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Research Article

Control of Thrombopoietin-Induced Megakaryocytic Differentiation by the Mitogen-Activated Protein Kinase Pathway

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Pages 4991-5000 | Received 08 Apr 1997, Accepted 21 Jun 1997, Published online: 29 Mar 2023

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V. S. Gryshkova, R. I. Albu & S. N. Constatinescu. (2014) The mechanisms of activation of the single chain cytokine receptors: preformed and ligand-induced dimerization. Biopolymers and Cell 30:3, pages 184-189.
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Dominique Bluteau, Alessandra Balduini, Nathalie Balayn, Manuela Currao, Paquita Nurden, Caroline Deswarte, Guy Leverger, Patrizia Noris, Silverio Perrotta, Eric Solary, William Vainchenker, Najet Debili, Remi Favier & Hana Raslova. (2014) Thrombocytopenia-associated mutations in the ANKRD26 regulatory region induce MAPK hyperactivation. Journal of Clinical Investigation 124:2, pages 580-591.
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L Liu, Q Wen, R Gong, L Gilles, M J Stankiewicz, W Li, M Guo, L Li, X Sun, W Li, J D Crispino & Z Huang. (2014) PSTPIP2 dysregulation contributes to aberrant terminal differentiation in GATA-1-deficient megakaryocytes by activating LYN. Cell Death & Disease 5:1, pages e988-e988.
Crossref
Xin He, Zhigang Chen, Yangyan Jiang, Xi Qiu & Xiaoying Zhao. (2013) Different mutations of the human c-mpl gene indicate distinct haematopoietic diseases. Journal of Hematology & Oncology 6:1.
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Qiong Wang, Rui Sun, Leyan Wu, Junfeng Huang, Ping Wang, Hailong Yuan, Feifei Qiu, Xiaohong Xu, Di Wu, Ying Yu, Xin Liu & Qing Zhang. (2013) Identification and characterization of an alternative splice variant of Mpl with a high affinity for TPO and its activation of ERK1/2 signaling. The International Journal of Biochemistry & Cell Biology 45:12, pages 2852-2863.
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K. Hirose, S. Monzen, H. Sato, M. Sato, M. Aoki, Y. Hatayama, H. Kawaguchi, Y. Narita, Y. Takai & I. Kashiwakura. (2012) Megakaryocytic differentiation in human chronic myelogenous leukemia K562 cells induced by ionizing radiation in combination with phorbol 12-myristate 13-acetate. Journal of Radiation Research 54:3, pages 438-446.
Crossref
Nathalie Saulnier, Soizic Guihard, Xavier Holy, Elodie Decembre, Pierre Jurdic, Denis Clay, Vincent Feuillet, Gilles Pagès, Jacques Pouysségur, Françoise Porteu & Murielle Gaudry. (2012) ERK1 Regulates the Hematopoietic Stem Cell Niches. PLoS ONE 7:1, pages e30788.
Crossref
Vandana S. Nikam, Gesa Wecker, Ralph Schermuly, Ulf Rapp, Kirsten Szelepusa, Werner Seeger & Robert Voswinckel. (2011) Treprostinil Inhibits the Adhesion and Differentiation of Fibrocytes via the Cyclic Adenosine Monophosphate–Dependent and Ras-Proximate Protein–Dependent Inactivation of Extracellular Regulated Kinase. American Journal of Respiratory Cell and Molecular Biology 45:4, pages 692-703.
Crossref
Eva Chung & Motonari Kondo. (2010) Role of Ras/Raf/MEK/ERK signaling in physiological hematopoiesis and leukemia development. Immunologic Research 49:1-3, pages 248-268.
Crossref
Rodolphe Besancenot, Ronan Chaligné, Carole Tonetti, Florence Pasquier, Caroline Marty, Yann Lécluse, William Vainchenker, Stefan N. Constantinescu & Stéphane Giraudier. (2010) A Senescence-Like Cell-Cycle Arrest Occurs During Megakaryocytic Maturation: Implications for Physiological and Pathological Megakaryocytic Proliferation. PLoS Biology 8:9, pages e1000476.
