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Review

A systematic review of adherence, treatment satisfaction and costs, in fixed-dose combination regimens in type 2 diabetes

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Pages 1157-1168 | Accepted 08 Mar 2011, Published online: 05 Apr 2011

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Hirotaka Watada, Toshimasa Yamauchi, Fumiko Yamamoto, Atsushi Taniguchi, Larisa Yarush, Clemens Heilmann & Atsutaka Yasui. (2020) Safety and tolerability of empagliflozin and linagliptin combination therapy in patients with type 2 diabetes mellitus: a pooled analysis of data from five randomized, controlled clinical trials. Expert Opinion on Drug Safety 19:9, pages 1193-1202.
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Ildiko Lingvay, Nadine Beetz, Regina Sennewald, Annette Schuler-Metz, Julia Bertulis, Christina Loley, Benjamin Lang, Caroline Lippert, Jisoo Lee, Linda Shapiro Manning & Derek Terada. (2020) Triple fixed-dose combination empagliflozin, linagliptin, and metformin for patients with type 2 diabetes. Postgraduate Medicine 132:4, pages 337-345.
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Elizabeth Mary Lamos, Maka Hedrington & Stephen N Davis. (2019) An update on the safety and efficacy of oral antidiabetic drugs: DPP-4 inhibitors and SGLT-2 inhibitors. Expert Opinion on Drug Safety 18:8, pages 691-701.
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Hong Yu, Li Ming Lim, Bingxue Dong & Kunn Hadinoto. (2019) Proof-of-concept preparation and characterization of dual-drug amorphous nanoparticle complex as fixed-dose combination of poorly soluble drugs. Drug Development and Industrial Pharmacy 45:1, pages 105-116.
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Godfrey Mutashambara Rwegerera, Thato Moshomo, Marea Gaenamong, Taibat Aderonke Oyewo, Sivasomnath Gollakota, Francis Apolinary Mhimbira, Joseph Fadare, Brian Godman, Johanna C. Meyer & Yordanka Piña Rivera. (2018) RETRACTED ARTICLE: Antidiabetic medication adherence and associated factors among patients in Botswana; implications for the future. Alexandria Journal of Medicine 54:2, pages 103-109.
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Christos V. Rizos, Theodosios D. Filippatos & Moses S. Elisaf. (2018) Pharmacokinetic drug evaluation of empagliflozin plus linagliptin for the treatment of type 2 diabetes. Expert Opinion on Drug Metabolism & Toxicology 14:1, pages 117-125.
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Danilo D. Trevisan, Thaís M. São-João, Marilia E. Cornélio, Fernanda F. Jannuzzi, Roberta C. M. Rodrigues & Maria Helena M. Lima. (2017) A randomized controlled trial on the effect of behavioral strategies for adherence to oral antidiabetic drugs: study protocol. Contemporary Nurse 53:6, pages 658-668.
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Jingbo Hu, Ping Zou, Shuo Zhang, Minzhi Zhou & Xueying Tan. (2016) Empagliflozin/metformin fixed-dose combination: a review in patients with type 2 diabetes. Expert Opinion on Pharmacotherapy 17:18, pages 2471-2477.
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Catherine M Kuecker & Eva M Vivian. (2016) Patient considerations in type 2 diabetes – role of combination dapagliflozin–metformin XR. Diabetes, Metabolic Syndrome and Obesity 9, pages 25-35.
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Stuart A. Ross, A. Enrique Caballero, Stefano Del Prato, Baptist Gallwitz, Diane Lewis-D’Agostino, Zelie Bailes, Sandra Thiemann, Sanjay Patel, Hans-Juergen Woerle & Maximilian von Eynatten. (2016) Linagliptin plus metformin in patients with newly diagnosed type 2 diabetes and marked hyperglycemia. Postgraduate Medicine 128:8, pages 747-754.
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Stewart B. Harris. (2016) The power of two: an update on fixed-dose combinations for type 2 diabetes. Expert Review of Clinical Pharmacology 9:11, pages 1453-1462.
