243
Views
67
CrossRef citations to date
0
Altmetric
Review

Peroxisome proliferator-activated receptor-γ ligands for the treatment of breast cancer

&
Pages 557-568 | Published online: 11 Jul 2005

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Gabriela A. Martínez-Nava, Ana I. Burguete-García, Lizbeth López-Carrillo, Raúl U. Hernández-Ramírez, Vicente Madrid-Marina & Mariano E. Cebrián. (2013) PPARγ and PPARGC1B polymorphisms modify the association between phthalate metabolites and breast cancer risk. Biomarkers 18:6, pages 493-501.
Read now
Jingxuan Pan, Chun Chen, Yanli Jin, Enrique Fuentes-Mattei, Guermarie Velazquez-Tores, Juliana Maria Benito, Marina Konopleva, Michael Andreeff, Mong-Hong Lee & Sai-Ching J. Yeung. (2012) Differential impact of structurally different anti-diabetic drugs on proliferation and chemosensitivity of acute lymphoblastic leukemia cells. Cell Cycle 11:12, pages 2314-2326.
Read now
Efstathia Papageorgiou, Nea Pitulis, Pavlos Msaouel, Peter Lembessis & Michael Koutsilieris. (2007) The non-genomic crosstalk between PPAR-γ ligands and ERK1/2 in cancer cell lines. Expert Opinion on Therapeutic Targets 11:8, pages 1071-1085.
Read now

Articles from other publishers (64)

Enrico Garattini, Marco Bolis, Maurizio Gianni’, Gabriela Paroni, Maddalena Fratelli & Mineko Terao. (2016) Lipid-sensors, enigmatic-orphan and orphan nuclear receptors as therapeutic targets in breast-cancer. Oncotarget 7:27, pages 42661-42682.
Crossref
Dongdong Yao, Yang Zou & Yonggang Lv. (2022) Maresin 1 enhances osteogenic potential of mesenchymal stem cells by modulating macrophage peroxisome proliferator-activated receptor-γ-mediated inflammation resolution. Biomaterials Advances 141, pages 213116.
Crossref
Shadi Esmaeili, Sina Salari, Vahid Kaveh, Seyed H. Ghaffari & Davood Bashash. (2021) Alteration of PPAR ‐ GAMMA ( PPARG ; PPARγ ) and PTEN gene expression in acute myeloid leukemia patients and the promising anticancer effects of PPARγ stimulation using pioglitazone on AML cells . Molecular Genetics & Genomic Medicine 9:11.
Crossref
Ping‐Chieh Chou, Hyun Ho Choi, Yizhi Huang, Enrique Fuentes‐Mattei, Guermarie Velazquez‐Torres, Fanmao Zhang, Liem Phan, Jaehyuk Lee, Yanxia Shi, James A. Bankson, Yun Wu, Huamin Wang, Ruiying Zhao, Sai‐Ching Jim Yeung & Mong‐Hong Lee. (2021) Impact of diabetes on promoting the growth of breast cancer. Cancer Communications 41:5, pages 414-431.
Crossref
Anna Trebo, Nina Ditsch, Tom Degenhardt, Christina Kuhn, Martina Rahmeh, Elisa Schmoeckel, Doris Mayr, Bastian Czogalla, Thomas Kolben, Sarah Meister, Sven Mahner, Udo Jeschke & Anna Hester. (2021) First Evidence for a Role of Siglec-8 in Breast Cancer. International Journal of Molecular Sciences 22:4, pages 2000.
Crossref
Wanting Shao, Christina Kuhn, Doris Mayr, Nina Ditsch, Magdalena Kailuwait, Verena Wolf, Nadia Harbeck, Sven Mahner, Udo Jeschke, Vincent Cavaillès & Sophie Sixou. (2020) Cytoplasmic PPARγ is a marker of poor prognosis in patients with Cox-1 negative primary breast cancers. Journal of Translational Medicine 18:1.