Crossref
Michael GirardotChristian PecquetSiham Boukour, Laurent Knoops, Augustin Ferrant, William Vainchenker, Stéphane Giraudier & Stefan N. Constantinescu. (2010) miR-28 is a thrombopoietin receptor targeting microRNA detected in a fraction of myeloproliferative neoplasm patient platelets. Blood 116:3, pages 437-445.
Crossref
Yuan-I Chang, Wei-Kai Hua, Chao-Ling Yao, Shiaw-Min Hwang, Yi-Chi Hung, Chih-Jen Kuan, Jiun-Shyang Leou & Wey-Jinq Lin. (2010) Protein-arginine Methyltransferase 1 Suppresses Megakaryocytic Differentiation via Modulation of the p38 MAPK Pathway in K562 Cells. Journal of Biological Chemistry 285:27, pages 20595-20606.
Crossref
Amy E. Geddis. (2010) Megakaryopoiesis. Seminars in Hematology 47:3, pages 212-219.
Crossref
Soizic GuihardDenis ClayLaurence CocaultNathalie SaulnierPaule Opolon, Michèle SouyriGilles Pagès, Jacques Pouysségur, Françoise PorteuMurielle Gaudry. (2010) The MAPK ERK1 is a negative regulator of the adult steady-state splenic erythropoiesis. Blood 115:18, pages 3686-3694.
Crossref
S. SÉVERIN, C. GHEVAERT & A. MAZHARIAN. (2010) The mitogen‐activated protein kinase signaling pathways: role in megakaryocyte differentiation. Journal of Thrombosis and Haemostasis 8:1, pages 17-26.
Crossref
Alexandra Mazharian, Steve P. Watson & Sonia Séverin. (2009) Critical role for ERK1/2 in bone marrow and fetal liver–derived primary megakaryocyte differentiation, motility, and proplatelet formation. Experimental Hematology 37:10, pages 1238-1249.e5.
Crossref
Yu-Chuen Huang, David K. Chao, K.S. Clifford Chao & Yu-Jen Chen. (2009) Oral small-molecule tyrosine kinase inhibitor midostaurin (PKC412) inhibits growth and induces megakaryocytic differentiation in human leukemia cells. Toxicology in Vitro 23:6, pages 979-985.
Crossref
Nicholas Papadantonakis & Katya Ravid. 2009. Molecular Basis of Hematopoiesis. Molecular Basis of Hematopoiesis 95 126 .
J Kota, N Caceres & S N Constantinescu. (2008) Aberrant signal transduction pathways in myeloproliferative neoplasms. Leukemia 22:10, pages 1828-1840.
Crossref
Azadeh Meshkini & Razieh Yazdanparast. (2008) Involvement of ERK/MAPK pathway in megakaryocytic differentiation of K562 cells induced by 3-hydrogenkwadaphnin. Toxicology in Vitro 22:6, pages 1503-1510.
Crossref
Viktor Janzen, Heather E. Fleming, Tamara Riedt, Göran Karlsson, Matthew J. Riese, Cristina Lo Celso, Griffin Reynolds, Craig D. Milne, Christopher J. Paige, Stefan Karlsson, Minna Woo & David T. Scadden. (2008) Hematopoietic Stem Cell Responsiveness to Exogenous Signals Is Limited by Caspase-3. Cell Stem Cell 2:6, pages 584-594.
Crossref
Y-S Tang, Y-P Zhang & P Xu. (2008) hNUDC promotes the cell proliferation and differentiation in a leukemic cell line via activation of the thrombopoietin receptor (Mpl). Leukemia 22:5, pages 1018-1025.
Crossref
David J. Kuter. (2008) New drugs for familiar therapeutic targets: thrombopoietin receptor agonists and immune thrombocytopenic purpura. European Journal of Haematology 80, pages 9-18.
Crossref
Yu Ping Zhang, Yong Song Tang, Xu Shen Chen & Peilin Xu. (2007) Regulation of cell differentiation by hNUDC via a Mpl-dependent mechanism in NIH 3T3 cells. Experimental Cell Research 313:15, pages 3210-3221.
