Citations (111)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (20)
Kexun Zhou, Yingping Liu, Shiman Yuan, Ziyu Zhou, Pengfei Ji, Qianhan Huang, Feng Wen & Qiu Li. (2023) Signalling in pancreatic cancer: from pathways to therapy. Journal of Drug Targeting 31:10, pages 1013-1026.
Read now
Read now
Xiaoxian Huang, Lingfei Han, Ruyi Wang, Wanfang Zhu, Ning Zhang, Wei Qu, Wenyuan Liu, Fulei Liu, Feng Feng & Jingwei Xue. (2022) Dual-responsive nanosystem based on TGF-β blockade and immunogenic chemotherapy for effective chemoimmunotherapy. Drug Delivery 29:1, pages 1358-1369.
Read now
Read now
Jessica Hung, Rohni Awasthi, Alexander L Klibanov & Kimberly A Kelly. (2021) Identification of Novel Ligands for Targeted Antifibrotic Therapy of Chronic Pancreatitis. International Journal of Nanomedicine 16, pages 5495-5512.
Read now
Read now
Russell Lewis, Jan Philipp Bewersdorf & Amer M Zeidan. (2021) Clinical Management of Anemia in Patients with Myelodysplastic Syndromes: An Update on Emerging Therapeutic Options. Cancer Management and Research 13, pages 645-657.
Read now
Read now
Jianzheng Wang, Qingli Li, Xiaojiao Cheng, Baiwen Zhang, Jiacheng Lin, Yao Tang, Fuli Li, Chung S Yang, Timothy C Wang & Shuiping Tu. (2020) Bone Marrow-Derived Myofibroblasts Promote Gastric Cancer Metastasis by Activating TGF-β1 and IL-6/STAT3 Signalling Loop. OncoTargets and Therapy 13, pages 10567-10580.
Read now
Read now
Alexander Ries, Karin Schelch, David Falch, Laura Pany, Mir Alireza Hoda & Michael Grusch. (2020) Activin A: an emerging target for improving cancer treatment?. Expert Opinion on Therapeutic Targets 24:10, pages 985-996.
Read now
Read now
Christopher Larson, Bryan Oronsky, Corey A. Carter, Arnold Oronsky, Susan J. Knox, David Sher & Tony R. Reid. (2020) TGF-beta: a master immune regulator. Expert Opinion on Therapeutic Targets 24:5, pages 427-438.
Read now
Read now
Myoung-Soon Park, Hyun-Ju Park, Young Jae An, Joon Hun Choi, Geunyoung Cha, Hwa Jeong Lee, So-Jung Park, Purushottam M. Dewang & Dae-Kee Kim. (2020) Synthesis, biological evaluation and molecular modelling of 2,4-disubstituted-5-(6-alkylpyridin-2-yl)-1H-imidazoles as ALK5 inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 702-712.
Read now
Read now
Ulrich Germing, Thomas Schroeder, Jennifer Kaivers, Andrea Kündgen, Guido Kobbe & Norbert Gattermann. (2019) Novel therapies in low- and high-risk myelodysplastic syndrome. Expert Review of Hematology 12:10, pages 893-908.
Read now
Read now
Daniel Newsted, Sunandan Banerjee, Kathleen Watt, Sarah Nersesian, Peter Truesdell, Levi L. Blazer, Lia Cardarelli, Jarrett J. Adams, Sachdev S. Sidhu & Andrew W. Craig. (2019) Blockade of TGF-β signaling with novel synthetic antibodies limits immune exclusion and improves chemotherapy response in metastatic ovarian cancer models. OncoImmunology 8:2.
Read now
Read now
Sreenivasa Chandana, Hani M. Babiker & Daruka Mahadevan. (2019) Therapeutic trends in pancreatic ductal adenocarcinoma (PDAC). Expert Opinion on Investigational Drugs 28:2, pages 161-177.
Read now
Read now
Kenneth C. Cassidy, Ivelina Gueorguieva, Colin Miles, Jessica Rehmel, Ping Yi & William J. Ehlhardt. (2018) Disposition and metabolism of [14C]-galunisertib, a TGF-βRI kinase/ALK5 inhibitor, following oral administration in healthy subjects and mechanistic prediction of the effect of itraconazole on galunisertib pharmacokinetics. Xenobiotica 48:4, pages 382-399.
Read now
Read now
Fernando J Velloso, Arthur FR Bianco, Jessica O Farias, Nadia EC Torres, Pault YM Ferruzo, Valesca Anschau, Henrique C Jesus-Ferreira, Ted Hung-Tse Chang, Mari Cleide Sogayar, Luiz F Zerbini & Ricardo G Correa. (2017) The crossroads of breast cancer progression: insights into the modulation of major signaling pathways. OncoTargets and Therapy 10, pages 5491-5524.
Read now
Read now
Mozhi Wang, Changwang Zhang, Yongxi Song, Zhenning Wang, Yaojia Wang, Fang Luo, Yujie Xu, Yi Zhao, Zhonghua Wu & Yingying Xu. (2017) Mechanism of immune evasion in breast cancer. OncoTargets and Therapy 10, pages 1561-1573.
