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Molecular and Cellular Biology Volume 23, 2003 - Issue 19
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Mammalian Genetic Models with Minimal or Complex Phenotypes

Disruption of the COP9 Signalosome Csn2 Subunit in Mice Causes Deficient Cell Proliferation, Accumulation of p53 and Cyclin E, and Early Embryonic Death

Karin Lykke-Andersen1 Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut06520-8104
,
Laura Schaefer2 Neuromuscular Biology & Disease Group, Boston Biomedical Research Institute, Watertown, Massachusetts02478
,
Suchithra Menon1 Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut06520-8104
,
Xing-Wang Deng1 Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut06520-8104
,
Jeffrey Boone Miller2 Neuromuscular Biology & Disease Group, Boston Biomedical Research Institute, Watertown, Massachusetts02478
&
Ning Wei1 Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut06520-8104Correspondence[email protected]
Pages 6790-6797 | Received 25 Apr 2003, Accepted 27 Jun 2003, Published online: 27 Mar 2023

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Crossref
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Crossref
Meenakshi Bhansali & Lirim Shemshedini. (2014) COP9 Subunits 4 and 5 Target Soluble Guanylyl Cyclase α1 and p53 in Prostate Cancer Cells. Molecular Endocrinology 28:6, pages 834-845.
Crossref
Lawrence D. Longo & Ravi Goyal. 2014. The Guide to Investigation of Mouse Pregnancy. The Guide to Investigation of Mouse Pregnancy 443 461 .
Jung-Hoon LeeLina Yi, Jixi Li, Katrin Schweitzer, Marc Borgmann, Michael Naumann & Hao Wu. (2013) Crystal structure and versatile functional roles of the COP9 signalosome subunit 1. Proceedings of the National Academy of Sciences 110:29, pages 11845-11850.
Crossref
Cheng Liu, Li-Quan Guo, Suchithra Menon, Dan Jin, Elah Pick, Xuejun Wang, Xing Wang Deng & Ning Wei. (2013) COP9 Signalosome Subunit Csn8 Is Involved in Maintaining Proper Duration of the G1 Phase. Journal of Biological Chemistry 288:28, pages 20443-20452.
Crossref
He Huang, Marcel Quint & William M. Gray. (2013) The eta7/csn3-3 Auxin Response Mutant of Arabidopsis Defines a Novel Function for the CSN3 Subunit of the COP9 Signalosome. PLoS ONE 8:6, pages e66578.
Crossref
Akihiro Yoshida, Noriko Yoneda-Kato & Jun-ya Kato. (2013) CSN5 specifically interacts with CDK2 and controls senescence in a cytoplasmic cyclin E-mediated manner. Scientific Reports 3:1.
Crossref
Adrian GombartPrashant Singh & Moray Campbell. 2012. Vitamin D. Vitamin D 37 64 .
Johannes W. Stratmann & Giuliana Gusmaroli. (2012) Many jobs for one good cop – The COP9 signalosome guards development and defense. Plant Science 185-186, pages 50-64.
Crossref
Saravanan RajanHuan Chu Pham DangHaig DjambazianHarry ZuzanYaroslav FedyshynTroy Ketela, Jason Moffat, Thomas J. Hudson & Rob Sladek. (2012) Analysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose knock-down inhibits myoblast differentiation. Physiological Genomics 44:2, pages 183-197.
Crossref
Ronny Hannß & Wolfgang Dubiel. (2011) COP9 signalosome function in the DDR. FEBS Letters 585:18, pages 2845-2852.
Crossref
Ruiying Zhao, Sai-Ching J. Yeung, Jian Chen, Tomoo Iwakuma, Chun-Hui Su, Bo Chen, Changju Qu, Fanmao Zhang, You-Tzung Chen, Yu-Li Lin, Dung-Fang Lee, Feng Jin, Rui Zhu, Tattym Shaikenov, Dos Sarbassov, Aysegul Sahin, Huamin Wang, Hua Wang, Chien-Chen Lai, Fuu-Jen Tsai, Guillermina Lozano & Mong-Hong Lee. (2011) Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers. Journal of Clinical Investigation 121:3, pages 851-865.
