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Original Research

The lung function profile of once-daily tiotropium and olodaterol via Respimat® is superior to that of twice-daily salmeterol and fluticasone propionate via Accuhaler® (ENERGITO® study)

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Pages 193-205 | Published online: 03 Feb 2016

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Read on this site (20)

Ying Lan, Nan Yang, Yirong Wang, Yan Yang, Min Xu & Qin He. (2023) Cost-Effectiveness Analysis of Fixed-Dose Tiotropium/Olodaterol versus Tiotropium for COPD Patients in China. International Journal of Chronic Obstructive Pulmonary Disease 18, pages 2093-2103.
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Yanling Ding, Lina Sun, Ying Wang, Jing Zhang & Yahong Chen. (2022) Efficacy of ICS versus Non-ICS Combination Therapy in COPD: A Meta-Analysis of Randomised Controlled Trials. International Journal of Chronic Obstructive Pulmonary Disease 17, pages 1051-1067.
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Mario Cazzola, Paola Rogliani, Luigino Calzetta, Josuel Ora & Maria Gabriella Matera. (2022) A single inhaler triple therapy fluticasone furoate/umeclidinium/vilanterol for the treatment of COPD. Expert Review of Clinical Pharmacology 15:3, pages 269-283.
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Leah B Sansbury, Chanchal Bains, David A Lipson, Afisi S Ismaila & Sarah H Landis. (2021) Real-World Treatment Patterns of Multiple-Inhaler Triple Therapy Among Patients with Chronic Obstructive Pulmonary Disease in UK General Practice. International Journal of Chronic Obstructive Pulmonary Disease 16, pages 1255-1264.
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Gerard Criner & Sean Duffy. (2021) Reducing and managing chronic obstructive pulmonary disease exacerbations with tiotropium + olodaterol. Current Medical Research and Opinion 37:2, pages 275-284.
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Andriana I Papaioannou, Stelios Loukides, Petros Bakakos, Epameinondas N Kosmas, Nikoletta Rovina, Paschalis Steiropoulos, Evangellia Fouka, Georgios Hillas, Georgios Patentalakis, Marousa Kouvela & Nikos Tzanakis. (2020) Dual Bronchodilator in the Era of Triple Therapy. International Journal of Chronic Obstructive Pulmonary Disease 15, pages 2695-2705.
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Roland Buhl, Michael Dreher, Stephanie Korn, Christian Taube, Christian Stock, Christoph M Zehendner, Anke Kondla & Claus F Vogelmeier. (2020) A Non-Interventional Study of Tiotropium/Olodaterol versus Any Triple Combination Therapy for Chronic Obstructive Pulmonary Disease: The EVELUT® Study Protocol. International Journal of Chronic Obstructive Pulmonary Disease 15, pages 2601-2608.
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Neil S. Skolnik, Trang Susan Nguyen, Aarisha Shrestha, Riju Ray, Thomas C. Corbridge & Stephen A. Brunton. (2020) Current evidence for COPD management with dual long-acting muscarinic antagonist/long-acting β2-agonist bronchodilators. Postgraduate Medicine 132:2, pages 198-205.
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Chad Moretz, Lucie Sharpsten, Lindsay GS Bengtson, Eleena Koep, Lisa Le, Junliang Tong, Richard H Stanford, Beth Hahn & Riju Ray. (2019) Real-world effectiveness of umeclidinium/vilanterol versus fluticasone propionate/salmeterol as initial maintenance therapy for chronic obstructive pulmonary disease (COPD): a retrospective cohort study. International Journal of Chronic Obstructive Pulmonary Disease 14, pages 1721-1737.
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Maria Gabriella Matera, Luigino Calzetta, Ermanno Puxeddu, Paola Rogliani & Mario Cazzola. (2018) A safety comparison of LABA+LAMA vs LABA+ICS combination therapy for COPD. Expert Opinion on Drug Safety 17:5, pages 509-517.