Crossref
Lingyan Xu, Xinran Ma, Narendra Verma, Luce Perie, Jay Pendse, Sama Shamloo, Anne Marie Josephson, Dongmei Wang, Jin Qiu, Mingwei Guo, Xiaodan Ping, Michele Allen, Audrey Noguchi, Danielle Springer, Fei Shen, Caizhi Liu, Shiwei Zhang, Lingyu Li, Jin Li, Junjie Xiao, Jian Lu, Zhenyu Du, Jian Luo, Jose O. Aleman, Philipp Leucht & Elisabetta Mueller. (2020) PPARγ agonists delay age‐associated metabolic disease and extend longevity. Aging Cell 19:11.
Crossref
Caroline Dani, Luciana Kneib Gonçalves, Isabel Teixeira Proença, Fabia de Oliveira Andrade & Leena Hilakivi-Clarke. (2020) Effects of Maternal Grape Juice Intake on Unfolded Protein Response in the Mammary Glands of Offspring of High Fat Diet Fed Rat Dams. Nutrients 12:8, pages 2253.
Crossref
Hannah E. Wilson, Kacey K. Rhodes, Daniel Rodriguez, Ikttesh Chahal, David A. Stanton, Joseph Bohlen, Mary Davis, Aniello M. Infante, Hannah Hazard-Jenkins, David J. Klinke, Elena N. Pugacheva & Emidio E. Pistilli. (2019) Human Breast Cancer Xenograft Model Implicates Peroxisome Proliferator–activated Receptor Signaling as Driver of Cancer-induced Muscle Fatigue. Clinical Cancer Research 25:7, pages 2336-2347.
Crossref
Amandine Girousse, Marta Gil-Ortega, Virginie Bourlier, Célia Bergeaud, Quentin Sastourné-Arrey, Cédric Moro, Corinne Barreau, Christophe Guissard, Julie Vion, Emmanuelle Arnaud, Jean-Philippe Pradère, Noémie Juin, Louis Casteilla & Coralie Sengenès. (2019) The Release of Adipose Stromal Cells from Subcutaneous Adipose Tissue Regulates Ectopic Intramuscular Adipocyte Deposition. Cell Reports 27:2, pages 323-333.e5.
Crossref
Guangsheng Wu, Juan Liu & Xiang Yue. (2019) Prediction of drug-disease associations based on ensemble meta paths and singular value decomposition. BMC Bioinformatics 20:S3.
Crossref
Noa Furth, Ioannis S Pateras, Ron Rotkopf, Vassiliki Vlachou, Irina Rivkin, Ina Schmitt, Deborah Bakaev, Anat Gershoni, Elena Ainbinder, Dena Leshkowitz, Randy L Johnson, Vassilis G Gorgoulis, Moshe Oren & Yael Aylon. (2018) LATS1 and LATS2 suppress breast cancer progression by maintaining cell identity and metabolic state. Life Science Alliance 1:5, pages e201800171.
Crossref
Jonathan D. Diedrich, Mackenzie K. Herroon, Erandi Rajagurubandara & Izabela Podgorski. (2018) The Lipid Side of Bone Marrow Adipocytes: How Tumor Cells Adapt and Survive in Bone. Current Osteoporosis Reports 16:4, pages 443-457.
Crossref
On-Yu HongHyun Jo YounHye-Yeon JangSung Hoo JungEun-Mi NohHee Suk ChaeYoung-Ju JeongWon KimCheorl-Ho KimJong-Suk Kim. (2018) Troglitazone Inhibits Matrix Metalloproteinase-9 Expression and Invasion of Breast Cancer Cell through a Peroxisome Proliferator-Activated Receptor γ-Dependent Mechanism. Journal of Breast Cancer 21:1, pages 28.
Crossref
Zhe Jin, Baoxing Jia, Yu Fu, Ludong Tan, Qingmin Chen, Peiqiang Jiang & Yahui Liu. (2017) Ligands of the peroxisome proliferator-activated receptor γ inhibit hepatoce llular carcinoma cell proliferation. Oncology Letters 14:4, pages 4767-4771.
Crossref
Ruben Nogales-Cadenas, Ying Cai, Jhih-Rong Lin, Quanwei Zhang, Wen Zhang, Cristina Montagna & Zhengdong D. Zhang. (2016) MicroRNA expression and gene regulation drive breast cancer progression and metastasis in PyMT mice. Breast Cancer Research 18:1.
