27
Views
166
CrossRef citations to date
0
Altmetric
Gene Expression

RanGTP-Regulated Interactions of CRM1 with Nucleoporins and a Shuttling DEAD-Box Helicase

, , , , , , , , , & show all
Pages 6276-6285 | Received 22 Mar 1999, Accepted 21 Jun 1999, Published online: 27 Mar 2023

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (13)

Shoko Saito, Sadik Cigdem, Mitsuru Okuwaki & Kyosuke Nagata. (2016) Leukemia-Associated Nup214 Fusion Proteins Disturb the XPO1-Mediated Nuclear-Cytoplasmic Transport Pathway and Thereby the NF-κB Signaling Pathway. Molecular and Cellular Biology 36:13, pages 1820-1835.
Read now
Deepak Sharma & Eckhard Jankowsky. (2014) The Ded1/DDX3 subfamily of DEAD-box RNA helicases. Critical Reviews in Biochemistry and Molecular Biology 49:4, pages 343-360.
Read now
Sang Sun Kang & Sung Hwa Shin. (2013) Phosphorylation of human chromosome maintenance 1 mediates association with 14-3-3 proteins. Animal Cells and Systems 17:3, pages 186-195.
Read now
Saskia Hutten & Ralph H. Kehlenbach. (2006) Nup214 Is Required for CRM1-Dependent Nuclear Protein Export In Vivo. Molecular and Cellular Biology 26:18, pages 6772-6785.
Read now
Dirk Daelemans, Sylvain V. Costes, Stephen Lockett & George N. Pavlakis. (2005) Kinetic and Molecular Analysis of Nuclear Export Factor CRM1 Association with Its Cargo In Vivo. Molecular and Cellular Biology 25:2, pages 728-739.
Read now
Rafael Bernad, Hella van der Velde, Maarten Fornerod & Helen Pickersgill. (2004) Nup358/RanBP2 Attaches to the Nuclear Pore Complex via Association with Nup88 and Nup214/CAN and Plays a Supporting Role in CRM1-Mediated Nuclear Protein Export. Molecular and Cellular Biology 24:6, pages 2373-2384.
Read now
Yoshiyuki Hakata, Masami Yamada & Hisatoshi Shida. (2003) A Multifunctional Domain in Human CRM1 (Exportin 1) Mediates RanBP3 Binding and Multimerization of Human T-Cell Leukemia Virus Type 1 Rex Protein. Molecular and Cellular Biology 23:23, pages 8751-8761.
Read now
Scott Kuersten, Gert-Jan Arts, Tobias C. Walther, Ludwig Englmeier & Iain W. Mattaj. (2002) Steady-State Nuclear Localization of Exportin-t Involves RanGTP Binding and Two Distinct Nuclear Pore Complex Interaction Domains. Molecular and Cellular Biology 22:16, pages 5708-5720.
Read now
Hanne Poulsen, Jakob Nilsson, Christian K. Damgaard, Jan Egebjerg & Jørgen Kjems. (2001) CRM1 Mediates the Export of ADAR1 through a Nuclear Export Signal within the Z-DNA Binding Domain. Molecular and Cellular Biology 21:22, pages 7862-7871.
Read now
Brian W. Guzik, Lyne Levesque, Susan Prasad, Yeou-Cherng Bor, Ben E. Black, Bryce M. Paschal, David Rekosh & Marie-Louise Hammarskjöld. (2001) NXT1 (p15) Is a Crucial Cellular Cofactor in TAP-Dependent Export of Intron-Containing RNA in Mammalian Cells. Molecular and Cellular Biology 21:7, pages 2545-2554.
Read now
Dirk Heerklotz, Pascal Döring, Frank Bonzelius, Sybille Winkelhaus & Lutz Nover. (2001) The Balance of Nuclear Import and Export Determines the Intracellular Distribution and Function of Tomato Heat Stress Transcription Factor HsfA2. Molecular and Cellular Biology 21:5, pages 1759-1768.
Read now
Tinglu Guan, Ralph H. Kehlenbach, Eric C. Schirmer, Angelika Kehlenbach, Fan Fan, Bruce E. Clurman, Norman Arnheim & Larry Gerace. (2000) Nup50, a Nucleoplasmically Oriented Nucleoporin with a Role in Nuclear Protein Export. Molecular and Cellular Biology 20:15, pages 5619-5630.
Read now
Markus Künzler, Thomas Gerstberger, Françoise Stutz, F. Ralf Bischoff & Ed Hurt. (2000) Yeast Ran-Binding Protein 1 (Yrb1) Shuttles between the Nucleus and Cytoplasm and Is Exported from the Nucleus via a CRM1(XPO1)-Dependent Pathway. Molecular and Cellular Biology 20:12, pages 4295-4308.
Read now

Articles from other publishers (153)

Ho Yee Joyce Fung & Yuh Min Chook. 2022. The Nuclear Pore Complex. The Nuclear Pore Complex 245 256 .
Sebastian Samer, Rajeev Raman, Gregor Laube, Michael R. Kreutz & Anna Karpova. (2021) The nuclear lamina is a hub for the nuclear function of Jacob. Molecular Brain 14:1.
Crossref
Mohamed Hamed, Birgit Caspar, Sarah A. Port & Ralph H. Kehlenbach. (2021) A nuclear export sequence promotes CRM1-dependent targeting of the nucleoporin Nup214 to the nuclear pore complex. Journal of Cell Science 134:6.
Crossref
Jie Mo, Huifang Liang, Chen Su, Pengcheng Li, Jin Chen & Bixiang Zhang. (2021) DDX3X: structure, physiologic functions and cancer. Molecular Cancer 20:1.
Crossref
Molka Mokdadi, Yosser Zina Abdelkrim, Josette Banroques, Emmeline Huvelle, Rafeh Oualha, Hilal Yeter-Alat, Ikram Guizani, Mourad Barhoumi & N. Kyle Tanner. (2021) The In Silico Identification of Potential Members of the Ded1/DDX3 Subfamily of DEAD-Box RNA Helicases from the Protozoan Parasite Leishmania infantum and Their Analyses in Yeast. Genes 12:2, pages 212.
