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Antagonists of TNF action: clinical experience and new developments

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Pages 279-292 | Published online: 08 Mar 2009

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Nattihda Parakasikron, Chatchai Chaotham, Pithi Chanvorachote, Chanida Vinayanuwattikun, Visarut Buranasudja, Pornchanok Taweecheep & Kannika Khantasup. (2021) Development of a human antibody fragment directed against the alpha folate receptor as a promising molecule for targeted application. Drug Delivery 28:1, pages 1443-1454.
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Fabian Richter, Oliver Seifert, Andreas Herrmann, Klaus Pfizenmaier & Roland E. Kontermann. (2019) Improved monovalent TNF receptor 1-selective inhibitor with novel heterodimerizing Fc. mAbs 11:4, pages 653-665.
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Fabian Richter, Kirstin A. Zettlitz, Oliver Seifert, Andreas Herrmann, Peter Scheurich, Klaus Pfizenmaier & Roland E. Kontermann. (2019) Monovalent TNF receptor 1-selective antibody with improved affinity and neutralizing activity. mAbs 11:1, pages 166-177.
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Kirstin A. Zettlitz, Verena Lorenz, Karlheinz Landauer, Sabine Münkel, Andreas Herrmann, Peter Scheurich, Klaus Pfizenmaier & Roland Kontermann. (2010) ATROSAB, a humanized antagonistic anti-tumor necrosis factor receptor one-specific antibody. mAbs 2:6, pages 639-647.
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Articles from other publishers (23)

