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c-Myc Target Genes Involved in Cell Growth, Apoptosis, and Metabolism

Pages 1-11 | Published online: 28 Mar 2023

Keep up to date with the latest research on this topic with citation updates for this article.

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Shuai Zhang, Ru Feng, Jiefei Bai, Shangyong Ning, Xiaodong Xu, Jie Sun, Meng Wu & Hui Liu. (2023) CDK7 inhibition induces apoptosis in acute myeloid leukemia cells and exerts synergistic antileukemic effects with azacitidine in vitro and in vivo. Leukemia & Lymphoma 64:3, pages 639-650.
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Teklie Mengie Ayele, Zelalem Tilahun Muche, Awgichew Behaile Teklemariam, Achenef Bogale Kassie & Endeshaw Chekol Abebe. (2022) Role of JAK2/STAT3 Signaling Pathway in the Tumorigenesis, Chemotherapy Resistance, and Treatment of Solid Tumors: A Systemic Review. Journal of Inflammation Research 15, pages 1349-1364.
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Rui Sun, Jinhui Liu, Sipei Nie, Siyue Li, Jing Yang, Yi Jiang & Wenjun Cheng. (2021) Construction of miRNA-mRNA Regulatory Network and Prognostic Signature in Endometrial Cancer. OncoTargets and Therapy 14, pages 2363-2378.
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Orlando Morales-Tarré, Ramiro Alonso-Bastida, Bolivar Arcos-Encarnación, Leonor Pérez-Martínez & Sergio Encarnación-Guevara. (2021) Protein lysine acetylation and its role in different human pathologies: a proteomic approach. Expert Review of Proteomics 18:11, pages 949-975.
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Audrey Sporrij & Leonard I. Zon. (2021) Nucleotide stress responses in neural crest cell fate and melanoma. Cell Cycle 20:15, pages 1455-1467.
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Hongyi Zhu, Yuanwen Chen, Jie Zhang, Changlin Qian, Weiqing Qiu, Huojian Shen & Zhiyong Shen. (2020) Knockdown of TRIM37 Promotes Apoptosis and Suppresses Tumor Growth in Gastric Cancer by Inactivation of the ERK1/2 Pathway. OncoTargets and Therapy 13, pages 5479-5491.
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Mahtab Keshvari, Mahdieh Nejadtaghi, Farnaz Hosseini-Beheshti, Ali Rastqar & Niraj Patel. (2020) Exploring the role of circadian clock gene and association with cancer pathophysiology. Chronobiology International 37:2, pages 151-175.
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Shuaibing Wang, Jiejie Qin, Hua Ye, Keyan Wang, Jianxiang Shi, Yan Ma, Yitao Duan, Chunhua Song, Xiao Wang, Liping Dai, Kaijuan Wang, Peng Wang & Jianying Zhang. (2018) Using a panel of multiple tumor-associated antigens to enhance autoantibody detection for immunodiagnosis of gastric cancer. OncoImmunology 7:8.
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Stefan Wallin. (2017) Intrinsically disordered proteins: structural and functional dynamics. Research and Reports in Biology 8, pages 7-16.
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Luciana R. Gomes, Carlos F. M. Menck & Ana Maria Cuervo. (2017) Chaperone-mediated autophagy prevents cellular transformation by regulating MYC proteasomal degradation. Autophagy 13:5, pages 928-940.
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Harsha S. Madapura, Daniel Salamon, Klas G. Wiman, Sonia Lain, Eva Klein & Noémi Nagy. (2016) cMyc-p53 feedback mechanism regulates the dynamics of T lymphocytes in the immune response. Cell Cycle 15:9, pages 1267-1275.
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Margarita L. Martinez-Fierro, Edwin A. Reyes-Oliva, Griselda A. Cabral-Pacheco, Idalia Garza-Veloz, Maria C. Aceves-Medina, Martha Luevano, Olga Y. Barbosa-Cisneros, Marisol Galvan-Valencia, Patricia Yahuaca-Mendoza, Ivan Delgado-Enciso, Michelle Zamudio-Osuna, Iram P. Rodriguez-Sanchez, Rosbel Vazquez-Castro & Marycruz Guerrero-Saucedo. (2016) MYC-induced nuclear antigen (MINA) and preeclampsia. Hypertension in Pregnancy 35:2, pages 189-201.