Crossref
Daniela Rovito, Giulia Gionfriddo, Ines Barone, Cinzia Giordano, Fedora Grande, Francesca De Amicis, Marilena Lanzino, Stefania Catalano, Sebastiano Andò & Daniela Bonofiglio. (2016) Ligand-activated PPARγ downregulates CXCR4 gene expression through a novel identified PPAR response element and inhibits breast cancer progression. Oncotarget 7:40, pages 65109-65124.
Crossref
Wing Yin Cheng, HoangDinh Huynh, Peiwen Chen, Samuel Peña-Llopis & Yihong Wan. (2016) Macrophage PPARγ inhibits Gpr132 to mediate the anti-tumor effects of rosiglitazone. eLife 5.
Crossref
Chang Woo Lee, Jung Eun Kim, Hackwon Do, Ryeo-Ok Kim, Sung Gu Lee, Hyun Ho Park, Jeong Ho Chang, Joung Han Yim, Hyun Park, Il-Chan Kim & Jun Hyuck Lee. (2015) Structural basis for the ligand-binding specificity of fatty acid-binding proteins (pFABP4 and pFABP5) in gentoo penguin. Biochemical and Biophysical Research Communications 465:1, pages 12-18.
Crossref
YANG ZHAO, JIANHUA GAO & FENG LU. (2013) Human adipose-derived stem cell adipogenesis induces paracrine regulation of the invasive ability of MCF-7 human breast cancer cells in vitro. Experimental and Therapeutic Medicine 6:4, pages 937-942.
Crossref
Jaya Nautiyal, Mark Christian & Malcolm G. Parker. (2013) Distinct functions for RIP140 in development, inflammation, and metabolism. Trends in Endocrinology & Metabolism 24:9, pages 451-459.
Crossref
Jaya NautiyalJennifer H. SteelMeritxell Rosell ManeOlayiwola OduwoleAriel PoliandriXanthippi AlexiNicholas WoodMatti PoutanenWilbert ZwartJohn StinglMalcolm G. Parker. (2013) The transcriptional co-factor RIP140 regulates mammary gland development by promoting the generation of key mitogenic signals. Development 140:5, pages 1079-1089.
Crossref
Jing-Ru Weng, Li-Yuan Bai, Chang-Fang Chiu, Jing-Lan Hu, Shih-Jiuan Chiu & Chia-Yung Wu. (2013) Cucurbitane Triterpenoid from Momordica charantia Induces Apoptosis and Autophagy in Breast Cancer Cells, in Part, through Peroxisome Proliferator-Activated Receptor γ Activation . Evidence-Based Complementary and Alternative Medicine 2013, pages 1-12.
Crossref
Paola Mascia, Gianluigi Tanda, Sevil Yasar, Stephen J. Heishman & Steven R. Goldberg. 2013. endoCANNABINOIDS. endoCANNABINOIDS 235 260 .
Ofer Margalit, Dingzhi Wang & Raymond N. DuBois. (2012) PPARγ Agonists Target Aromatase Via Both PGE2 and BRCA1. Cancer Prevention Research 5:10, pages 1169-1172.
Crossref
Khanh Vu, Naifa Busaidy, Maria E. Cabanillas, Marina Konopleva, Stefan Faderl, Deborah A. Thomas, Susan O'Brien, Kristine Broglio, Joe Ensor, Carmen Escalante, Michael Andreeff, Hagop Kantarjian, Victor Lavis & Sai-Ching Jim Yeung. (2012) A Randomized Controlled Trial of an Intensive Insulin Regimen in Patients With Hyperglycemic Acute Lymphoblastic Leukemia. Clinical Lymphoma Myeloma and Leukemia 12:5, pages 355-362.
Crossref
Inês A. Barbosa, Nuno G. Machado, Andrew J. Skildum, Patricia M. Scott & Paulo J. Oliveira. (2012) Mitochondrial remodeling in cancer metabolism and survival: Potential for new therapies. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1826:1, pages 238-254.