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Suhaj Abdulsalim, Munawar Peringadi Vayalil & Sonal Sekhar Miraj. (2016) New fixed dose chemical combinations: the way forward for better diabetes type II management?. Expert Opinion on Pharmacotherapy 17:16, pages 2207-2214.
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Tasneem Lokhandwala, Nancy Smith, Catarina Sternhufvud, Elisabeth Sörstadius, Won Chan Lee & Jayanti Mukherjee. (2016) A retrospective study of persistence, adherence, and health economic outcomes of fixed-dose combination vs loose-dose combination of oral anti-diabetes drugs. Journal of Medical Economics 19:3, pages 203-212.
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David S. H. Bell. (2016) Aspirin in the prevention of cardiovascular events in patients with diabetes. Postgraduate Medicine 128:2, pages 180-190.
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Xueying Tan & Jingbo Hu. (2016) Combination therapy for type 2 diabetes: dapagliflozin plus metformin. Expert Opinion on Pharmacotherapy 17:1, pages 117-126.
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Yoshifumi Saisho. (2015) Alogliptin benzoate for management of type 2 diabetes. Vascular Health and Risk Management 11, pages 229-243.
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Joshua W Fleming, Laurie W Fleming & Courtney S Davis. (2015) Fixed-dose combinations in type 2 diabetes – role of the canagliflozin metformin combination. Diabetes, Metabolic Syndrome and Obesity 8, pages 287-294.
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Frank Lavernia, Sarah E. Adkins & Jay H. Shubrook. (2015) Use of oral combination therapy for type 2 diabetes in primary care: Meeting individualized patient goals. Postgraduate Medicine 127:8, pages 808-817.
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Devada Singh-Franco. (2015) Potential for dipeptidyl peptidase-4 inhibitor and sodium glucose cotransporter 2 inhibitor single-pill combinations. Expert Review of Endocrinology & Metabolism 10:3, pages 305-317.
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Ronnie Aronson. (2015) Single-pill combination therapy for type 2 diabetes mellitus: linagliptin plus empagliflozin. Current Medical Research and Opinion 31:5, pages 901-911.
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Niki Katsiki, Vasilios G. Athyros & Asterios Karagiannis. (2013) Single-pill combinations: a therapeutic option or necessity for vascular risk treatment?. Journal of Drug Assessment 2:1, pages 67-71.
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André J Scheen. (2013) Linagliptin plus metformin: a pharmacokinetic and pharmacodynamic evaluation. Expert Opinion on Drug Metabolism & Toxicology 9:3, pages 363-377.
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André J Scheen. (2013) Efficacy and safety of Jentadueto® (linagliptin plus metformin). Expert Opinion on Drug Safety 12:2, pages 275-289.
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Stuart A. Ross, Elizabeth Rafeiro, Thomas Meinicke, Robert Toorawa, Sonja Weber-Born & Hans-Juergen Woerle. (2012) Efficacy and safety of linagliptin 2.5 mg twice daily versus 5 mg once daily in patients with type 2 diabetes inadequately controlled on metformin: a randomised, double-blind, placebo-controlled trial. Current Medical Research and Opinion 28:9, pages 1465-1474.
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André J Scheen. (2012) Pharmacokinetic evaluation of atorvastatin and sitagliptin in combination for the treatment of type 2 diabetes. Expert Opinion on Drug Metabolism & Toxicology 8:6, pages 745-758.
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Steven Han, Kristy Iglay, Michael J. Davies, Qiaoyi Zhang & Larry Radican. (2012) Glycemic effectiveness and medication adherence with fixed-dose combination or coadministered dual therapy of antihyperglycemic regimens: a meta-analysis. Current Medical Research and Opinion 28:6, pages 969-977.
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André J Scheen. (2012) Saxagliptin plus metformin combination therapy. Expert Review of Endocrinology & Metabolism 7:2, pages 151-164.
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Wei Zhang, Shan-Shan Xing, Huan-Jun Wang & Qi-Chong Xing. (2011) Fixed-dose single tablet combinations: an alternative for initial therapy of patients with Type 2 diabetes?. Current Medical Research and Opinion 27:12, pages 2321-2322.
