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Young‐Chang Kim, Aizhan Abdildinova, Ye Jin Shin, Dong Kyun Han, Jong Yeon Hwang, Hyae Gyeong Cheon & Young‐Dae Gong. (2023)
Development for a new 5‐lipoxygenase inhibitors of
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2‐methyl‐2
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Ben A. Chindo, Helmut Schröder, Andreas Koeberle, Oliver Werz & Axel Becker. (2016) Analgesic potential of standardized methanol stem bark extract of Ficus platyphylla in mice: Mechanisms of action. Journal of Ethnopharmacology 184, pages 101-106.
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Michelle M. Armstrong, Cody J. Freedman, Joo Eun Jung, Yi Zheng, Chakrapani Kalyanaraman, Matthew P. Jacobson, Anton Simeonov, David J. Maloney, Klaus van Leyen, Ajit Jadhav & Theodore R. Holman. (2016) A potent and selective inhibitor targeting human and murine 12/15-LOX. Bioorganic & Medicinal Chemistry 24:6, pages 1183-1190.
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Sebastian Essig, Björn Schmalzbauer, Sebastian Bretzke, Olga Scherer, Andreas Koeberle, Oliver Werz, Rolf Müller & Dirk Menche. (2016) Predictive Bioinformatic Assignment of Methyl-Bearing Stereocenters, Total Synthesis, and an Additional Molecular Target of Ajudazol B. The Journal of Organic Chemistry 81:4, pages 1333-1357.
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Elena B. Averina, Dmitry A. Vasilenko, Yulia A. Gracheva, Yuri K. Grishin, Eugene V. Radchenko, Vladimir V. Burmistrov, Gennady M. Butov, Margarita E. Neganova, Tatyana P. Serkova, Olga M. Redkozubova, Elena F. Shevtsova, Elena R. Milaeva, Tamara S. Kuznetsova & Nikolay S. Zefirov. (2016) Synthesis and biological evaluation of novel 5-hydroxylaminoisoxazole derivatives as lipoxygenase inhibitors and metabolism enhancing agents. Bioorganic & Medicinal Chemistry 24:4, pages 712-720.
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Shweta Sinha, T. V. Sravanthi, S. Yuvaraj, S. L. Manju & Mukesh Doble. (2016) 2-Amino-4-aryl thiazole: a promising scaffold identified as a potent 5-LOX inhibitor. RSC Advances 6:23, pages 19271-19279.
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Jessica Roos, Sabine Grösch, Oliver Werz, Peter Schröder, Slava Ziegler, Simone Fulda, Patrick Paulus, Anja Urbschat, Benjamin Kühn, Isabelle Maucher, Jasmin Fettel, Thomas Vorup-Jensen, Matthias Piesche, Carmela Matrone, Dieter Steinhilber, Michael J. Parnham & Thorsten J. Maier. (2016) Regulation of tumorigenic Wnt signaling by cyclooxygenase-2, 5-lipoxygenase and their pharmacological inhibitors: A basis for novel drugs targeting cancer cells?. Pharmacology & Therapeutics 157, pages 43-64.
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Chrysoula Gousiadou & Irene Kouskoumvekaki. (2016) LOX1 inhibition with small molecules. Journal of Molecular Graphics and Modelling 63, pages 99-109.
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Jana Wiemann, Lucie Heller, Vincent Perl, Ralph Kluge, Dieter Ströhl & René Csuk. (2015) Betulinic acid derived hydroxamates and betulin derived carbamates are interesting scaffolds for the synthesis of novel cytotoxic compounds. European Journal of Medicinal Chemistry 106, pages 194-210.
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Ju-Hee Kang, Zheng Ting, Mi-ran Moon, Jung-Seon Sim, Jung-Min Lee, Kyung-Eun Doh, Sunhye Hong, Minghua Cui, Sun Choi, Hyeun Wook Chang, Hea-Young Park Choo & Mijung Yim. (2015) 5-Lipoxygenase inhibitors suppress RANKL-induced osteoclast formation via NFATc1 expression. Bioorganic & Medicinal Chemistry 23:21, pages 7069-7078.
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Sunayana Mitra, Sue G. Bartlett & Marcia E. Newcomer. (2015) Identification of the Substrate Access Portal of 5-Lipoxygenase. Biochemistry 54:41, pages 6333-6342.