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Susmitha Ambadipudi & Markus Zweckstetter. (2016) Targeting intrinsically disordered proteins in rational drug discovery. Expert Opinion on Drug Discovery 11:1, pages 65-77.
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Eva Novotná, Aleš Tichý, Jaroslav Pejchal, Emílie Lukášová, Barbora Šalovská & Jiřina Vávrová. (2013) DNA-dependent protein kinase and its inhibition in support of radiotherapy. International Journal of Radiation Biology 89:6, pages 416-423.
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Christopher J. Pang, Wafaa Lemsaddek, Yousef N. Alhashem, Cornelius Bondzi, Latasha C. Redmond, Nicolas Ah-Son, Catherine I. Dumur, Kellie J. Archer, Jack L. Haar, Joyce A. Lloyd & Marie Trudel. (2012) Krüppel-Like Factor 1 (KLF1), KLF2, and Myc Control a Regulatory Network Essential for Embryonic Erythropoiesis. Molecular and Cellular Biology 32:13, pages 2628-2644.
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Vladimir N. Uversky. (2012) Intrinsically disordered proteins and novel strategies for drug discovery. Expert Opinion on Drug Discovery 7:6, pages 475-488.
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Iris Uribesalgo, Salvador Aznar Benitah & Luciano Di Croce. (2012) From oncogene to tumor suppressor. Cell Cycle 11:9, pages 1757-1764.
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Huawei Zeng, Mary Briske-Anderson, Min Wu & MaryP. Moyer. (2012) Methylselenol, a Selenium Metabolite, Plays Common and Different Roles in Cancerous Colon HCT116 Cell and Noncancerous NCM460 Colon Cell Proliferation. Nutrition and Cancer 64:1, pages 128-135.
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Sevil Dinçer, Mustafa Türk, Ayşe Karagöz & Gürhan Uzunalan. (2011) Potential c-myc Antisense Oligonucleotide Carriers: PCl/PEG/PEI and PLL/PEG/PEI. Artificial Cells, Blood Substitutes, and Biotechnology 39:3, pages 143-154.
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Birgit Janicke, Cecilia Hegardt, Morten Krogh, Gunilla Önning, Björn Åkesson, HelenaM. Cirenajwis & StinaM. Oredsson. (2011) The Antiproliferative Effect of Dietary Fiber Phenolic Compounds Ferulic Acid and p-Coumaric Acid on the Cell Cycle of Caco-2 Cells. Nutrition and Cancer 63:4, pages 611-622.
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Huawei Zeng, OliviaN. Trujillo, MaryP. Moyer & JamesH. Botnen. (2011) Prolonged Sulforaphane Treatment Activates Survival Signaling in Nontumorigenic NCM460 Colon Cells but Apoptotic Signaling in Tumorigenic HCT116 Colon Cells. Nutrition and Cancer 63:2, pages 248-255.
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Kai-Wen Hsu, Rong-Hong Hsieh, Yan-Hwa Wu Lee, Chi-Hong Chao, Kou-Juey Wu, Min-Jen Tseng & Tien-Shun Yeh. (2008) The Activated Notch1 Receptor Cooperates with α-Enolase and MBP-1 in Modulating c-myc Activity. Molecular and Cellular Biology 28:15, pages 4829-4842.
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Jung-whan Kim, Ping Gao, Yen-Chun Liu, Gregg L. Semenza & Chi V. Dang. (2007) Hypoxia-Inducible Factor 1 and Dysregulated c-Myc Cooperatively Induce Vascular Endothelial Growth Factor and Metabolic Switches Hexokinase 2 and Pyruvate Dehydrogenase Kinase 1. Molecular and Cellular Biology 27:21, pages 7381-7393.
