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Molecular and Cellular Biology Volume 17, 1997 - Issue 3
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Research Article

Antiapoptotic Signalling by the Insulin-Like Growth Factor I Receptor, Phosphatidylinositol 3-Kinase, and Akt

George KulikDepartment of Microbiology and Cancer Center, University of Virginia Health Sciences Center, Charlottesville, Virginia22908
,
Anke KlippelChiron Corporation, Emeryville, California94608
&
Michael J. WeberDepartment of Microbiology and Cancer Center, University of Virginia Health Sciences Center, Charlottesville, Virginia22908Correspondence[email protected]
Pages 1595-1606 | Received 23 Sep 1996, Accepted 18 Dec 1996, Published online: 29 Mar 2023

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Sheida Torabi & Nancy M DiMarco. (2016) Original Research: Polyphenols extracted from grape powder induce lipogenesis and glucose uptake during differentiation of murine preadipocytes. Experimental Biology and Medicine 241:16, pages 1776-1785.
Crossref
Pasquale Molinaro, Rossana Sirabella, Giuseppe Pignataro, Tiziana Petrozziello, Agnese Secondo, Francesca Boscia, Antonio Vinciguerra, Ornella Cuomo, Kenneth D Philipson, Mario De Felice, Roberto Di Lauro, Gianfranco Di Renzo & Lucio Annunziato. (2016) Neuronal NCX1 overexpression induces stroke resistance while knockout induces vulnerability via Akt. Journal of Cerebral Blood Flow & Metabolism 36:10, pages 1790-1803.
Crossref
Wing Yan So & Po Sing Leung. (2016) Irisin ameliorates hepatic glucose/lipid metabolism and enhances cell survival in insulin-resistant human HepG2 cells through adenosine monophosphate-activated protein kinase signaling. The International Journal of Biochemistry & Cell Biology 78, pages 237-247.
Crossref
Young Soo Park, Dong Joon Kim, Han Koo, Se Hwan Jang, Yeon-Mi You, Jung Hee Cho, Suk-Jin Yang, Eun Sil Yu, Yuri Jung, Dong Chul Lee, Jung-Ae Kim, Zee-Yong Park, Kyung Chan Park & Young Il Yeom. (2016) AKT-induced PKM2 phosphorylation signals for IGF-1-stimulated cancer cell growth. Oncotarget 7:30, pages 48155-48167.
Crossref
Qiang Zhang, Meimei Wan, Jinming Shi, David A. Horita, Lance D. Miller, Timothy E. Kute, Steven J. Kridel, George Kulik & Guangchao Sui. (2016) Yin Yang 1 promotes mTORC2-mediated AKT phosphorylation. Journal of Molecular Cell Biology 8:3, pages 232-243.
Crossref
Serena Vella, Alessia Gallo, Antonio Lo Nigro, Daniele Galvagno, Giuseppe Maria Raffa, Michele Pilato & Pier Giulio Conaldi. (2016) PIWI-interacting RNA (piRNA) signatures in human cardiac progenitor cells. The International Journal of Biochemistry & Cell Biology 76, pages 1-11.
Crossref
Yoshitomo Yanagimoto, Shuji Takiguchi, Yasuhiro Miyazaki, Tomoki Makino, Tsuyoshi Takahashi, Yukinori Kurokawa, Makoto Yamasaki, Hiroshi Miyata, Kiyokazu Nakajima, Hiroshi Hosoda, Kenji Kangawa, Masaki Mori & Yuichiro Doki. (2016) Improvement of cisplatin-related renal dysfunction by synthetic ghrelin: a prospective randomised phase II trial. British Journal of Cancer 114:12, pages 1318-1325.
Crossref
Marta Vieira, Sónia S. Leal, Cláudio M. Gomes & Maria João Saraiva. (2016) Evidence for synergistic action of transthyretin and IGF-I over the IGF-I receptor. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1862:4, pages 797-804.
Crossref
Han WangWeiwei Gao. (2016) DJ-1 Expression in Cervical Carcinoma and its Effects on Cell Viability and Apoptosis. Medical Science Monitor 22, pages 2943-2949.
Crossref
Mohamed Salah I Abaza, Khaled Y Orabi, Ebtehal Al-Quattan & Raja’a J Al-Attiyah. (2015) Growth inhibitory and chemo-sensitization effects of naringenin, a natural flavanone purified from Thymus vulgaris, on human breast and colorectal cancer. Cancer Cell International 15:1.