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Carlo Pergola, Anja M. Schaible, Felix Nikels, Gabriele Dodt, Hinnak Northoff & Oliver Werz. (2015) Progesterone rapidly down-regulates the biosynthesis of 5-lipoxygenase products in human primary monocytes. Pharmacological Research 94, pages 42-50.
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Rosanna Filosa, Antonella Peduto, Anja M. Schaible, Verena Krauth, Christina Weinigel, Dagmar Barz, Carmen Petronzi, Ferdinando Bruno, Fiorentina Roviezzo, Giuseppe Spaziano, Bruno D'Agostino, Mario De Rosa & Oliver Werz. (2015) Novel series of benzoquinones with high potency against 5-lipoxygenase in human polymorphonuclear leukocytes. European Journal of Medicinal Chemistry 94, pages 132-139.
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York Rudhard, Arundhati Sengupta Ghosh, Beatrix Lippert, Alexander Böcker, Mehdi Pedaran, Joachim Krämer, Hai Ngu, Oded Foreman, Yichin Liu & Joseph W. Lewcock. (2015) Identification of 12/15-Lipoxygenase as a Regulator of Axon Degeneration through High-Content Screening. The Journal of Neuroscience 35:7, pages 2927-2941.
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Zhong-Rong Zhang, Wing Nang Leung, Ho Yee Cheung & Chun Wai Chan. (2015) Osthole: A Review on Its Bioactivities, Pharmacological Properties, and Potential as Alternative Medicine. Evidence-Based Complementary and Alternative Medicine 2015, pages 1-10.
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I. H. Lambert, D. M. Kristensen, J. B. Holm & O. H. Mortensen. (2015) Physiological role of taurine - from organism to organelle. Acta Physiologica 213:1, pages 191-212.
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Oliver Werz, Olof Rådmark & Dieter Steinhilber. 2005. Encyclopedia of Life Sciences. Encyclopedia of Life Sciences.
Eduarda Moita, Carla Sousa, Paula Andrade, Fátima Fernandes, Brígida Pinho, Luís Silva & Patrícia Valentão. (2014) Effects of Echium plantagineum L. Bee Pollen on Basophil Degranulation: Relationship with Metabolic Profile. Molecules 19:7, pages 10635-10649.
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Rosalina Wisastra & Frank Dekker. (2014) Inflammation, Cancer and Oxidative Lipoxygenase Activity are Intimately Linked. Cancers 6:3, pages 1500-1521.
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Hercules Antônio da Silva-Souza, Maria Nathalia de Lira, Helio Miranda Costa-Junior, Cristiane Monteiro da Cruz, Jorge Silvio Silva Vasconcellos, Anderson Nogueira Mendes, Gabriela Pimenta-Reis, Cora Lilia Alvarez, Lucia Helena Faccioli, Carlos Henrique Serezani, Julieta Schachter & Pedro Muanis Persechini. (2014) Inhibitors of the 5-lipoxygenase arachidonic acid pathway induce ATP release and ATP-dependent organic cation transport in macrophages. Biochimica et Biophysica Acta (BBA) - Biomembranes 1838:7, pages 1967-1977.
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C Pergola, J Gerstmeier, B Mönch, B Çalışkan, S Luderer, C Weinigel, D Barz, J Maczewsky, S Pace, A Rossi, L Sautebin, E Banoglu & O Werz. (2014)
The novel benzimidazole derivative BRP-7 inhibits leukotriene biosynthesis
in vitro
and
in vivo
by targeting 5-lipoxygenase-activating protein (FLAP)
. British Journal of Pharmacology 171:12, pages 3051-3064.
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M. Benard, K. Straat, S. Omarsdottir, K. Leghmari, J. Bertrand, C. Davrinche, I. Duga-Neulat, C. Söderberg-Nauclér, A. Rahbar & C. Casper. (2014) Human cytomegalovirus infection induces leukotriene B4 and 5-lipoxygenase expression in human placentae and umbilical vein endothelial cells. Placenta 35:6, pages 345-350.
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Antonella Peduto, Ferdinando Bruno, Friedrike Dehm, Verena Krauth, Paolo de Caprariis, Christina Weinigel, Dagmar Barz, Antonio Massa, Mario De Rosa, Oliver Werz & Rosanna Filosa. (2014) Further studies on ethyl 5-hydroxy-indole-3-carboxylate scaffold: Design, synthesis and evaluation of 2-phenylthiomethyl-indole derivatives as efficient inhibitors of human 5-lipoxygenase. European Journal of Medicinal Chemistry 81, pages 492-498.
