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Expert Opinion on Drug Metabolism & Toxicology Volume 12, 2016 - Issue 3
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Regulation of drug-metabolizing enzymes by local and systemic liver injuries

Yan GuoCenter for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA, USA;Department of Pathology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
,
Bingfang HuCenter for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA, USA;Institute of Clinical Pharmacology, Sun Yat-Sen University, Guangzhou, China
,
Yang XieCenter for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA, USA
,
Timothy R. BilliarDepartment of Surgery, University of Pittsburgh, Pittsburgh, PA, USA
,
Jason L. SperryDepartment of Surgery, University of Pittsburgh, Pittsburgh, PA, USA
,
Min HuangInstitute of Clinical Pharmacology, Sun Yat-Sen University, Guangzhou, China
&
Wen XieCenter for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA, USACorrespondence[email protected]
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Pages 245-251 | Received 30 May 2015, Accepted 05 Jan 2016, Published online: 28 Jan 2016

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Tim MJ Ewoldt, Alan Abdulla, Nicole Hunfeld, Letao Li, Tim J.L. Smeets, Diederik Gommers, Birgit C.P. Koch & Henrik Endeman. (2022) The impact of sepsis on hepatic drug metabolism in critically ill patients: a narrative review. Expert Opinion on Drug Metabolism & Toxicology 18:6, pages 413-421.
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Da-Wei Chen, Zuo Du, Chun-Ze Zhang, Wei-Hua Zhang, Yun-Feng Cao, Hong-Zhi Sun, Zhi-Tu Zhu, Kun Yang, Yong-Zhe Liu, Ze-Wei Zhao, Zhi-Wei Fu, Wen-Qing Gu, Yang Yu & Zhong-Ze Fang. (2018) The inhibition of UDP-glucuronosyltransferases (UGTs) by tetraiodothyronine (T4) and triiodothyronine (T3). Xenobiotica 48:3, pages 250-257.
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Brandon Baer, Nathan D. Putz, Kyle Riedmann, Samantha Gonski, Jason Lin, Lorraine B. Ware, Shinji Toki, R. Stokes PeeblesJr.Jr., Katherine N. Cahill & Julie A. Bastarache. (2023) Liraglutide pretreatment attenuates sepsis-induced acute lung injury. American Journal of Physiology-Lung Cellular and Molecular Physiology 325:3, pages L368-L384.
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Omar Abdulhameed Almazroo, Imam H Shaik, Christopher B Hughes, Abhinav Humar & Raman Venkataramanan. (2022) Treprostinil Supplementation Ameliorates Hepatic Ischemia Reperfusion Injury and Regulates Expression of Hepatic Drug Transporters: An Isolated Perfused Rat Liver (IPRL) Study. Pharmaceutical Research 39:11, pages 2979-2990.
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Mingzhe Zhao, Jingsong Ma, Mo Li, Yingtian Zhang, Bixuan Jiang, Xianglong Zhao, Cong Huai, Lu Shen, Na Zhang, Lin He & Shengying Qin. (2021) Cytochrome P450 Enzymes and Drug Metabolism in Humans. International Journal of Molecular Sciences 22:23, pages 12808.
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Conor Bentley, Claire Potter, Kamal Makram Yakoub, Kristian Brock, Victoria Homer, Emma Toman, Angela E Taylor, Fozia Shaheen, Lorna C Gilligan, Amrita Athwal, Darren Barton, Ronald Carrera, Katie Young, Amisha Desai, Kirsty McGee, Christos Ermogenous, Gurneet Sur, Carolyn A Greig, Jon Hazeldine, Wiebke Arlt, Janet M Lord & Mark A Foster. (2021) A prospective, phase II, single-centre, cross-sectional, randomised study investigating Dehydroepiandrosterone supplementation and its Profile in Trauma: ADaPT. BMJ Open 11:7, pages e040823.
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Yurong Song, Chenxi Li, Guangzhi Liu, Rui Liu, Youwen Chen, Wen Li, Zhiwen Cao, Baosheng Zhao, Cheng Lu & Yuanyan Liu. (2021) Drug-Metabolizing Cytochrome P450 Enzymes Have Multifarious Influences on Treatment Outcomes. Clinical Pharmacokinetics 60:5, pages 585-601.
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Jonathan T. Abele, Monique Raubenheimer, Vincent G. Bain, Greg Wandzilak, Naji AlHulaimi, Richard Coulden, Robert A. deKemp, Ran Klein, Randall G. Williams, Robert S. Warshawski & Lucille D. Lalonde. (2018) Quantitative blood flow evaluation of vasodilation-stress compared with dobutamine-stress in patients with end-stage liver disease using 82Rb PET/CT. Journal of Nuclear Cardiology 27:6, pages 2048-2059.
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Patrick J. Coppler, Clifton W. Callaway, Francis X. Guyette, Maria Baldwin & Jonathan Elmer. (2020) Early risk stratification after resuscitation from cardiac arrest. Journal of the American College of Emergency Physicians Open 1:5, pages 922-931.
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Lijie Xu, Rongyao Zheng, Peng Xie, Qianqian Guo, Hui Ji & Tingting Li. (2020) Dysregulation of UDP-glucuronosyltransferases in CCl4 induced liver injury rats. Chemico-Biological Interactions 325, pages 109115.
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Jesús Alejandro Zamora-Briseño, Eliel Ruiz-May, José Miguel Elizalde-Contreras, Ioreni Margarita Hernández-Velázquez, Ariadne Hernández-Pérez, Ana Guadalupe Fuentes-García, Nancy Herrera-Salvatierra, Patricia Briones-Fourzán, Cristina Pascual-Jiménez, Enrique Lozano-Álvarez & Rossanna Rodríguez-Canul. (2020) iTRAQ-Based Proteomic Profile Analysis of the Hepatopancreas of Caribbean Spiny Lobsters Infected With Panulirus argus Virus 1: Metabolic and Physiological Implications. Frontiers in Microbiology 11.
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Yuhua Li, Qiang Meng, Mengbi Yang, Dongyang Liu, Xiangyu Hou, Lan Tang, Xin Wang, Yuanfeng Lyu, Xiaoyan Chen, Kexin Liu, Ai-Ming Yu, Zhong Zuo & Huichang Bi. (2019) Current trends in drug metabolism and pharmacokinetics. Acta Pharmaceutica Sinica B 9:6, pages 1113-1144.
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Huaqiao Tang, Min Xu, Fei Shi, Gang Ye, Cheng Lv, Jie Luo, Ling Zhao & Yinglun Li. (2018) Effects and Mechanism of Nano-Copper Exposure on Hepatic Cytochrome P450 Enzymes in Rats. International Journal of Molecular Sciences 19:7, pages 2140.
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Ai-Ming Yu, Magnus Ingelman-Sundberg, Nathan J. Cherrington, Lauren M. Aleksunes, Ulrich M. Zanger, Wen Xie, Hyunyoung Jeong, Edward T. Morgan, Peter J. Turnbaugh, Curtis D. Klaassen, Aadra P. Bhatt, Matthew R. Redinbo, Pengying Hao, David J. Waxman, Li Wang & Xiao-bo Zhong. (2017) Regulation of drug metabolism and toxicity by multiple factors of genetics, epigenetics, lncRNAs, gut microbiota, and diseases: a meeting report of the 21st International Symposium on Microsomes and Drug Oxidations (MDO). Acta Pharmaceutica Sinica B 7:2, pages 241-248.
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