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Review

Antigen discovery and delivery of subunit vaccines by nonliving bacterial ghost vectors

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Pages 681-691 | Published online: 09 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (9)

Ali M. Batah & Tarek A. Ahmad. (2020) The development of ghost vaccines trials. Expert Review of Vaccines 19:6, pages 549-562.
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Songwe Fanuel, Saeideh Tabesh, Huda Fatima Rajani, Sahel Heidari, Esmaeil Sadroddiny & Gholam Ali Kardar. (2017) Decorating and loading ghosts with allergens for allergen immunotherapy. Human Vaccines & Immunotherapeutics 13:10, pages 2428-2433.
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Abbas Muhammad, Jonathan Champeimont, Ulrike Beate Mayr, Werner Lubitz & Pavol Kudela. (2012) Bacterial ghosts as carriers of protein subunit and DNA-encoded antigens for vaccine applications. Expert Review of Vaccines 11:1, pages 97-116.
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Timo Langemann, Verena Juliana Koller, Abbas Muhammad, Pavol Kudela, Ulrike Beate Mayr & Werner Lubitz. (2010) The bacterial ghost platform system. Bioengineered Bugs 1:5, pages 326-336.
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Eva M Riedmann, Jennelle M Kyd, Allan W Cripps & Werner Lubitz. (2007) Bacterial ghosts as adjuvant particles. Expert Review of Vaccines 6:2, pages 241-253.
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José M. Lanao, Elsa Briones & Clara I. Colino. (2007) Recent advances in delivery systems for anti-HIV1 therapy. Journal of Drug Targeting 15:1, pages 21-36.
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Wolfgang Jechlinger. (2006) Optimization and delivery of plasmid DNA for vaccination. Expert Review of Vaccines 5:6, pages 803-825.
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Susanne Paukner, Thomas Stiedl, Pavol Kudela, Jozef Bizik, Firas Al Laham & Werner Lubitz. (2006) Bacterial ghosts as a novel advanced targeting system for drug and DNA delivery. Expert Opinion on Drug Delivery 3:1, pages 11-22.
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Articles from other publishers (28)

Chuan-Yu He, Jiang-Hua Yang, Yin-Bo Ye, Hai-Long Zhao, Meng-Zhi Liu, Qi-Lin Yang, Bao-Shan Liu, Sun He & Ze-Liang Chen. (2022) Proteomic and Antibody Profiles Reveal Antigenic Composition and Signatures of Bacterial Ghost Vaccine of Brucella abortus A19. Frontiers in Immunology 13.
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Sae-Ryung Kang, Dinh-Huy Nguyen, Su Woong Yoo & Jung-Joon Min. (2022) Bacteria and bacterial derivatives as delivery carriers for immunotherapy. Advanced Drug Delivery Reviews 181, pages 114085.
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Mounir M. Salem-Bekhit, Abdullah M. E. Youssof, Fars K. Alanazi, Fadilah Sfouq Aleanizy, Alsuwyeh Abdulaziz, Ehab I. Taha & Amro Abd Al Fattah Amara. (2021) Bacteria from Infectious Particles to Cell Based Anticancer Targeted Drug Delivery Systems. Pharmaceutics 13:12, pages 1984.
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Haojie Chen, Hao Ji, Xiangjun Kong, Pengyu Lei, Qinsi Yang, Wei Wu, Libo Jin & Da Sun. (2021) Bacterial Ghosts-Based Vaccine and Drug Delivery Systems. Pharmaceutics 13:11, pages 1892.
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Gamaleldin I. Harisa, Abdelrahman Y. Sherif, Abdullah M.E. Youssof, Fars K. Alanazi & Mounir M. Salem-Bekhit. (2020) Bacteriosomes as a Promising Tool in Biomedical Applications: Immunotherapy and Drug Delivery. AAPS PharmSciTech 21:5.
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Saisai Gong, Nan Nan, Yakun Sun, Zhili He, Jiajia Li, Fanghong Chen, Tao Li, Nianzhi Ning, Jianxin Wang, Zhan Li, Deyan Luo & Hui Wang. (2020) Protective Immunity Elicited by VP1 Chimeric Antigens of Bacterial Ghosts against Hand-Foot-and-Mouth Disease Virus. Vaccines 8:1, pages 61.
