ohad Golan, Kristina Preusse, Brittany Cain, Collin J Christensen, Joseph Salomone, Ian Campbell, FearGod V Okwubido-Williams, Matthew R Hass, Zhenyu Yuan, Nathanel Eafergan, Kenneth H Moberg, Rhett A Kovall, Raphael Kopan, David Sprinzak & Brian Gebelein. (2020) Enhancer architecture sensitizes cell specific responses to Notch gene dose via a bind and discard mechanism. eLife 9.
Crossref
Crossref
Allison C. Schier & Dylan J. Taatjes. (2020) Structure and mechanism of the RNA polymerase II transcription machinery. Genes & Development 34:7-8, pages 465-488.
Crossref
Crossref
Elina Parri, Heikki Kuusanmäki, Arjan J. van Adrichem, Meri Kaustio & Krister Wennerberg. (2020) Identification of novel regulators of STAT3 activity. PLOS ONE 15:3, pages e0230819.
Crossref
Crossref
Mohammad M. Al-Sanea. (2020) Synthesis and biological evaluation of small molecule modulators of CDK8/Cyclin C complex with phenylaminoquinoline scaffold. PeerJ 8, pages e8649.
Crossref
Crossref
Felix KlattAlexander Leitner, Iana V. KimHung Ho-XuanElisabeth V. SchneiderFranziska LanghammerRobin WeinmannMelanie R. MüllerRobert Huber, Gunter MeisterClaus-D. Kuhn. (2020) A precisely positioned MED12 activation helix stimulates CDK8 kinase activity. Proceedings of the National Academy of Sciences 117:6, pages 2894-2905.
Crossref
Crossref
Iris Steinparzer, Vitaly Sedlyarov, Jonathan D. Rubin, Kevin Eislmayr, Matthew D. Galbraith, Cecilia B. Levandowski, Terezia Vcelkova, Lucy Sneezum, Florian Wascher, Fabian Amman, Renata Kleinova, Heather Bender, Zdenek Andrysik, Joaquin M. Espinosa, Giulio Superti-Furga, Robin D. Dowell, Dylan J. Taatjes & Pavel Kovarik. (2019) Transcriptional Responses to IFN-γ Require Mediator Kinase-Dependent Pause Release and Mechanistically Distinct CDK8 and CDK19 Functions. Molecular Cell 76:3, pages 485-499.e8.
Crossref
Crossref
Rachel A. Minerath, Duane D. Hall & Chad E. Grueter. (2019) Targeting transcriptional machinery to inhibit enhancer-driven gene expression in heart failure. Heart Failure Reviews 24:5, pages 725-741.
Crossref
Crossref
David C Stieg, Kai-Ti Chang, Katrina F Cooper & Randy Strich. (2019)
Cyclin C Regulated Oxidative Stress Responsive Transcriptome in
Mus musculus
Embryonic Fibroblasts
. G3 Genes|Genomes|Genetics 9:6, pages 1901-1908.
Crossref
Crossref
Eduardo Calpena, Alexia Hervieu, Teresa Kaserer, Sigrid M.A. Swagemakers, Jacqueline A.C. Goos, Olajumoke Popoola, Maria Jesus Ortiz-Ruiz, Tina Barbaro-Dieber, Lucy Bownass, Eva H. Brilstra, Elise Brimble, Nicola Foulds, Theresa A. Grebe, Aster V.E. Harder, Melissa M. Lees, Kristin G. Monaghan, Ruth A. Newbury-Ecob, Kai-Ren Ong, Deborah Osio, Francis Jeshira Reynoso Santos, Maura R.Z. Ruzhnikov, Aida Telegrafi, Ellen van Binsbergen, Marieke F. van Dooren, Peter J. van der Spek, Julian Blagg, Stephen R.F. Twigg, Irene M.J. Mathijssen, Paul A. Clarke & Andrew O.M. Wilkie. (2019) De Novo Missense Substitutions in the Gene Encoding CDK8, a Regulator of the Mediator Complex, Cause a Syndromic Developmental Disorder. The American Journal of Human Genetics 104:4, pages 709-720.
Crossref
Crossref
Young Chai, Heejoon Chae, Kwangsoo Kim, Heonyi Lee, Seongmin Choi, Kyu Lee & Sang Kim. (2019) Comparative Gene Expression Profiles in Parathyroid Adenoma and Normal Parathyroid Tissue. Journal of Clinical Medicine 8:3, pages 297.
Crossref
Crossref
Meiyang Xi, Tingkai Chen, Chunlei Wu, Xiaozhong Gao, Yonghua Wu, Xiang Luo, Kui Du, Lemao Yu, Tao Cai, Runpu Shen & Haopeng Sun. (2019) CDK8 as a therapeutic target for cancers and recent developments in discovery of CDK8 inhibitors. European Journal of Medicinal Chemistry 164, pages 77-91.
Crossref
Crossref
Marius Volker Dannappel, Dhanya Sooraj, Jia Jian Loh & Ron Firestein. (2019) Molecular and in vivo Functions of the CDK8 and CDK19 Kinase Modules. Frontiers in Cell and Developmental Biology 6.