Crossref
Boon Yin Khoo, Noorizan Miswan, Prabha Balaram, Kalpanah Nadarajan & Elena Elstner. (2012) Modification of MCF-10A Cells with Pioglitazone and Serum-Rich Growth Medium Increases Soluble Factors in the Conditioned Medium, Likely Reducing BT-474 Cell Growth. International Journal of Molecular Sciences 13:5, pages 5607-5627.
Crossref
Jeffrey M. Peters, Yatrik M. Shah & Frank J. Gonzalez. (2012) The role of peroxisome proliferator-activated receptors in carcinogenesis and chemoprevention. Nature Reviews Cancer 12:3, pages 181-195.
Crossref
D. Ortuño Sahagún, A. L. Márquez-Aguirre, S. Quintero-Fabián, R. I. López-Roa & A. E. Rojas-Mayorquín. (2012) Modulation of PPAR- γ by Nutraceutics as Complementary Treatment for Obesity-Related Disorders and Inflammatory Diseases . PPAR Research 2012, pages 1-17.
Crossref
Ying Jiang, Yeqing Huang, Chun Cheng, Weiqi Lu, Yixin Zhang, Xiaojuan Liu, Lin Zou, Qiwen Ben & Aiguo Shen. (2011) Combination of thiazolidinedione and hydralazine suppresses proliferation and induces apoptosis by PPAR? up-expression in MDA-MB-231 cells. Experimental and Molecular Pathology 91:3, pages 768-774.
Crossref
Yi-Chen Li, Qing Chen, Xian-Zi Wan, Xiang-Ling Yang, Xin Liu & Ling Zhong. (2011) Effects of conjugated linoleic acid on cleavage of amyloid precursor protein via PPARγ. Neurological Sciences 32:6, pages 1095-1101.
Crossref
Sarra Chbicheb, Xiao Yao, Jean-Luc Rodeau, Stéphane Salamone, Michel Boisbrun, Gerald Thiel, Daniel Spohn, Isabelle Grillier-Vuissoz, Yves Chapleur, Stéphane Flament & Sabine Mazerbourg. (2011) EGR1 expression: A calcium and ERK1/2 mediated PPARγ-independent event involved in the antiproliferative effect of 15-deoxy-Δ12,14-prostaglandin J2 and thiazolidinediones in breast cancer cells. Biochemical Pharmacology 81:9, pages 1087-1097.
Crossref
Karen Bräutigam, Julia Biernath-Wüpping, Dirk O. Bauerschlag, Constantin S. von Kaisenberg, Walter Jonat, Nicolai Maass, Norbert Arnold & Ivo Meinhold-Heerlein. (2010) Combined treatment with TRAIL and PPARγ ligands overcomes chemoresistance of ovarian cancer cell lines. Journal of Cancer Research and Clinical Oncology 137:5, pages 875-886.
Crossref
Yin-Hsun Feng, Guermarie Velazquez-Torres, Christopher Gully, Jian Chen, Mong-Hong Lee & Sai-Ching Jim Yeung. (2011) The impact of type 2 diabetes and antidiabetic drugs on cancer cell growth. Journal of Cellular and Molecular Medicine 15:4, pages 825-836.
Crossref
Weiqiang Lu, Peng Che, Yanyan Zhang, Honglin Li, Shien Zou, Jin Zhu, Jing Deng, Xu Shen, Hualiang Jiang, Jian Li & Jin Huang. (2011) HL005?A new selective PPAR? antagonist specifically inhibits the proliferation of MCF-7. The Journal of Steroid Biochemistry and Molecular Biology 124:3-5, pages 112-120.
Crossref
Christelle Colin, Stéphane Salamone, Isabelle Grillier-Vuissoz, Michel Boisbrun, Sandra Kuntz, Julie Lecomte, Yves Chapleur & Stéphane Flament. (2010) New troglitazone derivatives devoid of PPARγ agonist activity display an increased antiproliferative effect in both hormone-dependent and hormone-independent breast cancer cell lines. Breast Cancer Research and Treatment 124:1, pages 101-110.
Crossref
Gerhard Rogler. 2010. Inflammatory Bowel Disease. Inflammatory Bowel Disease 337 359 .
Javier A. Menendez. (2010) Fine-tuning the lipogenic/lipolytic balance to optimize the metabolic requirements of cancer cell growth: Molecular mechanisms and therapeutic perspectives. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1801:3, pages 381-391.