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Rui Hou, Muzi Li, Tingting Tang, Ruichong Wang, Yijing Li, Yigang Xu, Lijie Tang, Li Wang, Min Liu, Yanping Jiang, Wen Cui & Xinyuan Qiao. (2018) Construction of Lactobacillus casei ghosts by Holin-mediated inactivation and the potential as a safe and effective vehicle for the delivery of DNA vaccines. BMC Microbiology 18:1.
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Boram Kim, Gayeon Won & John Hwa Lee. (2017) Construction of an inactivated typhoid vaccine candidate expressing Escherichia coli heat-labile enterotoxin B subunit and evaluation of its immunogenicity in a murine model. Journal of Medical Microbiology 66:8, pages 1235-1243.
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Gayeon Won, Boram Kim & John Hwa Lee. (2017) A novel approach for construction of an inactivated typhoid vaccine candidate that effectively augments both humoral and cellular immune responses. Vaccine 35:25, pages 3333-3341.
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Shui-Li Xia, Jian-Lin Lei, Mingliang Du, Yimin Wang, Xin Cong, Guang-Tao Xiang, Lian-Feng Li, Shenye Yu, Enqi Du, Siguo Liu, Yuan Sun & Hua-Ji Qiu. (2016) Enhanced protective immunity of the chimeric vector-based vaccine rAdV-SFV-E2 against classical swine fever in pigs by a Salmonella bacterial ghost adjuvant. Veterinary Research 47:1.
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Gayeon Won, Tae Hoon Kim & John Hwa Lee. (2017) A novel Salmonella strain inactivated by a regulated autolysis system and expressing the B subunit of Shiga toxin 2e efficiently elicits immune responses and confers protection against virulent Stx2e-producing Escherichia coli. BMC Veterinary Research 13:1.
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Gayeon Won & John H. Lee. (2016) Effectiveness of F18+ Fimbrial Antigens Released by a Novel Autolyzed Salmonella Expression System as a Vaccine Candidate against Lethal F18+ STEC Infection. Frontiers in Microbiology 7.
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Timo Langemann, Ulrike Beate Mayr, Andrea Meitz, Werner Lubitz & Christoph Herwig. (2015) Multi-parameter flow cytometry as a process analytical technology (PAT) approach for the assessment of bacterial ghost production. Applied Microbiology and Biotechnology 100:1, pages 409-418.
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Aleksandra Inic-Kanada, Marijana Stojanovic, Simone Schlacher, Elisabeth Stein, Sandra Belij-Rammerstorfer, Emilija Marinkovic, Ivana Lukic, Jacqueline Montanaro, Nadine Schuerer, Nora Bintner, Vesna Kovacevic-Jovanovic, Ognjen Krnjaja, Ulrike Beate Mayr, Werner Lubitz & Talin Barisani-Asenbauer. (2015) Delivery of a Chlamydial Adhesin N-PmpC Subunit Vaccine to the Ocular Mucosa Using Particulate Carriers. PLOS ONE 10:12, pages e0144380.
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M.R. Miri, A. Behzad-Behbahani, M. Fardaei, A. Farhadi, Y. Talebkhan, M. Mohammadi, M. Tayebinia, F. Farokhinejad, P. Alavi, M. Fanian, F. Zare, J. Saberzade, N. Nikouyan, M.A. Okhovat, R. Ranjbaran, G. Rafiei Dehbidi & S. Naderi. (2015) Construction of bacterial ghosts for transfer and expression of a chimeric hepatitis C virus gene in macrophages. Journal of Microbiological Methods 119, pages 228-232.
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Atul Srivastava, Devegowda Vishakante Gowda, SubbaRao V. Madhunapantula, Chetan G. Shinde & Meenakshi Iyer. (2015) Mucosal vaccines: a paradigm shift in the development of mucosal adjuvants and delivery vehicles. APMIS 123:4, pages 275-288.
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Mingming Hu, Yanhe Zhang, Fang Xie, Gang Li, Jianjun Li, Wei Si, Siguo Liu, Shouping Hu, Zhuo Zhang, Nan Shen & Chunlai Wang. (2013) Protection of Piglets by a Haemophilus parasuis Ghost Vaccine against Homologous Challenge. Clinical and Vaccine Immunology 20:6, pages 795-802.