Crossref
Luyang Sun, Lei Shi, Feng Wang, Peiwei Huangyang, Wenzhe Si, Jie Yang, Zhi Yao & Yongfeng Shang. (2011) Substrate Phosphorylation and Feedback Regulation in JFK-promoted p53 Destabilization. Journal of Biological Chemistry 286:6, pages 4226-4235.
Crossref
D Lei, F Li, H Su, Z Tian, B Ye, N Wei & X Wang. (2010) COP9 signalosome subunit 8 is required for postnatal hepatocyte survival and effective proliferation. Cell Death & Differentiation 18:2, pages 259-270.
Crossref
Huabo SuJie LiSuchithra MenonJinbao LiuAsangi R. KumarapeliNing WeiXuejun Wang. (2011) Perturbation of Cullin Deneddylation via Conditional Csn8 Ablation Impairs the Ubiquitin–Proteasome System and Causes Cardiomyocyte Necrosis and Dilated Cardiomyopathy in Mice. Circulation Research 108:1, pages 40-50.
Crossref
Alessandra Granata, Seong Joo Koo, Volker Haucke, Giampietro Schiavo & Thomas T Warner. (2011) CSN complex controls the stability of selected synaptic proteins via a torsinA-dependent process. The EMBO Journal 30:1, pages 181-193.
Crossref
Kerstin Helmstaedt, Elke U. Schwier, Martin Christmann, Krystyna Nahlik, Mieke Westermann, Rebekka Harting, Stephanie Grond, Silke Busch & Gerhard H. Braus. (2011) Recruitment of the inhibitor Cand1 to the cullin substrate adaptor site mediates interaction to the neddylation site. Molecular Biology of the Cell 22:1, pages 153-164.
Crossref
James Thorne & Moray J. Campbell. 2011. Vitamin D and Cancer. Vitamin D and Cancer 25 52 .
Jiyong Wang, Qiwen Hu, Huijie Chen, Zhipeng Zhou, Weihua Li, Ying Wang, Shaojie Li & Qun He. (2010) Role of Individual Subunits of the Neurospora crassa CSN Complex in Regulation of Deneddylation and Stability of Cullin Proteins. PLoS Genetics 6:12, pages e1001232.
Crossref
Gerhard H Braus, Stefan Irniger & Özgür Bayram. (2010) Fungal development and the COP9 signalosome. Current Opinion in Microbiology 13:6, pages 672-676.
Crossref
L Tian, G Peng, J M Parant, V Leventaki, E Drakos, Q Zhang, J Parker-Thornburg, T J Shackleford, H Dai, S-Y Lin, G Lozano, G Z Rassidakis & F X Claret. (2010) Essential roles of Jab1 in cell survival, spontaneous DNA damage and DNA repair. Oncogene 29:46, pages 6125-6137.
Crossref
Claus Schwechheimer & Erika Isono. (2010) The COP9 signalosome and its role in plant development. European Journal of Cell Biology 89:2-3, pages 157-162.
Crossref
Jun-ya Kato & Noriko Yoneda-Kato. (2009) Mammalian COP9 signalosome. Genes to Cells 14:11, pages 1209-1225.
Crossref
Daniel A Chamovitz. (2009) Revisiting the COP9 signalosome as a transcriptional regulator. EMBO reports 10:4, pages 352-358.
Crossref
Ning Wei. (2009) On the Structural Model of the COP9 Signalosome. Structure 17:1, pages 1-2.
Crossref
M. David Stewart & Jiemin Wong. 2009. 235 259 .
Suchithra Menon, Tomohiko Tsuge, Naoshi Dohmae, Koji Takio & Ning Wei. (2008) Association of SAP130/SF3b-3 with Cullin-RING ubiquitin ligase complexes and its regulation by the COP9 signalosome. BMC Biochemistry 9:1.
