5,921
Views
70
CrossRef citations to date
0
Altmetric
Reviews

Improved dissolution behavior of lipophilic drugs by solid dispersions: the production process as starting point for formulation considerations

, PhD, , PhD, & , PhD
Pages 1121-1140 | Published online: 02 Jul 2011

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (8)

Shambhavi Borde, Sagar Kumar Paul & Harsh Chauhan. (2021) Ternary solid dispersions: classification and formulation considerations. Drug Development and Industrial Pharmacy 47:7, pages 1011-1028.
Read now
Rujie Yang, Yingchao Li, Jing Li, Cuiru Liu, Ping Du & Tianhong Zhang. (2018) Application of scCO2 technology for preparing CoQ10 solid dispersion and SFC-MS/MS for analyzing in vivo bioavailability. Drug Development and Industrial Pharmacy 44:2, pages 289-295.
Read now
Ossi Korhonen, Katja Pajula & Riikka Laitinen. (2017) Rational excipient selection for co-amorphous formulations. Expert Opinion on Drug Delivery 14:4, pages 551-569.
Read now
Yuanyuan Zhang, Yuxin Liu, Yanfei Luo, Qing Yao, Yue Zhong, Bin Tian & Xing Tang. (2016) Extruded Soluplus/SIM as an oral delivery system: characterization, interactions, in vitro and in vivo evaluations. Drug Delivery 23:6, pages 1902-1911.
Read now
Jiannan Lu, Sejal Shah, Seongbong Jo, Soumyajit Majumdar, Andreas Gryczke, Karl Kolter, Nigel Langley & Michael A. Repka. (2015) Investigation of phase diagrams and physical stability of drug–polymer solid dispersions. Pharmaceutical Development and Technology 20:1, pages 105-117.
Read now
Ming Xu, Chungang Zhang, Yanfei Luo, Lishuang Xu, Xiaoguang Tao, Yanjiao Wang, Haibing He & Xing Tang. (2014) Application and functional characterization of POVACOAT, a hydrophilic co-polymer poly(vinyl alcohol/acrylic acid/methyl methacrylate) as a hot-melt extrusion carrier. Drug Development and Industrial Pharmacy 40:1, pages 126-135.
Read now
Min-Soo Kim, Jeong-Soo Kim, Hee Jun Park, Won Kyung Cho, Kwang-Ho Cha & Sung-Joo Hwang. (2011) Enhanced bioavailability of sirolimus via preparation of solid dispersion nanoparticles using a supercritical antisolvent process. International Journal of Nanomedicine 6, pages 2997-3009.
Read now

Articles from other publishers (62)

Arezoo Saberi, Maryam Kouhjani, Davood Yari, Afsaneh Jahani, Kofi Asare-Addo, Hossein Kamali & Ali Nokhodchi. (2023) Development, recent advances, and updates in binary, ternary co-amorphous systems, and ternary solid dispersions. Journal of Drug Delivery Science and Technology 86, pages 104746.
Crossref
María Elena Gamboa-Arancibia, Nelson Caro, Alexander Gamboa, Javier Octavio Morales, Jorge Enrique González Casanova, Diana Marcela Rojas Gómez & Sebastián Miranda-Rojas. (2023) Improving Lurasidone Hydrochloride’s Solubility and Stability by Higher-Order Complex Formation with Hydroxypropyl-β-cyclodextrin. Pharmaceutics 15:1, pages 232.
Crossref
Denise Steiner, Marius Tidau & Jan Henrik Finke. (2022) Embedding of Poorly Water-Soluble Drugs in Orodispersible Films—Comparison of Five Formulation Strategies. Pharmaceutics 15:1, pages 17.
Crossref
Ahmed M. Abdelhaleem Ali, Musarrat Husain Warsi, Mohammed A. S. Abourehab & Adel Ahmed Ali. (2022) Preparation and Transformation of Solid Glass Solutions of Clotrimazole to Nanosuspensions with Improved Physicochemical and Antifungal Properties. Journal of Pharmaceutical Innovation 17:4, pages 1420-1433.
Crossref
Srushti Tambe, Divya Jain, Sai Kishore Meruva, Gopinath Rongala, Abhishek Juluri, Girish Nihalani, Hemanth Kumar Mamidi, Pavan Kumar Nukala & Pradeep Kumar Bolla. (2022) Recent Advances in Amorphous Solid Dispersions: Preformulation, Formulation Strategies, Technological Advancements and Characterization. Pharmaceutics 14:10, pages 2203.