Crossref
Chuanbing Zang, Hongyu Liu, Janina Bertz, Kurt Possinger, H. Phillip Koeffler, Elena Elstner & Jan Eucker. (2009) Induction of endoplasmic reticulum stress response by TZD18, a novel dual ligand for peroxisome proliferator-activated receptor α/γ, in human breast cancer cells. Molecular Cancer Therapeutics 8:8, pages 2296-2307.
Crossref
Hong Jin Lee, Jihyeung Ju, Shiby Paul, Jae-Young So, Andrew DeCastro, Amanda Smolarek, Mao-Jung Lee, Chung S. Yang, Harold L. Newmark & Nanjoo Suh. (2009) Mixed Tocopherols Prevent Mammary Tumorigenesis by Inhibiting Estrogen Action and Activating PPAR-γ. Clinical Cancer Research 15:12, pages 4242-4249.
Crossref
Jennifer C. Carter & Frank C. Church. (2009) Obesity and Breast Cancer: The Roles of Peroxisome Proliferator-Activated Receptor- and Plasminogen Activator Inhibitor-1 . PPAR Research 2009, pages 1-13.
Crossref
Hong-Nu Yu, Eun-Mi Noh, Young-Rae Lee, Si-Gyun Roh, Eun-Kyung Song, Myung-Kwan Han, Yong-Chul Lee, In Kyong Shim, Seung Jin Lee, Sung Hoo Jung, Jong-Suk Kim & Hyun Jo Youn. (2008) Troglitazone enhances tamoxifen-induced growth inhibitory activity of MCF-7 cells. Biochemical and Biophysical Research Communications 377:1, pages 242-247.
Crossref
Julie Lecomte, Stéphane Flament, Stéphane Salamone, Michel Boisbrun, Sabine Mazerbourg, Yves Chapleur & Isabelle Grillier-Vuissoz. (2008) Disruption of ERα signalling pathway by PPARγ agonists: evidences of PPARγ-independent events in two hormone-dependent breast cancer cell lines. Breast Cancer Research and Treatment 112:3, pages 437-451.
Crossref
Olga Gealekman, Alison Burkart, My Chouinard, Sarah M. Nicoloro, Juerg Straubhaar & Silvia Corvera. (2008) Enhanced angiogenesis in obesity and in response to PPARγ activators through adipocyte VEGF and ANGPTL4 production. American Journal of Physiology-Endocrinology and Metabolism 295:5, pages E1056-E1064.
Crossref
Costas Giaginis, Stamatios Theocharis & Anna Tsantili-Kakoulidou. (2008) Quantitative Structure-Activity Relationships for PPAR-γ Binding and Gene Transactivation of Tyrosine-Based Agonists Using Multivariate Statistics. Chemical Biology & Drug Design 72:4, pages 257-264.
Crossref
Naomi Shimazaki, Noriko Togashi, Masaharu Hanai, Takeshi Isoyama, Kunio Wada, Takashi Fujita, Kosaku Fujiwara & Shinichi Kurakata. (2008) Anti-tumour activity of CS-7017, a selective peroxisome proliferator-activated receptor gamma agonist of thiazolidinedione class, in human tumour xenografts and a syngeneic tumour implant model. European Journal of Cancer 44:12, pages 1734-1743.
Crossref
Hong‐Nu Yu, Young‐Rae Lee, Eun‐Mi Noh, Kyung‐Sun Lee, Jong‐Suk Kim, Eun‐Kyung Song, Myung‐Kwan Han, Yong‐Chul Lee, Kang‐Beom Kwon, Seung‐Jin Lee, Hyun Jo Youn & Sung Hoo Jung. (2013) Induction of G 1 phase arrest and apoptosis in MDA‐MB‐231 breast cancer cells by troglitazone, a synthetic peroxisome proliferator‐activated receptor γ (PPARγ) ligand . Cell Biology International 32:8, pages 906-912.
Crossref
E. Dale Abel, Sheldon E. Litwin & Gary Sweeney. (2008) Cardiac Remodeling in Obesity. Physiological Reviews 88:2, pages 389-419.