Crossref
Esther Mirjam Natascha Dohmann, Mitchell Paul Levesque, Erika Isono, Markus Schmid & Claus Schwechheimer. (2008) Auxin Responses in Mutants of the Arabidopsis CONSTITUTIVE PHOTOMORPHOGENIC9 Signalosome      . Plant Physiology 147:3, pages 1369-1379.
Crossref
Esther M. N. DohmannMitchell P. LevesqueLieven De VeylderIlka ReichardtGerd JürgensMarkus SchmidClaus Schwechheimer. (2008) The Arabidopsis COP9 signalosome is essential for G2 phase progression and genomic stability . Development 135:11, pages 2013-2022.
Crossref
J F M Leal, J Fominaya, A Cascón, M V Guijarro, C Blanco-Aparicio, M Lleonart, M E Castro, S Ramon y Cajal, M Robledo, D H Beach & A Carnero. (2007) Cellular senescence bypass screen identifies new putative tumor suppressor genes. Oncogene 27:14, pages 1961-1970.
Crossref
Dawadschargal Bech-Otschir, Barbara Kapelari & Wolfgang Dubiel. 2008. Protein Science Encyclopedia. Protein Science Encyclopedia.
Martina Panattoni, Francesca Sanvito, Veronica Basso, Claudio Doglioni, Giulia Casorati, Eugenio Montini, Jeffrey R. Bender, Anna Mondino & Ruggero Pardi. (2008) Targeted inactivation of the COP9 signalosome impairs multiple stagesof T cell development. Journal of Experimental Medicine 205:2, pages 465-477.
Crossref
Wakana Sugano, Katsuhito Ohno, Noriko Yoneda-Kato, Jun-ya Kato & Masamitsu Yamaguchi. (2008) The myeloid leukemia factor interacts with COP9 signalosome subunit 3 in Drosophila melanogaster. FEBS Journal 275:3, pages 588-600.
Crossref
Jérôme Artus & Michel Cohen-Tannoudji. (2008) Cell cycle regulation during early mouse embryogenesis. Molecular and Cellular Endocrinology 282:1-2, pages 78-86.
Crossref
K. Vanya Ewart, Jason Williams, Robert C. Richards, Jeffrey W. Gallant, Krista Melville & Susan E. Douglas. (2008) The early response of Atlantic salmon (Salmo salar) macrophages exposed in vitro to Aeromonas salmonicida cultured in broth and in fish. Developmental & Comparative Immunology 32:4, pages 380-390.
Crossref
Éric Villiard, Henner Brinkmann, Olga Moiseeva, Frédérick A Mallette, Gerardo Ferbeyre & Stéphane Roy. (2007) Urodele p53 tolerates amino acid changes found in p53 variants linked to human cancer. BMC Evolutionary Biology 7:1.
Crossref
Andreas Peth, Christoph Berndt, Wolfgang Henke & Wolfgang Dubiel. (2007) Downregulation of COP9 signalosome subunits differentially affects the CSN complex and target protein stability. BMC Biochemistry 8:1.
Crossref
X. Wu, K. Li, M. Yerle & Y. C. Pan. (2007) Chromosomal assignments of the porcine COPS2, COPS4, COPS5, COPS6, USP6 and USP10 genes involved in the ubiquitin-proteasome system. Animal Genetics 38:6, pages 665-666.
Crossref
Suchithra Menon, Hongbo Chi, Huiyong Zhang, Xing Wang Deng, Richard A Flavell & Ning Wei. (2007) COP9 signalosome subunit 8 is essential for peripheral T cell homeostasis and antigen receptor–induced entry into the cell cycle from quiescence. Nature Immunology 8:11, pages 1236-1245.