Crossref
Aman Gupta, Gourav Paudwal, Rigzin Dolkar, Shaila Lewis & Prem N. Gupta. (2022) Recent Advances in the Surfactant and Controlled Release Polymer-based Solid Dispersion. Current Pharmaceutical Design 28:20, pages 1643-1659.
Crossref
Sílvia Castro Coelho, Berta Nogueiro Estevinho & Fernando Rocha. (2022) Recent Advances in Water-Soluble Vitamins Delivery Systems Prepared by Mechanical Processes (Electrospinning and Spray-Drying Techniques) for Food and Nutraceuticals Applications—A Review. Foods 11:9, pages 1271.
Crossref
Mohammed Jafar, Mohammed Saifuddin Khalid, Hajer Alghamdi, Mohd Amir, Sarah Aon Al Makki, Ohud Saud Alotaibi, Afnan Ali Al Rmais, Syed Sarim Imam, Sultan Alshehri & Sadaf Jamal Gilani. (2022) Formulation of Apigenin-Cyclodextrin-Chitosan Ternary Complex: Physicochemical Characterization, In Vitro and In Vivo Studies. AAPS PharmSciTech 23:2.
Crossref
Ya-Wei Li, Hong-Mei Zhang, Bai-Ji Cui, Cheng-Yi Hao, He-Yun Zhu, Jiao Guan, Dan Wang, Ying Jin, Bo Feng, Jian-Hui Cai, Xian-Rong Qi & Nian-Qiu Shi. (2021) “Felodipine-indomethacin” co-amorphous supersaturating drug delivery systems: “Spring-parachute” process, stability, in vivo bioavailability, and underlying molecular mechanisms. European Journal of Pharmaceutics and Biopharmaceutics 166, pages 111-125.
Crossref
Amit Bhanderi, Fiza Bari & Hisham Al-Obaidi. (2021) Evaluation of the impact of surfactants on miscibility of griseofulvin in spray dried amorphous solid dispersions. Journal of Drug Delivery Science and Technology 64, pages 102606.
Crossref
Sonal V. Bhujbal, Biplob Mitra, Uday Jain, Yuchuan Gong, Anjali Agrawal, Shyam Karki, Lynne S. Taylor, Sumit Kumar & Qi (Tony) Zhou. (2021) Pharmaceutical amorphous solid dispersion: A review of manufacturing strategies. Acta Pharmaceutica Sinica B 11:8, pages 2505-2536.
Crossref
Ankit Mishra, Priyanka Chaturvedi, Pranali Mishra & MS Sudheesh. (2021) Comparative Evaluation of Amorphous Polymers in Solubility and Bioavailability Enhancement of Famotidine Through Solid Dispersion. EJPPS EUROPEAN JOURNAL OF PARENTERAL AND PHARMACEUTICAL SCIENCES.
Crossref
Prativa Biswasroy, Deepak Pradhan, Biswakanth Kar, Goutam Ghosh & Goutam Rath. (2021) Recent Advancement in Topical Nanocarriers for the Treatment of Psoriasis. AAPS PharmSciTech 22:5.
Crossref
Emilia Jakubowska & Janina Lulek. (2021) The application of freeze-drying as a production method of drug nanocrystals and solid dispersions – A review. Journal of Drug Delivery Science and Technology 62, pages 102357.
Crossref
Dewi Setyaningsih, Yosua Agung Santoso, Yustina Sri Hartini, Yosi Bayu Murti, Wouter L.J. Hinrichs & Christine Patramurti. (2021) Isocratic high-performance liquid chromatography (HPLC) for simultaneous quantification of curcumin and piperine in a microparticle formulation containing Curcuma longa and Piper nigrum. Heliyon 7:3, pages e06541.
Crossref
Hangyi Wu, Huixia Lv & Zhenhai Zhang. 2021. Novel Drug Delivery Systems for Chinese Medicines. Novel Drug Delivery Systems for Chinese Medicines 277 293 .
Maciej Nowak, Maciej Gajda, Przemysław Baranowski, Patrycja Szymczyk, Bożena Karolewicz & Karol P. Nartowski. (2019) Stabilisation and Growth of Metastable Form II of Fluconazole in Amorphous Solid Dispersions. Pharmaceutics 12:1, pages 12.
Crossref
Mahbubur Rahman, Faustin Arevalo, Alexander Coelho & Ecevit Bilgili. (2019) Hybrid nanocrystal–amorphous solid dispersions (HyNASDs) as alternative to ASDs for enhanced release of BCS Class II drugs. European Journal of Pharmaceutics and Biopharmaceutics 145, pages 12-26.
