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Drug Evaluation

Ambroxol in the 21st century: pharmacological and clinical update

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Pages 1119-1129 | Published online: 04 Aug 2008

Keep up to date with the latest research on this topic with citation updates for this article.

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Arif Mahmood, Abdus Samad, Shazia Bano, Muhammad Umair, Amar Ajmal, Iqra Ilyas, Abid Ali Shah, Ping Li & Junjian Hu. (2023) Structural and dynamics insights into the GBA variants associated with Parkinson’s disease. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-13.
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Christiana Mantzourani, Sofia Vasilakaki, Velisaria-Eleni Gerogianni & George Kokotos. (2022) The discovery and development of transmembrane serine protease 2 (TMPRSS2) inhibitors as candidate drugs for the treatment of COVID-19. Expert Opinion on Drug Discovery 17:3, pages 231-246.
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Jin-Ryul Hu, Chul-Jong Jung, Seong-Min Ku, Dae-Hwa Jung, Khawaja Muhammad Imran Bashir, Sae-Kwang Ku & Jae-Suk Choi. (2021) Anti-inflammatory, expectorant, and antitussive properties of Kyeongok-go in ICR mice. Pharmaceutical Biology 59:1, pages 319-332.
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Dorotheea Cazan, Ludger Klimek, Annette Sperl, Manuel Plomer & Stephan Kölsch. (2018) Safety of ambroxol in the treatment of airway diseases in adult patients. Expert Opinion on Drug Safety 17:12, pages 1211-1224.
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Yongchun Shen, Shaoguang Huang, Jian Kang, Jiangtao Lin, Kefang Lai, Yongchang Sun, Wei Xiao, Lan Yang, Wanzhen Yao, Shaoxi Cai, Kewu Huang & Fuqiang Wen. (2018) Management of airway mucus hypersecretion in chronic airway inflammatory disease: Chinese expert consensus (English edition). International Journal of Chronic Obstructive Pulmonary Disease 13, pages 399-407.
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Kai-Uwe Kern & Myriam Schwickert. (2017) Ambroxol for the treatment of fibromyalgia: science or fiction?. Journal of Pain Research 10, pages 1905-1929.
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Suruchi Singh & Raja Roy. (2016) The application of absolute quantitative 1H NMR spectroscopy in drug discovery and development. Expert Opinion on Drug Discovery 11:7, pages 695-706.
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Shahida Hussain, Georgia Varelogianni, Eva Särndahl & Godfried M. Roomans. (2015) N-acetylcysteine and azithromycin affect the innate immune response in cystic fibrosis bronchial epithelial cells in vitro. Experimental Lung Research 41:5, pages 251-260.
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Sagar Pawar, Umesh Mahantshetty, Kedar Deodhar & Tanuja Teni. (2014) A simple cost-effective modification improves the quality of immunocytochemical staining in cervical scrape samples characterized by presence of excess mucus. Journal of Histotechnology 37:1, pages 3-8.
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A. Abd-Elbary, M. Haider & S. Sayed. (2012) In vitro characterization and release study of Ambroxol hydrochloride matrix tablets prepared by direct compression. Pharmaceutical Development and Technology 17:5, pages 562-573.
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Davide Paleari, Giovanni A Rossi, Gabriele Nicolini & Dario Olivieri. (2011) Ambroxol: a multifaceted molecule with additional therapeutic potentials in respiratory disorders of childhood. Expert Opinion on Drug Discovery 6:11, pages 1203-1214.
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Marc A. Russo, Ralf Baron, Anthony H. Dickenson, Kai-Uwe Kern & Danielle M. Santarelli. (2023) REPRINTED WITH PERMISSION OF IASP – PAIN 164 (2023) 3–13: Ambroxol for neuropathic pain: hiding in plain sight?. BÓL 24:3, pages 21-34.
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Tereza Uhlíková, Ivana Šlechtová, Jan Koucký, Patrik Kania, Jan Rohlíček & Štěpán Urban. (2023) Low Energy Vibrations and Crystalline Structure of Ambroxol Hydrochloride by THz Spectroscopy and DFT Calculations. ChemistrySelect 8:33.