Crossref
Saskia Hutten, Sinem Usluer, Benjamin Bourgeois, Francesca Simonetti, Hana M. Odeh, Charlotte M. Fare, Mareike Czuppa, Marian Hruska-Plochan, Mario Hofweber, Magdalini Polymenidou, James Shorter, Dieter Edbauer, Tobias Madl & Dorothee Dormann. (2020) Nuclear Import Receptors Directly Bind to Arginine-Rich Dipeptide Repeat Proteins and Suppress Their Pathological Interactions. Cell Reports 33:12, pages 108538.
Crossref
Adélia Mendes, Ramona Jühlen, Valérie Martinelli & Birthe Fahrenkrog. (2020) Targeted CRM1-inhibition perturbs leukemogenic NUP214 fusion proteins and exerts anti-cancer effects in leukemia cell lines with NUP214 rearrangements . Oncotarget 11:36, pages 3371-3386.
Crossref
Marlieke LM Jongsma, Jeroen Bakker, Birol Cabukusta, Nalan Liv, Daphne van Elsland, Job Fermie, Jimmy LL Akkermans, Coenraad Kuijl, Sabina Y van der Zanden, Lennert Janssen, Denise Hoogzaad, Rik van der Kant, Ruud H Wijdeven, Judith Klumperman, Ilana Berlin & Jacques Neefjes. (2020) SKIP ‐ HOPS recruits TBC 1D15 for a Rab7‐to‐Arl8b identity switch to control late endosome transport . The EMBO Journal 39:6.
Crossref
Masahiro Oka, Sonoko Mura, Mayumi Otani, Yoichi Miyamoto, Jumpei Nogami, Kazumitsu Maehara, Akihito Harada, Taro Tachibana, Yoshihiro Yoneda & Yasuyuki Ohkawa. (2019) Chromatin-bound CRM1 recruits SET-Nup214 and NPM1c onto HOX clusters causing aberrant HOX expression in leukemia cells. eLife 8.
Crossref
Steven M. Heaton, Sarah C. Atkinson, Melissa N. Sweeney, Sundy N. Y. Yang, David A. Jans & Natalie A. Borg. (2019) Exportin-1-Dependent Nuclear Export of DEAD-box Helicase DDX3X is Central to its Role in Antiviral Immunity. Cells 8:10, pages 1181.
Crossref
Maria L. Dufau & Raghuveer Kavarthapu. (2019) Gonadotropin Regulated Testicular RNA Helicase, Two Decades of Studies on Its Structure Function and Regulation From Its Discovery Opens a Window for Development of a Non-hormonal Oral Male Contraceptive. Frontiers in Endocrinology 10.
Crossref
Azra Lari, Arvind Arul Nambi Rajan, Rima Sandhu, Taylor Reiter, Rachel Montpetit, Barry P Young, Chris JR Loewen & Ben Montpetit. (2019) A nuclear role for the DEAD-box protein Dbp5 in tRNA export. eLife 8.
Crossref
Paulo A. Ferreira. (2019) The coming-of-age of nucleocytoplasmic transport in motor neuron disease and neurodegeneration. Cellular and Molecular Life Sciences 76:12, pages 2247-2273.
Crossref
Yuling Li, Jinhan Zhou, Sui Min, Yang Zhang, Yuqing Zhang, Qiao Zhou, Xiaofei Shen, Da Jia, Junhong Han & Qingxiang Sun. (2019) Distinct RanBP1 nuclear export and cargo dissociation mechanisms between fungi and animals. eLife 8.
Crossref
Natalia Dworak, Dawid Makosa, Mandovi Chatterjee, Kasey Jividen, Chun-Song Yang, Chelsi Snow, William C. Simke, Isaac G. Johnson, Joshua B. Kelley & Bryce M. Paschal. (2019) A nuclear lamina-chromatin-Ran GTPase axis modulates nuclear import and DNA damage signaling. Aging Cell 18:1, pages e12851.
Crossref
Adélia Mendes & Birthe Fahrenkrog. (2019) NUP214 in Leukemia: It’s More than Transport. Cells 8:1, pages 76.
Crossref
Ruth Brennan, Antje Haap-Hoff, Lili Gu, Virginie Gautier, Aideen Long & Martina Schröder. (2018) Investigating nucleo-cytoplasmic shuttling of the human DEAD-box helicase DDX3. European Journal of Cell Biology 97:7, pages 501-511.
Crossref
A. A. Glukhova, E. N. Nabirochkina & D. V. Kopytova. (2019) mRNP Transport in Eukaryotes. mRNP Export from the Nucleus. Molecular Genetics, Microbiology and Virology 33:3, pages 182-186.
Crossref
Xun X Bao, Christos Spanos, Tomoko Kojidani, Eric M Lynch, Juri Rappsilber, Yasushi Hiraoka, Tokuko Haraguchi & Kenneth E Sawin. (2018) Exportin Crm1 is repurposed as a docking protein to generate microtubule organizing centers at the nuclear pore. eLife 7.
Crossref
Qing Li, Hongdan Yang, Lin He & Qun Wang. (2018) Characterization of the Es -DDX52 involved in the spermatogonial mitosis and spermatid differentiation in Chinese mitten crab ( Eriocheir sinensis ). Gene 646, pages 106-119.
Crossref
Misato Ohtani. (2018) Plant snRNP Biogenesis: A Perspective from the Nucleolus and Cajal Bodies. Frontiers in Plant Science 8.
Crossref
A. A. Glukhova, E. N. Nabirochkina & D. V. Kopytova. (2018) mRNP transport in eukaryotes. mRNP export from the nucleus. Molecular Genetics Microbiology and Virology (Russian version) 36:3, pages 25.
Crossref
Nuno Martins, Adélia Mendes & Birthe Fahrenkrog. 2018. Nuclear-Cytoplasmic Transport. Nuclear-Cytoplasmic Transport 223 248 .
Liliana Milani, Andrea Pecci, Carmine Cifaldi & Maria Gabriella Maurizii. (2017) PL10 DEAD-Box Protein is Expressed during Germ Cell Differentiation in the Reptile Podarcis sicula (Family Lacertidae) . Journal of Experimental Zoology Part B: Molecular and Developmental Evolution 328:5, pages 433-448.