Crossref
Jeney Ramírez-Sánchez, Elisa Nicoloso Simões Pires, Yanier Nuñez-Figueredo, Gilberto L. Pardo-Andreu, Luis Arturo Fonseca-Fonseca, Alberto Ruiz-Reyes, Estael Ochoa-Rodríguez, Yamila Verdecia-Reyes, René Delgado-Hernández, Diogo O. Souza & Christianne Salbego. (2015) Neuroprotection by JM-20 against oxygen-glucose deprivation in rat hippocampal slices: Involvement of the Akt/GSK-3β pathway. Neurochemistry International 90, pages 215-223.
Crossref
Kujaany KanaHannah SongCarol LaschingerPeter W. ZandstraMilica Radisic. (2015) PI3K Phosphorylation Is Linked to Improved Electrical Excitability in an In Vitro Engineered Heart Tissue Disease Model System . Tissue Engineering Part A 21:17-18, pages 2379-2389.
Crossref
Sajad A. War, Brian Kim & Ujendra Kumar. (2015) Human somatostatin receptor-3 distinctively induces apoptosis in MCF-7 and cell cycle arrest in MDA-MB-231 breast cancer cells. Molecular and Cellular Endocrinology 413, pages 129-144.
Crossref
Yao-Chang Chen, Zhi-Hong Wen, Yen-Hsien Lee, Chu-Lun Chen, Han-Chun Hung, Chun-Hong Chen, Wu-Fu Chen & Min-Chien Tsai. (2015) Dihydroaustrasulfone Alcohol Inhibits PDGF-Induced Proliferation and Migration of Human Aortic Smooth Muscle Cells through Inhibition of the Cell Cycle. Marine Drugs 13:4, pages 2390-2406.
Crossref
C F de la Cruz-Herrera, M Campagna, V Lang, J del Carmen González-Santamaría, L Marcos-Villar, M S Rodríguez, A Vidal, M Collado & C Rivas. (2014) SUMOylation regulates AKT1 activity. Oncogene 34:11, pages 1442-1450.
Crossref
Christina M. Jones, María Eugenia Monge, Jaeyeon Kim, Martin M. Matzuk & Facundo M. Fernández. (2015) Metabolomic Serum Profiling Detects Early-Stage High-Grade Serous Ovarian Cancer in a Mouse Model. Journal of Proteome Research 14:2, pages 917-927.
Crossref
Yoshinori Imura, Hirohiko Yasui, Hidetatsu Outani, Toru Wakamatsu, Kenichiro Hamada, Takaaki Nakai, Shutaro Yamada, Akira Myoui, Nobuhito Araki, Takafumi Ueda, Kazuyuki Itoh, Hideki Yoshikawa & Norifumi Naka. (2014) Combined targeting of mTOR and c-MET signaling pathways for effective management of epithelioid sarcoma. Molecular Cancer 13:1.
Crossref
Bo Li, Jian Sun, Guoyi Lv, Yonghao Yu, Guolin Wang, Keliang Xie, Yang Jiao & Yang Yu. (2014) Sevoflurane postconditioning attenuates cerebral ischemia‐reperfusion injury via protein kinase B/nuclear factor‐erythroid 2‐related factor 2 pathway activation. International Journal of Developmental Neuroscience 38:1, pages 79-86.
Crossref
Marzieh Badinloo & Saeed Esmaeili-Mahani. (2014) Phosphatidylinositol 3-kinases inhibitor LY294002 potentiates the cytotoxic effects of doxorubicin, vincristine, and etoposide in a panel of cancer cell lines. Fundamental & Clinical Pharmacology 28:4, pages 414-422.
Crossref
Fares Bassil, Pierre-Olivier Fernagut, Erwan Bezard & Wassilios G. Meissner. (2014) Insulin, IGF-1 and GLP-1 signaling in neurodegenerative disorders: Targets for disease modification?. Progress in Neurobiology 118, pages 1-18.
Crossref
Muneeb A. Faiq, Rima Dada, Daman Saluja & Tanuj Dada. (2014) Glaucoma – Diabetes of the brain: A radical hypothesis about its nature and pathogenesis. Medical Hypotheses 82:5, pages 535-546.