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Binay Kumar Shah, Bivek Singh, Yukun Wang, Shuanshuan Xie & Changhui Wang. (2023) Mucus Hypersecretion in Chronic Obstructive Pulmonary Disease and Its Treatment. Mediators of Inflammation 2023, pages 1-15.
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Dongli Qi, Bei Jia, Hui Peng, Jiachen He, Jiaxin Pi, Pan Guo, Ying Zhang, Xiuping Deng, Jiawei Li & Zhidong Liu. (2023) Baicalin/ambroxol hydrochloride combined dry powder inhalation formulation targeting lung delivery for treatment of idiopathic pulmonary fibrosis: Fabrication, characterization, pharmacokinetics, and pharmacodynamics. European Journal of Pharmaceutics and Biopharmaceutics 188, pages 243-253.
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Jurga Bernatoniene, Arunas Sciupokas, Dalia Marija Kopustinskiene & Kestutis Petrikonis. (2023) Novel Drug Targets and Emerging Pharmacotherapies in Neuropathic Pain. Pharmaceutics 15:7, pages 1799.
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Nora A. Abdallah, Mona E. Fathy, Manar M. Tolba, Amina M. El-Brashy & Fawzia A. Ibrahim. (2023) A quality-by-design eco-friendly UV-HPLC method for the determination of four drugs used to treat symptoms of common cold and COVID-19. Scientific Reports 13:1.
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Marc A. Russo, Ralf Baron, Anthony H. Dickenson, Kai-Uwe Kern & Danielle M. Santarelli. (2023) Ambroxol for neuropathic pain: hiding in plain sight?. Pain 164:1, pages 3-13.
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Pritam D. Sonawane, Suraj R. Chaudhari, Saurabh B. Ganorkar, Amod S. Patil & Atul A. Shirkhedkar. (2022) A brief review on critical analytical aspects for quantification of ambroxol in biological samples. Analytical Biochemistry 657, pages 114888.
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Hao-Ran Zhang, Li Liu, Long-Yuan Zheng, Yu-Qing Song, Xiao-Min Chen, Gui-Mei Tang & Yong-Tao Wang. (2022) The luminescent behaviors based on Ambroxol: Syntheses, crystal structure and Hirshfeld surface analysis. Journal of Molecular Structure 1265, pages 133344.
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Hao-Ran Zhang, Yu-Qing Song, Zhao-Qi Gong, Long-Yuan Zheng, Gui-Mei Tang & Yong-Tao Wang. (2022) Drug Ambroxol-based luminescent materials with sulfonate group: Synthesis, crystal structure and Hirshfeld surface analysis. Journal of Solid State Chemistry 314, pages 123387.
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Simona Cavalu, Hossam Sharaf, Sameh Saber, Mahmoud E. Youssef, Amir Mohamed Abdelhamid, Ahmed A. E. Mourad, Samar Ibrahim, Shady Allam, Rehab Mohamed Elgharabawy, Eman El‐Ahwany, Noha A. Amin, Ahmed Shata, Mai Eldegla, Marina Atef, Maii Aboraya, Mayar Mohamed, Niera Anz, Dina Abd Elmotelb, Fayrouz Gabr, Dalia Elzablawy, Menna Hamada, Amr Yehia, Dalia Osama & Osama A. Mohammed. (2022) Ambroxol, a mucolytic agent, boosts HO ‐1, suppresses NF‐κB , and decreases the susceptibility of the inflamed rat colon to apoptosis: A new treatment option for treating ulcerative colitis . The FASEB Journal 36:9.
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Rui Wang, Yali Sun, Wenxiu He, Yiting Chen, Enhao Lu & Xianyi Sha. (2021) Pulmonary surfactants affinity Pluronic-hybridized liposomes enhance the treatment of drug-resistant lung cancer. International Journal of Pharmaceutics 607, pages 120973.
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Yuanfeng Zhang, Zheyi Wang, Yue Zhang, Hongxuan Tong, Yiling Zhang & Tao Lu. (2020) Potential Mechanisms for Traditional Chinese Medicine in Treating Airway Mucus Hypersecretion Associated With Coronavirus Disease 2019. Frontiers in Molecular Biosciences 7.