Crossref
Ryan T. Behrens, Mounavya Aligeti, Ginger M. Pocock, Christina A. Higgins & Nathan M. Sherer. (2017) Nuclear Export Signal Masking Regulates HIV-1 Rev Trafficking and Viral RNA Nuclear Export. Journal of Virology 91:3.
Crossref
Salini KonikkatJohn L. Woolford,JrJr. (2017) Principles of 60S ribosomal subunit assembly emerging from recent studies in yeast. Biochemical Journal 474:2, pages 195-214.
Crossref
Tobias Ritterhoff, Hrishikesh Das, Götz Hofhaus, Rasmus R. Schröder, Annette Flotho & Frauke Melchior. (2016) The RanBP2/RanGAP1*SUMO1/Ubc9 SUMO E3 ligase is a disassembly machine for Crm1-dependent nuclear export complexes. Nature Communications 7:1.
Crossref
Sarita Raghunayakula, Divya Subramonian, Mary Dasso, Rita Kumar & Xiang-Dong Zhang. (2015) Molecular Characterization and Functional Analysis of Annulate Lamellae Pore Complexes in Nuclear Transport in Mammalian Cells. PLOS ONE 10:12, pages e0144508.
Crossref
Malwina Hyjek, Natalia Wojciechowska, Magda Rudzka, Agnieszka Kołowerzo-Lubnau & Dariusz Jan Smoliński. (2015) Spatial regulation of cytoplasmic snRNP assembly at the cellular level. Journal of Experimental Botany 66:22, pages 7019-7030.
Crossref
Sarah A. Port, Thomas Monecke, Achim Dickmanns, Christiane Spillner, Romina Hofele, Henning Urlaub, Ralf Ficner & Ralph H. Kehlenbach. (2015) Structural and Functional Characterization of CRM1-Nup214 Interactions Reveals Multiple FG-Binding Sites Involved in Nuclear Export. Cell Reports 13:4, pages 690-702.
Crossref
Glenn Hauk & Gregory D. Bowman. (2015) Formation of a Trimeric Xpo1-Ran[GTP]-Ded1 Exportin Complex Modulates ATPase and Helicase Activities of Ded1. PLOS ONE 10:6, pages e0131690.
Crossref
Masumi Okamura, Haruko Inose & Seiji Masuda. (2015) RNA Export through the NPC in Eukaryotes. Genes 6:1, pages 124-149.
Crossref
Alan R Lowe, Jeffrey H Tang, Jaime Yassif, Michael Graf, William YC Huang, Jay T Groves, Karsten Weis & Jan T Liphardt. (2015) Importin-β modulates the permeability of the nuclear pore complex in a Ran-dependent manner. eLife 4.
Crossref
Bastien Cautain, Richard Hill, Nuria de Pedro & Wolfgang Link. (2015) Components and regulation of nuclear transport processes. FEBS Journal 282:3, pages 445-462.
Crossref
Purnima Nerurkar, Martin Altvater, Stefan Gerhardy, Sabina Schütz, Ute Fischer, Christine Weirich & Vikram Govind Panse. 2015. 107 140 .
David S Booth, Yifan Cheng & Alan D Frankel. (2014) The export receptor Crm1 forms a dimer to promote nuclear export of HIV RNA. eLife 3.
Crossref
Meriem Senissar, Agnès Le Saux, Naïma Belgareh-Touzé, Céline Adam, Josette Banroques & N. Kyle Tanner. (2014) The DEAD-box helicase Ded1 from yeast is an mRNP cap-associated protein that shuttles between the cytoplasm and nucleus. Nucleic Acids Research 42:15, pages 10005-10022.
Crossref
Ho Yee Joyce Fung & Yuh Min Chook. (2014) Atomic basis of CRM1-cargo recognition, release and inhibition. Seminars in Cancer Biology 27, pages 52-61.
Crossref
Nicole Dölker, Clement E. Blanchet, Béla Voß, David Haselbach, Christian Kappel, Thomas Monecke, Dmitri I. Svergun, Holger Stark, Ralf Ficner, Ulrich Zachariae, Helmut Grubmüller & Achim Dickmanns. (2013) Structural Determinants and Mechanism of Mammalian CRM1 Allostery. Structure 21:8, pages 1350-1360.
Crossref
Marlene Grünwald, Daniela Lazzaretti & Fulvia Bono. (2013) Structural basis for the nuclear export activity of Importin13. The EMBO Journal 32:6, pages 899-913.
Crossref
Stephanie Roloff, Christiane Spillner & Ralph H. Kehlenbach. (2013) Several Phenylalanine-Glycine Motives in the Nucleoporin Nup214 Are Essential for Binding of the Nuclear Export Receptor CRM1. Journal of Biological Chemistry 288:6, pages 3952-3963.
Crossref
Zhige Wu, Qing Jiang, Paul R. Clarke & Chuanmao Zhang. (2013) Phosphorylation of Crm1 by CDK1-cyclin B promotes Ran-dependent mitotic spindle assembly. Journal of Cell Science.
Crossref
Steven Santos, Yuri Obukhov, Sergei Nekhai, Michael Bukrinsky & Sergey Iordanskiy. (2012) Virus-producing cells determine the host protein profiles of HIV-1 virion cores. Retrovirology 9:1.
Crossref
Marianna Agassandian, Bill B. Chen, Roopa Pulijala, Leah Kaercher, Jennifer R. Glasser & Rama K. Mallampalli. (2012) Calcium-calmodulin kinase I cooperatively regulates nucleocytoplasmic shuttling of CCTα by accessing a nuclear export signal. Molecular Biology of the Cell 23:14, pages 2755-2769.
Crossref
Inga Waldmann, Christiane Spillner & Ralph H. Kehlenbach. (2012) The nucleoporin-like protein NLP1 (hCG1) promotes CRM1-dependent nuclear protein export. Journal of Cell Science 125:1, pages 144-154.
Crossref
Rami Doueiri & Patrick L. Green. 2012. Cancer Associated Viruses. Cancer Associated Viruses 647 675 .