Nasir Javaid, Mahesh Chandra Patra, Da-Eun Cho, Maria Batool, Yoongeun Kim, Gwang Muk Choi, Moon Suk Kim, Dae-Hyun Hahm & Sangdun Choi. (2022) An orally active, small-molecule TNF inhibitor that disrupts the homotrimerization interface improves inflammatory arthritis in mice. Science Signaling 15:759.
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Ali Akbar Alizadeh, Michael B. Morris, W. Bret Church, Shadi Yaqoubi & Siavoush Dastmalchi. (2022) A mechanistic perspective, clinical applications, and phage-display-assisted discovery of TNFα inhibitors. Drug Discovery Today 27:2, pages 503-518.
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Mark Farrugia & Byron Baron. 2022. Translational Autoimmunity. Translational Autoimmunity 115 133 .
Nikolett Bódi, Lalitha Chandrakumar, Afnan al Doghmi, Diána Mezei, Zita Szalai, Bence Pál Barta, János Balázs & Mária Bagyánszki. (2021) Intestinal Region-Specific and Layer-Dependent Induction of TNFα in Rats with Streptozotocin-Induced Diabetes and after Insulin Replacement. Cells 10:9, pages 2410.
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Roman Fischer, Roland E. Kontermann & Klaus Pfizenmaier. (2020) Selective Targeting of TNF Receptors as a Novel Therapeutic Approach. Frontiers in Cell and Developmental Biology 8.
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Mehreen Zaka, Bilal Haider Abbasi & Serdar Durdagi. (2018) Proposing novel TNFα direct inhibitor Scaffolds using fragment-docking based e-pharmacophore modeling and binary QSAR-based virtual screening protocols pipeline. Journal of Molecular Graphics and Modelling 85, pages 111-121.
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Sarah K. Williams, Richard Fairless, Olaf Maier, Patricia C. Liermann, Kira Pichi, Roman Fischer, Ulrich L. M. Eisel, Roland Kontermann, Andreas Herrmann, Babette Weksler, Nacho Romero, Pierre-Olivier Couraud, Klaus Pfizenmaier & Ricarda Diem. (2018) Anti-TNFR1 targeting in humanized mice ameliorates disease in a model of multiple sclerosis. Scientific Reports 8:1.
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Sujuan Yang, Julie Wang, David Douglass Brand & Song Guo Zheng. (2018) Role of TNF–TNF Receptor 2 Signal in Regulatory T Cells and Its Therapeutic Implications. Frontiers in Immunology 9.
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Eugene Varfolomeev & Domagoj Vucic. (2018) Intracellular regulation of TNF activity in health and disease. Cytokine 101, pages 26-32.
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Laura Wistlich, Juliane Kums, Angela Rossi, Karl-Heinz Heffels, Harald Wajant & Jürgen Groll. (2017) Multimodal Bioactivation of Hydrophilic Electrospun Nanofibers Enables Simultaneous Tuning of Cell Adhesivity and Immunomodulatory Effects. Advanced Functional Materials 27:46, pages 1702903.
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Kohei Hosokawa, Sachiko Kajigaya, Keyvan Keyvanfar, Wangmin Qiao, Yanling Xie, Danielle M. Townsley, Xingmin Feng & Neal S. Young. (2017) T Cell Transcriptomes from Paroxysmal Nocturnal Hemoglobinuria Patients Reveal Novel Signaling Pathways. The Journal of Immunology 199:2, pages 477-488.
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Georgia Melagraki, Evangelos Ntougkos, Vagelis Rinotas, Christos Papaneophytou, Georgios Leonis, Thomas Mavromoustakos, George Kontopidis, Eleni Douni, Antreas Afantitis & George Kollias. (2017) Cheminformatics-aided discovery of small-molecule Protein-Protein Interaction (PPI) dual inhibitors of Tumor Necrosis Factor (TNF) and Receptor Activator of NF-κB Ligand (RANKL). PLOS Computational Biology 13:4, pages e1005372.
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L. Probert. (2015) TNF and its receptors in the CNS: The essential, the desirable and the deleterious effects. Neuroscience 302, pages 2-22.
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Roman Fischer, Roland Kontermann & Olaf Maier. (2015) Targeting sTNF/TNFR1 Signaling as a New Therapeutic Strategy. Antibodies 4:1, pages 48-70.
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Roman Fischer & Olaf Maier. (2015) Interrelation of Oxidative Stress and Inflammation in Neurodegenerative Disease: Role of TNF. Oxidative Medicine and Cellular Longevity 2015, pages 1-18.
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Bernhard Neuhaus, Annika Frede, Astrid Maria Westendorf & Matthias Epple. (2015) Gene silencing of the pro-inflammatory cytokine TNF-α with siRNA delivered by calcium phosphate nanoparticles, quantified by different methods. Journal of Materials Chemistry B 3:36, pages 7186-7193.
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V. Berger, F. Richter, K. Zettlitz, F. Unverdorben, P. Scheurich, A. Herrmann, K. Pfizenmaier & R. E. Kontermann. (2013) An anti-TNFR1 scFv-HSA fusion protein as selective antagonist of TNF action. Protein Engineering Design and Selection 26:10, pages 581-587.
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Fabian Richter, Timo Liebig, Eric Guenzi, Andreas Herrmann, Peter Scheurich, Klaus Pfizenmaier & Roland E. Kontermann. (2013) Antagonistic TNF Receptor One-Specific Antibody (ATROSAB): Receptor Binding and In Vitro Bioactivity. PLoS ONE 8:8, pages e72156.
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Simon Neumann, Peter Scheurich & Olaf Maier. 2005. Encyclopedia of Life Sciences. Encyclopedia of Life Sciences.
Jessica M DavisJulie Colangelo. (2013) Small-molecule inhibitors of the interaction between TNF and TNFR. Future Medicinal Chemistry 5:1, pages 69-79.
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Bryan E. Essien & Michael Kotiw. (2011) Anti-inflammatory Activity of Hyperimmune Plasma in a Lipopolysaccharide-Mediated Rat Air Pouch Model of Inflammation. Inflammation 35:1, pages 58-64.
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Roland E. Kontermann. 2011. Bispecific Antibodies. Bispecific Antibodies 1 28 .
Yohei MukaiTeruya NakamuraMai YoshikawaYasuo YoshiokaShin-ichi TsunodaShinsaku NakagawaYuriko YamagataYasuo Tsutsumi. (2010) Solution of the Structure of the TNF-TNFR2 Complex. Science Signaling 3:148.
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