Crossref
B J Lannutti, J Minear, N Blake & J G Drachman. (2006) Increased megakaryocytopoiesis in Lyn-deficient mice. Oncogene 25:23, pages 3316-3324.
Crossref
Virginie HamelinClaire LetourneuxPaul-Henri RomeoFrançoise PorteuMurielle Gaudry. (2006) Thrombopoietin regulates IEX-1 gene expression through ERK-induced AML1 phosphorylation. Blood 107:8, pages 3106-3113.
Crossref
Raffaella Guerriero, Isabella Parolini, Ugo Testa, Paola Samoggia, Eleonora Petrucci, Massimo Sargiacomo, Cristiana Chelucci, Marco Gabbianelli & Cesare Peschle. (2006) Inhibition of TPO-induced MEK or mTOR activity induces opposite effects on the ploidy of human differentiating megakaryocytes. Journal of Cell Science 119:4, pages 744-752.
Crossref
A Jacquel, M Herrant, V Defamie, N Belhacene, P Colosetti, S Marchetti, L Legros, M Deckert, B Mari, J-P Cassuto, P Hofman & P Auberger. (2005) A survey of the signaling pathways involved in megakaryocytic differentiation of the human K562 leukemia cell line by molecular and c-DNA array analysis. Oncogene 25:5, pages 781-794.
Crossref
Philip J. S. StorkTara J. Dillon. (2005) Multiple roles of Rap1 in hematopoietic cells: complementary versus antagonistic functions. Blood 106:9, pages 2952-2961.
Crossref
Francis W Ruscetti, Salem Akel & Stephen H Bartelmez. (2005) Autocrine transforming growth factor-β regulation of hematopoiesis: many outcomes that depend on the context. Oncogene 24:37, pages 5751-5763.
Crossref
Yohan Royer, Judith Staerk, Marcel Costuleanu, Pierre J. Courtoy & Stefan N. Constantinescu. (2005) Janus Kinases Affect Thrombopoietin Receptor Cell Surface Localization and Stability. Journal of Biological Chemistry 280:29, pages 27251-27261.
Crossref
Pierre WalrafenFrédérique VerdierZahra KadriStany ChrétienCatherine LacombePatrick Mayeux. (2005) Both proteasomes and lysosomes degrade the activated erythropoietin receptor. Blood 105:2, pages 600-608.
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Charles M. Rudin, John L. Marshall, Chao Hui Huang, Hedy L. Kindler, Chuanbo Zhang, Deepak Kumar, Prafulla C. Gokhale, Joyce Steinberg, Steve Wanaski, Usha N. Kasid & Mark J. Ratain. (2004) Delivery of a Liposomal c-raf-1 Antisense Oligonucleotide by Weekly Bolus Dosing in Patients with Advanced Solid Tumors . Clinical Cancer Research 10:21, pages 7244-7251.
Crossref
Shengming Zhao, Michael A. Weinreich, Kenji Ihara, Robert E. Richard & C.Anthony Blau. (2004) In Vivo Selection of Genetically Modified Erythroid Cells Using a Jak2-Based Cell Growth Switch. Molecular Therapy 10:3, pages 456-468.
Crossref
Brian J. LannuttiJonathan G. Drachman. (2004) Lyn tyrosine kinase regulates thrombopoietin-induced proliferation of hematopoietic cell lines and primary megakaryocytic progenitors. Blood 103:10, pages 3736-3743.
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Heath L. BradleyChristine CouldreyKevin D. Bunting. (2004) Hematopoietic-repopulating defects from STAT5-deficient bone marrow are not fully accounted for by loss of thrombopoietin responsiveness. Blood 103:8, pages 2965-2972.
Crossref
Tamihiro KamataCatrin A. PritchardAndrew D. Leavitt. (2004) Raf-1 is not required for megakaryocytopoiesis or TPO-induced ERK phosphorylation. Blood 103:7, pages 2568-2570.
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Michael D. Feese, Taro Tamada, Yoichi Kato, Yoshitake Maeda, Masako Hirose, Yasuko Matsukura, Hideki Shigematsu, Takanori Muto, Atsushi Matsumoto, Hiroshi Watarai, Kinya Ogami, Tomoyuki Tahara, Takashi Kato, Hiroshi Miyazaki & Ryota Kuroki. (2004) Structure of the receptor-binding domain of human thrombopoietin determined by complexation with a neutralizing antibody fragment. Proceedings of the National Academy of Sciences 101:7, pages 1816-1821.