Brian M. Friedrich, Natallia Dziuba, Guangyu Li, Mark A. Endsley, James L. Murray & Monique R. Ferguson. (2011) Host factors mediating HIV-1 replication. Virus Research 161:2, pages 101-114.
Crossref
Utz Fischer, Clemens Englbrecht & Ashwin Chari. (2011) Biogenesis of spliceosomal small nuclear ribonucleoproteins. WIREs RNA 2:5, pages 718-731.
Crossref
Thomas Güttler & Dirk Görlich. (2011) Ran-dependent nuclear export mediators: a structural perspective. The EMBO Journal 30:17, pages 3457-3474.
Crossref
Karla Langer, Cyril Dian, Vladimir Rybin, Christoph W. Müller & Carlo Petosa. (2011) Insights into the Function of the CRM1 Cofactor RanBP3 from the Structure of Its Ran-Binding Domain. PLoS ONE 6:2, pages e17011.
Crossref
Thomas Güttler, Tobias Madl, Piotr Neumann, Danilo Deichsel, Lorenzo Corsini, Thomas Monecke, Ralf Ficner, Michael Sattler & Dirk Görlich. (2010) NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1. Nature Structural & Molecular Biology 17:11, pages 1367-1376.
Crossref
Mark Hilliard, Cornelia Frohnert, Christiane Spillner, Simone Marcone, Annegret Nath, Tina Lampe, Desmond J. Fitzgerald & Ralph H. Kehlenbach. (2010) The Anti-inflammatory Prostaglandin 15-Deoxy-Δ12,14-PGJ2 Inhibits CRM1-dependent Nuclear Protein Export. Journal of Biological Chemistry 285:29, pages 22202-22210.
Crossref
Masako Koyama & Yoshiyuki Matsuura. (2010) An allosteric mechanism to displace nuclear export cargo from CRM1 and RanGTP by RanBP1. The EMBO Journal 29:12, pages 2002-2013.
Crossref
Svetlana Atasheva, Alexander Fish, Maarten Fornerod & Elena I. Frolova. (2010) Venezuelan Equine Encephalitis Virus Capsid Protein Forms a Tetrameric Complex with CRM1 and Importin α/β That Obstructs Nuclear Pore Complex Function. Journal of Virology 84:9, pages 4158-4171.
Crossref
Akiko Takeda, Nayan J. Sarma, Anmaar M. Abdul-Nabi & Nabeel R. Yaseen. (2010) Inhibition of CRM1-mediated Nuclear Export of Transcription Factors by Leukemogenic NUP98 Fusion Proteins. Journal of Biological Chemistry 285:21, pages 16248-16257.
Crossref
Andreas von Knethen, Nico Tzieply, Carla Jennewein & Bernhard Brüne. (2010) Casein-kinase-II-dependent phosphorylation of PPARγ provokes CRM1-mediated shuttling of PPARγ from the nucleus to the cytosol. Journal of Cell Science 123:2, pages 192-201.
Crossref
Iris Ben-Efraim, Phyllis D Frosst & Larry Gerace. (2009) Karyopherin binding interactions and nuclear import mechanism of nuclear pore complex protein Tpr. BMC Cell Biology 10:1.
Crossref
Haizhen Wang, Xueliang Gao, Yun Huang, Jenny Yang & Zhi-Ren Liu. (2009) P68 RNA helicase is a nucleocytoplasmic shuttling protein. Cell Research 19:12, pages 1388-1400.
Crossref
Paul Michel Aloyse Antony, Simone Mäntele, Phillip Mollenkopf, Jana Boy, Ralph H. Kehlenbach, Olaf Riess & Thorsten Schmidt. (2009) Identification and functional dissection of localization signals within ataxin-3. Neurobiology of Disease 36:2, pages 280-292.
Crossref
Amy Hubert & Philip Anderson. (2009) The C. elegans sex determination gene laf-1 encodes a putative DEAD-box RNA helicase. Developmental Biology 330:2, pages 358-367.
Crossref
Dzmitry G. Batrakou, Alastair R.W. Kerr & Eric C. Schirmer. (2009) Comparative proteomic analyses of the nuclear envelope and pore complex suggests a wide range of heretofore unexpected functions. Journal of Proteomics 72:1, pages 56-70.
Crossref
Tine Van Neck, Christophe Pannecouque, Els Vanstreels, Miguel Stevens, Wim Dehaen & Dirk Daelemans. (2008) Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: Structure–activity relationship and mechanism of action. Bioorganic & Medicinal Chemistry 16:21, pages 9487-9497.
Crossref
Ming-Chih Lai, Yan-Hwa Wu Lee & Woan-Yuh Tarn. (2008) The DEAD-Box RNA Helicase DDX3 Associates with Export Messenger Ribonucleoproteins as well asTip-associated Protein and Participates in Translational Control. Molecular Biology of the Cell 19:9, pages 3847-3858.
Crossref
Matthew D. Daugherty, Iván D'Orso & Alan D. Frankel. (2008) A Solution to Limited Genomic Capacity: Using Adaptable Binding Surfaces to Assemble the Functional HIV Rev Oligomer on RNA. Molecular Cell 31:6, pages 824-834.
Crossref
Maria Lombardi, Gabriella Castoria, Antimo Migliaccio, Maria Vittoria Barone, Rosina Di Stasio, Alessandra Ciociola, Daniela Bottero, Hiroshi Yamaguchi, Ettore Appella & Ferdinando Auricchio. (2008) Hormone-dependent nuclear export of estradiol receptor and DNA synthesis in breast cancer cells. Journal of Cell Biology 182:2, pages 327-340.
Crossref
C.-S. Lee, A. P. Dias, M. Jedrychowski, A. H. Patel, J. L. Hsu & R. Reed. (2008) Human DDX3 functions in translation and interacts with the translation initiation factor eIF3. Nucleic Acids Research 36:14, pages 4708-4718.
Crossref
Nils Neuenkirchen, Ashwin Chari & Utz Fischer. (2008) Deciphering the assembly pathway of Sm-class U snRNPs. FEBS Letters 582:14, pages 1997-2003.
Crossref
Dieuwke Engelsma, Noelia Valle, Alexander FishNathalie Salomé, José M. Almendral & Maarten Fornerod. (2008) A Supraphysiological Nuclear Export Signal Is Required for Parvovirus Nuclear Export. Molecular Biology of the Cell 19:6, pages 2544-2552.