Crossref
Crossref
Xiao Li, Mengmeng Liu & Jun-Yuan Ji. 2019. The Drosophila Model in Cancer. The Drosophila Model in Cancer
129
155
.
Susannah Hallal, Benjamin P. Russell, Heng Wei, Maggie Yuk T. Lee, Christopher W. Toon, Joanne Sy, Brindha Shivalingam, Michael E. Buckland & Kimberley L. Kaufman. (2019) Extracellular Vesicles from Neurosurgical Aspirates Identifies Chaperonin Containing TCP1 Subunit 6A as a Potential Glioblastoma Biomarker with Prognostic Significance. PROTEOMICS 19:1-2, pages 1800157.
Crossref
Crossref
Jia Xie, Julianne Ubango, Yanli Ban, Debabrata Chakravarti, J. Julie Kim & Jian-Jun Wei. (2018)
Comparative analysis of
AKT
and the related biomarkers in uterine leiomyomas with
MED12, HMGA2
, and
FH
mutations
. Genes, Chromosomes and Cancer 57:10, pages 485-494.
Crossref
Crossref
Thomas M. Harper & Dylan J. Taatjes. (2018) The complex structure and function of Mediator. Journal of Biological Chemistry 293:36, pages 13778-13785.
Crossref
Crossref
Yuri Choi, Chae Hwa Kwon, Seon Jin Lee, Joonghoon Park, Jong-Yeon Shin & Do Youn Park. (2018) Integrative analysis of oncogenic fusion genes and their functional impact in colorectal cancer. British Journal of Cancer 119:2, pages 230-240.
Crossref
Crossref
Stephen Philip, Malika Kumarasiri, Theodosia Teo, Mingfeng Yu & Shudong Wang. (2017) Cyclin-Dependent Kinase 8: A New Hope in Targeted Cancer Therapy?. Journal of Medicinal Chemistry 61:12, pages 5073-5092.
Crossref
Crossref
John M. Hatcher, Eric S. Wang, Liv Johannessen, Nicholas Kwiatkowski, Taebo Sim & Nathanael S. Gray. (2018) Development of Highly Potent and Selective Steroidal Inhibitors and Degraders of CDK8. ACS Medicinal Chemistry Letters 9:6, pages 540-545.
Crossref
Crossref
E. V. Putlyaev, A. N. Ibragimov, L. A. Lebedeva, P. G. Georgiev & Y. V. Shidlovskii. (2018) Structure and Functions of the Mediator Complex. Biochemistry (Moscow) 83:4, pages 423-436.
Crossref
Crossref
Min Ju Park, Hailian Shen, Jason M. Spaeth, Jaana H. Tolvanen, Courtney Failor, Jennifer F. Knudtson, Jessica McLaughlin, Sunil K. Halder, Qiwei Yang, Serdar E. Bulun, Ayman Al-Hendy, Robert S. Schenken, Lauri A. Aaltonen & Thomas G. Boyer. (2018) Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8/19. Journal of Biological Chemistry 293:13, pages 4870-4882.
Crossref
Crossref
David C. Stieg, Stephen D. Willis, Vidyaramanan Ganesan, Kai Li Ong, Joseph Scuorzo, Mia Song, Julianne Grose, Randy Strich & Katrina F. Cooper. (2018)
A complex molecular switch directs stress-induced cyclin C nuclear release through SCF
Grr1
-mediated degradation of Med13
. Molecular Biology of the Cell 29:3, pages 363-375.
Crossref
Crossref
Lingyao Kong & Cheng Chang. (2017) Suppression of wheat TaCDK8/TaWIN1 interaction negatively affects germination of Blumeria graminis f.sp. tritici by interfering with very-long-chain aldehyde biosynthesis. Plant Molecular Biology 96:1-2, pages 165-178.
Crossref
Crossref
Xinye Wang, Priya Mittal, Carlos A Castro, Gabriel Rajkovic & Aleksandar Rajkovic. (2017) Med12 regulates ovarian steroidogenesis, uterine development and maternal effects in the mammalian egg†. Biology of Reproduction 97:6, pages 822-834.
Crossref
Crossref
Ryan S Underwood, Yuting Deng & Iva Greenwald. (2017)
Integration of EGFR and LIN-12/Notch Signaling by LIN-1/Elk1, the Cdk8 Kinase Module, and SUR-2/Med23 in Vulval Precursor Cell Fate Patterning in
Caenorhabditis elegans
. Genetics 207:4, pages 1473-1488.
Crossref
Crossref
Bian Wu, Mikołaj Słabicki, Leopold Sellner, Sascha Dietrich, Xiyang Liu, Alexander Jethwa, Jennifer Hüllein, Tatjana Walther, Lena Wagner, Zhiqin Huang, Marc Zapatka & Thorsten Zenz. (2017)
MED12
mutations and NOTCH signalling in chronic lymphocytic leukaemia
. British Journal of Haematology 179:3, pages 421-429.
Crossref
Crossref
Matthew D. Galbraith, Zdenek Andrysik, Ahwan Pandey, Maria Hoh, Elizabeth A. Bonner, Amanda A. Hill, Kelly D. Sullivan & Joaquín M. Espinosa. (2017) CDK8 Kinase Activity Promotes Glycolysis. Cell Reports 21:6, pages 1495-1506.
