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Gene Expression

Exon Selection in α-Tropomyosin mRNA Is Regulated by the Antagonistic Action of RBM4 and PTB

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Pages 10111-10121 | Received 01 Jun 2005, Accepted 19 Aug 2005, Published online: 27 Mar 2023

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Zeng-Zhang Zheng, Xia Sun, Bei Zhang, Jia Pu, Ze-Yu Jiang, Muwang Li, Yu-Jie Fan & Yong-Zhen Xu. (2019) Alternative splicing regulation of doublesex gene by RNA-binding proteins in the silkworm Bombyx mori. RNA Biology 16:6, pages 809-820.
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Chun-Hao Su, Kuan-Yang Hung, Shih-Chieh Hung & Woan-Yuh Tarn. (2017) RBM4 Regulates Neuronal Differentiation of Mesenchymal Stem Cells by Modulating Alternative Splicing of Pyruvate Kinase M. Molecular and Cellular Biology 37:3.
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Agnès Méreau, Vincent Anquetil, Hubert Lerivray, Justine Viet, Claire Schirmer, Yann Audic, Vincent Legagneux, Serge Hardy & Luc Paillard. (2015) A Posttranscriptional Mechanism That Controls Ptbp1 Abundance in the Epidermis. Molecular and Cellular Biology 35:4, pages 758-768.
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Jung-Chun Lin, Yu-Ting Yan, Wen-Kou Hsieh, Pey-Jey Peng, Chun-Hao Su & Woan-Yuh Tarn. (2013) RBM4 Promotes Pancreas Cell Differentiation and Insulin Expression. Molecular and Cellular Biology 33:2, pages 319-327.
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Yun Yang, Feng Sun, Xuebin Wang, Yuan Yue, Wenfeng Wang, Wenjing Zhang, Leilei Zhan, Nan Tian, feng shi & Yongfeng Jin. (2012) Conservation and regulation of alternative splicing by dynamic inter- and intra-intron base pairings in Lepidoptera 14-3-3z pre-mRNAs. RNA Biology 9:5, pages 691-700.
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Amar Kar, Kazuo Fushimi, Xiaohong Zhou, Payal Ray, Chen Shi, Xiaoping Chen, Zhiren Liu, She Chen & Jane Y. Wu. (2011) RNA Helicase p68 (DDX5) Regulates tau Exon 10 Splicing by Modulating a Stem-Loop Structure at the 5′ Splice Site. Molecular and Cellular Biology 31:9, pages 1812-1821.
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Hung-Hsi Chen, Jan-Growth Chang, Ruei-Min Lu, Tsui-Yi Peng & Woan-Yuh Tarn. (2008) The RNA Binding Protein hnRNP Q Modulates the Utilization of Exon 7 in the Survival Motor Neuron 2 (SMN2) Gene. Molecular and Cellular Biology 28:22, pages 6929-6938.
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De-Li Shi & Raphaëlle Grifone. (2021) RNA-Binding Proteins in the Post-transcriptional Control of Skeletal Muscle Development, Regeneration and Disease. Frontiers in Cell and Developmental Biology 9.
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Jun Cao, Andrew L. Routh & Muge N. Kuyumcu‐Martinez. (2021) Nanopore sequencing reveals full‐length Tropomyosin 1 isoforms and their regulation by RNA‐binding proteins during rat heart development. Journal of Cellular and Molecular Medicine 25:17, pages 8352-8362.
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Justin Parreno, Michael B. Amadeo, Elizabeth H. Kwon & Velia M. Fowler. (2020) Tropomyosin 3.1 Association With Actin Stress Fibers is Required for Lens Epithelial to Mesenchymal Transition. Investigative Opthalmology & Visual Science 61:6, pages 2.
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Ching-Sheng Hung & Jung-Chun Lin. (2020) Alternatively spliced MBNL1 isoforms exhibit differential influence on enhancing brown adipogenesis. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1863:1, pages 194437.
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Wei-Yang Wang, Weili Quan, Fan Yang, Ya-Xun Wei, Jia-Jun Chen, Han Yu, Jie Xie, Yi Zhang & Zhan-Fei Li. (2019) RBM4 modulates the proliferation and expression of inflammatory factors via the alternative splicing of regulatory factors in HeLa cells. Molecular Genetics and Genomics 295:1, pages 95-106.
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Philippe Kieffer-Kwon, Christine Happel, Thomas S. Uldrick, Dhivya Ramalingam & Joseph M. Ziegelbauer. (2015) KSHV MicroRNAs Repress Tropomyosin 1 and Increase Anchorage-Independent Growth and Endothelial Tube Formation. PLOS ONE 10:8, pages e0135560.