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Ulrike Beate Mayr, Pavol Kudela, Alena Atrasheuskaya, Eugenij Bukin, Georgy Ignatyev & Werner Lubitz. (2012) Rectal single dose immunization of mice with Escherichia coli O157:H7 bacterial ghosts induces efficient humoral and cellular immune responses and protects against the lethal heterologous challenge . Microbial Biotechnology 5:2, pages 283-294.
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Carmen Gutiérrez Millán, Clara Isabel Colino Gandarillas, María Luisa Sayalero Marinero & José M Lanao. (2012) Cell-based drug-delivery platforms. Therapeutic Delivery 3:1, pages 25-41.
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Yu. A. Popov & N. I. Mikshis. (2010) Genetic (DNA) Vaccines. Problems of Particularly Dangerous Infections:3(105), pages 20-24.
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Xianlan Cui, Janine A. Duckworth, Petra Lubitz, Frank C. Molinia, Christoph Haller, Werner Lubitz & Phil E. Cowan. (2010) Humoral immune responses in brushtail possums (Trichosurus vulpecula) induced by bacterial ghosts expressing possum zona pellucida 3 protein. Vaccine 28:26, pages 4268-4274.
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Petra Walcher, Xianlan Cui, Jane A. Arrow, Susie Scobie, Frank C. Molinia, Phil E. Cowan, Werner Lubitz & Janine A. Duckworth. (2008) Bacterial ghosts as a delivery system for zona pellucida-2 fertility control vaccines for brushtail possums (Trichosurus vulpecula). Vaccine 26:52, pages 6832-6838.
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Janine A. Duckworth, Xianlan Cui, Susie Scobie, Jane Arrow & Phil E. Cowan. (2008) Development of a contraceptive vaccine for the marsupial brushtail possum (Trichosurus vulpecula): lack of effects in mice and chickens immunised with recombinant possum ZP3 protein and a possum ZP3 antifertility epitope. Wildlife Research 35:6, pages 563.
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Yugang Wu, Liang Wang, Xiaozhou He, Haiyan Xu, Lechang Zhou, Fang Zhao & Yanyun Zhang. (2008) Expression of CD40 and growth-inhibitory activity of CD40 ligand in colon cancer ex vivo. Cellular Immunology 253:1-2, pages 102-109.
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Vito G. DelVecchio, Joseph P. Connolly, Timothy G. Alefantis, Alexander Walz, Marian A. Quan, Guy Patra, John M. Ashton, Jessica T. Whittington, Ryan D. Chafin, Xudong Liang, Paul Grewal, Akbar S. Khan & Cesar V. Mujer. (2006) Proteomic Profiling and Identification of Immunodominant Spore Antigens of Bacillus anthracis , Bacillus cereus , and Bacillus thuringiensis . Applied and Environmental Microbiology 72:9, pages 6355-6363.
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Akbar S. Khan, Cesar V. Mujer, Timothy G. Alefantis, Joseph P. Connolly, Ulrike Beate Mayr, Petra Walcher, Werner Lubitz & Vito G. DelVecchio. (2005) Proteomics and Bioinformatics Strategies to Design Countermeasures against Infectious Threat Agents. Journal of Chemical Information and Modeling 46:1, pages 111-115.
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Ulrike Beate Mayr, Christoph Haller, Wolfgang Haidinger, Alena Atrasheuskaya, Eugenij Bukin, Werner Lubitz & Georgy Ignatyev. (2005) Bacterial Ghosts as an Oral Vaccine: a Single Dose of Escherichia coli O157:H7 Bacterial Ghosts Protects Mice against Lethal Challenge . Infection and Immunity 73:8, pages 4810-4817.
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Wolfgang Jechlinger, Chakameh Azimpour Tabrizi, Werner Lubitz & Peter Mayrhofer. (2004) Minicircle DNA Immobilized in Bacterial Ghosts: In vivo Production of Safe Non-Viral DNA Delivery Vehicles. Journal of Molecular Microbiology and Biotechnology 8:4, pages 222-231.
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