Read now
Read now
Justin M. David, Charli Dominguez, Kristen K. McCampbell, James L. Gulley, Jeffrey Schlom & Claudia Palena. (2017) A novel bifunctional anti-PD-L1/TGF-β Trap fusion protein (M7824) efficiently reverts mesenchymalization of human lung cancer cells. OncoImmunology 6:10.
Read now
Read now
Sulsal Haque & John C. Morris. (2017) Transforming growth factor-β: A therapeutic target for cancer. Human Vaccines & Immunotherapeutics 13:8, pages 1741-1750.
Read now
Read now
Claudio Festuccia. (2017) Investigational serine/threonine kinase inhibitors against prostate cancer metastases. Expert Opinion on Investigational Drugs 26:1, pages 25-34.
Read now
Read now
Amer M. Zeidan, Maximilian Stahl & Rami Komrokji. (2016) Emerging biological therapies for the treatment of myelodysplastic syndromes. Expert Opinion on Emerging Drugs 21:3, pages 283-300.
Read now
Read now
Aitziber Buqué, Norma Bloy, Fernando Aranda, Isabelle Cremer, Alexander Eggermont, Wolf Hervé Fridman, Jitka Fucikova, Jérôme Galon, Radek Spisek, Eric Tartour, Laurence Zitvogel, Guido Kroemer & Lorenzo Galluzzi. (2016) Trial Watch—Small molecules targeting the immunological tumor microenvironment for cancer therapy. OncoImmunology 5:6.
Read now
Read now
Ji-Hua Nie, Zhi-Hai Chen, Chun-Lin Shao, Wei-Wei Pei, Jie Zhang, Shu-Yu Zhang, Yang Jiao & Jian Tong. (2016) Analysis of the miRNA–mRNA networks in malignant transformation BEAS-2B cells induced by alpha-particles. Journal of Toxicology and Environmental Health, Part A 79:9-10, pages 427-435.
Read now
Read now
Articles from other publishers (91)
Carlos Giovanni Silva-García. (2023) Devo-Aging: Intersections Between Development and Aging. GeroScience.
Crossref
Crossref
Max Kam-Kwan Chan, Emily Lok-Yiu Chan, Zoey Zeyuan Ji, Alex Siu-Wing Chan, Chunjie Li, Kam-Tong Leung, Ka-Fai To & Patrick Ming-Kuen Tang. (2023) Transforming growth factor-β signaling: from tumor microenvironment to anticancer therapy. Exploration of Targeted Anti-tumor Therapy, pages 316-343.
Crossref
Crossref
Kalliopi Tzavlaki, Yae Ohata, Anita Morén, Yukihide Watanabe, Jens Eriksson, Maiko Tsuchiya, Yuki Kubo, Kouhei Yamamoto, Mikael E. Sellin, Mitsuyasu Kato, Laia Caja, Carl‐Henrik Heldin & Aristidis Moustakas. (2023) The liver kinase B1 supports mammary epithelial morphogenesis by inhibiting critical factors that mediate epithelial‐mesenchymal transition. Journal of Cellular Physiology 238:4, pages 790-812.
Crossref
Crossref
Chunxue Zhang, Yuxiang Fei, Hui Wang, Sheng Hu, Chao Liu, Rong Hu & Qianming Du. (2023) CAFs orchestrates tumor immune microenvironment—A new target in cancer therapy?. Frontiers in Pharmacology 14.
Crossref
Crossref
Chen Chen, Zehua Wang, Yi Ding & Yanru Qin. (2023) Tumor microenvironment-mediated immune evasion in hepatocellular carcinoma. Frontiers in Immunology 14.
Crossref
Crossref
Ming Yi, Tianye Li, Mengke Niu, Yuze Wu, Zhenyu Zhao & Kongming Wu. (2022) TGF-β: A novel predictor and target for anti-PD-1/PD-L1 therapy. Frontiers in Immunology 13.
Crossref
Crossref
Yalei Wen, Yingjie Zhu, Caishi Zhang, Xiao Yang, Yuchen Gao, Mei Li, Hongyan Yang, Tongzheng Liu & Hui Tang. (2022) Chronic inflammation, cancer development and immunotherapy. Frontiers in Pharmacology 13.
Crossref
Crossref
Charles B. Trelford, Lina Dagnino & Gianni M. Di Guglielmo. (2022) Transforming growth factor-β in tumour development. Frontiers in Molecular Biosciences 9.
Crossref
Crossref
Yulia Vugmeyster, Ana-Marija Grisic, Justin J. Wilkins, Anja H. Loos, Roland Hallwachs, Motonobu Osada, Karthik Venkatakrishnan & Akash Khandelwal. (2022) Model-informed approach for risk management of bleeding toxicities for bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1. Cancer Chemotherapy and Pharmacology 90:4, pages 369-379.