Crossref
Saskia Hutten, Annette Flotho, Frauke Melchior & Ralph H. Kehlenbach. (2008) The Nup358-RanGAP Complex Is Required for Efficient Importin α/β-dependent Nuclear Import. Molecular Biology of the Cell 19:5, pages 2300-2310.
Crossref
César López-Camarillo, María de la Luz García-Hernández, Laurence A. Marchat, Juan P. Luna-Arias, Olga Hernández de la Cruz, Leobardo Mendoza & Esther Orozco. (2008) Entamoeba histolytica EhDEAD1 is a conserved DEAD-box RNA helicase with ATPase and ATP-dependent RNA unwinding activities. Gene 414:1-2, pages 19-31.
Crossref
Julia Dorfman & Ian G. Macara. (2008) STRADα Regulates LKB1 Localization by Blocking Access to Importin-α, and by Association with Crm1 and Exportin-7. Molecular Biology of the Cell 19:4, pages 1614-1626.
Crossref
Coenraad Kuijl, Nigel D. L. Savage, Marije Marsman, Adriaan W. Tuin, Lennert Janssen, David A. Egan, Mirjam Ketema, Rian van den Nieuwendijk, Susan J. F. van den Eeden, Annemieke Geluk, Alex Poot, Gijs van der Marel, Roderick L. Beijersbergen, Hermen Overkleeft, Tom H. M. Ottenhoff & Jacques Neefjes. (2007) Intracellular bacterial growth is controlled by a kinase network around PKB/AKT1. Nature 450:7170, pages 725-730.
Crossref
Dieuwke Engelsma, Jose A. Rodriguez, Alexander Fish, Giuseppe Giaccone & Maarten Fornerod. (2007) Homodimerization Antagonizes Nuclear Export of Survivin. Traffic 8:11, pages 1495-1502.
Crossref
L. Silvia Salinas, Ernesto Maldonado, Marina Macías-Silva, T. Keith Blackwell & Rosa E. Navarro. (2007) The DEAD box RNA helicase VBH-1 is required for germ cell function in C. elegans . genesis 45:9, pages 533-546.
Crossref
Ugur Özbek, Ayten Kandilci, Sjozef van Baal, Jacqueline Bonten, Kelli Boyd, Patrick Franken, Riccardo Fodde & Gerard C. Grosveld. (2007) SET-CAN, the Product of the t(9;9) in Acute Undifferentiated Leukemia, Causes Expansion of Early Hematopoietic Progenitors and Hyperproliferation of Stomach Mucosa in Transgenic Mice. The American Journal of Pathology 171:2, pages 654-666.
Crossref
Matthew West, John B. Hedges, Kai-Yin Lo & Arlen W. Johnson. (2007) Novel Interaction of the 60S Ribosomal Subunit Export Adapter Nmd3 at the Nuclear Pore Complex. Journal of Biological Chemistry 282:19, pages 14028-14037.
Crossref
Saskia Hutten & Ralph H. Kehlenbach. (2007) CRM1-mediated nuclear export: to the pore and beyond. Trends in Cell Biology 17:4, pages 193-201.
Crossref
Sébastien Boulo, Hatice Akarsu, Rob W.H. Ruigrok & Florence Baudin. (2007) Nuclear traffic of influenza virus proteins and ribonucleoprotein complexes. Virus Research 124:1-2, pages 12-21.
Crossref
Greg Riddick & Ian G Macara. (2007) The adapter importin‐α provides flexible control of nuclear import at the expense of efficiency. Molecular Systems Biology 3:1.
Crossref
Takao Honda & Kazunori Nakajima. (2006) Mouse Disabled1 (DAB1) Is a Nucleocytoplasmic Shuttling Protein. Journal of Biological Chemistry 281:50, pages 38951-38965.
Crossref
Nikos Xylourgidis, Peggy Roth, Nafiseh Sabri, Vasilios Tsarouhas & Christos Samakovlis. (2006) The nucleoporin Nup214 sequesters CRM1 at the nuclear rim and modulates NFκB activation in Drosophila . Journal of Cell Science 119:21, pages 4409-4419.
Crossref
Marc Arnold, Annegret Nath, Joachim Hauber & Ralph H. Kehlenbach. (2006) Multiple Importins Function as Nuclear Transport Receptors for the Rev Protein of Human Immunodeficiency Virus Type 1. Journal of Biological Chemistry 281:30, pages 20883-20890.
Crossref
Rafael Bernad, Dieuwke Engelsma, Helen Sanderson, Helen Pickersgill & Maarten Fornerod. (2006) Nup214-Nup88 Nucleoporin Subcomplex Is Required for CRM1-mediated 60 S Preribosomal Nuclear Export. Journal of Biological Chemistry 281:28, pages 19378-19386.
Crossref
Amalia Rosner, Guy Paz & Baruch Rinkevich. (2006) Divergent roles of the DEAD-box protein BS-PL10, the urochordate homologue of human DDX3 and DDX3Y proteins, in colony astogeny and ontogeny. Developmental Dynamics 235:6, pages 1508-1521.
Crossref
Dmitri Nashchekin, Jian Zhao, Neus Visa & Bertil Daneholt. (2006) A Novel Ded1-like RNA Helicase Interacts with the Y-box Protein ctYB-1 in Nuclear mRNP Particles and in Polysomes. Journal of Biological Chemistry 281:20, pages 14263-14272.
Crossref
Takuro Nakamura. (2005) NUP98 Fusion in Human Leukemia: Dysregulation of the Nuclear Pore and Homeodomain Proteins. International Journal of Hematology 82:1, pages 21-27.
Crossref
Lisa Z. Scheifele, Eileen P. Ryan & Leslie J. Parent. (2005) Detailed Mapping of the Nuclear Export Signal in the Rous Sarcoma Virus Gag Protein. Journal of Virology 79:14, pages 8732-8741.
