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Molecular and Cellular Biology Volume 22, 2002 - Issue 14
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Gene Expression

Mammalian PRP4 Kinase Copurifies and Interacts with Components of Both the U5 snRNP and the N-CoR Deacetylase Complexes

Graham Dellaire1 MRC-Human Genetics Unit, Western General Hospital, Edinburgh, United Kingdom
,
Evgeny M. Makarov2 Department of Cellular Biochemistry, Max-Planck-Institute for Biophysical Chemistry, Gottingen, Germany
,
JeffJ.M. Cowger3 Department of Pharmacology and Toxicology and Oncology, Cancer Research Laboratories, London Regional Cancer Centre, The University of Western Ontario, London, Ontario, Canada
,
Dasa Longman1 MRC-Human Genetics Unit, Western General Hospital, Edinburgh, United Kingdom
,
Heidi G. E. Sutherland1 MRC-Human Genetics Unit, Western General Hospital, Edinburgh, United Kingdom
,
Reinhard Lührmann2 Department of Cellular Biochemistry, Max-Planck-Institute for Biophysical Chemistry, Gottingen, Germany
,
Joseph Torchia3 Department of Pharmacology and Toxicology and Oncology, Cancer Research Laboratories, London Regional Cancer Centre, The University of Western Ontario, London, Ontario, Canada
&
Wendy A. Bickmore1 MRC-Human Genetics Unit, Western General Hospital, Edinburgh, United KingdomCorrespondence[email protected]
 show all
Pages 5141-5156 | Received 08 Mar 2002, Accepted 11 Apr 2002, Published online: 27 Mar 2023