Crossref
Ted Weita Lai, Shu Zhang & Yu Tian Wang. (2014) Excitotoxicity and stroke: Identifying novel targets for neuroprotection. Progress in Neurobiology 115, pages 157-188.
Crossref
Seok Joo ParkYoon Hee ChungJeong Hyun LeeDuy-Khanh DangYunsung NamJi Hoon JeongYong Sun KimToshitaka NabeshimaEun-Joo ShinHyoung-Chun Kim. (2014) Growth Hormone-Releaser Diet Attenuates Cognitive Dysfunction in Klotho Mutant Mice via Insulin-Like Growth Factor-1 Receptor Activation in a Genetic Aging Model. Endocrinology and Metabolism 29:3, pages 336.
Crossref
Dongye Li, Xueyou Jiang, Tongda Xu, Jiantao Song, Hong zhu & Yuanyuan Luo. 2014. Frontier and Future Development of Information Technology in Medicine and Education. Frontier and Future Development of Information Technology in Medicine and Education 1 9 .
Mi Kwon Son, Ye-Lim Ryu, Kyung Hee Jung, Hyunseung Lee, Hee Seung Lee, Hong Hua Yan, Heon Joo Park, Ji-Kan Ryu, Jun–Kyu Suh, Sungwoo Hong & Soon-Sun Hong. (2013) HS-173, a Novel PI3K Inhibitor, Attenuates the Activation of Hepatic Stellate Cells in Liver Fibrosis. Scientific Reports 3:1.
Crossref
Maite Solas & Maria J. Ramírez. 2013. Metabolic Syndrome and Neurological Disorders. Metabolic Syndrome and Neurological Disorders 115 135 .
Sazzad Hassan, Yelena Karpova, Anabel Flores, Ralph D’Agostino & George Kulik. (2013) Surgical Stress Delays Prostate Involution in Mice. PLoS ONE 8:11, pages e78175.
Crossref
Rocío Gallego-Durán, Javier Ampuero, Jorge Funuyet & Manuel Romero-Gómez. (2013) Esteatohepatitis alcohólica y no alcohólica: ¿quiénes son los pacientes y qué podemos hacer por ellos?. Gastroenterología y Hepatología 36:9, pages 587-596.
Crossref
Dana Yancey, Kyle C. Nelson, Daniele Baiz, Sazzad Hassan, Anabel Flores, Ashok Pullikuth, Yelena Karpova, Linara Axanova, Victoria Moore, Guangchao Sui & George Kulik. (2013) BAD Dephosphorylation and Decreased Expression of MCL-1 Induce Rapid Apoptosis in Prostate Cancer Cells. PLoS ONE 8:9, pages e74561.
Crossref
RM Castilho, CH Squarize & JS Gutkind. (2013) Exploiting PI3K/mTOR signaling to accelerate epithelial wound healing. Oral Diseases 19:6, pages 551-558.
Crossref
Yang Liu, Zhao Zhao, Fan Yang, Yimei Gao, Jian Song & Yu Wan. (2013) microRNA-181a is involved in insulin-like growth factor-1-mediated regulation of the transcription factor CREB1. Journal of Neurochemistry 126:6, pages 771-780.
Crossref
XIN LI, ZENGXIA LI, NA LI, JINGJING QI, KUN FAN, PENG YIN, CHAO ZHAO, YONGLEI LIU, WANTONG YAO, XIUMEI CAI, LIYING WANG & XILIANG ZHA. (2013) MAGI2 enhances the sensitivity of BEL-7404 human hepatocellular carcinoma cells to staurosporine-induced apoptosis by increasing PTEN stability. International Journal of Molecular Medicine 32:2, pages 439-447.
Crossref
KYUNG HEE JUNG, YE-LIM RYU, HEE-SEUNG LEE, HYUNSEUNG LEE, MI KWON SON, HONG HUA YAN, SANG-WON HONG, JI-KAN RYU, SUNGWOO HONG, JUN-KYU SUH & SOON-SUN HONG. (2013) A novel PI3K inhibitor alleviates fibrotic responses in fibroblasts derived from Peyronie’s plaques. International Journal of Oncology 42:6, pages 2001-2008.