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Yuxing Zhao, Brian J. Altman, Jonathan L. Coloff, Catherine E. Herman, Sarah R. Jacobs, Heather L. Wieman, Jessica A. Wofford, Leah N. Dimascio, Olga Ilkayeva, Ameeta Kelekar, Tannishtha Reya & Jeffrey C. Rathmell. (2007) Glycogen Synthase Kinase 3α and 3β Mediate a Glucose-Sensitive Antiapoptotic Signaling Pathway To Stabilize Mcl-1. Molecular and Cellular Biology 27:12, pages 4328-4339.
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Kai Uwe Chow, Daniel Nowak, Bettina Trepohl, Simone Hochmuth, Bernd Schneider, Dieter Hoelzer, Paris S. Mitrou, Lothar Bergmann, Oliver Gerhard Ottmann & Simone Boehrer. (2007) The tyrosine kinase inhibitor AMN107 (Nilotinib) exhibits off-target effects in lymphoblastic cell lines. Leukemia & Lymphoma 48:7, pages 1379-1388.
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Amit Kumar, Miriam Marqués & Ana C. Carrera. (2006) Phosphoinositide 3-Kinase Activation in Late G1 Is Required for c-Myc Stabilization and S Phase Entry. Molecular and Cellular Biology 26:23, pages 9116-9125.
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Victoria H. Cowling, Sanjay Chandriani, Michael L. Whitfield & Michael D. Cole. (2006) A Conserved Myc Protein Domain, MBIV, Regulates DNA Binding, Apoptosis, Transformation, and G2 Arrest. Molecular and Cellular Biology 26:11, pages 4226-4239.
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Kathryn A. O'Donnell, Duonan Yu, Karen I. Zeller, Jung-whan Kim, Frederick Racke, Andrei Thomas-Tikhonenko & Chi V. Dang. (2006) Activation of Transferrin Receptor 1 by c-Myc Enhances Cellular Proliferation and Tumorigenesis. Molecular and Cellular Biology 26:6, pages 2373-2386.
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C. Benassayag, L. Montero, N. Colombié, P. Gallant, D. Cribbs & D. Morello. (2005) Human c-Myc Isoforms Differentially Regulate Cell Growth and Apoptosis in Drosophila melanogaster. Molecular and Cellular Biology 25:22, pages 9897-9909.
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Feng Li, Yunyue Wang, Karen I. Zeller, James J. Potter, Diane R. Wonsey, Kathryn A. O'Donnell, Jung-whan Kim, Jason T. Yustein, Linda A. Lee & Chi V. Dang. (2005) Myc Stimulates Nuclearly Encoded Mitochondrial Genes and Mitochondrial Biogenesis. Molecular and Cellular Biology 25:14, pages 6225-6234.
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Toby Hulf, Paola Bellosta, Michael Furrer, Dominik Steiger, David Svensson, Andrew Barbour & Peter Gallant. (2005) Whole-Genome Analysis Reveals a Strong Positional Bias of Conserved dMyc-Dependent E-Boxes. Molecular and Cellular Biology 25:9, pages 3401-3410.
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Paula M. B. Pahl & Lawrence D. Horwitz. (2005) Cell Permeable Iron Chelators as Potential Cancer Chemotherapeutic Agents. Cancer Investigation 23:8, pages 683-691.
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Joel Pradines, Laura Rudolph-Owen, John Hunter, Patrick Leroy, Michael Cary, Robert Coopersmith, Vlado Dancik, Yelena Eltsefon, Victor Farutin, Christophe Leroy, Jonathan Rees, David Rose, Steve Rowley, Alan Ruttenberg, Patrick Wieghardt, Chris Sander & Christian Reich. (2004) Detection of Activity Centers in Cellular Pathways Using Transcript Profiling. Journal of Biopharmaceutical Statistics 14:3, pages 701-721.
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Paula L. Miliani de Marval, Everardo Macias, Robert Rounbehler, Piotr Sicinski, Hiroaki Kiyokawa, David G. Johnson, Claudio J. Conti & Marcelo L. Rodriguez-Puebla. (2004) Lack of Cyclin-Dependent Kinase 4 Inhibits c-myc Tumorigenic Activities in Epithelial Tissues. Molecular and Cellular Biology 24:17, pages 7538-7547.