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Jose Russo & Irma H. RussoJose Russo & Irma H. Russo. 2013. Role of the Transcriptome in Breast Cancer Prevention. Role of the Transcriptome in Breast Cancer Prevention 337 390 .
Rebecca Easley, Lawrence Carpio, Luke Dannenberg, Soyun Choi, Dowser Alani, Rachel Van Duyne, Irene Guendel, Zachary Klase, Emmanuel Agbottah, Kylene Kehn-Hall & Fatah Kashanchi. (2010) Transcription through the HIV-1 nucleosomes: Effects of the PBAF complex in Tat activated transcription. Virology 405:2, pages 322-333.
Crossref
Domenic Di Paola, Emmanouil Rampakakis, Man Kid Chan, Dina N. Arvanitis & Maria Zannis-Hadjopoulos. (2010) Increased origin activity in transformed versus normal cells: identification of novel protein players involved in DNA replication and cellular transformation. Nucleic Acids Research 38:7, pages 2314-2331.
Crossref
Martin Lützelberger, Claudia A. Bottner, Wiebke Schwelnus, Susanne Zock-Emmenthal, Aleh Razanau & Norbert F. Käufer. (2010) The N-terminus of Prp1 (Prp6/U5-102 K) is essential for spliceosome activation in vivo. Nucleic Acids Research 38:5, pages 1610-1622.
Crossref
Marc Schneider, He-Hsuan Hsiao, Cindy L Will, Régis Giet, Henning Urlaub & Reinhard Lührmann. (2010) Human PRP4 kinase is required for stable tri-snRNP association during spliceosomal B complex formation. Nature Structural & Molecular Biology 17:2, pages 216-221.
Crossref
Felizza Q. Gunderson & Tracy L. Johnson. (2009) Acetylation by the Transcriptional Coactivator Gcn5 Plays a Novel Role in Co-Transcriptional Spliceosome Assembly. PLoS Genetics 5:10, pages e1000682.
Crossref
D. J. Pappas, G. Coppola, P. A. Gabatto, F. Gao, D. H. Geschwind, J. R. Oksenberg & S. E. Baranzini. (2009) Longitudinal system-based analysis of transcriptional responses to type I interferons. Physiological Genomics 38:3, pages 362-371.
Crossref
E. A. Tonevitsky, E. V. Trushkin, M. U. Shkurnikov, E. B. Akimov & D. A. Sakharov. (2009) Changed Profile of Expression of Splicing Regulator Genes in Response to Exercise. Bulletin of Experimental Biology and Medicine 147:6, pages 733-736.
Crossref
Anu Tyagi, Jessica Ryme, David Brodin, Ann Kristin Östlund Farrants & Neus Visa. (2009) SWI/SNF Associates with Nascent Pre-mRNPs and Regulates Alternative Pre-mRNA Processing. PLoS Genetics 5:5, pages e1000470.
Crossref
Emilie Montembault, Stéphanie Dutertre, Claude Prigent & Régis Giet. (2007) PRP4 is a spindle assembly checkpoint protein required for MPS1, MAD1, and MAD2 localization to the kinetochores. Journal of Cell Biology 179:4, pages 601-609.
Crossref
Woan-Yuh Tarn. (2007) Cellular signals modulate alternative splicing. Journal of Biomedical Science 14:4, pages 517-522.
Crossref
Boli Huang, Yong-Tae Ahn, Lisa McPherson, Carol Clayberger & Alan M. Krensky. (2007) Interaction of PRP4 with Krüppel-Like Factor 13 Regulates CCL5 Transcription. The Journal of Immunology 178:11, pages 7081-7087.
Crossref
Yen-I G. Chen, Roger E. Moore, Helen Y. Ge, Mary K. Young, Terry D. Lee & Scott W. Stevens. (2007) Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors. Nucleic Acids Research 35:12, pages 3928-3944.
Crossref
J J M Cowger, Q Zhao, M Isovic & J Torchia. (2006) Biochemical characterization of the zinc-finger protein 217 transcriptional repressor complex: identification of a ZNF217 consensus recognition sequence. Oncogene 26:23, pages 3378-3386.
Crossref
Didier Auboeuf, Eric Batsché, Martin Dutertre, Christian Muchardt & Bert W. O’Malley. (2007) Coregulators: transducing signal from transcription to alternative splicing. Trends in Endocrinology & Metabolism 18:3, pages 122-129.
Crossref
Alain N. S. Newo, Martin Lützelberger, Claudia A. Bottner, Jürgen Wehland, Josef Wissing, Lothar Jänsch & Norbert F. Käufer. (2007) Proteomic analysis of the U1 snRNP of Schizosaccharomyces pombe reveals three essential organism-specific proteins. Nucleic Acids Research 35:5, pages 1391-1401.
Crossref
Shengrong Lin & Xiang-Dong Fu. 2007. Alternative Splicing in the Postgenomic Era. Alternative Splicing in the Postgenomic Era 107 122 .
Elisabet Costa, Silvia Canudas, Ivan Garcia-Bassets, Silvia Pérez, Irene Fernández, Ernest Giralt, Fernando Azorín & M. Lluïsa Espinás. (2006) Drosophila dSAP18 is a nuclear protein that associates with chromosomes and the nuclear matrix, and interacts with pinin, a protein factor involved in RNA splicing. Chromosome Research 14:5, pages 515-526.
Crossref
Jagreet Kaur, Jose Sebastian & Imran Siddiqi. (2006) The Arabidopsis - mei2 - Like Genes Play a Role in Meiosis and Vegetative Growth in Arabidopsis . The Plant Cell 18:3, pages 545-559.
Crossref
Yali Chiu & Pin Ouyang. (2006) Loss of Pnn expression attenuates expression levels of SR family splicing factors and modulates alternative pre-mRNA splicing in vivo. Biochemical and Biophysical Research Communications 341:2, pages 663-671.
Crossref
Shuli Fan, Kiminobu Goto, Guangchun Chen, Hidetaka Morinaga, Masatoshi Nomura, Taijiro Okabe, Hajime Nawata & Toshihiko Yanase. (2006) Identification of the functional domains of ANT-1, a novel coactivator of the androgen receptor. Biochemical and Biophysical Research Communications 341:1, pages 192-201.
Crossref
Eric Batsché, Moshe Yaniv & Christian Muchardt. (2005) The human SWI/SNF subunit Brm is a regulator of alternative splicing. Nature Structural & Molecular Biology 13:1, pages 22-29.
Crossref
Claudia A. Bottner, Henning Schmidt, Sven Vogel, Melanie Michele & Norbert F. Käufer. (2005) Multiple genetic and biochemical interactions of Brr2, Prp8, Prp31, Prp1 and Prp4 kinase suggest a function in the control of the activation of spliceosomes in Schizosaccharomyces pombe. Current Genetics 48:3, pages 151-161.
Crossref
Vanessa Brès, Nathan Gomes, Loni Pickle & Katherine A. Jones. (2005) A human splicing factor, SKIP, associates with P-TEFb and enhances transcription elongation by HIV-1 Tat. Genes & Development 19:10, pages 1211-1226.
Crossref
RICHARD J. GRAINGER & JEAN D. BEGGS. (2005) Prp8 protein: At the heart of the spliceosome. RNA 11:5, pages 533-557.
Crossref
Pauline Ward, Leila Equinet, Jeremy Packer & Christian Doerig. (2004) Protein kinases of the human malaria parasite Plasmodium falciparum: the kinome of a divergent eukaryote. BMC Genomics 5:1.
Crossref
Olga V Makarova, Evgeny M Makarov, Henning Urlaub, Cindy L Will, Marc Gentzel, Matthias Wilm & Reinhard Lührmann. (2004) A subset of human 35S U5 proteins, including Prp19, function prior to catalytic step 1 of splicing. The EMBO Journal 23:12, pages 2381-2391.
Crossref
Andreas N. Kuhn & Norbert E. Käufer. 2004. The Molecular Biology of Schizosaccharomyces pombe. The Molecular Biology of Schizosaccharomyces pombe 353 368 .
Helen H Tai, Margit Geisterfer, John C Bell, Mariko Moniwa, James R Davie, Lorrie Boucher & Michael W McBurney. (2003) CHD1 associates with NCoR and histone deacetylase as well as with RNA splicing proteins. Biochemical and Biophysical Research Communications 308:1, pages 170-176.
Crossref
Andreas N. Kuhn & Norbert F. Käufer. (2002) Pre-mRNA splicing in Schizosaccharomyces pombe. Current Genetics 42:5, pages 241-251.
Crossref
Graham Dellaire, Rozalia Nisman & David P Bazett-Jones. 2003. Chromatin and Chromatin Remodeling Enzymes, Part A. Chromatin and Chromatin Remodeling Enzymes, Part A 456 478 .

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