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Erchang Shang, Yiran Wu, Pei Liu, Ying Liu, Wei Zhu, Xiaobing Deng, Chong He, Shan He, Cong Li & Luhua Lai. (2014) Benzo[d]isothiazole 1,1-dioxide derivatives as dual functional inhibitors of 5-lipoxygenase and microsomal prostaglandin E2 synthase-1. Bioorganic & Medicinal Chemistry Letters 24:12, pages 2764-2767.
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Carlo Pergola, Nicolas Gaboriaud-Kolar, Nadine Jestädt, Stefanie König, Marina Kritsanida, Anja M. Schaible, Haokun Li, Ulrike Garscha, Christina Weinigel, Dagmar Barz, Kai F. Albring, Otmar Huber, Alexios L. Skaltsounis & Oliver Werz. (2014) Indirubin Core Structure of Glycogen Synthase Kinase-3 Inhibitors as Novel Chemotype for Intervention with 5-Lipoxygenase. Journal of Medicinal Chemistry 57:9, pages 3715-3723.
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A M Schaible, R Filosa, V Temml, V Krauth, M Matteis, A Peduto, F Bruno, S Luderer, F Roviezzo, A Di Mola, M de Rosa, B D'Agostino, C Weinigel, D Barz, A Koeberle, C Pergola, D Schuster & O Werz. (2014)
Elucidation of the molecular mechanism and the efficacy
in vivo
of a novel 1,4-benzoquinone that inhibits 5-lipoxygenase
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Phillipp Richter, Gregor Schubert, Anja Maria Schaible, Levent Cavas, Oliver Werz & Georg Pohnert. (2014) Caulerpenyne and Related Bis-enol Esters Are Novel-Type Inhibitors of Human 5-Lipoxygenase. ChemMedChem, pages n/a-n/a.
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Stavroula Markoutsa, Duran Sürün, Michael Karas, Bettina Hofmann, Dieter Steinhilber & Bernd L. Sorg. (2014) Analysis of 5-lipoxygenase phosphorylation on molecular level by MALDI-MS. FEBS Journal 281:8, pages 1931-1947.
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Erchang Shang, Ying Liu, Yiran Wu, Wei Zhu, Chong He & Luhua Lai. (2014) Development of 3,5-dinitrobenzoate-based 5-lipoxygenase inhibitors. Bioorganic & Medicinal Chemistry 22:8, pages 2396-2402.
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Phillip F. Giannopoulos, Yash B. Joshi & Domenico Praticò. (2014) Novel lipid signaling pathways in Alzheimer's disease pathogenesis. Biochemical Pharmacology 88:4, pages 560-564.
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Parteek Prasher, Pooja & Palwinder Singh. (2014) Lead modification: Amino acid appended indoles as highly effective 5-LOX inhibitors. Bioorganic & Medicinal Chemistry 22:5, pages 1642-1648.
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Jérémie A. Doiron, Benoît Métayer, Ryan R. Richard, Dany Desjardins, Luc H. Boudreau, Natalie A. Levesque, Jacques Jean-François, Samuel J. Poirier, Marc E. Surette & Mohamed Touaibia. (2014) Clicked Cinnamic/Caffeic Esters and Amides as Radical Scavengers and 5-Lipoxygenase Inhibitors. International Journal of Medicinal Chemistry 2014, pages 1-12.
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Sangchul Lee, Youngsam Park, Junghwan Kim & Sung-Jun Han. (2014) A Fluorescence-Based Assay for Measuring the Redox Potential of 5-Lipoxygenase Inhibitors. PLoS ONE 9:2, pages e87708.
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Mayuri Napagoda, Jana Gerstmeier, Andreas Koeberle, Sandra Wesely, Sven Popella, Sybille Lorenz, Kerstin Scheubert, Sebastian Böcker, Aleš Svatoš & Oliver Werz. (2014) Munronia pinnata (Wall.) Theob.: Unveiling phytochemistry and dual inhibition of 5-lipoxygenase and microsomal prostaglandin E2 synthase (mPGES)-1. Journal of Ethnopharmacology 151:2, pages 882-890.