Crossref
Brian J Lannutti, Mi-Hyun Shim, Noel Blake, Jo Anna Reems & Jonathan G Drachman. (2003) Identification and activation of Src family kinases in primary megakaryocytes. Experimental Hematology 31:12, pages 1268-1274.
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Debra D. DahlenVirginia C. BroudyJonathan G. Drachman. (2003) Internalization of the thrombopoietin receptor is regulated by 2 cytoplasmic motifs. Blood 102:1, pages 102-108.
Crossref
Lorrie L. DelehantyMichael MogassSara L. GoniasFrederick K. RackeBrian JohnstoneAdam N. Goldfarb. (2003) Stromal inhibition of megakaryocytic differentiation is associated with blockade of sustained Rap1 activation. Blood 101:5, pages 1744-1751.
Crossref
A. L. Drayer & E. Vellenga. 2003. Cellular Engineering and Cellular Therapies. Cellular Engineering and Cellular Therapies 119 131 .
Josefina Garcia, Yunbin Ye, Valérie Arranz, Claire Letourneux, Guillaume Pezeron & Françoise Porteu. (2002) IEX-1: a new ERK substrate involved in both ERK survival activity and ERK activation. The EMBO Journal 21:19, pages 5151-5163.
Crossref
Chisato Mizutani, Yumi Tohyama, Yasuo Miura, Terutoshi Hishita, Toshio Nishihara, Hirohei Yamamura, Satoshi Ichiyama, Takashi Uchiyama & Kaoru Tohyama. (2002) Sustained activation of MEK1-ERK1/2 pathway in membrane skeleton occurs dependently on cell adhesion in megakaryocytic differentiation. Biochemical and Biophysical Research Communications 297:3, pages 664-671.
Crossref
M Abe, K Suzuki, O Inagaki, S Sassa & H Shikama. (2002) A novel MPL point mutation resulting in thrombopoietin-independent activation. Leukemia 16:8, pages 1500-1506.
Crossref
Gaël A. Millot, William Vainchenker, Dominique Duménil & Fédor Svinarchuk. (2002) Distinct effects of thrombopoietin depending on a threshold level of activated Mpl in BaF-3 cells. Journal of Cell Science 115:11, pages 2329-2337.
Crossref
Emiko Okuma, Yuko Inazawa, Kumiko Saeki & Akira Yuo. (2002) Potential roles of extracellular signal-regulated kinase but not p38 during myeloid differentiation of U937 cells stimulated by cytokines. Experimental Hematology 30:6, pages 571-581.
Crossref
Itaru Matsumura & Yuzuru Kanakura. (2002) Molecular Control of Megakaryopoiesis and Thrombopoiesis. International Journal of Hematology 75:5, pages 473-483.
Crossref
Fabrice Piu, Michael Magnani & Max E Ader. (2002) Dissection of the cytoplasmic domains of cytokine receptors involved in STAT and Ras dependent proliferation. Oncogene 21:22, pages 3579-3591.
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Kenneth Kaushansky & Jonathan G Drachman. (2002) The molecular and cellular biology of thrombopoietin: the primary regulator of platelet production. Oncogene 21:21, pages 3359-3367.
Crossref
Caroline Meunier, Didier Bordereaux, Françoise Porteu, Sylvie Gisselbrecht, Stany Chrétien & Geneviève Courtois. (2002) Cloning and Characterization of a Family of Proteins Associated with Mpl. Journal of Biological Chemistry 277:11, pages 9139-9147.
Crossref
David Tulasne, Teresa Bori & Steve P. Watson. (2002) Regulation of RAS in human platelets. European Journal of Biochemistry 269:5, pages 1511-1517.
Crossref
Marie-Dominique FilippiFrançoise PorteuFrançoise Le PesteurValérie SchiavonGaël A. MillotWilliam VainchenkerFrédéric J. de SauvageAnne Dubart KupperschmittFrancoise Sainteny. (2002) Requirement for mitogen-activated protein kinase activation in the response of embryonic stem cell–derived hematopoietic cells to thrombopoietin in vitro. Blood 99:4, pages 1174-1182.