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Ildiko Lingvay. (2017) Sodium Glucose Cotransporter 2 and Dipeptidyl Peptidase-4 Inhibition: Promise of a Dynamic Duo. Endocrine Practice 23:7, pages 831-840.
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Zachary T. Bloomgarden, Kaan Tunceli, Jinan Liu, Kimberly G. Brodovicz, Panagiotis Mavros, Samuel S. Engel, Larry Radican, Yong Chen, Swapnil Rajpathak, Ying Qiu, Philippe Brudi & Vivian Fonseca. (2017) Adherence, persistence, and treatment discontinuation with sitagliptin compared with sulfonylureas as add-ons to metformin: A retrospective cohort database study. Journal of Diabetes 9:7, pages 677-688.
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Aymen Elsous, Mahmoud Radwan, Hasnaa Al-Sharif & Ayman Abu Mustafa. (2017) Medications Adherence and Associated Factors among Patients with Type 2 Diabetes Mellitus in the Gaza Strip, Palestine. Frontiers in Endocrinology 8.
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Jaime A. Davidson & Lance Sloan. (2016) Fixed-Dose Combination of Canagliflozin and Metformin for the Treatment of Type 2 Diabetes: An Overview. Advances in Therapy 34:1, pages 41-59.
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Joel Zonszein & Per-Henrik Groop. (2016) Strategies for Diabetes Management: Using Newer Oral Combination Therapies Early in the Disease. Diabetes Therapy 7:4, pages 621-639.
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Samuel StolpeMichel A. KroesNeil WebbTami Wisniewski. (2016) A Systematic Review of Insulin Adherence Measures in Patients with Diabetes. Journal of Managed Care & Specialty Pharmacy 22:11, pages 1224-1246.
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. (2016) Parte III. Control clínico del tratamiento con fenofibrato. Clínica e Investigación en Arteriosclerosis 28, pages 20-25.
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Francesca Brundisini, Meredith Vanstone, Danielle Hulan, Deirdre DeJean & Mita Giacomini. (2015) Type 2 diabetes patients’ and providers’ differing perspectives on medication nonadherence: a qualitative meta-synthesis. BMC Health Services Research 15:1.
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Masato Odawara, Mika Yoshiki, Misako Sano, Izumi Hamada, Valentina Lukashevich & Wolfgang Kothny. (2015) Efficacy and Safety of a Single-Pill Combination of Vildagliptin and Metformin in Japanese Patients with Type 2 Diabetes Mellitus: A Randomized, Double-Blind, Placebo-Controlled Trial. Diabetes Therapy 6:1, pages 17-27.
Crossref
S. A. Ross, A. E. Caballero, S. Del Prato, B. Gallwitz, D. Lewis‐D'Agostino, Z. Bailes, S. Thiemann, S. Patel, H.‐J. Woerle & M. von Eynatten. (2014) Initial combination of linagliptin and metformin compared with linagliptin monotherapy in patients with newly diagnosed type 2 diabetes and marked hyperglycaemia: a randomized, double‐blind, active‐controlled, parallel group, multinational clinical trial. Diabetes, Obesity and Metabolism 17:2, pages 136-144.
Crossref
M. Chris Runken, Bridgett Goodwin, Manan Shah, Michael Eaddy, Anna D’Souza, Brian Bowers & Christopher F. Bell. (2014) Migraine-Related Healthcare Resource Use and Costs for Subjects Prescribed Fixed-Dose Combination Sumatriptan/Naproxen Sodium vs. Single-Entity Oral Triptans in a Managed Care Population in the USA. Applied Health Economics and Health Policy 13:1, pages 109-120.
Crossref
Thomas Haak. (2015) Combination of Linagliptin and Metformin for the Treatment of Patients with Type 2 Diabetes. Clinical Medicine Insights: Endocrinology and Diabetes 8, pages CMED.S10360.