Crossref
Crossref
Tihana Ibrahimpasic, Bin Xu, Iñigo Landa, Snjezana Dogan, Sumit Middha, Venkatraman Seshan, Shyam Deraje, Diane L. Carlson, Jocelyn Migliacci, Jeffrey A. Knauf, Brian Untch, Michael F. Berger, Luc Morris, R. Michael Tuttle, Timothy Chan, James A. Fagin, Ronald Ghossein & Ian Ganly. (2017)
Genomic Alterations in Fatal Forms of Non-Anaplastic Thyroid Cancer: Identification of
MED12
and
RBM10
as Novel Thyroid Cancer Genes Associated with Tumor Virulence
. Clinical Cancer Research 23:19, pages 5970-5980.
Crossref
Crossref
Célia Jeronimo & François Robert. (2017) The Mediator Complex: At the Nexus of RNA Polymerase II Transcription. Trends in Cell Biology 27:10, pages 765-783.
Crossref
Crossref
Răzvan V. Chereji, Vasudha Bharatula, Nils Elfving, Jeanette Blomberg, Miriam Larsson, Alexandre V. Morozov, James R. Broach & Stefan Björklund. (2017) Mediator binds to boundaries of chromosomal interaction domains and to proteins involved in DNA looping, RNA metabolism, chromatin remodeling, and actin assembly. Nucleic Acids Research 45:15, pages 8806-8821.
Crossref
Crossref
Ivan Krivega & Ann Dean. (2017) LDB1-mediated enhancer looping can be established independent of mediator and cohesin. Nucleic Acids Research 45:14, pages 8255-8268.
Crossref
Crossref
Duane D. Hall, Jessica M. Ponce, Biyi Chen, Kathryn M. Spitler, Adrianne Alexia, Gavin Y. Oudit, Long-Sheng Song & Chad E. Grueter. (2017) Ectopic expression of Cdk8 induces eccentric hypertrophy and heart failure. JCI Insight 2:15.
Crossref
Crossref
Lise-Marie Donnio, Baptiste Bidon, Satoru Hashimoto, Melanie May, Alexey Epanchintsev, Colm Ryan, William Allen, Anna Hackett, Jozef Gecz, Cindy Skinner, Roger E. Stevenson, Arjan P.M. de Brouwer, Charles Coutton, Christine Francannet, Pierre-Simon Jouk, Charles E. Schwartz & Jean-Marc Egly. (2017) MED12-related XLID disorders are dose-dependent of immediate early genes (IEGs) expression. Human Molecular Genetics 26:11, pages 2062-2075.
Crossref
Crossref
Steven R. Whittaker, Aurélie Mallinger, Paul Workman & Paul A. Clarke. (2017) Inhibitors of cyclin-dependent kinases as cancer therapeutics. Pharmacology & Therapeutics 173, pages 83-105.
Crossref
Crossref
Koji Ono, Hiroshi Banno, Masanori Okaniwa, Takaharu Hirayama, Naoki Iwamura, Yukiko Hikichi, Saomi Murai, Maki Hasegawa, Yuka Hasegawa, Kazuko Yonemori, Akito Hata, Kazunobu Aoyama & Douglas R. Cary. (2017) Design and synthesis of selective CDK8/19 dual inhibitors: Discovery of 4,5-dihydrothieno[3′,4′:3,4]benzo[1,2- d ]isothiazole derivatives. Bioorganic & Medicinal Chemistry 25:8, pages 2336-2350.
Crossref
Crossref
Shuo Luo & H. Robert Horvitz. (2017) The CDK8 Complex and Proneural Proteins Together Drive Neurogenesis from a Mesodermal Lineage. Current Biology 27:5, pages 661-672.
Crossref
Crossref
Nam Hee Kim, Carolina B. Livi, P. Renee Yew & Thomas G. Boyer. (2016) Mediator subunit Med12 contributes to the maintenance of neural stem cell identity. BMC Developmental Biology 16:1.
Crossref
Crossref
Beatriz Aranda-Orgilles, Ricardo Saldaña-Meyer, Eric Wang, Eirini Trompouki, Anne Fassl, Stephanie Lau, Jasper Mullenders, Pedro P. Rocha, Ramya Raviram, María Guillamot, María Sánchez-Díaz, Kun Wang, Clarisse Kayembe, Nan Zhang, Leonela Amoasii, Avik Choudhuri, Jane A. Skok, Markus Schober, Danny Reinberg, Piotr Sicinski, Heinrich Schrewe, Aristotelis Tsirigos, Leonard I. Zon & Iannis Aifantis. (2016) MED12 Regulates HSC-Specific Enhancers Independently of Mediator Kinase Activity to Control Hematopoiesis. Cell Stem Cell 19:6, pages 784-799.
Crossref
Crossref
Priya Mittal, Xinye Wang & Aleksandar Rajkovic. (2016) The Role of Mediator Complex Subunit 12 in Leiomyoma Biology. Current Genetic Medicine Reports 4:4, pages 196-206.