Crossref
Karla Monik Alves da Silva, Fernando José de Lima Ramos Júnior, José Venâncio Chaves Júnior, Deysiane Oliveira Brandão, Taynara Batista Lins, Rui Oliveira Macêdo & Fábio Santos de Souza. (2019) Characterization of solid dispersions of a powerful statin using thermoanalytical techniques. Journal of Thermal Analysis and Calorimetry 138:5, pages 3701-3714.
Crossref
Esra’a Albarahmieh, Muthaffer Albarahmieh & Bashar A. Alkhalidi. (2018) Fabrication of Hierarchical Polymeric Thin Films by Spin Coating Toward Production of Amorphous Solid Dispersion for Buccal Drug Delivery System: Preparation, Characterization, and In Vitro Release Investigations. Journal of Pharmaceutical Sciences 107:12, pages 3112-3122.
Crossref
Luís Padrela, Miguel A. Rodrigues, Andreia Duarte, Ana M.A. Dias, Mara E.M. Braga & Hermínio C. de Sousa. (2018) Supercritical carbon dioxide-based technologies for the production of drug nanoparticles/nanocrystals – A comprehensive review. Advanced Drug Delivery Reviews 131, pages 22-78.
Crossref
Ludmila A.G. Pinho, Stephania G.B. Lima, Lorena F.B. Malaquias, Felipe de Q. Pires, Lívia L. Sá-Barreto, Lucio Cardozo-Filho, Tais Gratieri, Guilherme M. Gelfuso & Marcilio Cunha-Filho. (2018) Improvements of theobromine pharmaceutical properties using solid dispersions prepared with newfound technologies. Chemical Engineering Research and Design 132, pages 1193-1201.
Crossref
Ari Kauppinen, Joep Broekhuis, Niels Grasmeijer, Wouter Tonnis, Jarkko Ketolainen, Henderik W. Frijlink & Wouter L.J. Hinrichs. (2018) Efficient production of solid dispersions by spray drying solutions of high solid content using a 3-fluid nozzle. European Journal of Pharmaceutics and Biopharmaceutics 123, pages 50-58.
Crossref
Kazunori Kadota, Hiroshi Arima, Ryosuke Shakudo, Kumi Semba, Hiromasa Uchiyama, Kazumasa Sugiyama & Yuichi Tozuka. (2018) Emergent composite structures following the amorphization of itraconazole with α-glucosyl rutin by over-grinding. Powder Technology 323, pages 69-75.
Crossref
Wei Zhang, Chen-ning Zhang, Yue He, Ban-yan Duan, Guang-yi Yang, Wei-dong Ma & Yong-hong Zhang. (2017) Factors Affecting the Dissolution of Indomethacin Solid Dispersions. AAPS PharmSciTech 18:8, pages 3258-3273.
Crossref
Riikka Laitinen, Korbinian Löbmann, Holger Grohganz, Petra Priemel, Clare J. Strachan & Thomas Rades. (2017) Supersaturating drug delivery systems: The potential of co-amorphous drug formulations. International Journal of Pharmaceutics 532:1, pages 1-12.
Crossref
Andreas Beyer, Holger Grohganz, Korbinian Löbmann, Thomas Rades & Claudia S. Leopold. (2017) Improvement of the physicochemical properties of Co-amorphous naproxen-indomethacin by naproxen-sodium. International Journal of Pharmaceutics 526:1-2, pages 88-94.
Crossref
Yanxian Hou, Jingbo Shao, Qiang Fu, Jingru Li, Jin Sun & Zhonggui He. (2017) Spray-dried nanocrystals for a highly hydrophobic drug: Increased drug loading, enhanced redispersity, and improved oral bioavailability. International Journal of Pharmaceutics 516:1-2, pages 372-379.
Crossref
Andreas Beyer, Holger Grohganz, Korbinian Löbmann, Thomas Rades & Claudia S. Leopold. (2016) Influence of the cooling rate and the blend ratio on the physical stability of co-amorphous naproxen/indomethacin. European Journal of Pharmaceutics and Biopharmaceutics 109, pages 140-148.
Crossref
K. Wlodarski, L. Tajber & W. Sawicki. (2016) Physicochemical properties of direct compression tablets with spray dried and ball milled solid dispersions of tadalafil in PVP-VA. European Journal of Pharmaceutics and Biopharmaceutics 109, pages 14-23.
Crossref
Ahmed Mahmoud Abdelhaleem Ali & Mayyas Mohammad Ahmad Al-Remawi. (2016) Freeze Dried Quetiapine-Nicotinamide Binary Solid Dispersions: A New Strategy for Improving Physicochemical Properties and Ex Vivo Diffusion. Journal of Pharmaceutics 2016, pages 1-11.