Crossref
Young-Ah Suh, Jai-Hyun Kim, Myung A Sung, Hye-Jin Boo, Hye Jeong Yun, Sun-Hye Lee, Hyo-Jong Lee, Hye-Young Min, Young-Ger Suh, Kyu-Won Kim & Ho-Young Lee. (2013) A novel antitumor activity of deguelin targeting the insulin-like growth factor (IGF) receptor pathway via up-regulation of IGF-binding protein-3 expression in breast cancer. Cancer Letters 332:1, pages 102-109.
Crossref
K. Chomwisarutkun, E. Murani, R. Brunner, S. Ponsuksili & K. Wimmers. (2013) QTL region-specific microarrays reveal differential expression of positional candidate genes of signaling pathways associated with the liability for the inverted teat defect. Animal Genetics 44:2, pages 139-148.
Crossref
Jingxian Wu, Qiong Li, Xiaoyan Wang, Shanshan Yu, Lan Li, Xuemei Wu, Yanlin Chen, Jing Zhao & Yong Zhao. (2013) Neuroprotection by Curcumin in Ischemic Brain Injury Involves the Akt/Nrf2 Pathway. PLoS ONE 8:3, pages e59843.
Crossref
Sazzad Hassan, Yelena Karpova, Daniele Baiz, Dana Yancey, Ashok Pullikuth, Anabel Flores, Thomas Register, J. Mark Cline, Ralph D’AgostinoJr.Jr., Nika Danial, Sandeep Robert Datta & George Kulik. (2013) Behavioral stress accelerates prostate cancer development in mice. Journal of Clinical Investigation.
Crossref
Philippe M D'Onofrio & Paulo D Koeberle. (2012) What can we learn about stroke from retinal ischemia models?. Acta Pharmacologica Sinica 34:1, pages 91-103.
Crossref
Monika Joshi, Ayodele Ayoola & Chandra P. Belani. 2013. Impact of Genetic Targets on Cancer Therapy. Impact of Genetic Targets on Cancer Therapy 385 404 .
Dana Faingold, Dawn Russell-Hermanns & Silvin Bakalian. 2013. Experimental and Clinical Metastasis. Experimental and Clinical Metastasis 403 444 .
B. D. StamperB. MechamS. S. ParkH. Wilkerson, F. M. Farin, R. P. Beyer, T. K. Bammler, L. M. MangraviteM. L. Cunningham. (2012) Transcriptome correlation analysis identifies two unique craniosynostosis subtypes associated with IRS1 activation. Physiological Genomics 44:23, pages 1154-1163.
Crossref
Vijay Ramakrishnan, Teresa Kimlinger, Jessica Haug, Utkarsh Painuly, Linda Wellik, Timothy Halling, S. Vincent Rajkumar & Shaji Kumar. (2012) Anti-Myeloma Activity of Akt Inhibition Is Linked to the Activation Status of PI3K/Akt and MEK/ERK Pathway. PLoS ONE 7:11, pages e50005.
Crossref
LU YUE, YING WANG, HUAMAO WANG, HUIPING GAO, JUN LIANG, AIHUA SUI, JINYU XIANG, FANG ZHOU, CONGCONG XU, WENWEN ZHAO, WANHUA LIANG & RUYONG YAO. (2012) Inhibition of hepatocellular carcinoma cell growth by an anti-insulin-like growth factor-I receptor monoclonal antibody. Oncology Reports 28:4, pages 1453-1460.
Crossref
K. Floratou, E. Giannopoulou, A. Antonacopoulou, M. Karakantza, G. Adonakis, D. Kardamakis & P. Matsouka. (2012) Oxidative stress due to radiation in CD34+ Hematopoietic progenitor cells: protection by IGF-1. Journal of Radiation Research 53:5, pages 672-685.
Crossref
Lifeng Liu, Yue Zhu, Ying Xu & Russel J. Reiter. (2012) Prevention of ERK activation involves melatonin-induced G1 and G2/M phase arrest in the human osteoblastic cell line hFOB 1.19. Journal of Pineal Research 53:1, pages 60-66.
Crossref
Raúl Vivar, Claudio Humeres, Marcelo Varela, Pedro Ayala, Nancy Guzmán, Ivonne Olmedo, Mabel Catalán, Pía Boza, Claudia Muñoz & Guillermo Díaz Araya. (2012) Cardiac fibroblast death by ischemia/reperfusion is partially inhibited by IGF-1 through both PI3K/Akt and MEK–ERK pathways. Experimental and Molecular Pathology 93:1, pages 1-7.