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Xue Zhao, Weiqiang Lu, Cheng Song & Jin Huang. (2013) Detection of mammalian 5‐lipoxygenase activity using the fluorescent probe dihydrorhodamine 123. European Journal of Lipid Science and Technology 116:2, pages 119-125.
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Karin Meirer, Dieter Steinhilber & Ewgenij Proschak. (2014) Inhibitors of the Arachidonic Acid Cascade: Interfering with Multiple Pathways. Basic & Clinical Pharmacology & Toxicology 114:1, pages 83-91.
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Rosanna Filosa, Antonella Peduto, Polamarasetty Aparoy, Anja M. Schaible, Susann Luderer, Verena Krauth, Carmen Petronzi, Antonio Massa, Mario de Rosa, Pallu Reddanna & Oliver Werz. (2013) Discovery and biological evaluation of novel 1,4-benzoquinone and related resorcinol derivatives that inhibit 5-lipoxygenase. European Journal of Medicinal Chemistry 67, pages 269-279.
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Eric K. Hoobler, Charles Holz & Theodore R. Holman. (2013) Pseudoperoxidase investigations of hydroperoxides and inhibitors with human lipoxygenases. Bioorganic & Medicinal Chemistry 21:13, pages 3894-3899.
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Estel.la Buscató, Joanna M Wisniewska, Carmen B Rödl, Astrid Brüggerhoff, Astrid Kaiser, Florian Rörsch, Edmund Kostewicz, Mario Wurglics, Manfred Schubert-Zsilavecz, Sabine Grösch, Dieter Steinhilber, Bettina HofmannEwgenij Proschak. (2013)
Structure–activity relationship and
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a
]pyridine-based inhibitors of 5-LO
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Katarzyna Wejksza, Catalina Lee-Chang, Monica Bodogai, Jessica Bonzo, Frank J. Gonzalez, Elin Lehrmann, Kevin Becker & Arya Biragyn. (2013) Cancer-Produced Metabolites of 5-Lipoxygenase Induce Tumor-Evoked Regulatory B Cells via Peroxisome Proliferator–Activated Receptor α. The Journal of Immunology 190:6, pages 2575-2584.
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Karin Meirer, Carmen B. Rödl, Joanna M. Wisniewska, Sven George, Ann-Kathrin Häfner, Estel·la Buscató, Franca-Maria Klingler, Steffen Hahn, Dirk Berressem, Sandra K. Wittmann, Dieter Steinhilber, Bettina Hofmann & Ewgenij Proschak. (2013) Synthesis and Structure–Activity Relationship Studies of Novel Dual Inhibitors of Soluble Epoxide Hydrolase and 5-Lipoxygenase. Journal of Medicinal Chemistry 56:4, pages 1777-1781.
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Fátima Churruca, Susana Hernández, María Perea, Raul SanMartin & Esther Domínguez. (2013) Direct access to pyrazolo(benzo)thienoquinolines. Highly effective palladium catalysts for the intramolecular C–H heteroarylation of arenes. Chemical Communications 49:14, pages 1413.
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Maria Giovanna Chini, Rosa De Simone, Ines Bruno, Raffaele Riccio, Friederike Dehm, Christina Weinigel, Dagmar Barz, Oliver Werz & Giuseppe Bifulco. (2012) Design and synthesis of a second series of triazole-based compounds as potent dual mPGES-1 and 5-lipoxygenase inhibitors. European Journal of Medicinal Chemistry 54, pages 311-323.
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Rosalina Wisastra, Massimo Ghizzoni, André Boltjes, Hidde J. Haisma & Frank J. Dekker. (2012) Anacardic acid derived salicylates are inhibitors or activators of lipoxygenases. Bioorganic & Medicinal Chemistry 20:16, pages 5027-5032.
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Yue Lu, Ying Li, Yurndong Jahng, Jong-Keun Son & Hyeun Wook Chang. (2012) Citreorosein inhibits degranulation and leukotriene C4 generation through suppression of Syk pathway in mast cells. Molecular and Cellular Biochemistry 365:1-2, pages 333-341.
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Yiran Wu, Chong He, Yang Gao, Shan He, Ying Liu & Luhua Lai. (2012) Dynamic Modeling of Human 5-Lipoxygenase–Inhibitor Interactions Helps To Discover Novel Inhibitors. Journal of Medicinal Chemistry 55:6, pages 2597-2605.