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Celine Ollier, Ulrike Sent, Margarida Mesquita & Martin C. Michel. (2020) Pharmacokinetics of Ambroxol Sustained Release (Mucosolvan® Retard) Compared with Other Formulations in Healthy Volunteers. Pulmonary Therapy 6:1, pages 119-130.
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Alexandra Bouscary & Cyril Quessada. (2020) Potentiel thérapeutique de l’ambroxol contre les maladies du motoneurone. médecine/sciences 36:5, pages 447-448.
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Wenjun Jiang, Mengni Yi, Gustavo H. B. Maegawa & Huiwen Zhang. (2019) Ambroxol improves skeletal and hematological manifestations on a child with Gaucher disease. Journal of Human Genetics 65:3, pages 345-349.
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Akanksha Mishra & Sairam Krishnamurthy. (2019) Neurorestorative effects of sub-chronic administration of ambroxol in rodent model of Parkinson’s disease. Naunyn-Schmiedeberg's Archives of Pharmacology 393:3, pages 429-444.
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Junwu Wang, Wensu Yu, Na Wu, ElaineN Gitonga & Haitao Shen. (2020) Efficacy of high-dose ambroxol for paraquat poisoning: A meta-analysis of randomized controlled trials. Journal of Research in Medical Sciences 25:1, pages 67.
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A. Zanasi, M. Mazzolini & U. Caliceti. 2020. Cough: Pathophysiology, Diagnosis and Treatment. Cough: Pathophysiology, Diagnosis and Treatment 157 173 .
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C. R. A. Silveira, J. MacKinley, K. Coleman, Z. Li, E. Finger, R. Bartha, S. A. Morrow, J. Wells, M. Borrie, R. G. Tirona, C. A. Rupar, G. Zou, R. A. Hegele, D. Mahuran, P. MacDonald, M. E. Jenkins, M. Jog & S. H. Pasternak. (2019) Ambroxol as a novel disease-modifying treatment for Parkinson’s disease dementia: protocol for a single-centre, randomized, double-blind, placebo-controlled trial. BMC Neurology 19:1.
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Rita Sousa, Deepak R. Lakha, Sandrine Brette & Simon Hitier. (2019) A Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of Ambroxol Hard-Boiled Lozenges in Patients with Acute Pharyngitis. Pulmonary Therapy 5:2, pages 201-211.
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Pedro Modesto Nascimento Menezes, Mariana Coelho Brito, Pedro Guilherme Sousa de Sá, Luciano Augusto de Araújo Ribeiro, Larissa Araújo Rolim & Fabrício Souza Silva. (2019) Analytical and pharmacological validation of the quantification of phenol red in a mouse model: An optimized method to evaluate expectorant drugs. Journal of Pharmacological and Toxicological Methods 98, pages 106586.
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Shruthi Sunkari, Sowjanya Thatikonda, Venkatesh Pooladanda, Veerabhadra Swamy Challa & Chandraiah Godugu. (2019) Protective effects of ambroxol in psoriasis like skin inflammation: Exploration of possible mechanisms. International Immunopharmacology 71, pages 301-312.
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Kai‐Uwe Kern, Myriam Schwickert‐Nieswandt, Christian Maihöfner & Charly Gaul. (2019) Topical Ambroxol 20% for the Treatment of Classical Trigeminal Neuralgia – A New Option? Initial Clinical Case Observations. Headache: The Journal of Head and Face Pain 59:3, pages 418-429.
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Arturo Cortes-Telles, José Luis Che-Morales & Diana Lizbeth Ortiz-Farías. (2019) Estrategias actuales en el manejo de las secreciones traqueobronquiales. NCT Neumología y Cirugía de Tórax 78:3, pages 313-323.
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Francesco Scaglione & Orlando Petrini. (2019) Mucoactive Agents in the Therapy of Upper Respiratory Airways Infections: Fair to Describe Them Just as Mucoactive?. Clinical Medicine Insights: Ear, Nose and Throat 12, pages 117955061882193.
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Harsha P. Uskaikar, Nagaraj P. Shetti, Shikandar D. Bukkitgar, Shweta J. Malode, Nikita V. Jamakandi & T.M. Manu. (2019) Applications of zinc oxide nanoparticles as an electrode modifier for ambroxol. Materials Today: Proceedings 18, pages 963-967.