Crossref
Dorina Veliceasa, Frank Thilo Schulze-Hoëpfner & Olga V. Volpert. (2008) PPAR and Agonists against Cancer: Rational Design of Complementation Treatments. PPAR Research 2008, pages 1-13.
Crossref
Elke Burgermeister & Rony Seger. (2008) PPAR and MEK Interactions in Cancer . PPAR Research 2008, pages 1-16.
Crossref
Robert I. Glazer, Hongyan Yuan, Zhihui Xie & Yuzhi Yin. (2008) PPAR and PPAR as Modulators of Neoplasia and Cell Fate . PPAR Research 2008, pages 1-8.
Crossref
Ancha Baranova. (2008) PPAR Ligands as Potential Modifiers of Breast Carcinoma Outcomes. PPAR Research 2008, pages 1-10.
Crossref
S E O'Sullivan. (2009) Cannabinoids go nuclear: evidence for activation of peroxisome proliferator‐activated receptors. British Journal of Pharmacology 152:5, pages 576-582.
Crossref
Richard E. Gillilan, Stephen D. Ayers & Noa Noy. (2007) Structural Basis for Activation of Fatty Acid-binding Protein 4. Journal of Molecular Biology 372:5, pages 1246-1260.
Crossref
Claudia Bocca, Francesca Bozzo, Simona Francica, Sebastiano Colombatto & Antonella Miglietta. (2007) Involvement of PPARγ and E-cadherin/β-catenin pathway in the antiproliferative effect of conjugated linoleic acid in MCF-7 cells. International Journal of Cancer 121:2, pages 248-256.
Crossref
ShouWei Han & Jesse Roman. (2007) Peroxisome proliferator-activated receptor γ: a novel target for cancer therapeutics?. Anti-Cancer Drugs 18:3, pages 237-244.
Crossref
Monica R. Smith, Theodore J. Standiford & Raju C. Reddy. (2007) PPARs in Alveolar Macrophage Biology. PPAR Research 2007, pages 1-12.
Crossref
Mohammed H. Jarrar & Ancha Baranova. (2007) PPAR? activation by thiazolidinediones (TZDs) may modulate breast carcinoma outcome: the importance of interplay with TGF? signalling. Journal of Cellular and Molecular Medicine 11:1, pages 71-87.
Crossref
Alan N. Elias & Paul Lizotte. (2006) Enhanced Radioiodine Uptake in a Patient With Poorly Differentiated Papillary Thyroid Cancer After Treatment With Rosiglitazone. Clinical Nuclear Medicine 31:9, pages 517-519.
Crossref
Hongyu LiuChuanbing ZangMartin H. FennerDachuan LiuKurt PossingerH. Phillip KoefflerElena Elstner. (2006) Growth inhibition and apoptosis in human Philadelphia chromosome-positive lymphoblastic leukemia cell lines by treatment with the dual PPARα/γ ligand TZD18. Blood 107:9, pages 3683-3692.
Crossref
Hirozumi Sawai, Joey Liu, Howard A. Reber, Oscar J. Hines & Guido Eibl. (2006) Activation of Peroxisome Proliferator-Activated Receptor-γ Decreases Pancreatic Cancer Cell Invasion through Modulation of the Plasminogen Activator System. Molecular Cancer Research 4:3, pages 159-167.
Crossref
Eun Jeong JoHyun Jo YounSung Hoo Jung. (2006) Peroxisome proliferator-activated receptor gamma activator inhibits cell growth of MDA-MB-231 breast cancer cells through induction of apoptosis. Journal of Breast Cancer 9:4, pages 293.
Crossref
Rachid Safi, Agnes Kovacic, Stéphanie Gaillard, Yoko Murata, Evan R. Simpson, Donald P. McDonnell & Colin D. Clyne. (2005) Coactivation of Liver Receptor Homologue-1 by Peroxisome Proliferator-Activated Receptor γ Coactivator-1α on Aromatase Promoter II and Its Inhibition by Activated Retinoid X Receptor Suggest a Novel Target for Breast-Specific Antiestrogen Therapy. Cancer Research 65:24, pages 11762-11770.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.