Crossref
CHRISTIANE BRUNE, SARAH E. MUNCHEL, NICOLE FISCHER, ALEXANDRE V. PODTELEJNIKOV & KARSTEN WEIS. (2005) Yeast poly(A)-binding protein Pab1 shuttles between the nucleus and the cytoplasm and functions in mRNA export. RNA 11:4, pages 517-531.
Crossref
Maria Rosario Fernandez-Fernandez, Dmitry B. Veprintsev & Alan R. Fersht. (2005) Proteins of the S100 family regulate the oligomerization of p53 tumor suppressor. Proceedings of the National Academy of Sciences 102:13, pages 4735-4740.
Crossref
Ulrike Kutay & Stephan Güttinger. (2005) Leucine-rich nuclear-export signals: born to be weak. Trends in Cell Biology 15:3, pages 121-124.
Crossref
Oona Johnstone, Renate Deuring, Ronald Bock, Patrick Linder, Margaret T. Fuller & Paul Lasko. (2005) Belle is a Drosophila DEAD-box protein required for viability and in the germ line. Developmental Biology 277:1, pages 92-101.
Crossref
U. F. Greber & M. Fornerod. 2005. Membrane Trafficking in Viral Replication. Membrane Trafficking in Viral Replication 109 138 .
Tetsuya Taura, Mikiko C. Siomi & Haruhiko Siomi. 2005. Nuclear Import and Export in Plants and Animals. Nuclear Import and Export in Plants and Animals 161 174 .
Yoshiyuki Matsuura & Murray Stewart. (2004) Structural basis for the assembly of a nuclear export complex. Nature 432:7019, pages 872-877.
Crossref
Carlo Petosa, Guy Schoehn, Peter Askjaer, Ulrike Bauer, Martine Moulin, Ulrich Steuerwald, Montserrat Soler-López, Florence Baudin, Iain W. Mattaj & Christoph W. Müller. (2004) Architecture of CRM1/Exportin1 Suggests How Cooperativity Is Achieved during Formation of a Nuclear Export Complex. Molecular Cell 16:5, pages 761-775.
Crossref
Takeshi Sekiguchi, Hiroshi Iida, Junko Fukumura & Takeharu Nishimoto. (2004) Human DDX3Y, the Y-encoded isoform of RNA helicase DDX3, rescues a hamster temperature-sensitive ET24 mutant cell line with a DDX3X mutation. Experimental Cell Research 300:1, pages 213-222.
Crossref
Venkat S.R.K. Yedavalli, Christine Neuveut, Ya-hui Chi, Lawrence Kleiman & Kuan-Teh Jeang. (2004) Requirement of DDX3 DEAD Box RNA Helicase for HIV-1 Rev-RRE Export Function. Cell 119:3, pages 381-392.
Crossref
Dieuwke Engelsma, Rafael Bernad, Jero Calafat & Maarten Fornerod. (2004) Supraphysiological nuclear export signals bind CRM1 independently of RanGTP and arrest at Nup358. The EMBO Journal 23:18, pages 3643-3652.
Crossref
Shoko Saito, Mary Miyaji-Yamaguchi & Kyosuke Nagata. (2004) Aberrant intracellular localization of SET-CAN fusion protein, associated with a leukemia, disorganizes nuclear export. International Journal of Cancer 111:4, pages 501-507.
Crossref
Jian Zhao, Shao-Bo Jin & Lars Wieslander. (2004) CRM1 and Ran are present but a NES-CRM1-RanGTP complex is not required in Balbiani ring mRNP particles from the gene to the cytoplasm. Journal of Cell Science 117:8, pages 1553-1566.
Crossref
Angelique W. Whitehurst, Fred L. Robinson, Mary Shannon Moore & Melanie H. Cobb. (2004) The Death Effector Domain Protein PEA-15 Prevents Nuclear Entry of ERK2 by Inhibiting Required Interactions. Journal of Biological Chemistry 279:13, pages 12840-12847.
Crossref
Dorthe L. C. AlmholtFrosty LoechelSøren J. NielsenChristian Krog-JensenRobert TerrySara P. BjørnHans C. PedersenMorten PraestegaardSøren MøllerMorten HeideLen PagliaroAnthony J. MasonSteven ButcherSøren W. Dahl. (2004) Nuclear Export Inhibitors and Kinase Inhibitors Identified Using a MAPK-Activated Protein Kinase 2 Redistribution ® Screen . ASSAY and Drug Development Technologies 2:1, pages 7-20.
Crossref
Nicola Wiechens, Karolin Heinle, Ludwig Englmeier, Anne Schohl & François Fagotto. (2004) Nucleo-cytoplasmic Shuttling of Axin, a Negative Regulator of the Wnt-β-Catenin Pathway. Journal of Biological Chemistry 279:7, pages 5263-5267.
Crossref
Ian Cushman, David Stenoien & Mary Shannon Moore. (2004) The Dynamic Association of RCC1 with Chromatin Is Modulated by Ran-dependent Nuclear Transport. Molecular Biology of the Cell 15:1, pages 245-255.
Crossref
Christina N. Alavian, Joan C. Ritland Politz, Laura B. Lewandowski, Christine M. Powers & Thoru Pederson. (2004) Nuclear export of signal recognition particle RNA in mammalian cells. Biochemical and Biophysical Research Communications 313:2, pages 351-355.
Crossref
A Kiss, L Li, T Gettemeier & L.K Venkatesh. (2003) Functional analysis of the interaction of the human immunodeficiency virus type 1 Rev nuclear export signal with its cofactors. Virology 314:2, pages 591-600.
Crossref
L. K. Venkatesh, T. Gettemeier & G. Chinnadurai. (2003) A Nuclear Kinesin-Like Protein Interacts with and Stimulates the Activity of the Leucine-Rich Nuclear Export Signal of the Human Immunodeficiency Virus Type 1 Rev Protein. Journal of Virology 77:13, pages 7236-7243.
Crossref
Mario Köster, Søren Lykke-Andersen, Yasser A Elnakady, Klaus Gerth, Peter Washausen, Gerhard Höfle, Florenz Sasse, Jørgen Kjems & Hansjörg Hauser. (2003) Ratjadones inhibit nuclear export by blocking CRM1/exportin 1. Experimental Cell Research 286:2, pages 321-331.