Crossref
Crossref
Dou Yeon Youn, Alus M. Xiaoli, Jeffrey E. Pessin & Fajun Yang. (2016) Regulation of metabolism by the Mediator complex. Biophysics Reports 2:2-4, pages 69-77.
Crossref
Crossref
Babajan Banaganapalli, Kaleemuddin Mohammed, Imran Ali Khan, Jumana Y. Al-Aama, Ramu Elango & Noor Ahmad Shaik. (2016) A Computational Protein Phenotype Prediction Approach to Analyze the Deleterious Mutations of Human MED12 Gene. Journal of Cellular Biochemistry 117:9, pages 2023-2035.
Crossref
Crossref
Ayman Al-Hendy, Michael P. Diamond, Thomas G. Boyer & Sunil K. Halder. (2016) Vitamin D3 Inhibits Wnt/β-Catenin and mTOR Signaling Pathways in Human Uterine Fibroid Cells. The Journal of Clinical Endocrinology & Metabolism 101:4, pages 1542-1551.
Crossref
Crossref
Yinü LiFeng JiangXiaofeng ShiXingjian LiuHuipeng YangZhifang Zhang. (2016)
Identification and Characterization of the
Cyclin-Dependent Kinases
Gene Family in Silkworm,
Bombyx mori
. DNA and Cell Biology 35:1, pages 13-23.
Crossref
Crossref
Jong Chan Hong. 2016. Plant Transcription Factors. Plant Transcription Factors
35
56
.
Cameron A. Rogers & Catherine J. Pallen. 2016. Protein Tyrosine Phosphatases in Cancer. Protein Tyrosine Phosphatases in Cancer
261
282
.
MingHua Li, LinLi Tian, Hui Ren, XiaoXue Chen, Yu Wang, JingChun Ge, ShuLiang Wu, YaNan Sun, Ming Liu & Hui Xiao. (2015) MicroRNA-101 is a potential prognostic indicator of laryngeal squamous cell carcinoma and modulates CDK8. Journal of Translational Medicine 13:1.
Crossref
Crossref
Lu WangHao ZengQiang WangZibo ZhaoThomas G. BoyerXiuwu BianWei Xu. (2015) MED12 methylation by CARM1 sensitizes human breast cancer cells to chemotherapy drugs. Science Advances 1:9.
Crossref
Crossref
Henry E. Pelish, Brian B. Liau, Ioana I. Nitulescu, Anupong Tangpeerachaikul, Zachary C. Poss, Diogo H. Da Silva, Brittany T. Caruso, Alexander Arefolov, Olugbeminiyi Fadeyi, Amanda L. Christie, Karrie Du, Deepti Banka, Elisabeth V. Schneider, Anja Jestel, Ge Zou, Chong Si, Christopher C. Ebmeier, Roderick T. Bronson, Andrei V. Krivtsov, Andrew G. Myers, Nancy E. Kohl, Andrew L. Kung, Scott A. Armstrong, Madeleine E. Lemieux, Dylan J. Taatjes & Matthew D. Shair. (2015) Mediator kinase inhibition further activates super-enhancer-associated genes in AML. Nature 526:7572, pages 273-276.
Crossref
Crossref
Tomasz Rzymski, Michał Mikula, Katarzyna Wiklik & Krzysztof Brzózka. (2015) CDK8 kinase—An emerging target in targeted cancer therapy. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1854:10, pages 1617-1629.
Crossref
Crossref
Sabrina Croce & Frédéric Chibon. (2015) MED12 and uterine smooth muscle oncogenesis: State of the art and perspectives. European Journal of Cancer 51:12, pages 1603-1610.
Crossref
Crossref
Xiao-Jun Xie, Fu-Ning Hsu, Xinsheng Gao, Wu Xu, Jian-Quan Ni, Yue Xing, Liying Huang, Hao-Ching Hsiao, Haiyan Zheng, Chenguang Wang, Yani Zheng, Alus M. Xiaoli, Fajun Yang, Sarah E. Bondos & Jun-Yuan Ji. (2015) CDK8-Cyclin C Mediates Nutritional Regulation of Developmental Transitions through the Ecdysone Receptor in Drosophila. PLOS Biology 13:7, pages e1002207.
Crossref
Crossref
Sebastian Wienerroither, Priyank Shukla, Matthias Farlik, Andrea Majoros, Bernadette Stych, Claus Vogl, HyeonJoo Cheon, George R. Stark, Birgit Strobl, Mathias Müller & Thomas Decker. (2015) Cooperative Transcriptional Activation of Antimicrobial Genes by STAT and NF-κB Pathways by Concerted Recruitment of the Mediator Complex. Cell Reports 12:2, pages 300-312.
Crossref
Crossref
Jehad Shaikhali, Céline Davoine, Kristoffer Brännström, Nicolas Rouhier, Joakim Bygdell, Stefan Björklund & Gunnar Wingsle. (2015) Biochemical and redox characterization of the mediator complex and its associated transcription factor GeBPL, a GLABROUS1 enhancer binding protein. Biochemical Journal 468:3, pages 385-400.