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Rebecca Kristeleit, Lindsay Stimson, Paul Workman & Wynne Aherne. (2004) Histone modification enzymes: novel targets for cancer drugs. Expert Opinion on Emerging Drugs 9:1, pages 135-154.
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Edward V Prochownik. (2004) c-Myc as a therapeutic target in cancer. Expert Review of Anticancer Therapy 4:2, pages 289-302.
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Zhongdong Huang, Jolinda A. Traugh & J. Michael Bishop. (2004) Negative Control of the Myc Protein by the Stress-Responsive Kinase Pak2. Molecular and Cellular Biology 24:4, pages 1582-1594.
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Melanie J. McConnell, Nathalie Chevallier, Windy Berkofsky-Fessler, Jena M. Giltnane, Rupal B. Malani, Louis M. Staudt & Jonathan D. Licht. (2003) Growth Suppression by Acute PromyelocyticLeukemia-Associated Protein PLZF Is Mediated by Repression of c-myc Expression. Molecular and Cellular Biology 23:24, pages 9375-9388.
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Stella Pelengaris & Mike Khan. (2003) The c-MYC oncoprotein as a treatment target in cancer and other disorders of cell growth. Expert Opinion on Therapeutic Targets 7:5, pages 623-642.
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A. Enomoto, N. Suzuki, Y. Kang, K. Hirano, Y. Matsumoto, J. Zhu, A. Morita, Y. Hosoi, K. Sakai & H. Koyama. (2003) Decreased c‐Myc expression and its involvement in X‐ray‐induced apoptotic cell death of human T‐cell leukaemia cell line MOLT‐4. International Journal of Radiation Biology 79:8, pages 589-600.
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Jong Heon Kim, Ki Young Paek, Kobong Choi, Tae-Don Kim, Bumsuk Hahm, Kyong-Tai Kim & Sung Key Jang. (2003) Heterogeneous Nuclear Ribonucleoprotein C Modulates Translation of c-myc mRNA in a Cell Cycle Phase-Dependent Manner. Molecular and Cellular Biology 23:2, pages 708-720.
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Mikhail A. Nikiforov, Sanjay Chandriani, Brenda O'Connell, Oleksi Petrenko, Iulia Kotenko, Andrew Beavis, John M. Sedivy & Michael D. Cole. (2002) A Functional Screen for Myc-Responsive Genes Reveals Serine Hydroxymethyltransferase, a Major Source of the One-Carbon Unit for Cell Metabolism. Molecular and Cellular Biology 22:16, pages 5793-5800.
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Mikhail A. Nikiforov, Sanjay Chandriani, Jeonghyeon Park, Iulia Kotenko, Dina Matheos, Anna Johnsson, Steven B. McMahon & Michael D. Cole. (2002) TRRAP-Dependent and TRRAP-Independent Transcriptional Activation by Myc Family Oncoproteins. Molecular and Cellular Biology 22:14, pages 5054-5063.
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Han-Fei Ding & David E Fisher. (2002) Induction of apoptosis in cancer: new therapeutic opportunities. Annals of Medicine 34:6, pages 451-469.
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Susumu Adachi, Alvaro J. Obaya, Zhiyong Han, Noemi Ramos-Desimone, James H. Wyche & John M. Sedivy. (2001) c-Myc Is Necessary for DNA Damage-Induced Apoptosis in the G2 Phase of the Cell Cycle. Molecular and Cellular Biology 21:15, pages 4929-4937.
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Lisa M. Johansen, Atsushi Iwama, Tracey A. Lodie, Koichi Sasaki, Dean W. Felsher, Todd R. Golub & Daniel G. Tenen. (2001) c-Myc Is a Critical Target for C/EBPα in Granulopoiesis. Molecular and Cellular Biology 21:11, pages 3789-3806.
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Nabeel Bardeesy, Boris C. Bastian, Aram Hezel, Dan Pinkel, Ronald A. DePinho & Lynda Chin. (2001) Dual Inactivation of RB and p53 Pathways in RAS-Induced Melanomas. Molecular and Cellular Biology 21:6, pages 2144-2153.
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Troy A. Baudino & John L. Cleveland. (2001) The Max Network Gone Mad. Molecular and Cellular Biology 21:3, pages 691-702.