Crossref
Janna Bednenko, Gino Cingolani & Larry Gerace. (2003) Nucleocytoplasmic Transport: Navigating the Channel. Traffic 4:3, pages 127-135.
Crossref
Attila Becskei & Iain W. Mattaj. (2003) The strategy for coupling the RanGTP gradient to nuclear protein export. Proceedings of the National Academy of Sciences 100:4, pages 1717-1722.
Crossref
Michael K. Connor, Rouslan Kotchetkov, Sandrine Cariou, Ansgar Resch, Rafaella Lupetti, Richard G. Beniston, Frauke Melchior, Ludger Hengst & Joyce M. Slingerland. (2003) CRM1/Ran-Mediated Nuclear Export of p27 Kip1 Involves a Nuclear Export Signal and Links p27 Export and Proteolysis . Molecular Biology of the Cell 14:1, pages 201-213.
Crossref
Peter Askjaer, Vincent Galy, Eva Hannak & Iain W. Mattaj. (2002) Ran GTPase Cycle and Importins α and β Are Essential for Spindle Formation and Nuclear Envelope Assembly in Living Caenorhabditis elegans Embryos . Molecular Biology of the Cell 13:12, pages 4355-4370.
Crossref
Nadia P.C. Allen, Samir S. Patel, Lan Huang, Robert J. Chalkley, Al Burlingame, Malik Lutzmann, Eduard C. Hurt & Michael Rexach. (2002) Deciphering Networks of Protein Interactions at the Nuclear Pore Complex. Molecular & Cellular Proteomics 1:12, pages 930-946.
Crossref
Monee K. Shamsher, Jonathan Ploski & Aurelian Radu. (2002) Karyopherin β2B participates in mRNA export from the nucleus. Proceedings of the National Academy of Sciences 99:22, pages 14195-14199.
Crossref
Dirk Daelemans, Elena Afonina, Jakob Nilsson, Gudrun Werner, Jørgen Kjems, Erik De Clercq, George N. Pavlakis & Anne-Mieke Vandamme. (2002) A synthetic HIV-1 Rev inhibitor interfering with the CRM1-mediated nuclear export. Proceedings of the National Academy of Sciences 99:22, pages 14440-14445.
Crossref
Virginie Eichwald, Laurent Daeffler, Michèle Klein, Jean Rommelaere & Nathalie Salomé. (2002) The NS2 Proteins of Parvovirus Minute Virus of Mice Are Required for Efficient Nuclear Egress of Progeny Virions in Mouse Cells. Journal of Virology 76:20, pages 10307-10319.
Crossref
Kirstie Murdoch, Susanne Loop, Falko Rudt & Tomas Pieler. (2002) Nuclear export of 5S rRNA-containing ribonucleoprotein complexes requires CRM1 and the RanGTPase cycle. European Journal of Cell Biology 81:10, pages 549-556.
Crossref
Jan Peter Siebrasse, Elias Coutavas & Reiner Peters. (2002) Reconstitution of nuclear protein export in isolated nuclear envelopes. Journal of Cell Biology 158:5, pages 849-854.
Crossref
Kendra Plafker & Ian G. Macara. (2002) Fluorescence Resonance Energy Transfer Biosensors That Detect Ran Conformational Changes and a Ran·GDP-Importin-β-RanBP1 Complexin Vitro and in Intact Cells. Journal of Biological Chemistry 277:33, pages 30121-30127.
Crossref
Tobias C. Walther, Helen S. PickersgillVolker C. Cordes, Martin W. GoldbergTerry D. AllenIain W. Mattaj & Maarten Fornerod. (2002) The cytoplasmic filaments of the nuclear pore complex are dispensable for selective nuclear protein import. Journal of Cell Biology 158:1, pages 63-77.
Crossref
Cathy L. Miller & David J. Pintel. (2002) Interaction between Parvovirus NS2 Protein and Nuclear Export Factor Crm1 Is Important for Viral Egress from the Nucleus of Murine Cells. Journal of Virology 76:7, pages 3257-3266.
Crossref
Jakob Nilsson, Karsten Weis & Jørgen Kjems. (2002) The C-Terminal Extension of the Small GTPase Ran is Essential for Defining the GDP-Bound Form. Journal of Molecular Biology 318:2, pages 583-593.
Crossref
Ruth S. Phillips, Silvia B.V. Ramos & Perry J. Blackshear. (2002) Members of the Tristetraprolin Family of Tandem CCCH Zinc Finger Proteins Exhibit CRM1-dependent Nucleocytoplasmic Shuttling. Journal of Biological Chemistry 277:13, pages 11606-11613.
Crossref
Maarten Fornerod & Mutsuhito Ohno. 2002. Nuclear Transport. Nuclear Transport 67 91 .
Iris Schmitt & Larry Gerace. (2001) In Vitro Analysis of Nuclear Transport Mediated by the C-terminal Shuttle Domain of Tap. Journal of Biological Chemistry 276:45, pages 42355-42363.
Crossref
Ludwig Englmeier, Maarten Fornerod, F Ralf Bischoff, Carlo Petosa, Iain W Mattaj & Ulrike Kutay. (2001) RanBP3 influences interactions between CRM1 and its nuclear protein export substrates. EMBO reports 2:10, pages 926-932.
Crossref
Batool Ossareh-Nazari, Carole Gwizdek & Catherine Dargemont. (2001) Protein Export from the Nucleus. Traffic 2:10, pages 684-689.
Crossref
Jason Paragas, Julie Talon, Robert E. O'Neill, D. Karl Anderson, Adolfo Garcı́a-Sastre & Peter Palese. (2001) Influenza B and C Virus NEP (NS2) Proteins Possess Nuclear Export Activities. Journal of Virology 75:16, pages 7375-7383.
Crossref
Peter Heger, Jens Lohmaier, Grit Schneider, Kristian Schweimer & Roland H. Stauber. (2001) Qualitative Highly Divergent Nuclear Export Signals Can Regulate Export by the Competition for Transport Cofactors in Vivo . Traffic 2:8, pages 544-555.
Crossref
Susan K. Lyman & Larry Gerace. (2001) Nuclear pore complexes: dynamics in unexpected places. Journal of Cell Biology 154:1, pages 17-20.