Crossref
Amy E Geddis, Hannah M Linden & Kenneth Kaushansky. (2002) Thrombopoietin: a pan-hematopoietic cytokine. Cytokine & Growth Factor Reviews 13:1, pages 61-73.
Crossref
Gaël A Millot, Fréderic Feger, Loic Garçon, William Vainchenker, Dominique Dumenil & Fédor Svinarchuk. (2002) MplK, a natural variant of the thrombopoietin receptor with a truncated cytoplasmic domain, binds thrombopoietin but does not interfere with thrombopoietin-mediated cell growth. Experimental Hematology 30:2, pages 166-175.
Crossref
Kevin D. BuntingHeath L. BradleyTeresa S. HawleyRichard MorigglBrian P. SorrentinoJames N. Ihle. (2002) Reduced lymphomyeloid repopulating activity from adult bone marrow and fetal liver of mice lacking expression of STAT5. Blood 99:2, pages 479-487.
Crossref
Fabrice Gouilleux. 2002. Hormone Signaling. Hormone Signaling 145 178 .
Ying Zhang, Shishinn Sun, Zhengyu Wang, Alexander Thompson, Yulia Kaluzhny, Jeffrey Zimmet & Katya Ravid. (2002) Signaling by the Mpl receptor involves IKK and NF-?B. Journal of Cellular Biochemistry 85:3, pages 523-535.
Crossref
Jean-Michel Paulus, Jack Levin, Najet Debili, Adelin Albert & William Vainchenker. (2001) Genesis of clone size heterogeneity in megakaryocytic and other hemopoietic colonies. Experimental Hematology 29:11, pages 1256-1269.
Crossref
Adam N. Goldfarb, Loretta L. Delehanty, Dongyan Wang, Frederick K. Racke & Isa M. Hussaini. (2001) Stromal Inhibition of Megakaryocytic Differentiation Correlates with Blockade of Signaling by Protein Kinase C-ε and ERK/MAPK. Journal of Biological Chemistry 276:31, pages 29526-29530.
Crossref
Didier Bouscary, Carinne Lecoq-Lafon, Stany Chrétien, Simona Zompi, Serge Fichelson, Odile Muller, Françoise Porteu, Isabelle Dusanter-Fourt, Sylvie Gisselbrecht, Patrick Mayeux & Catherine Lacombe. (2001) Role of Gab proteins in phosphatidylinositol 3-kinase activation by thrombopoietin (Tpo). Oncogene 20:18, pages 2197-2204.
Crossref
Meenakshi GaurGeorge J. MurphyFrederic J. deSauvageAndrew D. Leavitt. (2001) Characterization of Mpl mutants using primary megakaryocyte-lineage cells from mpl−/−mice: a new system for Mpl structure–function studies. Blood 97:6, pages 1653-1661.
Crossref
Yoshitaka Miyakawa, Ponlapat Rojnuckarin, Tania Habib & Kenneth Kaushansky. (2001) Thrombopoietin Induces Phosphoinositol 3-Kinase Activation through SHP2, Gab, and Insulin Receptor Substrate Proteins in BAF3 Cells and Primary Murine Megakaryocytes. Journal of Biological Chemistry 276:4, pages 2494-2502.
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Natalie G. Ahn, Theresa Stines Nahreini, Nicholas S. Tolwinski & Katheryn A. Resing. 2001. Part F: Regulators and Effectors of Small GTPases. Part F: Regulators and Effectors of Small GTPases 417 431 .
Mie Uchida, Keita Kirito, Ritsuko Shimizu, Yasusada Miura, Keiya Ozawa & Norio Komatsu. (2001) A functional role of mitogen-activated protein kinases, Erk1 and Erk2, in the differentiation of a human leukemia cell line, UT-7/GM: A possible key factor for cell fate determination toward erythroid and megakaryocytic lineages. International Journal of Hematology 73:1, pages 78-83.