Crossref
Crossref
Claire H. Birkenheuer, Connie D. Brewster, Sandra L. Quackenbush & Joel Rovnak. (2015) Retroviral Cyclin Controls Cyclin-Dependent Kinase 8-Mediated Transcription Elongation and Reinitiation. Journal of Virology 89:10, pages 5450-5461.
Crossref
Crossref
Benjamin L. Allen & Dylan J. Taatjes. (2015) The Mediator complex: a central integrator of transcription. Nature Reviews Molecular Cell Biology 16:3, pages 155-166.
Crossref
Crossref
Subhasis Samanta & Jitendra Kumar Thakur. 2015. Elucidation of Abiotic Stress Signaling in Plants. Elucidation of Abiotic Stress Signaling in Plants
3
28
.
Yingfang Zhu, Craig M. Schluttenhoffer, Pengcheng Wang, Fuyou Fu, Jyothi Thimmapuram, Jian-Kang Zhu, Sang Yeol Lee, Dae-Jin Yun & Tesfaye Mengiste. (2014)
CYCLIN-DEPENDENT KINASE8 Differentially Regulates Plant Immunity to Fungal Pathogens through Kinase-Dependent and -Independent Functions in
Arabidopsis
. The Plant Cell 26:10, pages 4149-4170.
Crossref
Crossref
Svetlana Khakhina, Katrina F. Cooper & Randy Strich. (2014) Med13p prevents mitochondrial fission and programmed cell death in yeast through nuclear retention of cyclin C. Molecular Biology of the Cell 25:18, pages 2807-2816.
Crossref
Crossref
Miika Mehine, Netta Mäkinen, Hanna-Riikka Heinonen, Lauri A. Aaltonen & Pia Vahteristo. (2014) Genomics of uterine leiomyomas: insights from high-throughput sequencing. Fertility and Sterility 102:3, pages 621-629.
Crossref
Crossref
Zaki Shaikhibrahim, Anne Offermann, Martin Braun, Roopika Menon, Isabella Syring, Michael Nowak, Rebecca Halbach, Wenzel Vogel, Christian Ruiz, Tobias Zellweger, Cyrill A Rentsch, Maria Svensson, Ove Andren, Lukas Bubendorf, Saskia Biskup, Stefan Duensing, Jutta Kirfel & Sven Perner. (2014) MED12 overexpression is a frequent event in castration-resistant prostate cancer. Endocrine-Related Cancer 21:4, pages 663-675.
Crossref
Crossref
Monica Rienzo, Valerio Costa, Margherita Scarpato, Concetta Schiano, Amelia Casamassimi, Vincenzo Grimaldi, Alfredo Ciccodicola & Claudio Napoli. (2014) RNA-Seq for the identification of novel Mediator transcripts in endothelial progenitor cells. Gene 547:1, pages 98-105.
Crossref
Crossref
Mikko Turunen, Jason M. Spaeth, Salla Keskitalo, Min Ju Park, Teemu Kivioja, Alison D. Clark, Netta Mäkinen, Fangjian Gao, Kimmo Palin, Helka Nurkkala, Anna Vähärautio, Mervi Aavikko, Kati Kämpjärvi, Pia Vahteristo, Chongwoo A. Kim, Lauri A. Aaltonen, Markku Varjosalo, Jussi Taipale & Thomas G. Boyer. (2014) Uterine Leiomyoma-Linked MED12 Mutations Disrupt Mediator-Associated CDK Activity. Cell Reports 7:3, pages 654-660.
Crossref
Crossref
N Mäkinen, H-R Heinonen, J Sjöberg, J Taipale, P Vahteristo & L A Aaltonen. (2014) Mutation analysis of components of the Mediator kinase module in MED12 mutation-negative uterine leiomyomas. British Journal of Cancer 110:9, pages 2246-2249.
Crossref
Crossref
Joseph Rosenbluh, Xiaoxing Wang & William C. Hahn. (2014) Genomic insights into WNT/β-catenin signaling. Trends in Pharmacological Sciences 35:2, pages 103-109.
Crossref
Crossref
Josipa Nemet, Branka Jelicic, Ivica Rubelj & Mary Sopta. (2014) The two faces of Cdk8, a positive/negative regulator of transcription. Biochimie 97, pages 22-27.
Crossref
Crossref
Neus Serrat, Carlos Sebastian, Selma Pereira-Lopes, Lorena Valverde-Estrella, Jorge Lloberas & Antonio Celada. (2014) The Response of Secondary Genes to Lipopolysaccharides in Macrophages Depends on Histone Deacetylase and Phosphorylation of C/EBPβ. The Journal of Immunology 192:1, pages 418-426.
Crossref
Crossref
Concetta Schiano, Amelia Casamassimi, Monica Rienzo, Filomena de Nigris, Linda Sommese & Claudio Napoli. (2014) Involvement of Mediator complex in malignancy. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1845:1, pages 66-83.
Crossref
Crossref
Chenguang Wang, Jun-Yuan Ji, Lifeng Tian & Richard G. Pestell. 2014. Nuclear Signaling Pathways and Targeting Transcription in Cancer. Nuclear Signaling Pathways and Targeting Transcription in Cancer
259
275
.