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Jung-Chun Lin, Ching-Yu Lin, Woan-Yuh Tarn & Fang-Yu Li. (2014) Elevated SRPK1 lessens apoptosis in breast cancer cells through RBM4-regulated splicing events. RNA 20:10, pages 1621-1631.
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Yang Wang, Dan Chen, Haili Qian, Yihsuan S. Tsai, Shujuan Shao, Quentin Liu, Daniel Dominguez & Zefeng Wang. (2014) The Splicing Factor RBM4 Controls Apoptosis, Proliferation, and Migration to Suppress Tumor Progression. Cancer Cell 26:3, pages 374-389.
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Jung-Chun Lin, Woan-Yuh Tarn & Wen-Kou Hsieh. (2014) Emerging role for RNA binding motif protein 4 in the development of brown adipocytes. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1843:4, pages 769-779.
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Rui Guan, Suzan El-Rass, David Spillane, Simon Lam, Yuodong Wang, Jing Wu, Zhuchu Chen, Anan Wang, Zhengping Jia, Armand Keating, Jim Hu & Xiao-Yan Wen. (2013) rbm47 , a novel RNA binding protein, regulates zebrafish head development . Developmental Dynamics 242:12, pages 1395-1404.
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Maria Romanelli, Erica Diani & Patricia Lievens. (2013) New Insights into Functional Roles of the Polypyrimidine Tract-Binding Protein. International Journal of Molecular Sciences 14:11, pages 22906-22932.
Crossref
Andrie Koutsoulidou, Nikolaos P. Mastroyiannopoulos & Leonidas A. Phylactou. 2006. Encyclopedia of Molecular Cell Biology and Molecular Medicine. Encyclopedia of Molecular Cell Biology and Molecular Medicine 1 28 .
Chia-Chen Lu, Tz-Hao Chen, Jhe-Rong Wu, Hung-Hsi Chen, Hsin-Yi Yu & Woan-Yuh Tarn. (2013) Phylogenetic and Molecular Characterization of the Splicing Factor RBM4. PLoS ONE 8:3, pages e59092.
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Olga Kelemen, Paolo Convertini, Zhaiyi Zhang, Yuan Wen, Manli Shen, Marina Falaleeva & Stefan Stamm. (2013) Function of alternative splicing. Gene 514:1, pages 1-30.
Crossref
Yang Wang, Meng Ma, Xinshu Xiao & Zefeng Wang. (2012) Intronic splicing enhancers, cognate splicing factors and context-dependent regulation rules. Nature Structural & Molecular Biology 19:10, pages 1044-1052.
Crossref
Nagham George Abd Al-Ahad Sabbagha, Hsiao-Jung Kao, Chih-Fu Yang, Cheng-Chih Huang, Wei-De Lin, Fuu-Jen Tsai, Tzu-Ho Chen, Woan-Yuh Tarn, Jer-Yuarn Wu & Yuan-Tsong Chen. (2011) Alternative Splicing in Acad8 Resulting a Mitochondrial Defect and Progressive Hepatic Steatosis in Mice. Pediatric Research 70:1, pages 31-36.
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Jung-Chun Lin & Woan-Yuh Tarn. (2011) RBM4 down-regulates PTB and antagonizes its activity in muscle cell–specific alternative splicing. Journal of Cell Biology 193:3, pages 509-520.
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Emma Heath, Fred Sablitzky & Garry T. Morgan. (2010) Subnuclear targeting of the RNA-binding motif protein RBM6 to splicing speckles and nascent transcripts. Chromosome Research 18:8, pages 851-872.
Crossref
Mark Robida, Vinod Sridharan, Sheridan Morgan, Timsi Rao & Ravinder Singh. (2010) Drosophila polypyrimidine tract-binding protein is necessary for spermatid individualization . Proceedings of the National Academy of Sciences 107:28, pages 12570-12575.
Crossref
Berenike Henneberg, Sascha Swiniarski, Sabine Becke & Susanne Illenberger. (2010) A conserved peptide motif in Raver2 mediates its interaction with the polypyrimidine tract-binding protein. Experimental Cell Research 316:6, pages 966-979.
Crossref
Jan M. Pawlicki & Joan A. Steitz. (2010) Nuclear networking fashions pre-messenger RNA and primary microRNA transcripts for function. Trends in Cell Biology 20:1, pages 52-61.