Crossref
David L Mack, Corinne A Boulanger, Robert Callahan & Gilbert H Smith. (2007) Expression of truncated Int6/eIF3e in mammary alveolar epithelium leads to persistent hyperplasia and tumorigenesis. Breast Cancer Research 9:4.
Crossref
Katja M. Schwager, Luz Irina A. Calderon-Villalobos, Esther M.N. Dohmann, Björn C. Willige, Stephan Knierer, Carola Nill & Claus Schwechheimer. (2007) Characterization of the VIER F-BOX PROTEINE Genes from Arabidopsis Reveals Their Importance for Plant Growth and Development . The Plant Cell 19:4, pages 1163-1178.
Crossref
Silke BuschElke U. SchwierKrystyna NahlikÖzür BayramKerstin Helmstaedt, Oliver W. DrahtSven KrappmannOliver ValeriusWilliam N. Lipscomb & Gerhard H. Braus. (2007) An eight-subunit COP9 signalosome with an intact JAMM motif is required for fungal fruit body formation. Proceedings of the National Academy of Sciences 104:19, pages 8089-8094.
Crossref
Udo Moehren, Maria Papaioannou, Christina A. Reeb, Wei Hong & Aria Baniahmad. (2007) Alien Interacts with the Human Androgen Receptor and Inhibits Prostate Cancer Cell Growth. Molecular Endocrinology 21:5, pages 1039-1048.
Crossref
Jean da Silva Correia, Yvonne Miranda, Nikki Leonard & Richard J. Ulevitch. (2007) The Subunit CSN6 of the COP9 Signalosome Is Cleaved during Apoptosis. Journal of Biological Chemistry 282:17, pages 12557-12565.
Crossref
Giuliana Gusmaroli, Pablo Figueroa, Giovanna Serino & Xing Wang Deng. (2007) Role of the MPN Subunits in COP9 Signalosome Assembly and Activity, and Their Regulatory Interaction with Arabidopsis Cullin3-Based E3 Ligases . The Plant Cell 19:2, pages 564-581.
Crossref
Wananit Wimuttisuk & Jeffrey D. Singer. (2007) The Cullin3 Ubiquitin Ligase Functions as a Nedd8-bound Heterodimer. Molecular Biology of the Cell 18:3, pages 899-909.
Crossref
Efrat Oron, Tamir Tuller, Ling Li, Nina Rozovsky, Daniel Yekutieli, Sigal Rencus‐Lazar, Daniel Segal, Benny Chor, Bruce A Edgar & Daniel A Chamovitz. (2007) Genomic analysis of COP9 signalosome function in Drosophila melanogaster reveals a role in temporal regulation of gene expression . Molecular Systems Biology 3:1.
Crossref
Wei Zhang & Deanna M. Koepp. (2006) Fbw7 Isoform Interaction Contributes to Cyclin E Proteolysis. Molecular Cancer Research 4:12, pages 935-943.
Crossref
Simona Denti, Maria Elena Fernandez-Sanchez, Lars Rogge & Elisabetta Bianchi. (2006) The COP9 Signalosome Regulates Skp2 Levels and Proliferation of Human Cells. Journal of Biological Chemistry 281:43, pages 32188-32196.
Crossref
Helena E. Richardson, Leonie M. Quinn, Nancy Amin, Anabel Herr, Anthony M. Brumby, Kathryn M. Doyle, Patrick O. Humbert & Julie Secombe. 2006. Encyclopedia of Molecular Cell Biology and Molecular Medicine. Encyclopedia of Molecular Cell Biology and Molecular Medicine.
Vicente Rubio & Xing Wang Deng. 2006. Protein Degradation. Protein Degradation 48 75 .
Przemyslaw Malec & Daniel A. Chamovitz. (2006) Characterization and Purification of Kinase Activities against Arabidopsis COP9 Signalosome Subunit 7. Israel Journal of Chemistry 46:2, pages 239-246.
Crossref
Daniel Rosel & Alan R. Kimmel. (2006) The COP9 signalosome regulates cell proliferation of Dictyostelium discoideum. European Journal of Cell Biology 85:9-10, pages 1023-1034.