Xuejuan Wang, Jianye Wang, Zhenrui Ding, Jinhua Ji, Qianqian Sun & Gang Cai. (2013) Structural flexibility and functional interaction of mediator Cdk8 module. Protein & Cell 4:12, pages 911-920.
Crossref
Crossref
Jeffry L. Corden. (2013) RNA Polymerase II C-Terminal Domain: Tethering Transcription to Transcript and Template. Chemical Reviews 113:11, pages 8423-8455.
Crossref
Crossref
Célia Jeronimo, Alain R. Bataille & François Robert. (2013) The Writers, Readers, and Functions of the RNA Polymerase II C-Terminal Domain Code. Chemical Reviews 113:11, pages 8491-8522.
Crossref
Crossref
Jiannan Guo & David H. Price. (2013) RNA Polymerase II Transcription Elongation Control. Chemical Reviews 113:11, pages 8583-8603.
Crossref
Crossref
Netta Mäkinen, Pia Vahteristo, Kati Kämpjärvi, Johanna Arola, Ralf Bützow & Lauri A Aaltonen. (2013) MED12 exon 2 mutations in histopathological uterine leiomyoma variants. European Journal of Human Genetics 21:11, pages 1300-1303.
Crossref
Crossref
Zsolt Szilagyi & Claes M. Gustafsson. (2013) Emerging roles of Cdk8 in cell cycle control. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1829:9, pages 916-920.
Crossref
Crossref
Hua Wang, Qin Shen, Li-hua Ye & Jun Ye. (2013) MED12 mutations in human diseases. Protein & Cell 4:9, pages 643-646.
Crossref
Crossref
Marieke A. de Graaff, Anne-Marie Cleton-Jansen, Károly Szuhai & Judith V.M.G. Bovée. (2013) Mediator complex subunit 12 exon 2 mutation analysis in different subtypes of smooth muscle tumors confirms genetic heterogeneity. Human Pathology 44:8, pages 1597-1604.
Crossref
Crossref
Pei-Yin Hsu, Hang-Kai Hsu, Xun Lan, Liran Juan, Pearlly S. Yan, Jadwiga Labanowska, Nyla Heerema, Tzu-Hung Hsiao, Yu-Chiao Chiu, Yidong Chen, Yunlong Liu, Lang Li, Rong Li, Ian M. Thompson, Kenneth P. Nephew, Zelton D. Sharp, Nameer B. Kirma, Victor X. Jin & Tim H.-M. Huang. (2013) Amplification of Distant Estrogen Response Elements Deregulates Target Genes Associated with Tamoxifen Resistance in Breast Cancer. Cancer Cell 24:2, pages 197-212.
Crossref
Crossref
J Zhao, R Ramos & M Demma. (2012) CDK8 regulates E2F1 transcriptional activity through S375 phosphorylation. Oncogene 32:30, pages 3520-3530.
Crossref
Crossref
Matthew D. Galbraith, Mary A. Allen, Claire L. Bensard, Xiaoxing Wang, Marie K. Schwinn, Bo Qin, Henry W. Long, Danette L. Daniels, William C. Hahn, Robin D. Dowell & Joaquín M. Espinosa. (2013) HIF1A Employs CDK8-Mediator to Stimulate RNAPII Elongation in Response to Hypoxia. Cell 153:6, pages 1327-1339.
Crossref
Crossref
Kuang-Lei Tsai, Shigeo Sato, Chieri Tomomori-Sato, Ronald C Conaway, Joan W Conaway & Francisco J Asturias. (2013) A conserved Mediator–CDK8 kinase module association regulates Mediator–RNA polymerase II interaction. Nature Structural & Molecular Biology 20:5, pages 611-619.
Crossref
Crossref
Gloria Ravegnini, Adrian Mariño-Enriquez, Jaime Slater, Grant Eilers, Yuexiang Wang, Meijun Zhu, Marisa R Nucci, Suzanne George, Sabrina Angelini, Chandrajit P Raut & Jonathan A Fletcher. (2013) MED12 mutations in leiomyosarcoma and extrauterine leiomyoma. Modern Pathology 26:5, pages 743-749.
Crossref
Crossref
Andreas Steimel, Jinkyo Suh, Angela Hussainkhel, Samineh Deheshi, Jennifer M. Grants, Richard Zapf, Donald G. Moerman, Stefan Taubert & Harald Hutter. (2013) The C. elegans CDK8 Mediator module regulates axon guidance decisions in the ventral nerve cord and during dorsal axon navigation. Developmental Biology 377:2, pages 385-398.
Crossref
Crossref
Michael R. Vogl, Simone Reiprich, Melanie Küspert, Thomas Kosian, Heinrich Schrewe, Klaus-Armin Nave & Michael Wegner. (2013) Sox10 Cooperates with the Mediator Subunit 12 during Terminal Differentiation of Myelinating Glia. The Journal of Neuroscience 33:15, pages 6679-6690.
Crossref
Crossref
Fan Lai, Ulf A. Orom, Matteo Cesaroni, Malte Beringer, Dylan J. Taatjes, Gerd A. Blobel & Ramin Shiekhattar. (2013) Activating RNAs associate with Mediator to enhance chromatin architecture and transcription. Nature 494:7438, pages 497-501.