Crossref
Jung-Chun Lin & Woan-Yuh Tarn. (2009) RNA-binding Motif Protein 4 Translocates to Cytoplasmic Granules and Suppresses Translation via Argonaute2 during Muscle Cell Differentiation. Journal of Biological Chemistry 284:50, pages 34658-34665.
Crossref
Yang S. Brooks, Guanghu Wang, Zheqiong Yang, Kimberly K. Smith, Erhard Bieberich & Lan Ko. (2009) Functional Pre- mRNA trans-Splicing of Coactivator CoAA and Corepressor RBM4 during Stem/Progenitor Cell Differentiation. Journal of Biological Chemistry 284:27, pages 18033-18046.
Crossref
M. Andrea Markus & Brian J. Morris. (2009) RBM4: A multifunctional RNA-binding protein. The International Journal of Biochemistry & Cell Biology 41:4, pages 740-743.
Crossref
Gabriela Alvite & Adriana Esteves. (2009) Echinococcus granulosus tropomyosin isoforms: From gene structure to expression analysis. Gene 433:1-2, pages 40-49.
Crossref
Anne Cammas, Stephen M. Lewis, Stephan Vagner & Martin Holcik. (2008) Post-transcriptional control of gene expression through subcellular relocalization of mRNA binding proteins. Biochemical Pharmacology 76:11, pages 1395-1403.
Crossref
Thorsten Pfuhl, Alfredo Mamiani, Matthias Dürr, Susanne Welter, Johanna Stieber, Jasmin Ankara, Michael Liss, Thomas Dobner, Andrea Schmitt, Peter Falkai, Elisabeth Kremmer, Volker Jung, Stephanie Barth & Friedrich A. Grässer. (2008) The LARK/RBM4a protein is highly expressed in cerebellum as compared to cerebrum. Neuroscience Letters 444:1, pages 11-15.
Crossref
Monika Somberg, Xiaomin Zhao, Monika Fröhlich, Magnus Evander & Stefan Schwartz. (2008) Polypyrimidine Tract Binding Protein Induces Human Papillomavirus Type 16 Late Gene Expression by Interfering with Splicing Inhibitory Elements at the Major Late 5′ Splice Site, SD3632. Journal of Virology 82:7, pages 3665-3678.
Crossref
Genta Ohno, Masatoshi Hagiwara & Hidehito Kuroyanagi. (2008) STAR family RNA-binding protein ASD-2 regulates developmental switching of mutually exclusive alternative splicing in vivo. Genes & Development 22:3, pages 360-374.
Crossref
Avril A. Morrison, Rebecca L. Viney & Michael R. Ladomery. (2008) The post-transcriptional roles of WT1, a multifunctional zinc-finger protein. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1785:1, pages 55-62.
Crossref
Clare Gooding & Christopher W. J. Smith. 2008. Tropomyosin. Tropomyosin 27 42 .
Yanmei Huang, Ginka Genova, Mary Roberts & F. Rob Jackson. (2007) The LARK RNA-Binding Protein Selectively Regulates the Circadian Eclosion Rhythm by Controlling E74 Protein Expression. PLoS ONE 2:10, pages e1107.
Crossref
Jung-Chun Lin, Min Hsu & Woan-Yuh Tarn. (2007) Cell stress modulates the function of splicing regulatory protein RBM4 in translation control. Proceedings of the National Academy of Sciences 104:7, pages 2235-2240.
Crossref
Shihoko Kojima, Ken MatsumotoMatsumi HiroseMiyuki ShimadaMamoru NaganoYasufumi ShigeyoshiShin-ichi HoshinoKumiko Ui-TeiKaoru SaigoCarla B. Green, Yoshiyuki Sakaki & Hajime Tei. (2007) LARK activates posttranscriptional expression of an essential mammalian clock protein, PERIOD1. Proceedings of the National Academy of Sciences 104:6, pages 1859-1864.
Crossref
M. Andrea Markus, Bettina Heinrich, Oleg Raitskin, David J. Adams, Helena Mangs, Christine Goy, Michael Ladomery, Ruth Sperling, Stefan Stamm & Brian J. Morris. (2006) WT1 interacts with the splicing protein RBM4 and regulates its ability to modulate alternative splicing in vivo. Experimental Cell Research 312:17, pages 3379-3388.
Crossref
Amar Kar, Necat Havlioglu, Woan-Yuh Tarn & Jane Y. Wu. (2006) RBM4 Interacts with an Intronic Element and Stimulates Tau Exon 10 Inclusion. Journal of Biological Chemistry 281:34, pages 24479-24488.
Crossref

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