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Amnon Ariel, Alan Altraja, Andrey Belevskiy, Piotr W Boros, Edvardas Danila, Matjaz Fležar, Vladimir Koblizek, Zvi G Fridlender, Kosta Kostov, Alvils Krams, Branislava Milenkovic, Attila Somfay, Ruzena Tkacova, Neven Tudoric, Ruxandra Ulmeanu & Arschang Valipour. (2018) Inhaled therapies in patients with moderate COPD in clinical practice: current thinking. International Journal of Chronic Obstructive Pulmonary Disease 13, pages 45-56.
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Syed Mohammad Tariq & Enson C Thomas. (2017) Maintenance therapy in COPD: time to phase out ICS and switch to the new LAMA/LABA inhalers?. International Journal of Chronic Obstructive Pulmonary Disease 12, pages 1877-1882.
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Chunxue Bai, Masakazu Ichinose, Sang Haak Lee, Kwan Ho Lee, Olaf Jöns, Ulrich Bothner, Yihua Zhao & Roland Buhl. (2017) Lung function and long-term safety of tiotropium/olodaterol in East Asian patients with chronic obstructive pulmonary disease. International Journal of Chronic Obstructive Pulmonary Disease 12, pages 3329-3339.
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Gustavo J Rodrigo, David Price, Antonio Anzueto, Dave Singh, Pablo Altman, Giovanni Bader, Francesco Patalano, Robert Fogel & Konstantinos Kostikas. (2017) LABA/LAMA combinations versus LAMA monotherapy or LABA/ICS in COPD: a systematic review and meta-analysis. International Journal of Chronic Obstructive Pulmonary Disease 12, pages 907-922.
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Eric Derom, Guy G Brusselle & Guy F Joos. (2016) Efficacy of tiotropium–olodaterol fixed-dose combination in COPD. International Journal of Chronic Obstructive Pulmonary Disease 11, pages 3163-3177.
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Claus Vogelmeier, Nanshan Zhong, Michael J Humphries, Karen Mezzi, Robert Fogel, Giovanni Bader, Francesco Patalano & Donald Banerji. (2016) Indacaterol/glycopyrronium in symptomatic patients with COPD (GOLD B and GOLD D) versus salmeterol/fluticasone: ILLUMINATE/LANTERN pooled analysis. International Journal of Chronic Obstructive Pulmonary Disease 11, pages 3189-3197.
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Masakazu Ichinose, Hiroyuki Taniguchi, Ayako Takizawa, Lars Grönke, Lazaro Loaiza, Florian Voß, Yihua Zhao & Yoshinosuke Fukuchi. (2016) The efficacy and safety of combined tiotropium and olodaterol via the Respimat® inhaler in patients with COPD: results from the Japanese sub-population of the Tonado® studies. International Journal of Chronic Obstructive Pulmonary Disease 11, pages 2017-2027.
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Tomohiro Tamura & Hiroaki Satoh. (2016) Superiority of tiotropium plus olodaterol in comparison with salmeterol plus fluticasone. International Journal of Chronic Obstructive Pulmonary Disease 11, pages 2909-2911.
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Crossref
Dave Singh, Marc Miravitlles & Claus Vogelmeier. (2016) Chronic Obstructive Pulmonary Disease Individualized Therapy: Tailored Approach to Symptom Management. Advances in Therapy 34:2, pages 281-299.
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M. Zysman, F. Chabot, P. Devillier, B. Housset, C. Morelot-Panzini & N. Roche. (2016) Pharmacological treatment optimization for stable chronic obstructive pulmonary disease. Proposals from the Société de Pneumologie de Langue Française. Revue des Maladies Respiratoires 33:10, pages 911-936.
Crossref
Edward Kerwin. (2016) A new alphabet for COPD care. European Respiratory Journal 48:4, pages 972-975.
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Kai M. Beeh. (2016) The Role of Bronchodilators in Preventing Exacerbations of Chronic Obstructive Pulmonary Disease. Tuberculosis and Respiratory Diseases 79:4, pages 241.
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