Crossref
Shreya Thakkar, Kunnal Sharma, Sakshi Khurana & Arvind Kumar Bansal. 2016. Pharmaceutical Excipients. Pharmaceutical Excipients 97 143 .
E. Sawicki, J.H.M. Schellens, J.H. Beijnen & B. Nuijen. (2016) Inventory of oral anticancer agents: Pharmaceutical formulation aspects with focus on the solid dispersion technique. Cancer Treatment Reviews 50, pages 247-263.
Crossref
Shrawan Baghel, Helen Cathcart & Niall J. O'Reilly. (2016) Polymeric Amorphous Solid Dispersions: A Review of Amorphization, Crystallization, Stabilization, Solid-State Characterization, and Aqueous Solubilization of Biopharmaceutical Classification System Class II Drugs. Journal of Pharmaceutical Sciences 105:9, pages 2527-2544.
Crossref
Andreas Beyer, Lydia Radi, Holger Grohganz, Korbinian Löbmann, Thomas Rades & Claudia S. Leopold. (2016) Preparation and recrystallization behavior of spray-dried co-amorphous naproxen–indomethacin. European Journal of Pharmaceutics and Biopharmaceutics 104, pages 72-81.
Crossref
Teófilo Vasconcelos, Sara Marques, José das Neves & Bruno Sarmento. (2016) Amorphous solid dispersions: Rational selection of a manufacturing process. Advanced Drug Delivery Reviews 100, pages 85-101.
Crossref
Goedele Craye, Korbinian Löbmann, Holger Grohganz, Thomas Rades & Riikka Laitinen. (2015) Characterization of Amorphous and Co-Amorphous Simvastatin Formulations Prepared by Spray Drying. Molecules 20:12, pages 21532-21548.
Crossref
M. Maniruzzaman, A. Nair, N. Scoutaris, Michael S.A. Bradley, M.J. Snowden & D. Douroumis. (2015) One-step continuous extrusion process for the manufacturing of solid dispersions. International Journal of Pharmaceutics 496:1, pages 42-51.
Crossref
Andreas Beyer, Holger Grohganz, Korbinian Löbmann, Thomas Rades & Claudia Leopold. (2015) Multivariate Quantification of the Solid State Phase Composition of Co-Amorphous Naproxen-Indomethacin. Molecules 20:10, pages 19571-19587.
Crossref
Milica Stanković, Henderik W. Frijlink & Wouter L.J. Hinrichs. (2015) Polymeric formulations for drug release prepared by hot melt extrusion: application and characterization. Drug Discovery Today 20:7, pages 812-823.
Crossref
Tapan Sanghvi, Jeff Katstra, Brian Patrick Quinn, Hayden Thomas & Patricia Hurter. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia 1 34 .
Ling Wang, Yinghua Sun, Chen Kuang & Xiangrong Zhang. (2015) Preparation and evaluation of taste masked oral suspension of arbidol hydrochloride. Asian Journal of Pharmaceutical Sciences 10:1, pages 73-79.
Crossref
Ravikiran Panakanti & Ajit S. Narang. 2015. Excipient Applications in Formulation Design and Drug Delivery. Excipient Applications in Formulation Design and Drug Delivery 273 310 .
Samuel O. Kyeremateng, Marieke Pudlas & Gerd H. Woehrle. (2014) A Fast and Reliable Empirical Approach for Estimating Solubility of Crystalline Drugs in Polymers for Hot Melt Extrusion Formulations. Journal of Pharmaceutical Sciences 103:9, pages 2847-2858.
Crossref
Ken-ichi Izutsu, Chikako Yomota, Haruhiro Okuda, Toru Kawanishi, Takuya Yamaki, Ryohei Ohdate, Zhaokun Yu, Etsuo Yonemochi & Katsuhide Terada. (2014) Effects of Formulation and Process Factors on the Crystal Structure of Freeze-Dried Myo-Inositol. Journal of Pharmaceutical Sciences 103:8, pages 2347-2355.
Crossref
Riikka Laitinen, Korbinian Löbmann, Holger Grohganz, Clare Strachan & Thomas Rades. (2014) Amino Acids as Co-amorphous Excipients for Simvastatin and Glibenclamide: Physical Properties and Stability. Molecular Pharmaceutics 11:7, pages 2381-2389.
Crossref
Ahmad Reza Parsian, Alireza Vatanara, Mohammad Reza Rahmati, Kambiz Gilani, Khosrow Malek Khosravi & Abdolhossein Rouholamini Najafabadi. (2014) Inhalable budesonide porous microparticles tailored by spray freeze drying technique. Powder Technology 260, pages 36-41.