Crossref
Qing L. Zhang & Li-Ya Qiao. (2012) Regulation of IGF-1 but not TGF-β1 by NGF in the smooth muscle of the inflamed urinary bladder. Regulatory Peptides 177:1-3, pages 73-78.
Crossref
S.-I. Lee, K.-L. Kang, S.-I. Shin, Y. Herr, Y.-M. Lee & E.-C. Kim. (2012) Endoplasmic reticulum stress modulates nicotine-induced extracellular matrix degradation in human periodontal ligament cells. Journal of Periodontal Research 47:3, pages 299-308.
Crossref
Jennifer C. Carter & Frank C. Church. (2012) Mature breast adipocytes promote breast cancer cell motility. Experimental and Molecular Pathology 92:3, pages 312-317.
Crossref
Galit Shahaf, Noa Rotem-Dai, Gabriela Koifman, Hadas Raveh-Amit, Sigal A. Frost & Etta Livneh. (2012) PKCη is a negative regulator of AKT inhibiting the IGF-I induced proliferation. Experimental Cell Research 318:7, pages 789-799.
Crossref
Suzanne de la Monte, Zoltan Derdak & Jack R Wands. (2012) Alcohol, insulin resistance and the liver-brain axis. Journal of Gastroenterology and Hepatology 27, pages 33-41.
Crossref
Bart Vanhaesebroeck, Len Stephens & Phillip Hawkins. (2012) PI3K signalling: the path to discovery and understanding. Nature Reviews Molecular Cell Biology 13:3, pages 195-203.
Crossref
Derrick D. Rowe, Christopher C. Leonardo, Jesus A. Recio, Lisa A. Collier, Alison E. Willing & Keith R. Pennypacker. (2012) Human Umbilical Cord Blood Cells Protect Oligodendrocytes from Brain Ischemia through Akt Signal Transduction. Journal of Biological Chemistry 287:6, pages 4177-4187.
Crossref
Jung-Hee Kim, Heejong Kim, Yesol Bak, Jeong-Woo Kang, Dong Hun Lee, Man Sub Kim, Yun Sun Park, Eun-Jin Kim, Kang-Yeoun Jung, Yoongho Lim, Jintae Hong & Do-Young Yoon. (2012) Naringenin derivative diethyl (5,4′-dihydroxy flavanone-7-yl) phosphate inhibits cell growth and induces apoptosis in A549 human lung cancer cells. Journal of the Korean Society for Applied Biological Chemistry 55:1, pages 75-82.
Crossref
Charlotte M. Miller & Florence O. McCarthy. (2012) Isolation, biological activity and synthesis of the natural product ellipticine and related pyridocarbazoles. RSC Advances 2:24, pages 8883.
Crossref
Majid Ghayour-Mobarhan, Hamidreza Saber & Gordon A.A. Ferns. (2012) The potential role of heat shock protein 27 in cardiovascular disease. Clinica Chimica Acta 413:1-2, pages 15-24.
Crossref
Leonard R. Johnson & Ramesh M. Ray. 2012. Physiology of the Gastrointestinal Tract. Physiology of the Gastrointestinal Tract 379 414 .
Qi Jiang, Bang-Min Han, Fu-Jun Zhao, Yan Hong & Shu-Jie Xia. (2011) The differential effects of prostate stromal cells derived from different zones on prostate cancer epithelial cells under the action of sex hormones. Asian Journal of Andrology 13:6, pages 798-805.
Crossref
Phuoc T. TranPavan K. BendapudiH. Jill LinPeter ChoiShan KohJoy ChenGeorge HorngNicholas P. HughesLawrence H. SchwartzVincent A. MillerToshiyuki KawashimaToshio KitamuraDavid PaikDean W. Felsher. (2011) Survival and Death Signals Can Predict Tumor Response to Therapy After Oncogene Inactivation. Science Translational Medicine 3:103.
Crossref
Ingeborg Hers, Emma E. Vincent & Jeremy M. Tavaré. (2011) Akt signalling in health and disease. Cellular Signalling 23:10, pages 1515-1527.