Crossref
Crossref
Yuling Xu, Anbiao Wu, Jingyang Chen, Xudong Song, Minsheng Chen & Qicai Liu. (2022) Limb-Bud and Heart (LBH) Upregulation in Cardiomyocytes under Hypoxia Promotes the Activation of Cardiac Fibroblasts via Exosome Secretion. Mediators of Inflammation 2022, pages 1-16.
Crossref
Crossref
Xiaoshan Su, Weijing Wu, Zhixing Zhu, Xiaoping Lin & Yiming Zeng. (2022) The effects of epithelial–mesenchymal transitions in COPD induced by cigarette smoke: an update. Respiratory Research 23:1.
Crossref
Crossref
Monica A. Kamal, Yasmine M. Mandour, Mostafa K. Abd El-Aziz, Ulrike Stein & Hend M. El Tayebi. (2022) Small Molecule Inhibitors for Hepatocellular Carcinoma: Advances and Challenges. Molecules 27:17, pages 5537.
Crossref
Crossref
Carmelo Laface, Palma Fedele, Felicia Maria Maselli, Francesca Ambrogio, Caterina Foti, Pasquale Molinari, Michele Ammendola, Marco Lioce & Girolamo Ranieri. (2022) Targeted Therapy for Hepatocellular Carcinoma: Old and New Opportunities. Cancers 14:16, pages 4028.
Crossref
Crossref
Xiaoxiao Li, Ling Chen, Xiaobo Peng & Xianbao Zhan. (2022) Progress of tumor-associated macrophages in the epithelial-mesenchymal transition of tumor. Frontiers in Oncology 12.
Crossref
Crossref
Amandeep Thakur, Chetna Faujdar, Ram Sharma, Sachin Sharma, Basant Malik, Kunal Nepali & Jing Ping Liou. (2022) Glioblastoma: Current Status, Emerging Targets, and Recent Advances. Journal of Medicinal Chemistry 65:13, pages 8596-8685.
Crossref
Crossref
Pedro Silva Cunha, Sérgio Laranjo, Jordi Heijman & Mário Martins Oliveira. (2022) The Atrium in Atrial Fibrillation – A Clinical Review on How to Manage Atrial Fibrotic Substrates. Frontiers in Cardiovascular Medicine 9.
Crossref
Crossref
E. A. Pasechnikova, V. N. Bodnya, D. V. Kadomtsev, A. Yu. Georgieva, V. A. Porhanov & D. D. Shevchuk. (2022) The epithelial-to-mesenchymal transition in cancer: pathogenetic features. Innovative Medicine of Kuban:2, pages 85-92.
Crossref
Crossref
Bernhard J. Jank, Teresa Lenz, Markus Haas, Lorenz Kadletz-Wanke, Nicholas J. Campion, Julia Schnoell, Gregor Heiduschka & Karin Macfelda. (2022) Radiosensitizing effect of galunisertib, a TGF-ß receptor I inhibitor, on head and neck squamous cell carcinoma in vitro. Investigational New Drugs 40:3, pages 478-486.
Crossref
Crossref
Naoya Hirata, Shigeru Yamada, Shota Yanagida, Atsushi Ono, Yukuto Yasuhiko & Yasunari Kanda. (2022) Transforming Growth Factor Beta Promotes the Expansion of Cancer Stem Cells <i>via</i> S1PR3 by Ligand-Independent Notch Activation. Biological and Pharmaceutical Bulletin 45:5, pages 649-658.
Crossref
Crossref
Elisa Ceccherini, Nicoletta Di Giorgi, Elena Michelucci, Giovanni Signore, Lorena Tedeschi, Federico Vozzi, Silvia Rocchiccioli & Antonella Cecchettini. (2022) Biological Effects of Transforming Growth Factor Beta in Human Cholangiocytes. Biology 11:4, pages 566.
Crossref
Crossref
Masaru Ogasawara, Shino Yamasaki-Yashiki, Masahiro Hamada, Tomomi Yamaguchi-Miyamoto, Toru Kawasuji, Hiroe Honda, Tsutomu Yanagibashi, Masashi Ikutani, Yasuharu Watanabe, Ryota Fujimoto, Takayuki Matsunaga, Noriyuki Nakajima, Yoshinori Nagai & Kiyoshi Takatsu. (2022) Betulin Attenuates TGF-β1- and PGE<sub>2</sub>-Mediated Inhibition of NK Cell Activity to Suppress Tumor Progression and Metastasis in Mice. Biological and Pharmaceutical Bulletin 45:3, pages 339-353.
Crossref
Crossref
Syedia R. Rahman, James A. Roper, Jane I. Grove, Guruprasad P. Aithal, K. Tao Pun & Andrew J. Bennett. (2022) Integrins as a drug target in liver fibrosis. Liver International 42:3, pages 507-521.
Crossref
Crossref
Thai Minh Duy Le, A-Rum Yoon, Thavasyappan Thambi & Chae-Ok Yun. (2022) Polymeric Systems for Cancer Immunotherapy: A Review. Frontiers in Immunology 13.
Crossref
Crossref
Naresh Kumar & Nidhi Goel. (2022) Recent development of imidazole derivatives as potential anticancer agents. Physical Sciences Reviews 0:0.