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Timothy S. Lewis, John B. Hunt, Lauren D. Aveline, Karen R. Jonscher, Donna F. Louie, Jennifer M. Yeh, Theresa S. Nahreini, Katheryn A. Resing & Natalie G. Ahn. (2000) Identification of Novel MAP Kinase Pathway Signaling Targets by Functional Proteomics and Mass Spectrometry. Molecular Cell 6:6, pages 1343-1354.
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Marie-Dominique Filippi, Françoise Porteu, Françoise Le Pesteur, Philippe Rameau, Maria Manuela Nogueira, Najet Debili, William Vainchenker, Frederic J de Sauvage, Anne Dubart Kupperschmitt & Françoise Sainteny. (2000) Embryonic stem cell differentiation to hematopoietic cells. Experimental Hematology 28:12, pages 1363-1372.
Crossref
Jonathan G. Drachman. (2000) Role of thrombopoietin in hematopoietic stem cell and progenitor regulation. Current Opinion in Hematology 7:3, pages 183-190.
Crossref
C Challier, L Cocault, M Flon, M Pauchard, F Porteu, S Gisselbrecht & M Souyri. (2000) A new feature of Mpl receptor: ligand-induced transforming activity in FRE rat fibroblasts. Oncogene 19:16, pages 2033-2042.
Crossref
Nuria Ajenjo, David S. Aaronson, Eva Ceballos, Carlos Richard, Javier León & Piero Crespo. (2000) Myeloid Leukemia Cell Growth and Differentiation Are Independent of Mitogen-activated Protein Kinase ERK1/2 Activation. Journal of Biological Chemistry 275:10, pages 7189-7197.
Crossref
Shishinn Sun, Carl W. Jackson & Katya Ravid. (2000) MAP kinase localizes to the platelet-yielding demarcation membrane system in megakaryocytes. Blood 95:4, pages 1511-1512.
Crossref
Keiko HodoharaNobutaka FujiiNaoki YamamotoKenneth Kaushansky. (2000) Stromal cell-derived factor-1 (SDF-1) acts together with thrombopoietin to enhance the development of megakaryocytic progenitor cells (CFU-MK). Blood 95:3, pages 769-775.
Crossref
Itaru Matsumura, Hirokazu Tanaka, Akira Kawasaki, Junko Odajima, Hanako Daino, Koji Hashimoto, Hiroshi Wakao, Koichi Nakajima, Takashi Kato, Hiroshi Miyazaki & Yuzuru Kanakura. (2000) Increased D-type Cyclin Expression Together with Decreased cdc2 Activity Confers Megakaryocytic Differentiation of a Human Thrombopoietin-dependent Hematopoietic Cell Line. Journal of Biological Chemistry 275:8, pages 5553-5559.
Crossref
Shishinn Sun & Katya Ravid. (2000) Role of a serine/threonine kinase, Mst1, in megakaryocyte differentiation. Journal of Cellular Biochemistry 76:1, pages 44-60.
Crossref
Marion DorschNika N. DanialPaul B. RothmanStephen P. Goff. (1999) A Thrombopoietin Receptor Mutant Deficient in Jak-STAT Activation Mediates Proliferation But Not Differentiation in UT-7 Cells. Blood 94:8, pages 2676-2685.
Crossref
Serge FichelsonJean-Marc FreyssinierFrançoise PicardMichaela Fontenay-RoupieMartine GuesnuMustapha CheraiSylvie GisselbrechtFrançoise Porteu. (1999) Megakaryocyte Growth and Development Factor-Induced Proliferation and Differentiation Are Regulated by the Mitogen-Activated Protein Kinase Pathway in Primitive Cord Blood Hematopoietic Progenitors. Blood 94:5, pages 1601-1613.
Crossref
Serge FichelsonJean-Marc FreyssinierFrançoise PicardMichaela Fontenay-RoupieMartine GuesnuMustapha CheraiSylvie GisselbrechtFrançoise Porteu. (1999) Megakaryocyte Growth and Development Factor-Induced Proliferation and Differentiation Are Regulated by the Mitogen-Activated Protein Kinase Pathway in Primitive Cord Blood Hematopoietic Progenitors. Blood 94:5, pages 1601-1613.