Crossref
Yesol Bak, Heejong Kim, Jeong-Woo Kang, Dong Hun Lee, Man Sub Kim, Yun Sun Park, Jung-Hee Kim, Kang-Yeoun Jung, Yoongho Lim, Jintae Hong & Do-Young Yoon. (2011) A Synthetic Naringenin Derivative, 5-Hydroxy-7,4′-diacetyloxyflavanone- N -phenyl Hydrazone (N101-43), Induces Apoptosis through Up-regulation of Fas/FasL Expression and Inhibition of PI3K/Akt Signaling Pathways in Non-Small-Cell Lung Cancer Cells . Journal of Agricultural and Food Chemistry 59:18, pages 10286-10297.
Crossref
Alexandre Orsato, Emanuela Barbagallo, Barbara Costa, Sandro Olivieri, Luca De Gioia, Francesco Nicotra & Barbara La Ferla. (2011) Iminosugar Analogues of Phosphatidyl Inositol as Potential Inhibitors of Protein Kinase B (Akt). European Journal of Organic Chemistry 2011:26, pages 5012-5019.
Crossref
Sun Yu-qin, Han Hai-ling & Song Wen-gang. (2011) Hydroxysafflor yellow a the protective effect of endothelial cells induced by LPC. Hydroxysafflor yellow a the protective effect of endothelial cells induced by LPC.
Maria Spiliotaki, Haris Markomanolaki, Marilena Mela, Dimitris Mavroudis, Vassilis Georgoulias & Sofia Agelaki. (2011) Targeting the insulin-like growth factor I receptor inhibits proliferation and VEGF production of non-small cell lung cancer cells and enhances paclitaxel-mediated anti-tumor effect. Lung Cancer 73:2, pages 158-165.
Crossref
Engin Ulukaya, Ceyda Acilan & Yusuf Yilmaz. (2011) Apoptosis: why and how does it occur in biology?. Cell Biochemistry and Function 29:6, pages 468-480.
Crossref
Mark A. Sussman, Mirko Völkers, Kimberlee Fischer, Brandi Bailey, Christopher T. Cottage, Shabana Din, Natalie Gude, Daniele Avitabile, Roberto Alvarez, Balaji Sundararaman, Pearl Quijada, Matt Mason, Mathias H. Konstandin, Amy Malhowski, Zhaokang Cheng, Mohsin Khan & Michael McGregor. (2011) Myocardial AKT: The Omnipresent Nexus. Physiological Reviews 91:3, pages 1023-1070.
Crossref
Ying Xu, Lifeng Liu, Xueshan Qiu, Lili Jiang, Bo Huang, Haiying Li, Zixuan Li, Wenting Luo & Enhua Wang. (2011) CCL21/CCR7 Promotes G2/M Phase Progression via the ERK Pathway in Human Non-Small Cell Lung Cancer Cells. PLoS ONE 6:6, pages e21119.
Crossref
Xiuli Liu, Wei Jiang, Federico Aucejo, Richard Kim, Charles Miller, Michael Byrne, Rocio Lopez & Lisa Yerian. (2011) Insulin-like growth factor I receptor β expression in hepatocellular carcinoma. Human Pathology 42:6, pages 882-891.
Crossref
Li Yang, Jianjun Li, Li Ran, Feng Pan, Xiaoxin Zhao, Zhenyu Ding, Yuying Chen, Qiuping Peng & Houjie Liang. (2011) Phosphorylated Insulin-Like Growth Factor 1 Receptor is Implicated in Resistance to the Cytostatic Effect of Gefitinib in Colorectal Cancer Cells. Journal of Gastrointestinal Surgery 15:6, pages 942-957.
Crossref
Xunxian Liu, Renee Y. Choi, Shayma M. Jawad & Julia T. Arnold. (2011) Androgen-induced PSA expression requires not only activation of AR but also endogenous IGF-I or IGF-I/PI3K/Akt signaling in human prostate cancer epithelial cells. The Prostate 71:7, pages 766-777.
Crossref
Estelle Woldt, Rachel L. Matz, Jérome Terrand, Mohamed Mlih, Céline Gracia, Sophie Foppolo, Sophie Martin, Véronique Bruban, Julie Ji, Emilie Velot, Joachim Herz & Philippe Boucher. (2011) Differential Signaling by Adaptor Molecules LRP1 and ShcA Regulates Adipogenesis by the Insulin-like Growth Factor-1 Receptor. Journal of Biological Chemistry 286:19, pages 16775-16782.
Crossref
Aneta Kwiatkowska, Magdalena Kijewska, Maciej Lipko, Urszula Hibner & Bozena Kaminska. (2011) Downregulation of Akt and FAK phosphorylation reduces invasion of glioblastoma cells by impairment of MT1-MMP shuttling to lamellipodia and downregulates MMPs expression. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1813:5, pages 655-667.