Crossref
Crossref
Daniele V. F. Tauriello, Elena Sancho & Eduard Batlle. (2021) Overcoming TGFβ-mediated immune evasion in cancer. Nature Reviews Cancer 22:1, pages 25-44.
Crossref
Crossref
Antonio Tejera-Muñoz, Laura Marquez-Exposito, Lucía Tejedor-Santamaría, Sandra Rayego-Mateos, Macarena Orejudo, Beatriz Suarez-Álvarez, Carlos López-Larrea, Marta Ruíz-Ortega & Raúl R. Rodrigues-Díez. (2021) CCN2 Increases TGF-β Receptor Type II Expression in Vascular Smooth Muscle Cells: Essential Role of CCN2 in the TGF-β Pathway Regulation. International Journal of Molecular Sciences 23:1, pages 375.
Crossref
Crossref
Hao Wang, Junjie Pan, Livnat Barsky, Jule Caroline Jacob, Yan Zheng, Chao Gao, Shun Wang, Wenwei Zhu, Haoting Sun, Lu Lu, Huliang Jia, Yue Zhao, Christiane Bruns, Razi Vago, Qiongzhu Dong & Lunxiu Qin. (2021) Characteristics of pre-metastatic niche: the landscape of molecular and cellular pathways. Molecular Biomedicine 2:1.
Crossref
Crossref
Samantha K. Von Rueden & Timothy M. Fan. (2021) Cancer-Immunity Cycle and Therapeutic Interventions- Opportunities for Including Pet Dogs With Cancer. Frontiers in Oncology 11.
Crossref
Crossref
Chiara Cilibrasi, Panagiotis Papanastasopoulos, Mark Samuels & Georgios Giamas. (2021) Reconstituting Immune Surveillance in Breast Cancer: Molecular Pathophysiology and Current Immunotherapy Strategies. International Journal of Molecular Sciences 22:21, pages 12015.
Crossref
Crossref
Chiara Tramontano, Bruno Miranda, Giovanna Chianese, Luca De Stefano, Carlo Forestiere, Marinella Pirozzi & Ilaria Rea. (2021) Design of Gelatin-Capped Plasmonic-Diatomite Nanoparticles with Enhanced Galunisertib Loading Capacity for Drug Delivery Applications. International Journal of Molecular Sciences 22:19, pages 10755.
Crossref
Crossref
Lisa Rooney & Chris Jones. (2021) Recent Advances in ALK2 Inhibitors. ACS Omega 6:32, pages 20729-20734.
Crossref
Crossref
Hyunjung Lee, Joon-Seog Kong, Seung-Sook Lee & Areumnuri Kim. (2021) Radiation-Induced Overexpression of TGFβ and PODXL Contributes to Colorectal Cancer Cell Radioresistance through Enhanced Motility. Cells 10:8, pages 2087.
Crossref
Crossref
Gabriela Morales-Guadarrama, Rocío García-Becerra, Edgar Armando Méndez-Pérez, Janice García-Quiroz, Euclides Avila & Lorenza Díaz. (2021) Vasculogenic Mimicry in Breast Cancer: Clinical Relevance and Drivers. Cells 10:7, pages 1758.
Crossref
Crossref
Ester Gonzalez-Sanchez, Javier Vaquero, Maite G. Férnandez-Barrena, Juan José Lasarte, Matías A. Avila, Pablo Sarobe, María Reig, Mariona Calvo & Isabel Fabregat. (2021) The TGF-β Pathway: A Pharmacological Target in Hepatocellular Carcinoma?. Cancers 13:13, pages 3248.
Crossref
Crossref
Ntombikayise Xelwa, Geoffrey Patrick Candy, John Devar, Jones Omoshoro-Jones, Martin Smith & Ekene Emmanuel Nweke. (2021) Targeting Growth Factor Signaling Pathways in Pancreatic Cancer: Towards Inhibiting Chemoresistance. Frontiers in Oncology 11.
Crossref
Crossref
Emily Murrell, Junchao Tong, David Smil, Taira Kiyota, Ahmed M. Aman, Methvin B. Isaac, Iain D. G. Watson & Neil Vasdev. (2021)
Leveraging Open Science Drug Development for PET: Preliminary Neuroimaging of
11
C-Labeled ALK2 Inhibitors
. ACS Medicinal Chemistry Letters 12:5, pages 846-850.
Crossref
Crossref
Sara Cherri, Silvia Noventa & Alberto Zaniboni. (2021) Pancreatic adenocarcinoma: Beyond first line, where are we?. World Journal of Gastroenterology 27:17, pages 1847-1863.
Crossref
Crossref
Jiayang Zhang, Xuesong Zhang, Ziyi Li, Qingshan Wang, Yan Shi, Xian Jiang & Xueying Sun. (2021) The miR-124-3p/Neuropilin-1 Axis Contributes to the Proliferation and Metastasis of Triple-Negative Breast Cancer Cells and Co-Activates the TGF-β Pathway. Frontiers in Oncology 11.