Crossref
Geoffrey N. HendyTong LiMartine GirardRichard C. FeldsteinShree MulayRoxane Desjardins, Robert Day, Andrew C. KaraplisMichel L. TremblayLucie Canaff. (2006) Targeted Ablation of the Chromogranin A (Chga) Gene: Normal Neuroendocrine Dense-Core Secretory Granules and Increased Expression of Other Granins. Molecular Endocrinology 20:8, pages 1935-1947.
Crossref
June-Tai Wu, Ya-Ru Chan & Cheng-Ting Chien. (2006) Protection of cullin–RING E3 ligases by CSN–UBP12. Trends in Cell Biology 16:7, pages 362-369.
Crossref
Ciprian Gheorghe, Subburaman Moham & Lawrence D. Longo. (2016) Gene Expression Patterns in the Developing Murine Placenta. Journal of the Society for Gynecologic Investigation 13:4, pages 256-262.
Crossref
D Duval, M Trouillas, C Thibault, D Dembelé, F Diemunsch, B Reinhardt, A L Mertz, A Dierich & H Bœuf. (2005) Apoptosis and differentiation commitment: novel insights revealed by gene profiling studies in mouse embryonic stem cells. Cell Death & Differentiation 13:4, pages 564-575.
Crossref
Timothy C. Hallstrom & Joseph R. Nevins. (2006) Jab1 is a specificity factor for E2F1-induced apoptosis. Genes & Development 20:5, pages 613-623.
Crossref
Dipankar Nandi, Pankaj Tahiliani, Anujith Kumar & Dilip Chandu. (2006) The ubiquitin-proteasome system. Journal of Biosciences 31:1, pages 137-155.
Crossref
Bernhard J.C. Eigl, Scott E. Eggener, Jenny Baybik, Susan Ettinger, Kim N. Chi, Colleen Nelson, Zhou Wang & Martin E. Gleave. (2005) Timing Is Everything: Preclinical Evidence Supporting Simultaneous Rather Than Sequential Chemohormonal Therapy for Prostate Cancer. Clinical Cancer Research 11:13, pages 4905-4911.
Crossref
Se-Jin Yoon, Hyung-Min Chung, Kwang-Yul Cha, Nam-Hyung Kim & Kyung-Ah Lee. (2005) Identification of differential gene expression in germinal vesicle vs. metaphase II mouse oocytes by using annealing control primers. Fertility and Sterility 83:4, pages 1293-1296.
Crossref
Claus Schwechheimer. (2004) The COP9 signalosome (CSN): an evolutionary conserved proteolysis regulator in eukaryotic development. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1695:1-3, pages 45-54.
Crossref
Kiichiro Tomoda, Noriko Yoneda-Kato, Akihisa Fukumoto, Shinya Yamanaka & Jun-ya Kato. (2004) Multiple Functions of Jab1 Are Required for Early Embryonic Development and Growth Potential in Mice. Journal of Biological Chemistry 279:41, pages 43013-43018.
Crossref
Salvatore Carrabino, Emanuela Carminati, Daniela Talarico, Ruggero Pardi & Elisabetta Bianchi. (2004) Expression pattern of the JAB1/CSN5 gene during murine embryogenesis: colocalization with NEDD8. Gene Expression Patterns 4:4, pages 423-431.
Crossref
Dimitris P Xirodimas, Mark K Saville, Jean-Christophe Bourdon, Ronald T Hay & David P Lane. (2004) Mdm2-Mediated NEDD8 Conjugation of p53 Inhibits Its Transcriptional Activity. Cell 118:1, pages 83-97.
Crossref
Zhen-Qiang Pan, Alex Kentsis, Dora C Dias, Kosj Yamoah & Kenneth Wu. (2004) Nedd8 on cullin: building an expressway to protein destruction. Oncogene 23:11, pages 1985-1997.
Crossref

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