Crossref
Crossref
Joanna Bancerek, Zachary C. Poss, Iris Steinparzer, Vitaly Sedlyarov, Thaddäus Pfaffenwimmer, Ivana Mikulic, Lars Dölken, Birgit Strobl, Mathias Müller, Dylan J. Taatjes & Pavel Kovarik. (2013) CDK8 Kinase Phosphorylates Transcription Factor STAT1 to Selectively Regulate the Interferon Response. Immunity 38:2, pages 250-262.
Crossref
Crossref
Jiandong Chen, Nader Ezzeddine, Bernhard Waltenspiel, Todd R. Albrecht, William D. Warren, William F. Marzluff & Eric J. Wagner. (2012)
An RNAi screen identifies additional members of the
Drosophila
Integrator complex and a requirement for cyclin C/Cdk8 in snRNA 3′-end formation
. RNA 18:12, pages 2148-2156.
Crossref
Crossref
K Kämpjärvi, N Mäkinen, O Kilpivaara, J Arola, H-R Heinonen, J Böhm, O Abdel-Wahab, H J Lehtonen, L M Pelttari, M Mehine, H Schrewe, H Nevanlinna, R L Levine, P Hokland, T Böhling, J-P Mecklin, R Bützow, L A Aaltonen & P Vahteristo. (2012) Somatic MED12 mutations in uterine leiomyosarcoma and colorectal cancer. British Journal of Cancer 107:10, pages 1761-1765.
Crossref
Crossref
Xiaoping Zhao, Daorong Feng, Qun Wang, Arian Abdulla, Xiao-Jun Xie, Jie Zhou, Yan Sun, Ellen S. Yang, Lu-Ping Liu, Bhavapriya Vaitheesvaran, Lauren Bridges, Irwin J. Kurland, Randy Strich, Jian-Quan Ni, Chenguang Wang, Johan Ericsson, Jeffrey E. Pessin, Jun-Yuan Ji & Fajun Yang. (2012) Regulation of lipogenesis by cyclin-dependent kinase 8–mediated control of SREBP-1. Journal of Clinical Investigation 122:7, pages 2417-2427.
Crossref
Crossref
Joel Rovnak, Connie D. Brewster & Sandra L. Quackenbush. (2012) Retroviral Cyclin Enhances Cyclin-Dependent Kinase-8 Activity. Journal of Virology 86:10, pages 5742-5751.
Crossref
Crossref
Adam S. Adler, Mark L. McCleland, Tom Truong, Shari Lau, Zora Modrusan, Tim M. Soukup, Merone Roose-Girma, Elizabeth M. Blackwood & Ron Firestein. (2012) CDK8 Maintains Tumor Dedifferentiation and Embryonic Stem Cell Pluripotency. Cancer Research 72:8, pages 2129-2139.
Crossref
Crossref
Megan M. McGuire, Alexander Yatsenko, Lori Hoffner, Mirka Jones, Urvashi Surti & Aleksandar Rajkovic. (2012) Whole Exome Sequencing in a Random Sample of North American Women with Leiomyomas Identifies MED12 Mutations in Majority of Uterine Leiomyomas. PLoS ONE 7:3, pages e33251.
Crossref
Crossref
P. Blazsó, Ildikó Sinkó, Tünde Praznovszky, G. Hadlaczky & R. Katona. (2012) 3.6-KB mouse cyclin C promoter fragment is predominantly active in the testis. Acta Biologica Hungarica 63:1, pages 26-37.
Crossref
Crossref
Claudio Napoli, Marcella Sessa, Teresa Infante & Amelia Casamassimi. (2012) Unraveling framework of the ancestral Mediator complex in human diseases. Biochimie 94:3, pages 579-587.
Crossref
Crossref
Katrina F. Cooper, Matthew S. Scarnati, Elizabeth Krasley, Michael J. Mallory, Chunyan Jin, Michael J. Law & Randy Strich. (2012) Oxidative-stress-induced nuclear to cytoplasmic relocalization is required for Not4-dependent cyclin C destruction. Journal of Cell Science 125:4, pages 1015-1026.
Crossref
Crossref
Nadia Boutry-Kryza, Audrey Labalme, Marianne Till, Caroline Schluth-Bolard, Jacques Langue, Catherine Turleau, Patrick Edery & Damien Sanlaville. (2012) An 800 kb deletion at 17q23.2 including the MED13 (THRAP1) gene, revealed by aCGH in a patient with a SMC 17p. American Journal of Medical Genetics Part A 158A:2, pages 400-405.
Crossref
Crossref
Wu Xu & Jun-Yuan Ji. (2011) Dysregulation of CDK8 and Cyclin C in tumorigenesis. Journal of Genetics and Genomics 38:10, pages 439-452.
Crossref
Crossref
Jason M. Spaeth, Nam Hee Kim & Thomas G. Boyer. (2011) Mediator and human disease. Seminars in Cell & Developmental Biology 22:7, pages 776-787.
Crossref
Crossref
Tilman Borggrefe & Xiaojing Yue. (2011) Interactions between subunits of the Mediator complex with gene-specific transcription factors. Seminars in Cell & Developmental Biology 22:7, pages 759-768.