Crossref
Ponlapat RojnuckarinJonathan G. DrachmanKenneth Kaushansky. (1999) Thrombopoietin-Induced Activation of the Mitogen-Activated Protein Kinase (MAPK) Pathway in Normal Megakaryocytes: Role in Endomitosis. Blood 94:4, pages 1273-1282.
Crossref
Ponlapat RojnuckarinJonathan G. DrachmanKenneth Kaushansky. (1999) Thrombopoietin-Induced Activation of the Mitogen-Activated Protein Kinase (MAPK) Pathway in Normal Megakaryocytes: Role in Endomitosis. Blood 94:4, pages 1273-1282.
Crossref
Karine Cohen-SolalNatacha VitratMonique TiteuxWilliam VainchenkerFrançoise Wendling. (1999) High-Level Expression of Mpl in Platelets and Megakaryocytes Is Independent of Thrombopoietin. Blood 93:9, pages 2859-2866.
Crossref
Karine Cohen-SolalNatacha VitratMonique TiteuxWilliam VainchenkerFrançoise Wendling. (1999) High-Level Expression of Mpl in Platelets and Megakaryocytes Is Independent of Thrombopoietin. Blood 93:9, pages 2859-2866.
Crossref
Shishinn Sun, Yulia Kaluzhny & Katya Ravid. (1999) Ectopic expression of the Aspergillus nidulans mitotic inducer, nimA kinase, in megakaryocytes. Experimental Hematology 27:4, pages 594-604.
Crossref
Kenneth Kaushansky. (1999) The enigmatic megakaryocyte gradually reveals its secrets. BioEssays 21:4, pages 353-360.
Crossref
Mary M. ZutterAudrey D. PainterXun Yang. (1999) The Megakaryocyte/Platelet-Specific Enhancer of the 2β1 Integrin Gene: Two Tandem AP1 Sites and the Mitogen-Activated Protein Kinase Signaling Cascade. Blood 93:5, pages 1600-1611.
Crossref
Mary M. ZutterAudrey D. PainterXun Yang. (1999) The Megakaryocyte/Platelet-Specific Enhancer of the 2β1 Integrin Gene: Two Tandem AP1 Sites and the Mitogen-Activated Protein Kinase Signaling Cascade. Blood 93:5, pages 1600-1611.
Crossref
Jonathan G. Drachman, Ponlapot Rojnuckarin & Kenneth Kaushansky. (1999) Thrombopoietin Signal Transduction: Studies from Cell Lines and Primary Cells. Methods 17:3, pages 238-249.
Crossref
Alec Ritchie, Stephen E Braun, Johnny He & Hal E Broxmeyer. (1999) Thrombopoietin-induced conformational change in p53 lies downstream of the p44/p42 mitogen activated protein kinase cascade in the human growth factor-dependent cell line M07e. Oncogene 18:7, pages 1465-1477.
Crossref
Yuka NagataNoriko TakahashiRoger J. DavisKazuo Todokoro. (1998) Activation of p38 MAP Kinase and JNK But Not ERK Is Required for Erythropoietin-Induced Erythroid Differentiation. Blood 92:6, pages 1859-1869.
Crossref
Yuka NagataNoriko TakahashiRoger J. DavisKazuo Todokoro. (1998) Activation of p38 MAP Kinase and JNK But Not ERK Is Required for Erythropoietin-Induced Erythroid Differentiation. Blood 92:6, pages 1859-1869.
Crossref
Albert E.G. Kr von dem Borne, Claudia Folman, Gabor E. Linthorst, Leendert Porcelijn, Sonja van den Oudenrijn, Ellen van der Schoot & Masja de Haas. (1998) 10 Thrombopoietin and its receptor: structure, function and role in the regulation of platelet production. Baillière's Clinical Haematology 11:2, pages 409-426.
Crossref
Roman Herrera, Susan Hubbell, Stuart Decker & Lilli Petruzzelli. (1998) A Role for the MEK/MAPK Pathway in PMA-Induced Cell Cycle Arrest: Modulation of Megakaryocytic Differentiation of K562 Cells. Experimental Cell Research 238:2, pages 407-414.
Crossref

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