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Yu Liu, Huan Wang, Yanmei Zhu, Li Chen, Youyang Qu & Yulan Zhu. (2012) The protective effect of nordihydroguaiaretic acid on cerebral ischemia/reperfusion injury is mediated by the JNK pathway. Brain Research 1445, pages 73-81.
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Luc H. Boudreau, Jacques Maillet, Luc M. LeBlanc, Jacques Jean-François, Mohamed Touaibia, Nicolas Flamand & Marc E. Surette. (2012) Caffeic Acid Phenethyl Ester and Its Amide Analogue Are Potent Inhibitors of Leukotriene Biosynthesis in Human Polymorphonuclear Leukocytes. PLoS ONE 7:2, pages e31833.
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C Pergola, B Jazzar, A Rossi, H Northoff, M Hamburger, L Sautebin & O Werz. (2012) On the inhibition of 5-lipoxygenase product formation by tryptanthrin: mechanistic studies and efficacy in vivo. British Journal of Pharmacology 165:3, pages 765-776.
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Gokcen Eren, Antonio Macchiarulo & Erden Banoglu. (2012) From Molecular Docking to 3D-Quantitative Structure-Activity Relationships (3D-QSAR): Insights into the Binding Mode of 5-Lipoxygenase Inhibitors. Molecular Informatics 31:2, pages 123-134.
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α-Aryl-
N
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Claus Schneider & Ambra Pozzi. (2011) Cyclooxygenases and lipoxygenases in cancer. Cancer and Metastasis Reviews 30:3-4, pages 277-294.
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Punit Ray & Abhijit SrivastavaCarlo Pergola & Oliver Werz. 2011. Obstructive Airway Diseases. Obstructive Airway Diseases
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2‐(4‐(Biphenyl‐4‐ylamino)‐6‐chloropyrimidin‐2‐ylthio)octanoic acid (HZ52) – a novel type of 5‐lipoxygenase inhibitor with favourable molecular pharmacology and efficacy
in vivo
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Carlo Pergola, Bianca Jazzar, Antonietta Rossi, Ulrike Buehring, Susann Luderer, Friederike Dehm, Hinnak Northoff, Lidia Sautebin & Oliver Werz. (2011) Cinnamyl-3,4-Dihydroxy-α-Cyanocinnamate Is a Potent Inhibitor of 5-Lipoxygenase. Journal of Pharmacology and Experimental Therapeutics 338:1, pages 205-213.
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A.-M. Katsori, M. Chatzopoulou, K. Dimas, C. Kontogiorgis, A. Patsilinakos, T. Trangas & D. Hadjipavlou-Litina. (2011) Curcumin analogues as possible anti-proliferative & anti-inflammatory agents. European Journal of Medicinal Chemistry 46:7, pages 2722-2735.
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Christine Greiner, Heiko Zettl, Andreas Koeberle, Carlo Pergola, Hinnak Northoff, Manfred Schubert-Zsilavecz & Oliver Werz. (2011) Identification of 2-mercaptohexanoic acids as dual inhibitors of 5-lipoxygenase and microsomal prostaglandin E2 synthase-1. Bioorganic & Medicinal Chemistry 19:11, pages 3394-3401.
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Ian Henry Lambert & Daniel Bloch Hansen. (2011) Regulation of Taurine Transport Systems by Protein Kinase CK2 in Mammalian Cells. Cellular Physiology and Biochemistry 28:6, pages 1099-1110.
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Lianhai Li, Carl Berthelette, Anne Chateauneuf, Marc Ouellet, Claudio F. Sturino & Zhaoyin Wang. (2010) Potent and selective 5-LO inhibitor bearing benzothiophene pharmacophore: Discovery of MK-5286. Bioorganic & Medicinal Chemistry Letters 20:24, pages 7440-7443.
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Xiaowu Dong, Li Wang, Xueqin Huang, Tao Liu, Erqing Wei, Lilin Du, Bo Yang & Yongzhou Hu. (2010) Pharmacophore identification, synthesis, and biological evaluation of carboxylated chalcone derivatives as CysLT1 antagonists. Bioorganic & Medicinal Chemistry 18:15, pages 5519-5527.
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