Crossref
Mohammed Maniruzzaman, Muhammad T. Islam, Hiren G. Moradiya, Sheelagh A. Halsey, Ian J. Slipper, Baburz Chowdhry, Martin J. Snowden & Dennis Douroumis. (2014) Prediction of Polymorphic Transformations of Paracetamol in Solid Dispersions. Journal of Pharmaceutical Sciences 103:6, pages 1819-1828.
Crossref
Yi Lu, Ning Tang, Ruyue Lian, Jianping Qi & Wei Wu. (2014) Understanding the relationship between wettability and dissolution of solid dispersion. International Journal of Pharmaceutics 465:1-2, pages 25-31.
Crossref
Ashwinkumar D. Patel, Anjali Agrawal & Rutesh H. Dave. (2014) Investigation of the effects of process variables on derived properties of spray dried solid-dispersions using polymer based response surface model and ensemble artificial neural network models. European Journal of Pharmaceutics and Biopharmaceutics 86:3, pages 404-417.
Crossref
Maria Fátima Pina, Min Zhao, João F. Pinto, João J. Sousa & Duncan Q.M. Craig. (2014) The Influence of Drug Physical State on the Dissolution Enhancement of Solid Dispersions Prepared Via Hot-Melt Extrusion: A Case Study Using Olanzapine. Journal of Pharmaceutical Sciences 103:4, pages 1214-1223.
Crossref
Korbinian Löbmann, Katrine Tarp Jensen, Riikka Laitinen, Thomas Rades, Clare J. Strachan & Holger Grohganz. 2014. Amorphous Solid Dispersions. Amorphous Solid Dispersions 613 636 .
Chau Le-Ngoc Vo, Chulhun Park & Beom-Jin Lee. (2013) Current trends and future perspectives of solid dispersions containing poorly water-soluble drugs. European Journal of Pharmaceutics and Biopharmaceutics 85:3, pages 799-813.
Crossref
Yuqian Du, Yinglei Zhai, Juhong Zhang, Chunnuan Wu, Cong Luo, Jin Sun & Zhonggui He. (2013) Development and evaluation of taste-masked dry suspension of cefuroxime axetil for enhancement of oral bioavailability. Asian Journal of Pharmaceutical Sciences 8:5, pages 287-294.
Crossref
Amrit Paudel, Zelalem Ayenew Worku, Joke Meeus, Sandra Guns & Guy Van den Mooter. (2013) Manufacturing of solid dispersions of poorly water soluble drugs by spray drying: Formulation and process considerations. International Journal of Pharmaceutics 453:1, pages 253-284.
Crossref
Riikka Laitinen, Korbinian Löbmann, Clare J. Strachan, Holger Grohganz & Thomas Rades. (2013) Emerging trends in the stabilization of amorphous drugs. International Journal of Pharmaceutics 453:1, pages 65-79.
Crossref
Ziyi Yang, Kathrin Nollenberger, Jessica Albers, Duncan Craig & Sheng Qi. (2013) Microstructure of an Immiscible Polymer Blend and Its Stabilization Effect on Amorphous Solid Dispersions. Molecular Pharmaceutics 10:7, pages 2767-2780.
Crossref
Tapan Kumar Giri, Kulesh Kumar, Amit Alexander, Ajazuddin, Hemant Badwaik & Dulal Krishna Tripathi. (2012) A novel and alternative approach to controlled release drug delivery system based on solid dispersion technique. Bulletin of Faculty of Pharmacy, Cairo University 50:2, pages 147-159.
Crossref
Ravikiran Panakanti & Ajit S. Narang. (2012) Impact of Excipient Interactions on Drug Bioavailability from Solid Dosage Forms. Pharmaceutical Research 29:10, pages 2639-2659.
Crossref
Fei Lu, Yuan-Yuan Shen, Yan-Qing Shen, Jing-Wen Hou, Zhong-Min Wang & Sheng-Rong Guo. (2012) Treatments of paclitaxel with poly(vinyl pyrrolidone) to improve drug release from poly(ɛ-caprolactone) matrix for film-based stent. International Journal of Pharmaceutics 434:1-2, pages 161-168.
Crossref
Parinda Srinarong, Hans de Waard, Henderik W. Frijlink & Wouter L. J. Hinrichs. (2012) ChemInform Abstract: Improved Dissolution Behavior of Lipophilic Drugs by Solid Dispersions: The Production Process as Starting Point for Formulation Considerations. ChemInform 43:31.
Crossref
Francesca Buttini, Paolo Colombo, Alessandra Rossi, Fabio Sonvico & Gaia Colombo. (2012) Particles and powders: Tools of innovation for non-invasive drug administration. Journal of Controlled Release 161:2, pages 693-702.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.