Crossref
Crossref
Brendan N. Kidd, David M. Cahill, John M. Manners, Peer M. Schenk & Kemal Kazan. (2011) Diverse roles of the Mediator complex in plants. Seminars in Cell & Developmental Biology 22:7, pages 741-748.
Crossref
Crossref
E.V. Schneider, J. Böttcher, M. Blaesse, L. Neumann, R. Huber & K. Maskos. (2011) The Structure of CDK8/CycC Implicates Specificity in the CDK/Cyclin Family and Reveals Interaction with a Deep Pocket Binder. Journal of Molecular Biology 412:2, pages 251-266.
Crossref
Crossref
P Rump, RC Niessen, KT Verbruggen, OF Brouwer, M de Raad & R Hordijk. (2011) A novel mutation in MED12 causes FG syndrome (Opitz-Kaveggia syndrome). Clinical Genetics 79:2, pages 183-188.
Crossref
Crossref
PS Lagali, CP Corcoran & DJ Picketts. (2010) Hippocampus development and function: role of epigenetic factors and implications for cognitive disease. Clinical Genetics 78:4, pages 321-333.
Crossref
Crossref
Arijit Mukhopadhyay, Jamie M. Kramer, Gerard Merkx, Dorien Lugtenberg, Dominique F. Smeets, Merel A. W. Oortveld, Ellen A. W. Blokland, Jyoti Agrawal, Annette Schenck, Hans van Bokhoven, Erik Huys, Eric F. Schoenmakers, Ad Geurts van Kessel, C. Erik van Nouhuys & Frans P. M. Cremers. (2010) CDK19 is disrupted in a female patient with bilateral congenital retinal folds, microcephaly and mild mental retardation. Human Genetics 128:3, pages 281-291.
Crossref
Crossref
Pedro P. RochaManuela ScholzeWilfrid BleißHeinrich Schrewe. (2010) Med12 is essential for early mouse development and for canonical Wnt and Wnt/PCP signaling. Development 137:16, pages 2723-2731.
Crossref
Crossref
Hans van Bokhoven & Jamie M. Kramer. (2010) Disruption of the epigenetic code: An emerging mechanism in mental retardation. Neurobiology of Disease 39:1, pages 3-12.
Crossref
Crossref
Christopher C. Ebmeier & Dylan J. Taatjes. (2010) Activator-Mediator binding regulates Mediator-cofactor interactions. Proceedings of the National Academy of Sciences 107:25, pages 11283-11288.
Crossref
Crossref
Dylan J. Taatjes. (2010) The human Mediator complex: a versatile, genome-wide regulator of transcription. Trends in Biochemical Sciences 35:6, pages 315-322.
Crossref
Crossref
Nathan P. Gomes & Joaquín M. Espinosa. (2010) Gene-specific repression of the p53 target gene PUMA via intragenic CTCF–Cohesin binding. Genes & Development 24:10, pages 1022-1034.
Crossref
Crossref
David M. Greene, Duen-Wei Hsu & Catherine J. Pears. (2010) Control of Cyclin C Levels during Development of Dictyostelium. PLoS ONE 5:5, pages e10543.
Crossref
Crossref
Aaron J Donner, Christopher C Ebmeier, Dylan J Taatjes & Joaquín M Espinosa. (2010) CDK8 is a positive regulator of transcriptional elongation within the serum response network. Nature Structural & Molecular Biology 17:2, pages 194-201.
Crossref
Crossref
Jun-Yuan Ji & Nicholas J. Dyson. 2010. Cell Cycle Deregulation in Cancer. Cell Cycle Deregulation in Cancer
23
41
.
Natalia V. Kirienko, Kumaran Mani & David S. Fay. (2010)
Cancer models in
Caenorhabditis elegans
. Developmental Dynamics, pages NA-NA.
Crossref
Crossref
Ron Firestein & William C. Hahn. (2009) Revving the Throttle on an Oncogene: CDK8 Takes the Driver Seat. Cancer Research 69:20, pages 7899-7901.
Crossref
Crossref
Rachel Beckerman, Aaron J. Donner, Melissa Mattia, Melissa J. Peart, James L. Manley, Joaquin M. Espinosa & Carol Prives. (2009) A role for Chk1 in blocking transcriptional elongation of p21 RNA during the S-phase checkpoint. Genes & Development 23:11, pages 1364-1377.
Crossref
Crossref
Matthew T. Knuesel, Krista D. Meyer, Carrie Bernecky & Dylan J. Taatjes. (2009) The human CDK8 subcomplex is a molecular switch that controls Mediator coactivator function. Genes & Development 23:4, pages 439-451.
Crossref
Crossref
Christopher Ebmeier, Benjamin Erickson, Benjamin Allen, Mary Allen, Hyunmin Kim, Nova Fong, Jeremy Jacobsen, Kaiwei Liang, Ali Shilatifard, Robin Dowell, William Old, David Bentley & Dylan J. Taatjes. (2018) Human TFIIH Kinase CDK7 Regulates Transcription-Associated Epigenetic Modifications. SSRN Electronic Journal.
Crossref
Crossref