Crossref
Crossref
Evzen Krepela, Zdislava Vanickova, Petr Hrabal, Michal Zubal, Barbora Chmielova, Eva Balaziova, Petr Vymola, Ivana Matrasova, Petr Busek & Aleksi Sedo. (2021) Regulation of Fibroblast Activation Protein by Transforming Growth Factor Beta-1 in Glioblastoma Microenvironment. International Journal of Molecular Sciences 22:3, pages 1046.
Crossref
Crossref
Verónica Gómez-Gil. (2021) Therapeutic Implications of TGFβ in Cancer Treatment: A Systematic Review. Cancers 13:3, pages 379.
Crossref
Crossref
Yaoyao Shi, Katarzyna Tomczak, June Li, Joshua K. Ochieng, Younghee Lee & Cara Haymaker. (2021) Next-Generation Immunotherapies to Improve Anticancer Immunity. Frontiers in Pharmacology 11.
Crossref
Crossref
Ho-Jae Lee. (2020) Recent Advances in the Development of TGF-β Signaling Inhibitors for Anticancer Therapy. Journal of Cancer Prevention 25:4, pages 213-222.
Crossref
Crossref
Antje Wick, Annick Desjardins, Cristina Suarez, Peter Forsyth, Ivelina Gueorguieva, Tiana Burkholder, Ann Louise Cleverly, Shawn T. Estrem, Shuaicheng Wang, Michael M. Lahn, Susan C. Guba, David Capper & Jordi Rodon. (2020) Phase 1b/2a study of galunisertib, a small molecule inhibitor of transforming growth factor-beta receptor I, in combination with standard temozolomide-based radiochemotherapy in patients with newly diagnosed malignant glioma. Investigational New Drugs 38:5, pages 1570-1579.
Crossref
Crossref
Debolina Ganguly, Raghav Chandra, John Karalis, Martha Teke, Todd Aguilera, Ravikanth Maddipati, Megan B. Wachsmann, Dario Ghersi, Giulia Siravegna, Herbert J. ZehIIIIII, Rolf Brekken, David T. Ting & Matteo Ligorio. (2020) Cancer-Associated Fibroblasts: Versatile Players in the Tumor Microenvironment. Cancers 12:9, pages 2652.
Crossref
Crossref
David Smil, Jong Fu Wong, Eleanor P. Williams, Roslin J. Adamson, Alison Howarth, David A. McLeod, Ahmed Mamai, Soyoung Kim, Brian J. Wilson, Taira Kiyota, Ahmed Aman, Julie Owen, Gennady Poda, Kurumi Y. Horiuchi, Ekaterina Kuznetsova, Haiching Ma, J. Nicole Hamblin, Sue Cramp, Owen G. Roberts, Aled M. Edwards, David Uehling, Rima Al-awar, Alex N. Bullock, Jeff A. O’Meara & Methvin B. Isaac. (2020) Leveraging an Open Science Drug Discovery Model to Develop CNS-Penetrant ALK2 Inhibitors for the Treatment of Diffuse Intrinsic Pontine Glioma. Journal of Medicinal Chemistry 63:17, pages 10061-10085.
Crossref
Crossref
Wenjian Chen, Junfa Yang, Hui Fang, Lei Li & Jun Sun. (2020) Relevance Function of Linc-ROR in the Pathogenesis of Cancer. Frontiers in Cell and Developmental Biology 8.
Crossref
Crossref
Shin Foong Ngiow & Arabella Young. (2020) Re-education of the Tumor Microenvironment With Targeted Therapies and Immunotherapies. Frontiers in Immunology 11.
Crossref
Crossref
M. C. Wilkes, K. Siva, J. Chen, G. Varetti, M. Y. Youn, H. Chae, F. Ek, R. Olsson, T. Lundbäck, D. P. Dever, T. Nishimura, A. Narla, B. Glader, H. Nakauchi, M. H. Porteus, C. E. Repellin, H. T. Gazda, S. Lin, M. Serrano, J. Flygare & K. M. Sakamoto. (2020) Diamond Blackfan anemia is mediated by hyperactive Nemo-like kinase. Nature Communications 11:1.
Crossref
Crossref
Agnieszka Dominiak, Beata Chełstowska, Wioletta Olejarz & Grażyna Nowicka. (2020) Communication in the Cancer Microenvironment as a Target for Therapeutic Interventions. Cancers 12:5, pages 1232.
Crossref
Crossref
Deeba Ensan, David Smil, Carlos A. Zepeda-Velázquez, Dimitrios Panagopoulos, Jong Fu WongEleanor P. WilliamsRoslin AdamsonAlex N. BullockTaira Kiyota, Ahmed Aman, Owen G. Roberts, Aled M. Edwards, Jeff A. O’Meara, Methvin B. Isaac & Rima Al-awar. (2020) Targeting ALK2: An Open Science Approach to Developing Therapeutics for the Treatment of Diffuse Intrinsic Pontine Glioma. Journal of Medicinal Chemistry 63:9, pages 4978-4996.