Crossref
Mark E. Lindsay, James M. Holaska, Katie Welch, Bryce M. Paschal & Ian G. Macara. (2001) Ran-Binding Protein 3 Is a Cofactor for Crm1-Mediated Nuclear Protein Export. Journal of Cell Biology 153:7, pages 1391-1402.
Crossref
Sang-Hyun Lee & Mark Hannink. (2001) The N-terminal Nuclear Export Sequence of IκBα Is Required for RanGTP-dependent Binding to CRM1. Journal of Biological Chemistry 276:26, pages 23599-23606.
Crossref
Sanjay K Vasu & Douglass J Forbes. (2001) Nuclear pores and nuclear assembly. Current Opinion in Cell Biology 13:3, pages 363-375.
Crossref
E Ferrando-May, V Cordes, I Biller-Ckovric, J Mirkovic, D Görlich & P Nicotera. (2001) Caspases mediate nucleoporin cleavage, but not early redistribution of nuclear transport factors and modulation of nuclear permeability in apoptosis. Cell Death & Differentiation 8:5, pages 495-505.
Crossref
Ralph H. Kehlenbach, Ralf Assheuer, Angelika Kehlenbach, Jörg Becker & Larry Gerace. (2001) Stimulation of Nuclear Export and Inhibition of Nuclear Import by a Ran Mutant Deficient in Binding to Ran-binding Protein 1. Journal of Biological Chemistry 276:17, pages 14524-14531.
Crossref
Wilma Hofmann, Beate Reichart, Andrea Ewald, Eleonora Müller, Iris Schmitt, Roland H. Stauber, Friedrich Lottspeich, Brigitte M. Jockusch, Ulrich Scheer, Joachim Hauber & Marie-Christine Dabauvalle. (2001) Cofactor Requirements for Nuclear Export of Rev Response Element (Rre)–And Constitutive Transport Element (Cte)–Containing Retroviral Rnas. Journal of Cell Biology 152:5, pages 895-910.
Crossref
Patrick MaurerMichael ReddJens SolsbacherF. Ralf BischoffMarkus GreinerAlexandre V. PodtelejnikovMatthias MannKatrin StadeKarsten WeisGabriel Schlenstedt. (2001) The Nuclear Export Receptor Xpo1p Forms Distinct Complexes with NES Transport Substrates and the Yeast Ran Binding Protein 1 (Yrb1p). Molecular Biology of the Cell 12:3, pages 539-549.
Crossref
Ben E. Black, James M. Holaska, Lyne Lévesque, Batool Ossareh-Nazari, Carol Gwizdek, Catherine Dargemont & Bryce M. Paschal. (2001) Nxt1 Is Necessary for the Terminal Step of Crm1-Mediated Nuclear Export. Journal of Cell Biology 152:1, pages 141-156.
Crossref
James M. Holaska, Ben E. Black, Dona C. Love, John A. Hanover, John Leszyk & Bryce M. Paschal. (2001) Calreticulin Is a Receptor for Nuclear Export. Journal of Cell Biology 152:1, pages 127-140.
Crossref
M.-L. Hammarskjöld. 2001. Nuclear Export of Viral RNAs. Nuclear Export of Viral RNAs 77 93 .
J. Hauber. 2001. Nuclear Export of Viral RNAs. Nuclear Export of Viral RNAs 55 76 .
Elsebet Lund & James E. Dahlberg. 2001. The Small GTPase Ran. The Small GTPase Ran 59 83 .
Bryce M. Paschal & Catherine Dargemont. 2001. The Small GTPase Ran. The Small GTPase Ran 15 31 .
Jakob Nilsson, Peter Askjaer & Jørgen Kjems. (2001) A Role for the Basic Patch and the C Terminus of RanGTP in Regulating the Dynamic Interactions with Importin β, CRM1 and RanBP1. Journal of Molecular Biology 305:2, pages 231-243.
Crossref
Ulrike Kutay, Enno Hartmann, Nathalie Treichel, Angelo Calado, Maria Carmo-Fonseca, Siegfried Prehn, Regine Kraft, Dirk Görlich & F. Ralf Bischoff. (2000) Identification of Two Novel RanGTP-binding Proteins Belonging to the Importin β Superfamily. Journal of Biological Chemistry 275:51, pages 40163-40168.
Crossref
Anne E. Uv, Peggy Roth, Nikos Xylourgidis, Anna Wickberg, Rafael Cantera & Christos Samakovlis. (2000) members only encodes a Drosophila nucleoporin required for Rel protein import and immune response activation . Genes & Development 14:15, pages 1945-1957.
Crossref
Kathryn J Ryan & Susan R Wente. (2000) The nuclear pore complex: a protein machine bridging the nucleus and cytoplasm. Current Opinion in Cell Biology 12:3, pages 361-371.
Crossref
Peter Askjaer, Rita Rosendahl & Jørgen Kjems. (2000) Nuclear Export of the DEAD Box An3 Protein by CRM1 Is Coupled to An3 Helicase Activity. Journal of Biological Chemistry 275:16, pages 11561-11568.
Crossref
Mutsuhito Ohno, Alexandra Segref, Angela Bachi, Matthias Wilm & Iain W Mattaj. (2000) PHAX, a Mediator of U snRNA Nuclear Export Whose Activity Is Regulated by Phosphorylation. Cell 101:2, pages 187-198.
Crossref
Beric R. Henderson & Alexandra Eleftheriou. (2000) A Comparison of the Activity, Sequence Specificity, and CRM1-Dependence of Different Nuclear Export Signals. Experimental Cell Research 256:1, pages 213-224.
Crossref
Jørgen Kjems & Peter Askjaer. 2000. HIV-1: Molecular Biology and Pathogenesis Viral Mechanisms. HIV-1: Molecular Biology and Pathogenesis Viral Mechanisms 251 298 .
Sara Nakielny & Gideon Dreyfuss. (1999) Transport of Proteins and RNAs in and out of the Nucleus. Cell 99:7, pages 677-690.
Crossref
Dirk GörlichUlrike Kutay. (1999) Transport Between the Cell Nucleus and the Cytoplasm. Annual Review of Cell and Developmental Biology 15:1, pages 607-660.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.