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Shew-Fung Wong, Leslie C. Lai. (2001) THE ROLE OF TGFβ IN HUMAN CANCERS. Pathology 33:1, pages 85-92.
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Andrew N. Billin, Alanna L. Eilers, Kathryn L. Coulter, Jennifer S. Logan & Donald E. Ayer. (2000) MondoA, a Novel Basic Helix-Loop-Helix–Leucine Zipper Transcriptional Activator That Constitutes a Positive Branch of a Max-Like Network. Molecular and Cellular Biology 20:23, pages 8845-8854.
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Kuo-I Lin, Yi Lin & Kathryn Calame. (2000) Repression of c-myc Is Necessary but Not Sufficient for Terminal Differentiation of B Lymphocytes In Vitro. Molecular and Cellular Biology 20:23, pages 8684-8695.
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Yoon S Cho-Chung. (2000) Antisense and therapeutic oligonucleotides: toward a gene-targeting cancer clinic. Expert Opinion on Therapeutic Patents 10:11, pages 1711-1724.
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Suzanne D. Conzen, Kathrin Gottlob, Eugene S. Kandel, Pratibha Khanduri, Andrew J. Wagner, Maura O'Leary & Nissim Hay. (2000) Induction of Cell Cycle Progression and Acceleration of Apoptosis Are Two Separable Functions of c-Myc: Transrepression Correlates with Acceleration of Apoptosis. Molecular and Cellular Biology 20:16, pages 6008-6018.
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Lisa J. Wood, Mita Mukherjee, Christine E. Dolde, Yi Xu, Joseph F. Maher, Tracie E. Bunton, John B. Williams & Linda M. S. Resar. (2000) HMG-I/Y, a New c-Myc Target Gene and Potential Oncogene. Molecular and Cellular Biology 20:15, pages 5490-5502.
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David W. Chang, Gisela F. Claassen, Stephen R. Hann & Michael D. Cole. (2000) The c-Myc Transactivation Domain Is a Direct Modulator of Apoptotic versus Proliferative Signals. Molecular and Cellular Biology 20:12, pages 4309-4319.
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Eric Santoni-Rugiu, Jacob Falck, Niels Mailand, Jiri Bartek & Jiri Lukas. (2000) Involvement of Myc Activity in a G1/S-Promoting Mechanism Parallel to the pRb/E2F Pathway. Molecular and Cellular Biology 20:10, pages 3497-3509.
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Mark Stoneley, Stephen A. Chappell, Catherine L. Jopling, Martin Dickens, Marion MacFarlane & Anne E. Willis. (2000) c-Myc Protein Synthesis Is Initiated from the Internal Ribosome Entry Segment during Apoptosis. Molecular and Cellular Biology 20:4, pages 1162-1169.
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Steven B. McMahon, Marcelo A. Wood & Michael D. Cole. (2000) The Essential Cofactor TRRAP Recruits the Histone Acetyltransferase hGCN5 to c-Myc. Molecular and Cellular Biology 20:2, pages 556-562.
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Amy J. Williams, Stephen C. Blacklow & Tucker Collins. (1999) The Zinc Finger-Associated SCAN Box Is a Conserved Oligomerization Domain. Molecular and Cellular Biology 19:12, pages 8526-8535.
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Beverley J. Warner, Stacy W. Blain, Joan Seoane & Joan Massagué. (1999) Myc Downregulation by Transforming Growth Factor β Required for Activation of the p15Ink4b G1 Arrest Pathway. Molecular and Cellular Biology 19:9, pages 5913-5922.
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Frank T. Kolligs, Gang Hu, Chi V. Dang & Eric R. Fearon. (1999) Neoplastic Transformation of RK3E by Mutant β-Catenin Requires Deregulation of Tcf/Lef Transcription but Not Activation of c-myc Expression. Molecular and Cellular Biology 19:8, pages 5696-5706.
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Ittai Ben-Porath, Ofra Yanuka & Nissim Benvenisty. (1999) The Tmp Gene, Encoding a Membrane Protein, Is a c-Myc Target with a Tumorigenic Activity. Molecular and Cellular Biology 19:5, pages 3529-3539.
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