Crossref
Crossref
Thomas Hanke, Jong Fu Wong, Benedict-Tilman Berger, Ismahan Abdi, Lena Marie Berger, Roberta Tesch, Claudia Tredup, Alex N. Bullock, Susanne Müller & Stefan Knapp. (2020) A Highly Selective Chemical Probe for Activin Receptor-like Kinases ALK4 and ALK5. ACS Chemical Biology 15:4, pages 862-870.
Crossref
Crossref
Andrew J. Gunderson, Tomoko Yamazaki, Kayla McCarty, Nathaniel Fox, Michaela Phillips, Alejandro Alice, Tiffany Blair, Mark Whiteford, David O’Brien, Rehan Ahmad, Maria X. Kiely, Amanda Hayman, Todd Crocenzi, Michael J. Gough, Marka R. Crittenden & Kristina H. Young. (2020) TGFβ suppresses CD8+ T cell expression of CXCR3 and tumor trafficking. Nature Communications 11:1.
Crossref
Crossref
Upender Velaparthi, Chetan Padmakar Darne, Jayakumar Warrier, Peiying Liu, Hasibur Rahaman, Karen Augustine-Rauch, Karen Parrish, Zheng Yang, Jesse Swanson, Jennifer Brown, Gopal Dhar, Aravind Anandam, Vinay K. Holenarsipur, Kamalavenkatesh Palanisamy, Barri S. Wautlet, Mark P. Fereshteh, Jonathan Lippy, Andrew J. Tebben, Steven Sheriff, Max Ruzanov, Chunhong Yan, Anuradha Gupta, Arun Kumar Gupta, Muthalagu Vetrichelvan, Arvind Mathur, Marina Gelman, Rajinder Singh, Todd Kinsella, Anwar Murtaza, Joseph Fargnoli, Gregory Vite & Robert M. Borzilleri. (2020) Discovery of BMS-986260, a Potent, Selective, and Orally Bioavailable TGFβR1 Inhibitor as an Immuno-oncology Agent. ACS Medicinal Chemistry Letters 11:2, pages 172-178.
Crossref
Crossref
Jeong-Ho Park, Min-Seob Kim, Seokran Ham, Eon Sub Park, Koung Li Kim & Wonhee Suh. (2020) Transforming Growth Factor β Receptor Type I Inhibitor, Galunisertib, Has No Beneficial Effects on Aneurysmal Pathological Changes in Marfan Mice. Biomolecules & Therapeutics 28:1, pages 98-103.
Crossref
Crossref
Yuanke Li, Zhen Zhao, Hao Liu, John Peter Fetse, Akshay Jain, Chien-Yu Lin & Kun Cheng. (2019) Development of a Tumor-Responsive Nanopolyplex Targeting Pancreatic Cancer Cells and Stroma. ACS Applied Materials & Interfaces 11:49, pages 45390-45403.
Crossref
Crossref
Linh Huynh, Christopher Hipolito & Peter ten Dijke. (2019) A Perspective on the Development of TGF-β Inhibitors for Cancer Treatment. Biomolecules 9:11, pages 743.
Crossref
Crossref
Ivelina Gueorguieva, Josep Tabernero, Davide Melisi, Teresa Macarulla, Valeria Merz, Timothy H. Waterhouse, Colin Miles, Michael M. Lahn, Ann Cleverly & Karim A. Benhadji. (2019) Population pharmacokinetics and exposure–overall survival analysis of the transforming growth factor-β inhibitor galunisertib in patients with pancreatic cancer. Cancer Chemotherapy and Pharmacology 84:5, pages 1003-1015.
Crossref
Crossref
Xuan Zhu, Lijie Chen, Ling Liu & Xing Niu. (2019) EMT-Mediated Acquired EGFR-TKI Resistance in NSCLC: Mechanisms and Strategies. Frontiers in Oncology 9.
Crossref
Crossref
Rajni M. Bhardwaj, Jennifer A. McMahon, Jonas Nyman, Louise S. Price, Sumit Konar, Iain D. H. Oswald, Colin R. Pulham, Sarah L. Price & Susan M. Reutzel-Edens. (2019) A Prolific Solvate Former, Galunisertib, under the Pressure of Crystal Structure Prediction, Produces Ten Diverse Polymorphs. Journal of the American Chemical Society 141:35, pages 13887-13897.
Crossref
Crossref
Brown & Marshall. (2019) Integrin-Mediated TGFβ Activation Modulates the Tumour Microenvironment. Cancers 11:9, pages 1221.
Crossref
Crossref
Alex Bataller, Guillermo Montalban-Bravo, Kelly A. Soltysiak & Guillermo Garcia-Manero. (2019) The role of TGFβ in hematopoiesis and myeloid disorders. Leukemia 33:5, pages 1076-1089.
Crossref
Crossref
Bernardo Rapoport & Ronald Anderson. (2019) Realizing the Clinical Potential of Immunogenic Cell Death in Cancer Chemotherapy and Radiotherapy. International Journal of Molecular Sciences 20:4, pages 959.
Crossref
Crossref
Shweta Joshi & Donald L. Durden. (2019) Combinatorial Approach to Improve Cancer Immunotherapy: Rational Drug Design Strategy to Simultaneously Hit Multiple Targets to Kill Tumor Cells and to Activate the Immune System. Journal of Oncology 2019, pages 1-18.