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Peter Kardos, Kai-Michael Beeh, Ulrike Sent, Tobias Mueck, Heidemarie Gräter & Martin C. Michel. (2018) Characterization of differential patient profiles and therapeutic responses of pharmacy customers for four ambroxol formulations. BMC Pharmacology and Toxicology 19:1.
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Christian Maihöfner, Sabine Schneider, Patric Bialas, Helmut Gockel, Katrin-Grit Beer, Max Bartels & Kai-Uwe Kern. (2018) Successful treatment of complex regional pain syndrome with topical ambroxol: a case series. Pain Management 8:6, pages 427-436.
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Anna Furgała, Łukasz Fijałkowski, Alicja Nowaczyk, Robert Sałat & Kinga Sałat. (2018) Time-shifted co-administration of sub-analgesic doses of ambroxol and pregabalin attenuates oxaliplatin-induced cold allodynia in mice. Biomedicine & Pharmacotherapy 106, pages 930-940.
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Akanksha Mishra, Lalit Pratap Chandravanshi, Surendra Kumar Trigun & Sairam Krishnamurthy. (2018) Ambroxol modulates 6-Hydroxydopamine-induced temporal reduction in Glucocerebrosidase (GCase) enzymatic activity and Parkinson’s disease symptoms. Biochemical Pharmacology 155, pages 479-493.
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Walaa H. Mahmoud, Gehad G. Mohamed, Hoda A. Elsawy & Mostafa A. Radwan. (2018) Metal complexes of novel Schiff base derived from the condensation of 2-quinoline carboxaldehyde and ambroxol drug with some transition metal ions. Applied Organometallic Chemistry 32:7, pages e4392.
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Andrew T. Reid, Punnam Chander Veerati, Reinoud Gosens, Nathan W. Bartlett, Peter A. Wark, Chris L. Grainge, Stephen M. Stick, Anthony Kicic, Fatemeh Moheimani, Philip M. Hansbro & Darryl A. Knight. (2018) Persistent induction of goblet cell differentiation in the airways: Therapeutic approaches. Pharmacology & Therapeutics 185, pages 155-169.
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Thomas Haller, Alejandro Cerrada, Kristian Pfaller, Peter Braubach & Edward Felder. (2018) Polarized light microscopy reveals physiological and drug-induced changes in surfactant membrane assembly in alveolar type II pneumocytes. Biochimica et Biophysica Acta (BBA) - Biomembranes 1860:5, pages 1152-1161.
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J.D. Hull & R.A. Lyon. (2018) In vitro pharmacology of ambroxol: Potential serotonergic sites of action. Life Sciences 197, pages 67-72.
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L. Kalyani & Chava V.N. Rao. (2018) Simultaneous spectrophotometric estimation of Salbutamol, Theophylline and Ambroxol three component tablet formulation using simultaneous equation methods. Karbala International Journal of Modern Science 4:1, pages 171-179.
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J. Magalhaes, M. E. Gegg, A. Migdalska-Richards & A. H. Schapira. (2018) Effects of ambroxol on the autophagy-lysosome pathway and mitochondria in primary cortical neurons. Scientific Reports 8:1.
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David M. Pereira, Patrícia Valentão & Paula B. Andrade. (2018) Tuning protein folding in lysosomal storage diseases: the chemistry behind pharmacological chaperones. Chemical Science 9:7, pages 1740-1752.
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Xiuyun Li, Yuanhao Zhao, Xin Huang, Cuixiang Yu, Yilei Yang & Shujuan Sun. (2017) Ambroxol Hydrochloride Combined with Fluconazole Reverses the Resistance of Candida albicans to Fluconazole. Frontiers in Cellular and Infection Microbiology 7.
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Ling-tian Ge, Ya-nan Liu, Xi-xi Lin, Hui-juan Shen, Yong-liang Jia, Xin-wei Dong, Yun Sun & Qiang-min Xie. (2016) Inhalation of ambroxol inhibits cigarette smoke-induced acute lung injury in a mouse model by inhibiting the Erk pathway. International Immunopharmacology 33, pages 90-98.
