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Review

Bispecific antibodies: design, therapy, perspectives

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Pages 195-208 | Published online: 22 Jan 2018

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (13)

Divya Kandari & Rakesh Bhatnagar. (2023) Antibody engineering and its therapeutic applications. International Reviews of Immunology 42:2, pages 156-183.
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Monica L. Fernández-Quintero, Katharina B. Kroell, Lukas J. Grunewald, Anna-Lena M. Fischer, Jakob R. Riccabona & Klaus R. Liedl. (2022) CDR loop interactions can determine heavy and light chain pairing preferences in bispecific antibodies. mAbs 14:1.
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Celine A.N. Sewnath, Leonie M. Behrens & Marjolein van Egmond. (2022) Targeting myeloid cells with bispecific antibodies as novel immunotherapies of cancer. Expert Opinion on Biological Therapy 22:8, pages 983-995.
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Sivan Cohen, Shan Chung, Christoph Spiess, Victor Lundin, Eric Stefanich, Steven T. Laing, Vanessa Clark, Jochen Brumm, Ying Zhou, Catherine Huang, Joyce Guerrero, Srividya Myneni, Rajbharan Yadav, Ketevan Siradze & Kun Peng. (2021) An integrated approach for characterizing immunogenic responses toward a bispecific antibody. mAbs 13:1.
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Ruth Alonso-Alonso, Marta Rodriguez, Daniel Morillo, Raul Cordoba & Miguel A Piris. (2020) An analysis of genetic targets for guiding clinical management of follicular lymphoma. Expert Review of Hematology 13:12, pages 1361-1372.
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Christoph Gstöttner, Dietmar Reusch, Markus Haberger, Irina Dragan, Peter Van Veelen, David P. A. Kilgour, Yury O. Tsybin, Yuri E. M. van der Burgt, Manfred Wuhrer & Simone Nicolardi. (2020) Monitoring glycation levels of a bispecific monoclonal antibody at subunit level by ultrahigh-resolution MALDI FT-ICR mass spectrometry. mAbs 12:1.
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Deepak Mittal, Dipti Vijayan, Joost Neijssen, Joost Kreijtz, Maurice M. J. M. Habraken, Hans Van Eenennaam, Andrea Van Elsas & Mark J. Smyth. (2019) Blockade of ErbB2 and PD-L1 using a bispecific antibody to improve targeted anti-ErbB2 therapy. OncoImmunology 8:11.
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Adam R. Evans, Michael T. Capaldi, Geetha Goparaju, David Colter, Frank F. Shi, Sarah Aubert, Lian-Chao Li, Jingjie Mo, Michael J. Lewis, Ping Hu, Pedro Alfonso & Promod Mehndiratta. (2019) Using bispecific antibodies in forced degradation studies to analyze the structure–function relationships of symmetrically and asymmetrically modified antibodies. mAbs 11:6, pages 1101-1112.
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Kristina Ellwanger, Uwe Reusch, Ivica Fucek, Susanne Wingert, Thorsten Ross, Thomas Müller, Ute Schniegler-Mattox, Torsten Haneke, Erich Rajkovic, Joachim Koch, Martin Treder & Michael Tesar. (2019) Redirected optimized cell killing (ROCK®): A highly versatile multispecific fit-for-purpose antibody platform for engaging innate immunity. mAbs 11:5, pages 899-918.
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Oliver Seifert, Alexander Rau, Nadine Beha, Fabian Richter & Roland E. Kontermann. (2019) Diabody-Ig: a novel platform for the generation of multivalent and multispecific antibody molecules. mAbs 11:5, pages 919-929.
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Chen Chen, Tetsuya Wakabayashi, Masaru Muraoka, Feng Shu, Chia Wei Shan, Chong Chor Kun, Ching Tim Jang, Ishin Soehano, Yuichiro Shimizu, Tomoyuki Igawa & Jun-Ichi Nezu. (2019) Controlled conductivity at low pH in Protein L chromatography enables separation of bispecific and other antibody formats by their binding valency. mAbs 11:4, pages 632-638.
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