Crossref
Crossref
Charlotte Alexandra Mitz & Alicia Mercedes Viloria-Petit. (2019) TGF-beta signalling in bovine mammary gland involution and a comparative assessment of MAC-T and BME-UV1 cells as in vitro models for its study. PeerJ 6, pages e6210.
Crossref
Crossref
Katherine E. Liu. (2018) Rethinking Causation in Cancer with Evolutionary Developmental Biology. Biological Theory 13:4, pages 228-242.
Crossref
Crossref
Arjan van Caam, Madelon Vonk, Frank van den Hoogen, Peter van Lent & Peter van der Kraan. (2018) Unraveling SSc Pathophysiology; The Myofibroblast. Frontiers in Immunology 9.
Crossref
Crossref
Yong Zhang, Yufen Zhao, Andrew J. Tebben, Steven Sheriff, Max Ruzanov, Mark P. Fereshteh, Yi Fan, Jonathan Lippy, Jesse Swanson, Ching-Ping Ho, Barri S. Wautlet, Anne Rose, Karen Parrish, Zheng Yang, Andrew F. Donnell, Liping Zhang, Brian E. Fink, Gregory D. Vite, Karen Augustine-Rauch, Joseph Fargnoli & Robert M. Borzilleri. (2018) Discovery of 4-Azaindole Inhibitors of TGFβRI as Immuno-oncology Agents. ACS Medicinal Chemistry Letters 9:11, pages 1117-1122.
Crossref
Crossref
Bin Han, Fang-yuan Mao, Yong-liang Zhao, Yi-pin Lv, Yong-sheng Teng, Mubing Duan, Weisan Chen, Ping Cheng, Ting-ting Wang, Zhong-yuan Liang, Jin-yu Zhang, Yu-gang Liu, Gang Guo, Quan-ming Zou, Yuan Zhuang & Liu-sheng Peng. (2018) Altered NKp30, NKp46, NKG2D, and DNAM-1 Expression on Circulating NK Cells Is Associated with Tumor Progression in Human Gastric Cancer. Journal of Immunology Research 2018, pages 1-9.
Crossref
Crossref
Qing Zhang, Xiaonan Hou, Bradley Evans, Jamison VanBlaricom, Saravut Weroha & William Cliby. (2018) LY2157299 Monohydrate, a TGF-βR1 Inhibitor, Suppresses Tumor Growth and Ascites Development in Ovarian Cancer. Cancers 10:8, pages 260.
Crossref
Crossref
Yangyang Liu, Yadi Cai, Li Liu, Yudong Wu & Xiangyang Xiong. (2018) Crucial biological functions of CCL7 in cancer. PeerJ 6, pages e4928.
Crossref
Crossref
Amira Ouanouki, Sylvie Lamy & Borhane Annabi. (2018) Periostin, a signal transduction intermediate in TGF-β-induced EMT in U-87MG human glioblastoma cells, and its inhibition by anthocyanidins. Oncotarget 9:31, pages 22023-22037.
Crossref
Crossref
Jonathan M. Yingling, William T. McMillen, Lei Yan, Huocong Huang, J. Scott Sawyer, Jeremy Graff, David K. Clawson, Karen S. Britt, Bryan D. Anderson, Douglas W. Beight, Durisala Desaiah, Michael M. Lahn, Karim A. Benhadji, Maria J. Lallena, Rikke B. Holmgaard, Xiaohong Xu, Faming Zhang, Jason R. Manro, Philip W. Iversen, Chandrasekar V. Iyer, Rolf A. Brekken, Michael D. Kalos & Kyla E. Driscoll. (2017) Preclinical assessment of galunisertib (LY2157299 monohydrate), a first-in-class transforming growth factor-β receptor type I inhibitor. Oncotarget 9:6, pages 6659-6677.
Crossref
Crossref
Ajay P. Nayak, Deepak A. Deshpande & Raymond B. Penn. (2018) New targets for resolution of airway remodeling in obstructive lung diseases. F1000Research 7, pages 680.
Crossref
Crossref
Anna Mies, Amit Verma & Uwe Platzbecker. 2018. Myelodysplastic Syndromes. Myelodysplastic Syndromes
97
104
.
Jan L. Christian & Carl-Henrik Heldin. (2017) The TGFβ superfamily in Lisbon: navigating through development and disease. Development 144:24, pages 4476-4480.
Crossref
Crossref
Qi Wu, Ying Tian, Jingqiu Zhang, Hongpeng Zhang, Fengming Gu, Yongdie Lu, Shengnan Zou, Yuji Chen, Pengxiang Sun, Mengyue Xu, Xiaoming Sun, Chao Xia, Hao Chi, A Ying Zhu, Dong Tang & Daorong Wang. (2017) Functions of pancreatic stellate cell-derived soluble factors in the microenvironment of pancreatic ductal carcinoma. Oncotarget 8:60, pages 102721-102738.