Crossref
Okkyung Rho, Dae Joon Kim, Karou Kiguchi & John DiGiovanni. (2011) Growth factor signaling pathways as targets for prevention of epithelial carcinogenesis. Molecular Carcinogenesis 50:4, pages 264-279.
Crossref
Chrisostomi Gialeli, Achilleas D. Theocharis & Nikos K. Karamanos. (2011) Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting. FEBS Journal 278:1, pages 16-27.
Crossref
Jessica E. Hall, Wei Fu & Michael D. Schaller. 2011. 185 225 .
Himanshu Vashistha, Leonard G. Meggs & Ashwani Malhotra. 2011. Molecular Defects in Cardiovascular Disease. Molecular Defects in Cardiovascular Disease 353 363 .
Gabriela M. KusterStéphanie P. HäuselmannBerit I. Rosc-SchlüterVera LorenzOtmar Pfister. (2010) Reactive Oxygen/Nitrogen Species and the Myocardial Cell Homeostasis: An Ambiguous Relationship. Antioxidants & Redox Signaling 13:12, pages 1899-1910.
Crossref
John A Marwick, Indika Edirisinghe, Gnanapragasam Arunachalam, Christopher S Stevenson, William MacNee, Paul A Kirkham & Irfan Rahman. (2010) Cigarette smoke regulates VEGFR2-mediated survival signaling in rat lungs. Journal of Inflammation 7:1.
Crossref
Jane C. Deng & Theodore J. Standiford. 2011. Comprehensive Physiology. Comprehensive Physiology 81 104 .
Yuan AnYan CaiYongmei GuanLiying CaiYang YangXue FengJianhua Zheng. (2010) Inhibitory Effect of Small Interfering RNA Targeting Insulin-Like Growth Factor-I Receptor in Ovarian Cancer OVCAR3 Cells. Cancer Biotherapy and Radiopharmaceuticals 25:5, pages 545-552.
Crossref
Ren-Huei Jiang, Wen-Chi Su, Huei-Fang Liu, Hou-Syun Huang & Jui-I Chao. (2010) Opposite expression of securin and γ-H2AX regulates baicalein-induced cancer cell death. Journal of Cellular Biochemistry 111:2, pages 274-283.
Crossref
Alessandro Bitto, Chad Lerner, Claudio Torres, Michaela Roell, Marco Malaguti, Viviana Perez, Antonello Lorenzini, Silvana Hrelia, Yuji Ikeno, Michelle Elizabeth Matzko, Roger McCarter & Christian Sell. (2010) Long-Term IGF-I Exposure Decreases Autophagy and Cell Viability. PLoS ONE 5:9, pages e12592.
Crossref
Hsueh-Li Tan, Jennifer M. Thomas-Ahner, Elizabeth M. Grainger, Lei Wan, David M. Francis, Steven J. Schwartz, John W. ErdmanJr.Jr. & Steven K. Clinton. (2010) Tomato-based food products for prostate cancer prevention: what have we learned?. Cancer and Metastasis Reviews 29:3, pages 553-568.
Crossref
P. F. O’Tierney, N. N. Chattergoon, S. Louey, G. D. Giraud & K. L. Thornburg. (2010) Atrial natriuretic peptide inhibits angiotensin II-stimulated proliferation in fetal cardiomyocytes. The Journal of Physiology 588:15, pages 2879-2889.
Crossref
Hui Jing, Xinglu Zhou, Xiaowu Dong, Ji Cao, Hong Zhu, Jianshu Lou, Yongzhou Hu, Qiaojun He & Bo Yang. (2010) Abrogation of Akt signaling by Isobavachalcone contributes to its anti-proliferative effects towards human cancer cells. Cancer Letters 294:2, pages 167-177.
Crossref
Jun Liu, Sun Hong Cheng Sun, Sun Jing Sun, Chen Huang, Hong Hui Hu, Yu Biao Jin & Zheng Jun Qiu. (2010) Phosph-Akt1 Expression is Associated with a Favourable Prognosis in Pancreatic Cancer. Annals of the Academy of Medicine, Singapore 39:7, pages 548-554.