Crossref
Yvonne Gautam, Ole J. Bjerrum & Merete Schmiegelow. (2015) The Wider Use of Fixed-Dose Combinations Emphasizes the Need for a Global Approach to Regulatory Guideline Development. Therapeutic Innovation & Regulatory Science 49:1, pages 197-204.
Crossref
Grigorios Rombopoulos, Magdalini Hatzikou, Athanasios Athanasiadis & Moyses Elisaf. (2015) Treatment Compliance with Fixed-Dose Combination of Vildagliptin/Metformin in Patients with Type 2 Diabetes Mellitus Inadequately Controlled with Metformin Monotherapy: A 24-Week Observational Study. International Journal of Endocrinology 2015, pages 1-5.
Crossref
Domingo Orozco-Beltrán, Concepción Carratalá-Munuera & Vicente Gil-Guillén. (2015) Mejorar la adherencia: una de las acciones más eficientes para aumentar la supervivencia de los pacientes en prevención secundaria. Revista Española de Cardiología Suplementos 15, pages 12-18.
Crossref
Lawrence Blonde, Zinnia T. San Juan & Peggy Bolton. (2014) Fixed-Dose Combination Therapy in Type 2 Diabetes Mellitus. Endocrine Practice 20:12, pages 1322-1332.
Crossref
O. J. Phung, D. M. Sobieraj, S. S. Engel & S. N. Rajpathak. (2014) Early combination therapy for the treatment of type 2 diabetes mellitus: systematic review and meta-analysis. Diabetes, Obesity and Metabolism 16:5, pages 410-417.
Crossref
Jaime A. Davidson. (2013) Incretin-Based Therapies: Focus on Effects Beyond Glycemic Control Alone. Diabetes Therapy 4:2, pages 221-238.
Crossref
Luis-Emilio García-Pérez, María Álvarez, Tatiana Dilla, Vicente Gil-Guillén & Domingo Orozco-Beltrán. (2013) Adherence to Therapies in Patients with Type 2 Diabetes. Diabetes Therapy 4:2, pages 175-194.
Crossref
Lucas N. Marzec & Thomas M. Maddox. (2013) Medication Adherence in Patients with Diabetes and Dyslipidemia: Associated Factors and Strategies for Improvement. Current Cardiology Reports 15:11.
Crossref
Jun-Sing Wang, Chien-Ning Huang, Yi-Jen Hung, Ching-Fai Kwok, Jui-Hung Sun, Dee Pei, Chwen-Yi Yang, Ching-Chu Chen, Ching-Ling Lin & Wayne Huey-Herng Sheu. (2013) Acarbose plus metformin fixed-dose combination outperforms acarbose monotherapy for type 2 diabetes. Diabetes Research and Clinical Practice 102:1, pages 16-24.
Crossref
Stuart A. Ross. (2013) Breaking Down Patient and Physician Barriers to Optimize Glycemic Control in Type 2 Diabetes. The American Journal of Medicine 126:9, pages S38-S48.
Crossref
D. S. H. Bell. (2012) Combine and conquer: advantages and disadvantages of fixed‐dose combination therapy. Diabetes, Obesity and Metabolism 15:4, pages 291-300.
Crossref
Shinzo HiroiKenkichi SugiuraKumi MatsunoMasashi HirayamaKenji KuriyamaKohei KakuKoji Kawakami. (2013) A Multicenter, Phase III Evaluation of the Efficacy and Safety of a New Fixed-Dose Pioglitazone/Glimepiride Combination Tablet in Japanese Patients with Type 2 Diabetes. Diabetes Technology & Therapeutics 15:2, pages 158-165.
Crossref
Emilio Márquez Contreras. (2012) El incumplimiento en el tratamiento de la diabetes mellitus tipo 2 en España. Hipertensión y Riesgo Vascular 29, pages 8-13.
Crossref
Mike Benford, Gary Milligan, James Pike, Peter Anderson, James Piercy & Steve Fermer. (2012) Fixed-Dose Combination Antidiabetic Therapy: Real-World Factors Associated with Prescribing Choices and Relationship with Patient Satisfaction and Compliance. Advances in Therapy 29:1, pages 26-40.
Crossref

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