Crossref
Crossref
Sugandha Bhatia, James Monkman, Alan Kie Leong Toh, Shivashankar H. Nagaraj & Erik W. Thompson. (2017) Targeting epithelial–mesenchymal plasticity in cancer: clinical and preclinical advances in therapy and monitoring. Biochemical Journal 474:19, pages 3269-3306.
Crossref
Crossref
Maria Villalba, Stephanie R. Evans, Fernando Vidal-Vanaclocha & Alfonso Calvo. (2017) Role of TGF-β in metastatic colon cancer: it is finally time for targeted therapy. Cell and Tissue Research 370:1, pages 29-39.
Crossref
Crossref
Masafumi Ikeda, Hideaki Takahashi, Shunsuke Kondo, Michael Mauritius Fabio Lahn, Ken Ogasawara, Karim A. Benhadji, Hisaki Fujii & Hideki Ueno. (2017) Phase 1b study of galunisertib in combination with gemcitabine in Japanese patients with metastatic or locally advanced pancreatic cancer. Cancer Chemotherapy and Pharmacology 79:6, pages 1169-1177.
Crossref
Crossref
Yiran Zheng, Li Tang, Llian Mabardi, Sudha Kumari & Darrell J. Irvine. (2017) Enhancing Adoptive Cell Therapy of Cancer through Targeted Delivery of Small-Molecule Immunomodulators to Internalizing or Noninternalizing Receptors. ACS Nano 11:3, pages 3089-3100.
Crossref
Crossref
Devon M Fitzgerald & Susan M Rosenberg. (2017) Driving cancer evolution. eLife 6.
Crossref
Crossref
Janusz Franco-Barraza, Ralph Francescone, Tiffany Luong, Neelima Shah, Raj Madhani, Gil Cukierman, Essel Dulaimi, Karthik Devarajan, Brian L Egleston, Emmanuelle Nicolas, R Katherine Alpaugh, Ruchi Malik, Robert G Uzzo, John P Hoffman, Erica A Golemis & Edna Cukierman. (2017) Matrix-regulated integrin αvβ5 maintains α5β1-dependent desmoplastic traits prognostic of neoplastic recurrence. eLife 6.
Crossref
Crossref
Lindsay C. Spender & Gareth J. Inman. (2017) Targeting BRAF-mutant tumours with TGFBR1 inhibitors. Aging 9:1, pages 5-6.
Crossref
Crossref
Boyuan Huang, Hongbo Zhang, Lijuan Gu, Bainxin Ye, Zhihong Jian, Creed Stary & Xiaoxing Xiong. (2017) Advances in Immunotherapy for Glioblastoma Multiforme. Journal of Immunology Research 2017, pages 1-11.
Crossref
Crossref
Amanda Tivnan, Tatjana Heilinger, Ed C. Lavelle & Jochen H. M. Prehn. (2016) Advances in immunotherapy for the treatment of glioblastoma. Journal of Neuro-Oncology 131:1, pages 1-9.
Crossref
Crossref
Sioned Owen, Catherine Zabkiewicz, Lin Ye, Andrew J. Sanders, Chang Gong & Wen G. Jiang. 2017. Translational Research in Breast Cancer. Translational Research in Breast Cancer
197
216
.
Juan Du, Yu Yu, Jun Zhan & Hongquan Zhang. 2017. Translational Research in Breast Cancer. Translational Research in Breast Cancer
125
146
.
Lindsay C. Spender, G. John Ferguson, Sijia Liu, Chao Cui, Maria Romina Girotti, Gary Sibbet, Ellen B. Higgs, Morven K. Shuttleworth, Tom Hamilton, Paul Lorigan, Michael Weller, David F. Vincent, Owen J. Sansom, Margaret Frame, Peter ten Dijke, Richard Marais & Gareth J. Inman. (2016) Mutational activation of BRAF confers sensitivity to transforming growth factor beta inhibitors in human cancer cells. Oncotarget 7:50, pages 81995-82012.
Crossref
Crossref
Lukáš Tenora, Juraj Galeta, Eva Řezníčková, Vladimír Kryštof & Milan Potáček. (2016)
Application of Pd-Catalyzed Cross-Coupling Reactions in the Synthesis of 5,5-Dimethyl-5,6-dihydro-4
H
-pyrrolo[1,2-
b
]pyrazoles that Inhibit ALK5 Kinase
. The Journal of Organic Chemistry 81:23, pages 11841-11856.
Crossref
Crossref
Timothy P. Heffron. (2016) Small Molecule Kinase Inhibitors for the Treatment of Brain Cancer. Journal of Medicinal Chemistry 59:22, pages 10030-10066.
Crossref
Crossref
Ying Qu, Bo Zhou, Wei Yang, Bingchen Han, Yi Yu-Rice, Bowen Gao, Jeffery Johnson, Clive N. Svendsen, Michael R. Freeman, Armando E. Giuliano, Dhruv Sareen & Xiaojiang Cui. (2016) Transcriptome and proteome characterization of surface ectoderm cells differentiated from human iPSCs. Scientific Reports 6:1.
Crossref
Crossref