Crossref
Gloria S. Huang, Jurriaan Brouwer-Visser, Marissa J. Ramirez, Christine H. Kim, Tiffany M. Hebert, Juan Lin, Hugo Arias-Pulido, Clifford R. Qualls, Eric R. Prossnitz, Gary L. Goldberg, Harriet O. Smith & Susan Band Horwitz. (2010) Insulin-like Growth Factor 2 Expression Modulates Taxol Resistance and Is a Candidate Biomarker for Reduced Disease-Free Survival in Ovarian Cancer. Clinical Cancer Research 16:11, pages 2999-3010.
Crossref
Jiachi Ma, Hirozumi Sawai, Yoichi Matsuo, Nobuo Ochi, Akira Yasuda, Hiroki Takahashi, Takehiro Wakasugi, Hitoshi Funahashi, Mikinori Sato & Hiromitsu Takeyama. (2010) IGF-1 Mediates PTEN Suppression and Enhances Cell Invasion and Proliferation via Activation of the IGF-1/PI3K/Akt Signaling Pathway in Pancreatic Cancer Cells. Journal of Surgical Research 160:1, pages 90-101.
Crossref
Ping-Yuan Lin, Hung-Jen Liu, Ming-Huei Liao, Ching-Dong Chang, Chi-I Chang, Hsueh-Ling Cheng, Jeng-Woei Lee & Wen-Ling Shih. (2010) Activation of PI 3-kinase/Akt/NF-κB and Stat3 signaling by avian reovirus S1133 in the early stages of infection results in an inflammatory response and delayed apoptosis. Virology 400:1, pages 104-114.
Crossref
Wen-Ling Shih, Ming-Huei Liao, Ping-Yuan Lin, Chi-I Chang, Hsueh-Ling Cheng, Feng-Ling Yu & Jeng-Woei Lee. (2010) PI 3-kinase/Akt and STAT3 are required for the prevention of TGF-β-induced Hep3B cell apoptosis by autocrine motility factor/phosphoglucose isomerase. Cancer Letters 290:2, pages 223-237.
Crossref
Zengqiang Yuan, Donghwa Kim, Shaokun Shu, Junbing Wu, Jianping Guo, Lei Xiao, Satoshi Kaneko, Domenico Coppola & Jin Q. Cheng. (2010) Phosphoinositide 3-Kinase/Akt Inhibits MST1-Mediated Pro-apoptotic Signaling through Phosphorylation of Threonine 120. Journal of Biological Chemistry 285:6, pages 3815-3824.
Crossref
Yuko Ibuki, Marie Akaike & Tatsushi Toyooka. (2010) PI3-kinase/Akt Pathway Mediates Expression of p53 after UVB Irradiation. Genes and Environment 32:4, pages 85-91.
Crossref
Arul Murugan Mani, Mark A Fenwick, Zhangrui Cheng, Mohan K Sharma, Dheer Singh & D Claire Wathes. (2010) IGF1 induces up-regulation of steroidogenic and apoptotic regulatory genes via activation of phosphatidylinositol-dependent kinase/AKT in bovine granulosa cells. REPRODUCTION 139:1, pages 139-151.
Crossref
Claudia Diemer, Martha Schneider, Hermann M. Schätzl & Sabine Gilch. 2010. Molecular Biology of the SARS-Coronavirus. Molecular Biology of the SARS-Coronavirus 231 245 .
Rodrigo R Resende & Avishek Adhikari. (2009) Cholinergic receptor pathways involved in apoptosis, cell proliferation and neuronal differentiation. Cell Communication and Signaling 7:1.
Crossref
Ramaswamy Bhuvaneswari, Yik Yuen Gan, Khee Chee Soo & Malini Olivo. (2009) Targeting EGFR with photodynamic therapy in combination with Erbitux enhances in vivo bladder tumor response. Molecular Cancer 8:1.
Crossref
Christine M. Kusminski, Shoba Shetty, Lelio Orci, Roger H. Unger & Philipp E. Scherer. (2009) Diabetes and apoptosis: lipotoxicity. Apoptosis 14:12, pages 1484-1495.
Crossref
Gakuhei Son, Ian N. Hines, Jeff Lindquist, Laura W. Schrum & Richard A. Rippe. (2009) Inhibition of phosphatidylinositol 3-kinase signaling in hepatic stellate cells blocks the progression of hepatic fibrosis. Hepatology 50:5, pages 1512-1523.
Crossref
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