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Xinyang Su, Zefu Li, Meilin Wang, Zhenzhu Li, Qingbo Wang, Wenxian Lu, Xiaoli Li, Youfei Zhou & Hongmei Xu. (2016) The protective effect of different airway humidification liquids to lung after tracheotomy in traumatic brain injury: The role of pulmonary surfactant protein-A (SP-A). Gene 577:1, pages 89-95.
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Katsuyuki TakedaNobuaki MiyaharaShigeki MatsubaraChristian TaubeKenichi KitamuraAstushi HiranoMitsune TanimotoErwin W. Gelfand. (2016) Immunomodulatory Effects of Ambroxol on Airway Hyperresponsiveness and Inflammation. Immune Network 16:3, pages 165.
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Giorgio Fois, Nina Hobi, Edward Felder, Andreas Ziegler, Pika Miklavc, Paul Walther, Peter Radermacher, Thomas Haller & Paul Dietl. (2015) A new role for an old drug: Ambroxol triggers lysosomal exocytosis via pH-dependent Ca2+ release from acidic Ca2+ stores. Cell Calcium 58:6, pages 628-637.
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Arun K. Baranwal, Aparna S. Murthy & Sunit C. Singhi. (2015) High-dose Oral Ambroxol for Early Treatment of Pulmonary Acute Respiratory Distress Syndrome: an Exploratory, Randomized, Controlled Pilot Trial. Journal of Tropical Pediatrics 61:5, pages 339-350.
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Paulina Kubowicz, Henryk Marona & Elżbieta Pękala. (2015) Synthesis, Anticonvulsant Activity and Metabolism of 4-chlor-3-methylphenoxyethylamine Derivatives of Trans -2-aminocyclohexan-1-ol . Chirality 27:2, pages 163-169.
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I. L. Klyachkina. (2015) The new possibility for the treatment of acute cough. Vestnik otorinolaringologii 80:5, pages 85.
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Ola Ahmed Saleh, Ali Mohamed Yehia, Aida Abd-El Sattar El-Azzouny & Hassan Youssef Aboul-Enein. (2015) A validated chromatographic method for simultaneous determination of guaifenesin enantiomers and ambroxol HCl in pharmaceutical formulation. RSC Advances 5:114, pages 93749-93756.
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Abdulkadir Levent, Yavuz Yardım & Zühre Şentürk. (2014) Electrochemical performance of boron-doped diamond electrode in surfactant-containing media for ambroxol determination. Sensors and Actuators B: Chemical 203, pages 517-526.
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Yulia B. Monakhova, Matthias Kohl-Himmelseher, Thomas Kuballa & Dirk W. Lachenmeier. (2014) Determination of the purity of pharmaceutical reference materials by 1 H NMR using the standardless PULCON methodology. Journal of Pharmaceutical and Biomedical Analysis 100, pages 381-386.
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Xiangdong Wu, Suwei Li, Jiuzhi Zhang, Yongli Zhang, Lili Han, Qiuming Deng & Xianyao Wan. (2014) Meta-analysis of high doses of ambroxol treatment for acute lung injury/acute respiratory distress syndrome based on randomized controlled trials. The Journal of Clinical Pharmacology 54:11, pages 1199-1206.
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Irina Vyacheslavovna Brzheskaya, Vladimir Vsevolodovich Brjesky & Mukhammed Radukhan. (2014) Current trends in the therapy of the ocular surface epithelial xerosis. Ophthalmology Reports 7:3, pages 45-56.
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Muhammad Sharif, Anahit Pews-Davtyan, Jan Lukas, Susann Pohlers, Arndt Rolfs, Peter Langer & Matthias Beller. (2014) Palladium-catalysed Suzuki–Miyaura coupling reactions of Bromhexine and Ambroxol. Tetrahedron 70:34, pages 5128-5135.
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M. Cataldi, V. Sblendorio, A. Leo & O. Piazza. (2014) Biofilm-dependent airway infections: A role for ambroxol?. Pulmonary Pharmacology & Therapeutics 28:2, pages 98-108.
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TING ZHANG & XIANGDONG ZHOU. (2014) Clinical application of expectorant therapy in chronic inflammatory airway diseases (Review). Experimental and Therapeutic Medicine 7:4, pages 763-767.
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